Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T35862 | Target Info | |||
| Target Name | Lung surfactant protein D (SFTPD) | ||||
| Synonyms | SP-D; SFTP4; Pulmonary surfactant-associated protein D; PSPD; PSP-D; Collectin-7; COLEC7 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SFTPD | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Alpha-D-Mannose | Ligand Info | |||
| Canonical SMILES | C(C1C(C(C(C(O1)O)O)O)O)O | ||||
| InChI | 1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1 | ||||
| InChIKey | WQZGKKKJIJFFOK-PQMKYFCFSA-N | ||||
| PubChem Compound ID | 185698 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 3IKR Crystal structure of alpha 1-4 mannobiose bound trimeric human lung surfactant protein D | ||||||
| Method | X-ray diffraction | Resolution | 1.65 Å | Mutation | Yes | [1] |
| PDB Sequence |
VASLRQQVEA
213 LQGQVQHLQA223 AFSQYKKVEL233 FPNGQSVGEK243 IFKTAGFVKP253 FTEAQLLCTQ 263 AGGQLASPRS273 AAENAALQQL283 VVAKNEAAFL293 SMTDSKTEGK303 FTYPTGESLV 313 YSNWAPGEPN323 DDGGSEDCVE333 IFTNGKWNDR343 ACGEKRLVVC353 EF |
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| PDB ID: 3IKQ Crystal structure of alpha 1-2 mannobiose bound trimeric human lung surfactant protein D | ||||||
| Method | X-ray diffraction | Resolution | 2.25 Å | Mutation | Yes | [1] |
| PDB Sequence |
QVEALQGQVQ
219 HLQAAFSQYK229 KVELFPNGQS239 VGEKIFKTAG249 FVKPFTEAQL259 LCTQAGGQLA 269 SPRSAAENAA279 LQQLVVAKNE289 AAFLSMTDSK299 TEGKFTYPTG309 ESLVYSNWAP 319 GEPNDDGGSE329 DCVEIFTNGK339 WNDRACGEKR349 LVVCEF
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural characterisation of ligand-binding determinants in human lung surfactant protein D: influence of Asp325. J Mol Biol. 2009 Dec 11;394(4):776-88. | ||||
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