Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T35862 | Target Info | |||
| Target Name | Lung surfactant protein D (SFTPD) | ||||
| Synonyms | SP-D; SFTP4; Pulmonary surfactant-associated protein D; PSPD; PSP-D; Collectin-7; COLEC7 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SFTPD | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Myo-inositol | Ligand Info | |||||
| Structure Description | crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with myoinositol | PDB:2OS9 | ||||
| Method | X-ray diffraction | Resolution | 1.70 Å | Mutation | No | [1] |
| PDB Sequence |
ASLRQQVEAL
214 QGQVQHLQAA224 FSQYKKVELF234 PNGQSVGEKI244 FKTAGFVKPF254 TEAQLLCTQA 264 GGQLASPRSA274 AENAALQQLV284 VAKNEAAFLS294 MTDSKTEGKF304 TYPTGESLVY 314 SNWAPGEPND324 DGGSEDCVEI334 FTNGKWNDRA344 CGEKRLVVCE354 F |
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| Ligand Name: Alpha-D-Mannose | Ligand Info | |||||
| Structure Description | Crystal structure of alpha 1-4 mannobiose bound trimeric human lung surfactant protein D | PDB:3IKR | ||||
| Method | X-ray diffraction | Resolution | 1.65 Å | Mutation | Yes | [2] |
| PDB Sequence |
VASLRQQVEA
213 LQGQVQHLQA223 AFSQYKKVEL233 FPNGQSVGEK243 IFKTAGFVKP253 FTEAQLLCTQ 263 AGGQLASPRS273 AAENAALQQL283 VVAKNEAAFL293 SMTDSKTEGK303 FTYPTGESLV 313 YSNWAPGEPN323 DDGGSEDCVE333 IFTNGKWNDR343 ACGEKRLVVC353 EF |
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: beta-D-galactose | Ligand Info | |||||
| Structure Description | Crystal structure of galactose bound trimeric human lung surfactant protein D | PDB:3IKN | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | Yes | [2] |
| PDB Sequence |
VASLRQQVEA
213 LQGQVQHLQA223 AFSQYKKVEL233 FPNGQSVGEK243 IFKTAGFVKP253 FTEAQLLCTQ 263 AGGQLASPRS273 AAENAALQQL283 VVAKNEAAFL293 SMTDSKTEGK303 FTYPTGESLV 313 YSNWAPGEPN323 DDGGSEDCVE333 IFTNGKWNDR343 ACGEKRLVVC353 EF |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GAL or .GAL2 or .GAL3 or :3GAL;style chemicals stick;color identity;select .A:321 or .A:323 or .A:325 or .A:329 or .A:341 or .A:342 or .A:343; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: (2s,4r,5s,6r)-6-((S)-1,2-Dihydroxyethyl)tetrahydro-2h-Pyran-2,4,5-Triol | Ligand Info | |||||
| Structure Description | Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with 2-deoxy-L-glycero-D-manno-heptose | PDB:2RIE | ||||
| Method | X-ray diffraction | Resolution | 1.60 Å | Mutation | No | [3] |
| PDB Sequence |
VEALQGQVQH
220 LQAAFSQYKK230 VELFPNGQSV240 GEKIFKTAGF250 VKPFTEAQLL260 CTQAGGQLAS 270 PRSAAENAAL280 QQLVVAKNEA290 AFLSMTDSKT300 EGKFTYPTGE310 SLVYSNWAPG 320 EPNDDGGSED330 CVEIFTNGKW340 NDRACGEKRL350 VVCEF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .293 or .2932 or .2933 or :3293;style chemicals stick;color identity;select .A:321 or .A:323 or .A:325 or .A:329 or .A:341 or .A:342 or .A:343; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 2-(Acetylamino)-2-deoxy-alpha-D-mannopyranose | Ligand Info | |||||
| Structure Description | crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with N-acetyl mannosamine | PDB:2ORJ | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [1] |
| PDB Sequence |
ASLRQQVEAL
214 QGQVQHLQAA224 FSQYKKVELF234 PNGQSVGEKI244 FKTAGFVKPF254 TEAQLLCTQA 264 GGQLASPRSA274 AENAALQQLV284 VAKNEAAFLS294 MTDSKTEGKF304 TYPTGESLVY 314 SNWAPGEPND324 DGGSEDCVEI334 FTNGKWNDRA344 CGEKRLVVCE354 F |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .BM3 or .BM32 or .BM33 or :3BM3;style chemicals stick;color identity;select .A:321 or .A:323 or .A:325 or .A:329 or .A:341 or .A:342 or .A:343; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: D-glycero-alpha-D-manno-heptopyranose | Ligand Info | |||||
| Structure Description | Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with D-glycero-D-manno-heptose | PDB:2RIA | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [3] |
| PDB Sequence |
QVEALQGQVQ
219 HLQAAFSQYK229 KVELFPNGQS239 VGEKIFKTAG249 FVKPFTEAQL259 LCTQAGGQLA 269 SPRSAAENAA279 LQQLVVAKNE289 AAFLSMTDSK299 TEGKFTYPTG309 ESLVYSNWAP 319 GEPNDDGGSE329 DCVEIFTNGK339 WNDRACGEKR349 LVVCEF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .289 or .2892 or .2893 or :3289;style chemicals stick;color identity;select .A:321 or .A:323 or .A:325 or .A:329 or .A:335 or .A:341 or .A:342 or .A:343; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: L-glycero-alpha-D-manno-Heptopyranose | Ligand Info | |||||
| Structure Description | Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with L-glycero-D-manno-heptose | PDB:2RIB | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [3] |
| PDB Sequence |
SLRQQVEALQ
215 GQVQHLQAAF225 SQYKKVELFP235 NGQSVGEKIF245 KTAGFVKPFT255 EAQLLCTQAG 265 GQLASPRSAA275 ENAALQQLVV285 AKNEAAFLSM295 TDSKTEGKFT305 YPTGESLVYS 315 NWAPGEPNDD325 GGSEDCVEIF335 TNGKWNDRAC345 GEKRLVVCEF355 |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .GMH or .GMH2 or .GMH3 or :3GMH;style chemicals stick;color identity;select .A:321 or .A:323 or .A:325 or .A:329 or .A:341 or .A:342 or .A:343; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Methyl alpha-D-mannopyranoside | Ligand Info | |||||
| Structure Description | Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with alpha methyl mannoside | PDB:3G81 | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [4] |
| PDB Sequence |
ASLRQQVEAL
214 QGQVQHLQAA224 FSQYKKVELF234 PNGQSVGEKI244 FKTAGFVKPF254 TEAQLLCTQA 264 GGQLASPRSA274 AENAALQQLV284 VAKNEAAFLS294 MTDSKTEGKF304 TYPTGESLVY 314 SNWAPGEPND324 DGGSEDCVEI334 FTNGKWNDRA344 CGEKRLVVCE354 F |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MMA or .MMA2 or .MMA3 or :3MMA;style chemicals stick;color identity;select .A:321 or .A:323 or .A:325 or .A:329 or .A:335 or .A:341 or .A:342 or .A:343; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: Prop-2-En-1-Yl 7-O-Carbamoyl-L-Glycero-Alpha-D-Manno-Heptopyranoside | Ligand Info | |||||
| Structure Description | Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with Allyl 7-O-carbamoyl-L-glycero-D-manno-heptopyranoside | PDB:2RID | ||||
| Method | X-ray diffraction | Resolution | 1.80 Å | Mutation | No | [3] |
| PDB Sequence |
QQVEALQGQV
218 QHLQAAFSQY228 KKVELFPNGQ238 SVGEKIFKTA248 GFVKPFTEAQ258 LLCTQAGGQL 268 ASPRSAAENA278 ALQQLVVAKN288 EAAFLSMTDS298 KTEGKFTYPT308 GESLVYSNWA 318 PGEPNDDGGS328 EDCVEIFTNG338 KWNDRACGEK348 RLVVCEF
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .291 or .2912 or .2913 or :3291;style chemicals stick;color identity;select .A:321 or .A:323 or .A:325 or .A:329 or .A:335 or .A:341 or .A:342 or .A:343 or .A:347 or .A:349; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| Ligand Name: 4-Nitrophenyl 4-O-alpha-D-glucopyranosyl-alpha-D-galactopyranoside | Ligand Info | |||||
| Structure Description | Crystal structure of the trimer neck and carbohydrate recognition domain of human surfactant protein D in complex with p-nitrophenyl maltoside | PDB:2GGX | ||||
| Method | X-ray diffraction | Resolution | 1.90 Å | Mutation | No | [5] |
| PDB Sequence |
ASLRQQVEAL
214 QGQVQHLQAA224 FSQYKKVELF234 PNGQSVGEKI244 FKTAGFVKPF254 TEAQLLCTQA 264 GGQLASPRSA274 AENAALQQLV284 VAKNEAAFLS294 MTDSKTEGKF304 TYPTGESLVY 314 SNWAPGEPND324 DGGSEDCVEI334 FTNGKWNDRA344 CGEKRLVVCE354 F |
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .NPJ or .NPJ2 or .NPJ3 or :3NPJ;style chemicals stick;color identity;select .A:321 or .A:323 or .A:325 or .A:329 or .A:333 or .A:335 or .A:336 or .A:337 or .A:341 or .A:342 or .A:343; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Critical role of Arg/Lys343 in the species-dependent recognition of phosphatidylinositol by pulmonary surfactant protein D. Biochemistry. 2007 May 1;46(17):5160-9. | ||||
| REF 2 | Structural characterisation of ligand-binding determinants in human lung surfactant protein D: influence of Asp325. J Mol Biol. 2009 Dec 11;394(4):776-88. | ||||
| REF 3 | Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d. Biochemistry. 2008 Jan 15;47(2):710-20. | ||||
| REF 4 | Recognition of mannosylated ligands and influenza A virus by human surfactant protein D: contributions of an extended site and residue 343. Biochemistry. 2009 Apr 21;48(15):3335-45. | ||||
| REF 5 | Contributions of phenylalanine 335 to ligand recognition by human surfactant protein D: ring interactions with SP-D ligands. J Biol Chem. 2006 Jun 30;281(26):18008-14. | ||||
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