Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T35862 Target Info
Target Name Lung surfactant protein D (SFTPD)
Synonyms SP-D; SFTP4; Pulmonary surfactant-associated protein D; PSPD; PSP-D; Collectin-7; COLEC7
Target Type Literature-reported Target
Gene Name SFTPD
UniProt ID
SFTPD_HUMAN
Ligand General Information  Top
Ligand Name L-glycero-alpha-D-manno-Heptopyranose Ligand Info
Canonical SMILES C(C(C1C(C(C(C(O1)O)O)O)O)O)O
InChI 1S/C7H14O7/c8-1-2(9)6-4(11)3(10)5(12)7(13)14-6/h2-13H,1H2/t2-,3-,4-,5-,6+,7-/m0/s1
InChIKey BGWQRWREUZVRGI-QQABCQGCSA-N
PubChem Compound ID 125414
Drug Binding Sites of Target  Top
PDB ID: 2RIB      Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with L-glycero-D-manno-heptose
Method X-ray diffraction Resolution 1.80 Å Mutation No [1]
PDB Sequence
SLRQQVEALQ
215
GQVQHLQAAF
225
SQYKKVELFP
235
NGQSVGEKIF
245
KTAGFVKPFT
255

EAQLLCTQAG
265
GQLASPRSAA
275
ENAALQQLVV
285
AKNEAAFLSM
295
TDSKTEGKFT
305

YPTGESLVYS
315
NWAPGEPNDD
325
GGSEDCVEIF
335
TNGKWNDRAC
345
GEKRLVVCEF
355
Residue
Distance (Å)
GLU321
2.505
ASN323
3.191
ASP325
3.349
GLU329
2.685
Residue
Distance (Å)
ASN341
2.976
ASP342
3.423
ARG343
3.574
PDB ID: 2RIC      Crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with L-glycero-D-manno-heptopyranosyl-(1-3)-L-glycero-D-manno-heptopyranose
Method X-ray diffraction Resolution 1.80 Å Mutation No [1]
PDB Sequence
GSDVASLRQQ
210
VEALQGQVQH
220
LQAAFSQYKK
230
VELFPNGQSV
240
GEKIFKTAGF
250

VKPFTEAQLL
260
CTQAGGQLAS
270
PRSAAENAAL
280
QQLVVAKNEA
290
AFLSMTDSKT
300

EGKFTYPTGE
310
SLVYSNWAPG
320
EPNDDGGSED
330
CVEIFTNGKW
340
NDRACGEKRL
350

VVCEF
Residue
Distance (Å)
GLU321
2.604
ASN323
3.346
ASP325
3.551
GLU329
2.652
Residue
Distance (Å)
ASN341
2.990
ASP342
3.685
ARG343
3.519
References  Top
REF 1 Recognition of heptoses and the inner core of bacterial lipopolysaccharides by surfactant protein d. Biochemistry. 2008 Jan 15;47(2):710-20.

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