Binding Site Information of Target
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T12119 | Target Info | |||
| Target Name | Voltage-gated sodium channel alpha Nav1.7 (SCN9A) | ||||
| Synonyms | hNE-Na; Voltage-gated sodium channel subunit alpha Nav1.7; Sodium channel proteintype IX subunit alpha; Sodium channel proteintype 9 subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel protein type 9 subunit alpha; Peripheral sodium channel 1; PN1; Neuroendocrine sodium channel; NENA | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | SCN9A | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| Ligand Name: Tetrodotoxin | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (S6IV pi helix conformer) | PDB:7W9M | ||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | Yes | [1] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNNVS211 ALRTFRVLRA221 LKTISVIPGL 231 KTIVGALIQS241 VKKLSDVMIL251 TVFCLSVFAL261 IGLQLFMGNL271 KHKCFRNSLE 281 NNETLESIMN291 TLESEEDFRK301 YFYYLEGSKD311 ALLCGFSTDS321 GQCPEGYTCV 331 KIGRNPDYGY341 TSFDTFSWAF351 LALFRLMTQD361 YWENLYQQTL371 RAAGKTYMIF 381 FVVVIFLGSF391 YLINLILAVV401 AMAYKEQNQA411 NIEEAKQKEL421 EFQQMLDRLK 431 KEQEPYWIKF733 KKCIYFIVMD743 PFVDLAITIC753 IVLNTLFMAM763 EHHPMTEEFK 773 NVLAIGNLVF783 TGIFAAEMVL793 KLIAMDPYEY803 FQVGWNIFDS813 LIVTLSLVEL 823 FLADVEGLSV833 LRSFRLLRVF843 KLAKSWPTLN853 MLIKIIGNSV863 GALGNLTLVL 873 AIIVFIFAVV883 GMQLFGKSYK893 ECVCKINDDC903 TLPRWHMNDF913 FHSFLIVFRV 923 LCGEWIETMW933 DCMEVAGQAM943 CLIVYMMVMV953 IGNLVVLNLF963 LALLLSSFSS 973 DNLTAIEEDP983 DANNLQIAVT993 RIKKGINYVK1003 QTLREFILKA1013 FGKIWWNIRK 1183 TCYKIVEHSW1193 FESFIVLMIL1203 LSSGALAFED1213 IYIERKKTIK1223 IILEYADKIF 1233 TYIFILEMLL1243 KWIAYGYKTY1253 FTNAWCWLDF1263 LIVDVSLVTL1273 VANTLGYSDL 1283 GPIKSLRTLR1293 ALRPLRALSR1303 FEGMRVVVNA1313 LIGAIPSIMN1323 VLLVCLIFWL 1333 IFSIMGVNLF1343 AGKFYECINT1353 TDGSRFPASQ1363 VPNRSECFAL1373 MNVSQNVRWK 1383 NLKVNFDNVG1393 LGYLSLLQVA1403 TFKGWTIIMY1413 AAVDSVNVDK1423 QPKYEYSLYM 1433 YIYFVVFIIF1443 GSFFTLNLFI1453 GVIIDNFNQQ1463 KKKLGGQDIF1473 MTEEQKKYYN 1483 AMKKLGSKKP1493 QKPIPRPGNK1503 IQGCIFDLVT1513 NQAFDISIMV1523 LICLNMVTMM 1533 VEKEGQSQHM1543 TEVLYWINVV1553 FIILFTGECV1563 LKLISLRHYY1573 FTVGWNIFDF 1583 VVVIISIVGM1593 FLADLIETYF1603 VSPTLFRVIR1613 LARIGRILRL1623 VKGAKGIRTL 1633 LFALMMSLPA1643 LFNIGLLLFL1653 VMFIYAIFGM1663 SNFAYVKKED1673 GINDMFNFET 1683 FGNSMICLFQ1693 ITTSAGWDGL1703 LAPILNSKPP1713 DCDPKKVHPG1723 SSVEGDCGNP 1733 SVGIFYFVSY1743 IIISFLVVVN1753 MYIAVILENF1763 SVATEESTEP1773 LSEDDFEMFY 1783 EVWEKFDPDA1793 TQFIEFSKLS1803 DFAAALDPPL1813 LIAKPNKVQL1823 IAMDLPMVSG 1833 DRIHCLDILF1843 AFTKRVLGES1853 GEMDSLRSQM1863 EERFMSANPS1873 KVSYEPITTT 1883 LKRKQEDV
|
|||||
|
|
||||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Cholesterol | Ligand Info | |||||
| Structure Description | Human Nav1.7 mutant class-I | PDB:7XVE | ||||
| Method | Electron microscopy | Resolution | 2.70 Å | Mutation | Yes | [2] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVKYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNLGN209 VSALRTFRVL219 RALKTISVIP 229 GLKTIVGALI239 QSVKKLSDVM249 ILTVFCLSVF259 ALIGLQLFMG269 NLKHKCFRNS 279 LENNETLESI289 MNTLESEEDF299 RKYFYYLEGS309 KDALLCGFST319 DSGQCPEGYT 329 CVKIGRNPDY339 GYTSFDTFSW349 AFLALFRLMT359 QDYWENLYQQ369 TLRAAGKTYM 379 IFFVVVIFLG389 SFYLINLILA399 VVAMAYEEQN409 QANIEEAKQK419 ELEFQQMLCS 727 PYWIKFKKCI737 YFIVMDPFVD747 LAITICIVLN757 TLFMAMEHHP767 MTEEFKNVLA 777 IRNLVFTGIF787 AAEMVLKLIA797 MDPYEYFQVG807 WNIFDSLIVT817 LSLVELFGLS 832 VLRSFRLLRV842 FKLAKSWPTL852 NMLIKIIGNS862 VGAFGNLMLV872 LFIIVFIFAV 882 VGMQLFGKSY892 KECVCKINDD902 CTLPRWHMND912 FFHSFLIVFR922 VLCGEWIETM 932 WDCMEVAGQA942 MCLIFYMMVF952 FIGNLVVLNL962 FLALLLSSFS972 SDANNLQIAV 992 TRIKKGINYV1002 KQTLREFILK1012 AFGKIWWNIR1182 KTCYKIVEHS1192 WFESFIVLMI 1202 LLSSGALAFE1212 DIYIERKKTI1222 KIILEYADKI1232 FTYIFILEML1242 LKWIAYGYKT 1252 YFTNAWCWLD1262 FLIVDVSLVT1272 LVANTLGYSD1282 LGPIKSLRTL1292 RALRPLRALS 1302 RFEGMRVVVN1312 ALIGAIPSIM1322 NVLLVCLIFW1332 LIFSIMGVNL1342 FAGKFYECIN 1352 TTDGSRFPAS1362 QVPNRSECFA1372 LMNVSQNVRW1382 KNLKVNFDNV1392 GLGYLSLLQV 1402 ATFKGWTIIM1412 YAAVDSVNVD1422 KQPKYEYSLY1432 MYIYFIFFII1442 FGSFFTLNLF 1452 ICVIIDNFNQ1462 QKKKLGGQDI1472 FMTEEQKKYY1482 NAMKKLGSKK1492 PQKPIPRPGN 1502 KIQGCIFDLV1512 TNQAFDISIM1522 VLICLNMVTM1532 MVEKEGQSQH1542 MTEVLYWINV 1552 VFIILFTGEC1562 VLKLISLRHY1572 YFTVGWNIFD1582 FVVVIISIVG1592 MFLADLIETY 1602 FVSPTLFRVI1612 RLARIGRILR1622 LVKGAKGIRT1632 LLFALMMSLP1642 ALFNIGLLLF 1652 LVMFIYAIFG1662 MSNFAYVKKE1672 DGINDMFNFE1682 TFGNSMICLF1692 QITTSAGWDG 1702 LLAPILNSKP1712 PDCDPKKVHP1722 GSSVEGDCGN1732 PSVGIFYFVS1742 YIIISFLVVV 1752 NMYIAVILEN1762 FSVATE
|
|||||
|
|
ILE228
3.871
PRO229
3.991
VAL833
4.037
PHE837
4.057
VAL863
4.228
GLY864
3.761
GLY867
3.422
ASN868
3.461
MET870
3.826
LEU871
3.901
PHE874
2.515
TYR1250
3.690
LYS1251
3.841
PHE1254
3.525
THR1255
3.430
ASN1256
4.180
|
|||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Lpc-Ether | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution | PDB:7W9K | ||||
| Method | Electron microscopy | Resolution | 2.20 Å | Mutation | No | [1] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNNVS211 ALRTFRVLRA221 LKTISVIPGL 231 KTIVGALIQS241 VKKLSDVMIL251 TVFCLSVFAL261 IGLQLFMGNL271 KHKCFRNSLE 281 NNETLESIMN291 TLESEEDFRK301 YFYYLEGSKD311 ALLCGFSTDS321 GQCPEGYTCV 331 KIGRNPDYGY341 TSFDTFSWAF351 LALFRLMTQD361 YWENLYQQTL371 RAAGKTYMIF 381 FVVVIFLGSF391 YLINLILAVV401 AMAYEEQNQA411 NIEEAKQKEL421 EFQQMLDRLK 431 KEQEPYWIKF733 KKCIYFIVMD743 PFVDLAITIC753 IVLNTLFMAM763 EHHPMTEEFK 773 NVLAIGNLVF783 TGIFAAEMVL793 KLIAMDPYEY803 FQVGWNIFDS813 LIVTLSLVEL 823 FLLSVLRSFR838 LLRVFKLAKS848 WPTLNMLIKI858 IGNSVGALGN868 LTLVLAIIVF 878 IFAVVGMQLF888 GKSYKECVCK898 INDDCTLPRW908 HMNDFFHSFL918 IVFRVLCGEW 928 IETMWDCMEV938 AGQAMCLIVY948 MMVMVIGNLV958 VLNLFLALLL968 SSFSSDNLTA 978 IEEDPDANNL988 QIAVTRIKKG998 INYVKQTLRE1008 FILKAFGKIW1178 WNIRKTCYKI 1188 VEHSWFESFI1198 VLMILLSSGA1208 LAFEDIYIER1218 KKTIKIILEY1228 ADKIFTYIFI 1238 LEMLLKWIAY1248 GYKTYFTNAW1258 CWLDFLIVDV1268 SLVTLVANTL1278 GYSDLGPIKS 1288 LRTLRALRPL1298 RALSRFEGMR1308 VVVNALIGAI1318 PSIMNVLLVC1328 LIFWLIFSIM 1338 GVNLFAGKFY1348 ECINTTDGSR1358 FPASQVPNRS1368 ECFALMNVSQ1378 NVRWKNLKVN 1388 FDNVGLGYLS1398 LLQVATFKGW1408 TIIMYAAVDS1418 VNVDKQPKYE1428 YSLYMYIYFV 1438 VFIIFGSFFT1448 LNLFIGVIID1458 NFNQQKKKLG1468 GQDIFMTEEQ1478 KKYYNAMKKL 1488 GSKKPQKPIP1498 RPGNKIQGCI1508 FDLVTNQAFD1518 ISIMVLICLN1528 MVTMMVEKEG 1538 QSQHMTEVLY1548 WINVVFIILF1558 TGECVLKLIS1568 LRHYYFTVGW1578 NIFDFVVVII 1588 SIVGMFLADL1598 IETYFVSPTL1608 FRVIRLARIG1618 RILRLVKGAK1628 GIRTLLFALM 1638 MSLPALFNIG1648 LLLFLVMFIY1658 AIFGMSNFAY1668 VKKEDGINDM1678 FNFETFGNSM 1688 ICLFQITTSA1698 GWDGLLAPIL1708 NSKPPDCDPK1718 KVHPGSSVEG1728 DCGNPSVGIF 1738 YFVSYIIISF1748 LVVVNMYIAV1758 ILENFSVATE1768 ESTEPLSEDD1778 FEMFYEVWEK 1788 FDPDATQFIE1798 FSKLSDFAAA1808 LDPPLLIAKP1818 NKVQLIAMDL1828 PMVSGDRIHC 1838 LDILFAFTKR1848 VLGESGEMDS1858 LRSQMEERFM1868 SANPSKVSYE1878 PITTTLKRKQ 1888 EDV
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LPE or .LPE2 or .LPE3 or :3LPE;style chemicals stick;color identity;select .A:250 or .A:253 or .A:254 or .A:257 or .A:319 or .A:320 or .A:347 or .A:348 or .A:351 or .A:376 or .A:377 or .A:379 or .A:380 or .A:383 or .A:387 or .A:759 or .A:763 or .A:765 or .A:772 or .A:1178 or .A:1179 or .A:1182 or .A:1187 or .A:1188 or .A:1191 or .A:1193 or .A:1194 or .A:1197 or .A:1203 or .A:1206 or .A:1207 or .A:1210 or .A:1211 or .A:1213 or .A:1215 or .A:1218 or .A:1219 or .A:1239 or .A:1245 or .A:1250 or .A:1251 or .A:1256 or .A:1257 or .A:1258 or .A:1261 or .A:1292 or .A:1295 or .A:1298 or .A:1300 or .A:1301 or .A:1304 or .A:1307 or .A:1311 or .A:1312 or .A:1315 or .A:1329 or .A:1477 or .A:1478 or .A:1481 or .A:1484 or .A:1485 or .A:1488 or .A:1526 or .A:1529 or .A:1533 or .A:1623 or .A:1626 or .A:1627 or .A:1628 or .A:1638 or .A:1641 or .A:1642 or .A:1644 or .A:1645 or .A:1646 or .A:1648 or .A:1650 or .A:1652 or .A:1653 or .A:1654 or .A:1655 or .A:1656 or .A:1657 or .A:1658 or .A:1661 or .A:1683 or .A:1684 or .A:1685 or .A:1686 or .A:1688 or .A:1689 or .A:1692 or .A:1710 or .A:1732 or .A:1733 or .A:1734 or .A:1735 or .A:1737 or .A:1738 or .A:1739 or .A:1741 or .A:1742 or .A:1745 or .A:1746 or .A:1754 or .A:1181; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE250
3.867
VAL253
3.624
PHE254
4.014
SER257
3.565
THR319
4.291
ASP320
2.861
PHE347
3.838
SER348
4.399
PHE351
3.716
LYS376
3.421
THR377
3.131
MET379
3.629
ILE380
4.325
VAL383
3.893
PHE387
3.597
LEU759
4.875
MET763
3.682
HIS765
3.613
PHE772
3.224
TRP1178
3.411
TRP1179
2.856
ARG1182
2.927
LYS1187
3.636
ILE1188
3.373
HIS1191
3.579
TRP1193
3.450
PHE1194
2.754
PHE1197
3.966
LEU1203
3.663
SER1206
3.739
GLY1207
3.852
ALA1210
3.059
PHE1211
3.515
ASP1213
2.921
TYR1215
3.341
ARG1218
3.624
LYS1219
4.265
LEU1239
4.805
TRP1245
4.359
TYR1250
3.102
LYS1251
3.932
ASN1256
4.794
ALA1257
3.400
TRP1258
3.273
LEU1261
4.106
LEU1292
3.415
LEU1295
3.733
LEU1298
3.511
ALA1300
4.009
LEU1301
3.268
PHE1304
3.920
MET1307
3.863
VAL1311
3.309
ASN1312
3.368
ILE1315
3.430
LEU1329
4.770
GLU1477
3.518
GLN1478
2.807
TYR1481
3.401
ALA1484
3.352
MET1485
3.724
LEU1488
3.918
CYS1526
4.560
MET1529
3.799
MET1533
3.292
LEU1623
3.405
GLY1626
3.375
ALA1627
3.316
LYS1628
4.131
MET1638
4.123
LEU1641
3.568
PRO1642
3.282
LEU1644
4.095
PHE1645
3.607
ASN1646
4.349
GLY1648
4.571
LEU1650
3.711
PHE1652
3.608
LEU1653
3.316
VAL1654
3.486
MET1655
3.783
PHE1656
3.769
ILE1657
3.521
TYR1658
3.006
PHE1661
3.098
THR1683
3.478
PHE1684
3.265
GLY1685
3.784
ASN1686
4.065
MET1688
3.902
ILE1689
4.593
PHE1692
4.048
SER1710
3.715
ASN1732
4.418
PRO1733
3.690
SER1734
3.480
VAL1735
4.026
ILE1737
3.623
PHE1738
3.624
TYR1739
3.828
VAL1741
4.060
SER1742
3.935
ILE1745
4.339
ILE1746
4.069
MET1754
4.249
ILE1181
3.854
|
|||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Phosphatidylserine | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution | PDB:7W9K | ||||
| Method | Electron microscopy | Resolution | 2.20 Å | Mutation | No | [1] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNNVS211 ALRTFRVLRA221 LKTISVIPGL 231 KTIVGALIQS241 VKKLSDVMIL251 TVFCLSVFAL261 IGLQLFMGNL271 KHKCFRNSLE 281 NNETLESIMN291 TLESEEDFRK301 YFYYLEGSKD311 ALLCGFSTDS321 GQCPEGYTCV 331 KIGRNPDYGY341 TSFDTFSWAF351 LALFRLMTQD361 YWENLYQQTL371 RAAGKTYMIF 381 FVVVIFLGSF391 YLINLILAVV401 AMAYEEQNQA411 NIEEAKQKEL421 EFQQMLDRLK 431 KEQEPYWIKF733 KKCIYFIVMD743 PFVDLAITIC753 IVLNTLFMAM763 EHHPMTEEFK 773 NVLAIGNLVF783 TGIFAAEMVL793 KLIAMDPYEY803 FQVGWNIFDS813 LIVTLSLVEL 823 FLLSVLRSFR838 LLRVFKLAKS848 WPTLNMLIKI858 IGNSVGALGN868 LTLVLAIIVF 878 IFAVVGMQLF888 GKSYKECVCK898 INDDCTLPRW908 HMNDFFHSFL918 IVFRVLCGEW 928 IETMWDCMEV938 AGQAMCLIVY948 MMVMVIGNLV958 VLNLFLALLL968 SSFSSDNLTA 978 IEEDPDANNL988 QIAVTRIKKG998 INYVKQTLRE1008 FILKAFGKIW1178 WNIRKTCYKI 1188 VEHSWFESFI1198 VLMILLSSGA1208 LAFEDIYIER1218 KKTIKIILEY1228 ADKIFTYIFI 1238 LEMLLKWIAY1248 GYKTYFTNAW1258 CWLDFLIVDV1268 SLVTLVANTL1278 GYSDLGPIKS 1288 LRTLRALRPL1298 RALSRFEGMR1308 VVVNALIGAI1318 PSIMNVLLVC1328 LIFWLIFSIM 1338 GVNLFAGKFY1348 ECINTTDGSR1358 FPASQVPNRS1368 ECFALMNVSQ1378 NVRWKNLKVN 1388 FDNVGLGYLS1398 LLQVATFKGW1408 TIIMYAAVDS1418 VNVDKQPKYE1428 YSLYMYIYFV 1438 VFIIFGSFFT1448 LNLFIGVIID1458 NFNQQKKKLG1468 GQDIFMTEEQ1478 KKYYNAMKKL 1488 GSKKPQKPIP1498 RPGNKIQGCI1508 FDLVTNQAFD1518 ISIMVLICLN1528 MVTMMVEKEG 1538 QSQHMTEVLY1548 WINVVFIILF1558 TGECVLKLIS1568 LRHYYFTVGW1578 NIFDFVVVII 1588 SIVGMFLADL1598 IETYFVSPTL1608 FRVIRLARIG1618 RILRLVKGAK1628 GIRTLLFALM 1638 MSLPALFNIG1648 LLLFLVMFIY1658 AIFGMSNFAY1668 VKKEDGINDM1678 FNFETFGNSM 1688 ICLFQITTSA1698 GWDGLLAPIL1708 NSKPPDCDPK1718 KVHPGSSVEG1728 DCGNPSVGIF 1738 YFVSYIIISF1748 LVVVNMYIAV1758 ILENFSVATE1768 ESTEPLSEDD1778 FEMFYEVWEK 1788 FDPDATQFIE1798 FSKLSDFAAA1808 LDPPLLIAKP1818 NKVQLIAMDL1828 PMVSGDRIHC 1838 LDILFAFTKR1848 VLGESGEMDS1858 LRSQMEERFM1868 SANPSKVSYE1878 PITTTLKRKQ 1888 EDV
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .P5S or .P5S2 or .P5S3 or :3P5S;style chemicals stick;color identity;select .A:388 or .A:1178 or .A:1179 or .A:1182 or .A:1183 or .A:1186 or .A:1242 or .A:1245 or .A:1246 or .A:1247 or .A:1248 or .A:1249 or .A:1250 or .A:1251 or .A:1252 or .A:1489 or .A:1505 or .A:1563 or .A:1566 or .A:1567 or .A:1570 or .A:1571 or .A:1574 or .A:1577 or .A:1578 or .A:1581 or .A:1583 or .A:1621 or .A:1624 or .A:1628 or .A:1631 or .A:1632 or .A:1634 or .A:1635 or .A:1637 or .A:1638 or .A:1641; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU388
3.733
TRP1178
4.061
TRP1179
2.766
ARG1182
3.399
LYS1183
4.254
TYR1186
4.243
LEU1242
4.037
TRP1245
3.234
ILE1246
4.138
ALA1247
3.647
TYR1248
4.217
GLY1249
3.540
TYR1250
3.474
LYS1251
4.577
THR1252
4.382
GLY1489
3.179
GLN1505
4.209
VAL1563
3.916
LEU1566
3.296
|
|||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution | PDB:7W9K | ||||
| Method | Electron microscopy | Resolution | 2.20 Å | Mutation | No | [1] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNNVS211 ALRTFRVLRA221 LKTISVIPGL 231 KTIVGALIQS241 VKKLSDVMIL251 TVFCLSVFAL261 IGLQLFMGNL271 KHKCFRNSLE 281 NNETLESIMN291 TLESEEDFRK301 YFYYLEGSKD311 ALLCGFSTDS321 GQCPEGYTCV 331 KIGRNPDYGY341 TSFDTFSWAF351 LALFRLMTQD361 YWENLYQQTL371 RAAGKTYMIF 381 FVVVIFLGSF391 YLINLILAVV401 AMAYEEQNQA411 NIEEAKQKEL421 EFQQMLDRLK 431 KEQEPYWIKF733 KKCIYFIVMD743 PFVDLAITIC753 IVLNTLFMAM763 EHHPMTEEFK 773 NVLAIGNLVF783 TGIFAAEMVL793 KLIAMDPYEY803 FQVGWNIFDS813 LIVTLSLVEL 823 FLLSVLRSFR838 LLRVFKLAKS848 WPTLNMLIKI858 IGNSVGALGN868 LTLVLAIIVF 878 IFAVVGMQLF888 GKSYKECVCK898 INDDCTLPRW908 HMNDFFHSFL918 IVFRVLCGEW 928 IETMWDCMEV938 AGQAMCLIVY948 MMVMVIGNLV958 VLNLFLALLL968 SSFSSDNLTA 978 IEEDPDANNL988 QIAVTRIKKG998 INYVKQTLRE1008 FILKAFGKIW1178 WNIRKTCYKI 1188 VEHSWFESFI1198 VLMILLSSGA1208 LAFEDIYIER1218 KKTIKIILEY1228 ADKIFTYIFI 1238 LEMLLKWIAY1248 GYKTYFTNAW1258 CWLDFLIVDV1268 SLVTLVANTL1278 GYSDLGPIKS 1288 LRTLRALRPL1298 RALSRFEGMR1308 VVVNALIGAI1318 PSIMNVLLVC1328 LIFWLIFSIM 1338 GVNLFAGKFY1348 ECINTTDGSR1358 FPASQVPNRS1368 ECFALMNVSQ1378 NVRWKNLKVN 1388 FDNVGLGYLS1398 LLQVATFKGW1408 TIIMYAAVDS1418 VNVDKQPKYE1428 YSLYMYIYFV 1438 VFIIFGSFFT1448 LNLFIGVIID1458 NFNQQKKKLG1468 GQDIFMTEEQ1478 KKYYNAMKKL 1488 GSKKPQKPIP1498 RPGNKIQGCI1508 FDLVTNQAFD1518 ISIMVLICLN1528 MVTMMVEKEG 1538 QSQHMTEVLY1548 WINVVFIILF1558 TGECVLKLIS1568 LRHYYFTVGW1578 NIFDFVVVII 1588 SIVGMFLADL1598 IETYFVSPTL1608 FRVIRLARIG1618 RILRLVKGAK1628 GIRTLLFALM 1638 MSLPALFNIG1648 LLLFLVMFIY1658 AIFGMSNFAY1668 VKKEDGINDM1678 FNFETFGNSM 1688 ICLFQITTSA1698 GWDGLLAPIL1708 NSKPPDCDPK1718 KVHPGSSVEG1728 DCGNPSVGIF 1738 YFVSYIIISF1748 LVVVNMYIAV1758 ILENFSVATE1768 ESTEPLSEDD1778 FEMFYEVWEK 1788 FDPDATQFIE1798 FSKLSDFAAA1808 LDPPLLIAKP1818 NKVQLIAMDL1828 PMVSGDRIHC 1838 LDILFAFTKR1848 VLGESGEMDS1858 LRSQMEERFM1868 SANPSKVSYE1878 PITTTLKRKQ 1888 EDV
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .9Z9 or .9Z92 or .9Z93 or :39Z9;style chemicals stick;color identity;select .A:398 or .A:402 or .A:406 or .A:409 or .A:410 or .A:960 or .A:963 or .A:964 or .A:967 or .A:968 or .A:1449 or .A:1453 or .A:1457 or .A:1755 or .A:1759 or .A:1763; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Cholesterol hemisuccinate | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution | PDB:7W9K | ||||
| Method | Electron microscopy | Resolution | 2.20 Å | Mutation | No | [1] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNNVS211 ALRTFRVLRA221 LKTISVIPGL 231 KTIVGALIQS241 VKKLSDVMIL251 TVFCLSVFAL261 IGLQLFMGNL271 KHKCFRNSLE 281 NNETLESIMN291 TLESEEDFRK301 YFYYLEGSKD311 ALLCGFSTDS321 GQCPEGYTCV 331 KIGRNPDYGY341 TSFDTFSWAF351 LALFRLMTQD361 YWENLYQQTL371 RAAGKTYMIF 381 FVVVIFLGSF391 YLINLILAVV401 AMAYEEQNQA411 NIEEAKQKEL421 EFQQMLDRLK 431 KEQEPYWIKF733 KKCIYFIVMD743 PFVDLAITIC753 IVLNTLFMAM763 EHHPMTEEFK 773 NVLAIGNLVF783 TGIFAAEMVL793 KLIAMDPYEY803 FQVGWNIFDS813 LIVTLSLVEL 823 FLLSVLRSFR838 LLRVFKLAKS848 WPTLNMLIKI858 IGNSVGALGN868 LTLVLAIIVF 878 IFAVVGMQLF888 GKSYKECVCK898 INDDCTLPRW908 HMNDFFHSFL918 IVFRVLCGEW 928 IETMWDCMEV938 AGQAMCLIVY948 MMVMVIGNLV958 VLNLFLALLL968 SSFSSDNLTA 978 IEEDPDANNL988 QIAVTRIKKG998 INYVKQTLRE1008 FILKAFGKIW1178 WNIRKTCYKI 1188 VEHSWFESFI1198 VLMILLSSGA1208 LAFEDIYIER1218 KKTIKIILEY1228 ADKIFTYIFI 1238 LEMLLKWIAY1248 GYKTYFTNAW1258 CWLDFLIVDV1268 SLVTLVANTL1278 GYSDLGPIKS 1288 LRTLRALRPL1298 RALSRFEGMR1308 VVVNALIGAI1318 PSIMNVLLVC1328 LIFWLIFSIM 1338 GVNLFAGKFY1348 ECINTTDGSR1358 FPASQVPNRS1368 ECFALMNVSQ1378 NVRWKNLKVN 1388 FDNVGLGYLS1398 LLQVATFKGW1408 TIIMYAAVDS1418 VNVDKQPKYE1428 YSLYMYIYFV 1438 VFIIFGSFFT1448 LNLFIGVIID1458 NFNQQKKKLG1468 GQDIFMTEEQ1478 KKYYNAMKKL 1488 GSKKPQKPIP1498 RPGNKIQGCI1508 FDLVTNQAFD1518 ISIMVLICLN1528 MVTMMVEKEG 1538 QSQHMTEVLY1548 WINVVFIILF1558 TGECVLKLIS1568 LRHYYFTVGW1578 NIFDFVVVII 1588 SIVGMFLADL1598 IETYFVSPTL1608 FRVIRLARIG1618 RILRLVKGAK1628 GIRTLLFALM 1638 MSLPALFNIG1648 LLLFLVMFIY1658 AIFGMSNFAY1668 VKKEDGINDM1678 FNFETFGNSM 1688 ICLFQITTSA1698 GWDGLLAPIL1708 NSKPPDCDPK1718 KVHPGSSVEG1728 DCGNPSVGIF 1738 YFVSYIIISF1748 LVVVNMYIAV1758 ILENFSVATE1768 ESTEPLSEDD1778 FEMFYEVWEK 1788 FDPDATQFIE1798 FSKLSDFAAA1808 LDPPLLIAKP1818 NKVQLIAMDL1828 PMVSGDRIHC 1838 LDILFAFTKR1848 VLGESGEMDS1858 LRSQMEERFM1868 SANPSKVSYE1878 PITTTLKRKQ 1888 EDV
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y01 or .Y012 or .Y013 or :3Y01;style chemicals stick;color identity;select .A:209 or .A:212 or .A:215 or .A:216 or .A:219 or .A:222 or .A:755 or .A:758 or .A:759 or .A:762 or .A:763 or .A:765 or .A:767 or .A:842 or .A:845 or .A:848 or .A:849 or .A:850 or .A:876 or .A:879 or .A:880 or .A:883 or .A:887 or .A:943 or .A:947 or .A:950 or .A:954 or .A:981 or .A:988 or .A:1250 or .A:1251 or .A:1254 or .A:1255 or .A:1256 or .A:1257 or .A:1260 or .A:1264 or .A:1326 or .A:1329 or .A:1330 or .A:1333 or .A:1391 or .A:1392 or .A:1393 or .A:1396 or .A:1429 or .A:1432; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASN209
3.074
ALA212
3.400
THR215
3.500
PHE216
4.320
LEU219
3.986
LEU222
4.808
VAL755
3.678
THR758
3.583
LEU759
3.861
ALA762
3.185
MET763
4.127
HIS765
3.460
PRO767
3.849
VAL842
3.624
LEU845
3.298
SER848
3.786
TRP849
3.110
PRO850
3.532
ILE876
3.849
ILE879
3.403
PHE880
3.514
VAL883
3.808
LEU887
3.601
MET943
3.546
VAL947
4.481
MET950
2.869
ILE954
3.913
GLU981
2.299
LEU988
4.078
TYR1250
3.028
LYS1251
3.696
PHE1254
3.436
THR1255
3.237
ASN1256
4.727
ALA1257
4.244
TRP1260
3.014
LEU1264
4.141
LEU1326
3.899
LEU1329
3.883
ILE1330
3.609
LEU1333
3.603
ASN1391
3.982
VAL1392
4.152
GLY1393
3.900
TYR1396
2.694
TYR1429
4.566
TYR1432
3.207
|
|||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: N-acetylsphingosine 1-phosphate | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution | PDB:7W9K | ||||
| Method | Electron microscopy | Resolution | 2.20 Å | Mutation | No | [1] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNNVS211 ALRTFRVLRA221 LKTISVIPGL 231 KTIVGALIQS241 VKKLSDVMIL251 TVFCLSVFAL261 IGLQLFMGNL271 KHKCFRNSLE 281 NNETLESIMN291 TLESEEDFRK301 YFYYLEGSKD311 ALLCGFSTDS321 GQCPEGYTCV 331 KIGRNPDYGY341 TSFDTFSWAF351 LALFRLMTQD361 YWENLYQQTL371 RAAGKTYMIF 381 FVVVIFLGSF391 YLINLILAVV401 AMAYEEQNQA411 NIEEAKQKEL421 EFQQMLDRLK 431 KEQEPYWIKF733 KKCIYFIVMD743 PFVDLAITIC753 IVLNTLFMAM763 EHHPMTEEFK 773 NVLAIGNLVF783 TGIFAAEMVL793 KLIAMDPYEY803 FQVGWNIFDS813 LIVTLSLVEL 823 FLLSVLRSFR838 LLRVFKLAKS848 WPTLNMLIKI858 IGNSVGALGN868 LTLVLAIIVF 878 IFAVVGMQLF888 GKSYKECVCK898 INDDCTLPRW908 HMNDFFHSFL918 IVFRVLCGEW 928 IETMWDCMEV938 AGQAMCLIVY948 MMVMVIGNLV958 VLNLFLALLL968 SSFSSDNLTA 978 IEEDPDANNL988 QIAVTRIKKG998 INYVKQTLRE1008 FILKAFGKIW1178 WNIRKTCYKI 1188 VEHSWFESFI1198 VLMILLSSGA1208 LAFEDIYIER1218 KKTIKIILEY1228 ADKIFTYIFI 1238 LEMLLKWIAY1248 GYKTYFTNAW1258 CWLDFLIVDV1268 SLVTLVANTL1278 GYSDLGPIKS 1288 LRTLRALRPL1298 RALSRFEGMR1308 VVVNALIGAI1318 PSIMNVLLVC1328 LIFWLIFSIM 1338 GVNLFAGKFY1348 ECINTTDGSR1358 FPASQVPNRS1368 ECFALMNVSQ1378 NVRWKNLKVN 1388 FDNVGLGYLS1398 LLQVATFKGW1408 TIIMYAAVDS1418 VNVDKQPKYE1428 YSLYMYIYFV 1438 VFIIFGSFFT1448 LNLFIGVIID1458 NFNQQKKKLG1468 GQDIFMTEEQ1478 KKYYNAMKKL 1488 GSKKPQKPIP1498 RPGNKIQGCI1508 FDLVTNQAFD1518 ISIMVLICLN1528 MVTMMVEKEG 1538 QSQHMTEVLY1548 WINVVFIILF1558 TGECVLKLIS1568 LRHYYFTVGW1578 NIFDFVVVII 1588 SIVGMFLADL1598 IETYFVSPTL1608 FRVIRLARIG1618 RILRLVKGAK1628 GIRTLLFALM 1638 MSLPALFNIG1648 LLLFLVMFIY1658 AIFGMSNFAY1668 VKKEDGINDM1678 FNFETFGNSM 1688 ICLFQITTSA1698 GWDGLLAPIL1708 NSKPPDCDPK1718 KVHPGSSVEG1728 DCGNPSVGIF 1738 YFVSYIIISF1748 LVVVNMYIAV1758 ILENFSVATE1768 ESTEPLSEDD1778 FEMFYEVWEK 1788 FDPDATQFIE1798 FSKLSDFAAA1808 LDPPLLIAKP1818 NKVQLIAMDL1828 PMVSGDRIHC 1838 LDILFAFTKR1848 VLGESGEMDS1858 LRSQMEERFM1868 SANPSKVSYE1878 PITTTLKRKQ 1888 EDV
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .1PW or .1PW2 or .1PW3 or :31PW;style chemicals stick;color identity;select .A:1318 or .A:1321 or .A:1322 or .A:1325 or .A:1400 or .A:1404 or .A:1452 or .A:1694 or .A:1695 or .A:1696 or .A:1697 or .A:1744 or .A:1745 or .A:1747 or .A:1748 or .A:1749 or .A:1751; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate | Ligand Info | |||||
| Structure Description | Cryo-EM structure of a human-cockroach hybrid Nav channel. | PDB:6NT3 | ||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [3] |
| PDB Sequence |
ANKDRDGSAH
61 PDQALEQGSR71 LPARMRNIFP81 AELASNKKTF102 VVVTKASGEK118 SLWMLDPFTP 128 IRRVAISTMV138 QPIFSYFIMI148 TILIHCIFMI158 MPATQTTYIL168 ELVFLSIYTI 178 EVVVKVLARG188 FILHPFAYLR198 DPWNWLDFLV208 TLIGYITLVV218 DLGHLYALRA 228 FRVLRSWRTV238 TIVPGWRTIV248 DALSLSITSL258 KDLVLLLLFS268 LSVFALIGLQ 278 LFMGNLKHKC288 VKHFPADGSW298 GNFTDERWFN308 YTSNSSHWYI318 PDDWIEYPLC 328 GNSSGAGMCP338 PGYTCLQGYG348 GNPNYGYTSF358 DTFGWAFLSV368 FRLVTLDYWE 378 DLYQLALRSA388 GPWHILFFII398 VVFYGTFCFL408 NFILAVVVMS418 YTHMVKRADE 428 EKAAECVPWQ506 KLQGAIGAVV516 LSPFFELFIA526 VIIVLNITFM536 ALDHHDMNIE 546 FERILRTGNY556 IFTSIYIVEA566 VLKIIALSPK576 FYFKDSWNVF586 DFIIVVFAIL 596 ELGLEGVQGL606 SVFRSFRLLR616 VFRLAKFWPT626 LNNFMSVMTK636 SYGAFVNVMY 646 VMFLLLFIFA656 IIGMQLFGMN666 YIDNMERFPD676 GDLPRWNFTD686 FLHSFMIVFR 696 ALCGEWIESM706 WDCMLVGDWS716 CIPFFVAVFF726 VGNLVILNLL736 IALLLNNYGS 837 VQRMWSNIRR847 VCFLLAKNKY857 FQKFVTAVLV867 ITSVLLALED877 IYLPQRPVLV 887 NITLYVDYVL897 TAFFVIEMII907 MLFAVGFKKY917 FTSKWYWLDF927 IVVVAYLLNF 937 VLMCAGIEAL947 QTLRLLRVFR957 LFRPLSKVNG967 MQVVTSTLVE977 AVPHIFNVIL 987 VGIFFWLVFA997 IMGVQLFAGK1007 FYKCVDENST1017 VLSHEITMDR1027 NDCLHENYTW 1037 ENSPMNFDHV1047 GNAYLSLLQV1057 ATFKGWLQIM1067 NDAIDSREVH1077 KQPIRETNIY 1087 MYLYFIFFIV1097 FGSFFILKLF1107 VCILIDIFRQ1117 QRRKAEGLSA1127 TDSRTQLIYR 1137 RAVMRTMSAK1147 PVKRIPKPGN1157 KIQGCIFDLV1167 TNQAFDISIM1177 VLICLNMVTM 1187 MVEKEGQSQH1197 MTEVLYWINV1207 VFIILFTGEC1217 VLKLISLRHY1227 YFTVGWNIFD 1237 FVVVIISIVG1247 MFLADLIETY1257 FVSPTLFRVI1267 RLARIGRILR1277 LVKGAKGIRL 1287 LLLALRKALR1297 TLFNVSFLLF1307 VIMFVYAVFG1317 MEFFMHIRDA1327 GAIDDVYNFK 1337 TFGQSIILLF1347 QLATSAGWDG1357 VYFAIANEED1367 CRAPDHELGY1377 PGNCGSRALG 1387 IAYLVSYLII1397 TCLVVINMYA1407 AVILDYVLEV1417 YEDSKEGLTD1427 DDYDMFFEVW 1437 QQFDPEATQY1447 IRYDQLSELL1457 EALQPPLQVQ1467 KPNKYKILSM1477 NIPICKDDHI 1487 FYKDVLEALV1497 KDVFSRRG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .76F or .76F2 or .76F3 or :376F;style chemicals stick;color identity;select .A:265 or .A:266 or .A:269 or .A:275 or .A:279 or .A:331 or .A:332 or .A:360 or .A:362 or .A:363 or .A:365 or .A:366 or .A:369 or .A:391 or .A:392 or .A:394 or .A:395 or .A:398 or .A:714 or .A:715 or .A:718 or .A:719 or .A:722 or .A:723 or .A:726 or .A:921 or .A:922 or .A:925 or .A:928 or .A:956 or .A:959 or .A:963 or .A:969 or .A:972 or .A:975 or .A:976 or .A:979 or .A:982 or .A:986 or .A:989 or .A:990 or .A:993 or .A:1046 or .A:1048 or .A:1049 or .A:1051 or .A:1052 or .A:1055 or .A:1104 or .A:1107 or .A:1191 or .A:1260 or .A:1262 or .A:1263 or .A:1266 or .A:1269 or .A:1305 or .A:1309 or .A:1384 or .A:1385 or .A:1388 or .A:1389 or .A:1392 or .A:1396 or .A:1397 or .A:1401; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
LEU265
4.338
LEU266
4.288
LEU269
4.804
ILE275
4.822
LEU279
3.929
SER331
4.087
SER332
4.902
THR360
3.934
GLY362
4.294
TRP363
3.231
PHE365
3.777
LEU366
4.214
PHE369
4.250
TRP391
4.127
HIS392
4.013
LEU394
4.092
PHE395
4.603
ILE398
4.526
ASP714
4.215
TRP715
3.676
ILE718
3.881
PRO719
4.200
VAL722
4.118
ALA723
4.573
PHE726
4.862
LYS921
3.241
TRP922
3.523
LEU925
4.036
ILE928
4.919
PHE956
3.557
PHE959
3.588
SER963
3.913
GLN969
4.228
THR972
4.042
LEU975
4.185
VAL976
3.834
VAL979
4.004
ILE982
3.972
ILE986
4.145
GLY989
4.953
ILE990
3.681
TRP993
4.495
HIS1046
2.999
GLY1048
4.423
ASN1049
4.586
TYR1051
4.368
LEU1052
4.771
LEU1055
4.582
LEU1104
3.986
PHE1107
4.981
LYS1191
4.941
SER1260
3.627
THR1262
2.287
LEU1263
4.608
VAL1266
4.552
LEU1269
4.635
LEU1305
4.924
ILE1309
4.830
ARG1384
2.311
ALA1385
4.037
ILE1388
4.769
ALA1389
4.059
VAL1392
4.262
ILE1396
4.264
ILE1397
3.916
VAL1401
4.656
|
|||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: 1,2-Dipalmitoyl-phosphatidyl-glycerole | Ligand Info | |||||
| Structure Description | Cryo-EM structure of a human-cockroach hybrid Nav channel. | PDB:6NT3 | ||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [3] |
| PDB Sequence |
ANKDRDGSAH
61 PDQALEQGSR71 LPARMRNIFP81 AELASNKKTF102 VVVTKASGEK118 SLWMLDPFTP 128 IRRVAISTMV138 QPIFSYFIMI148 TILIHCIFMI158 MPATQTTYIL168 ELVFLSIYTI 178 EVVVKVLARG188 FILHPFAYLR198 DPWNWLDFLV208 TLIGYITLVV218 DLGHLYALRA 228 FRVLRSWRTV238 TIVPGWRTIV248 DALSLSITSL258 KDLVLLLLFS268 LSVFALIGLQ 278 LFMGNLKHKC288 VKHFPADGSW298 GNFTDERWFN308 YTSNSSHWYI318 PDDWIEYPLC 328 GNSSGAGMCP338 PGYTCLQGYG348 GNPNYGYTSF358 DTFGWAFLSV368 FRLVTLDYWE 378 DLYQLALRSA388 GPWHILFFII398 VVFYGTFCFL408 NFILAVVVMS418 YTHMVKRADE 428 EKAAECVPWQ506 KLQGAIGAVV516 LSPFFELFIA526 VIIVLNITFM536 ALDHHDMNIE 546 FERILRTGNY556 IFTSIYIVEA566 VLKIIALSPK576 FYFKDSWNVF586 DFIIVVFAIL 596 ELGLEGVQGL606 SVFRSFRLLR616 VFRLAKFWPT626 LNNFMSVMTK636 SYGAFVNVMY 646 VMFLLLFIFA656 IIGMQLFGMN666 YIDNMERFPD676 GDLPRWNFTD686 FLHSFMIVFR 696 ALCGEWIESM706 WDCMLVGDWS716 CIPFFVAVFF726 VGNLVILNLL736 IALLLNNYGS 837 VQRMWSNIRR847 VCFLLAKNKY857 FQKFVTAVLV867 ITSVLLALED877 IYLPQRPVLV 887 NITLYVDYVL897 TAFFVIEMII907 MLFAVGFKKY917 FTSKWYWLDF927 IVVVAYLLNF 937 VLMCAGIEAL947 QTLRLLRVFR957 LFRPLSKVNG967 MQVVTSTLVE977 AVPHIFNVIL 987 VGIFFWLVFA997 IMGVQLFAGK1007 FYKCVDENST1017 VLSHEITMDR1027 NDCLHENYTW 1037 ENSPMNFDHV1047 GNAYLSLLQV1057 ATFKGWLQIM1067 NDAIDSREVH1077 KQPIRETNIY 1087 MYLYFIFFIV1097 FGSFFILKLF1107 VCILIDIFRQ1117 QRRKAEGLSA1127 TDSRTQLIYR 1137 RAVMRTMSAK1147 PVKRIPKPGN1157 KIQGCIFDLV1167 TNQAFDISIM1177 VLICLNMVTM 1187 MVEKEGQSQH1197 MTEVLYWINV1207 VFIILFTGEC1217 VLKLISLRHY1227 YFTVGWNIFD 1237 FVVVIISIVG1247 MFLADLIETY1257 FVSPTLFRVI1267 RLARIGRILR1277 LVKGAKGIRL 1287 LLLALRKALR1297 TLFNVSFLLF1307 VIMFVYAVFG1317 MEFFMHIRDA1327 GAIDDVYNFK 1337 TFGQSIILLF1347 QLATSAGWDG1357 VYFAIANEED1367 CRAPDHELGY1377 PGNCGSRALG 1387 IAYLVSYLII1397 TCLVVINMYA1407 AVILDYVLEV1417 YEDSKEGLTD1427 DDYDMFFEVW 1437 QQFDPEATQY1447 IRYDQLSELL1457 EALQPPLQVQ1467 KPNKYKILSM1477 NIPICKDDHI 1487 FYKDVLEALV1497 KDVFSRRG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LHG or .LHG2 or .LHG3 or :3LHG;style chemicals stick;color identity;select .A:200 or .A:201 or .A:204 or .A:229 or .A:232 or .A:235 or .A:244 or .A:245 or .A:248 or .A:249 or .A:251 or .A:252 or .A:255 or .A:651 or .A:654 or .A:655 or .A:658 or .A:662 or .A:719 or .A:720 or .A:723 or .A:727; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
PRO200
3.673
TRP201
3.929
LEU204
4.684
PHE229
4.171
LEU232
4.747
TRP235
3.884
TRP244
4.569
ARG245
4.613
VAL248
3.171
ASP249
4.444
LEU251
4.404
|
|||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: Digitonin | Ligand Info | |||||
| Structure Description | Cryo-EM structure of a human-cockroach hybrid Nav channel. | PDB:6NT3 | ||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [3] |
| PDB Sequence |
ANKDRDGSAH
61 PDQALEQGSR71 LPARMRNIFP81 AELASNKKTF102 VVVTKASGEK118 SLWMLDPFTP 128 IRRVAISTMV138 QPIFSYFIMI148 TILIHCIFMI158 MPATQTTYIL168 ELVFLSIYTI 178 EVVVKVLARG188 FILHPFAYLR198 DPWNWLDFLV208 TLIGYITLVV218 DLGHLYALRA 228 FRVLRSWRTV238 TIVPGWRTIV248 DALSLSITSL258 KDLVLLLLFS268 LSVFALIGLQ 278 LFMGNLKHKC288 VKHFPADGSW298 GNFTDERWFN308 YTSNSSHWYI318 PDDWIEYPLC 328 GNSSGAGMCP338 PGYTCLQGYG348 GNPNYGYTSF358 DTFGWAFLSV368 FRLVTLDYWE 378 DLYQLALRSA388 GPWHILFFII398 VVFYGTFCFL408 NFILAVVVMS418 YTHMVKRADE 428 EKAAECVPWQ506 KLQGAIGAVV516 LSPFFELFIA526 VIIVLNITFM536 ALDHHDMNIE 546 FERILRTGNY556 IFTSIYIVEA566 VLKIIALSPK576 FYFKDSWNVF586 DFIIVVFAIL 596 ELGLEGVQGL606 SVFRSFRLLR616 VFRLAKFWPT626 LNNFMSVMTK636 SYGAFVNVMY 646 VMFLLLFIFA656 IIGMQLFGMN666 YIDNMERFPD676 GDLPRWNFTD686 FLHSFMIVFR 696 ALCGEWIESM706 WDCMLVGDWS716 CIPFFVAVFF726 VGNLVILNLL736 IALLLNNYGS 837 VQRMWSNIRR847 VCFLLAKNKY857 FQKFVTAVLV867 ITSVLLALED877 IYLPQRPVLV 887 NITLYVDYVL897 TAFFVIEMII907 MLFAVGFKKY917 FTSKWYWLDF927 IVVVAYLLNF 937 VLMCAGIEAL947 QTLRLLRVFR957 LFRPLSKVNG967 MQVVTSTLVE977 AVPHIFNVIL 987 VGIFFWLVFA997 IMGVQLFAGK1007 FYKCVDENST1017 VLSHEITMDR1027 NDCLHENYTW 1037 ENSPMNFDHV1047 GNAYLSLLQV1057 ATFKGWLQIM1067 NDAIDSREVH1077 KQPIRETNIY 1087 MYLYFIFFIV1097 FGSFFILKLF1107 VCILIDIFRQ1117 QRRKAEGLSA1127 TDSRTQLIYR 1137 RAVMRTMSAK1147 PVKRIPKPGN1157 KIQGCIFDLV1167 TNQAFDISIM1177 VLICLNMVTM 1187 MVEKEGQSQH1197 MTEVLYWINV1207 VFIILFTGEC1217 VLKLISLRHY1227 YFTVGWNIFD 1237 FVVVIISIVG1247 MFLADLIETY1257 FVSPTLFRVI1267 RLARIGRILR1277 LVKGAKGIRL 1287 LLLALRKALR1297 TLFNVSFLLF1307 VIMFVYAVFG1317 MEFFMHIRDA1327 GAIDDVYNFK 1337 TFGQSIILLF1347 QLATSAGWDG1357 VYFAIANEED1367 CRAPDHELGY1377 PGNCGSRALG 1387 IAYLVSYLII1397 TCLVVINMYA1407 AVILDYVLEV1417 YEDSKEGLTD1427 DDYDMFFEVW 1437 QQFDPEATQY1447 IRYDQLSELL1457 EALQPPLQVQ1467 KPNKYKILSM1477 NIPICKDDHI 1487 FYKDVLEALV1497 KDVFSRRG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .AJP or .AJP2 or .AJP3 or :3AJP;style chemicals stick;color identity;select .A:606 or .A:996 or .A:999 or .A:1003 or .A:1074 or .A:1075 or .A:1084 or .A:1085 or .A:1087 or .A:1088 or .A:1090 or .A:1091 or .A:1094; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Ligand Name: [(3aS,4R,10aS)-2,6-diamino-10,10-dihydroxy-3a,4,9,10-tetrahydro-3H,8H-pyrrolo[1,2-c]purin-4-yl]methyl carbamate | Ligand Info | |||||
| Structure Description | Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV pi helix conformer) | PDB:7W9P | ||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | Yes | [1] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNLGN209 VSALRTFRVL219 RALKTISVIP 229 GLKTIVGALI239 QSVKKLSDVM249 ILTVFCLSVF259 ALIGLQLFMG269 NLKHKCFRNS 279 LENNETLESI289 MNTLESEEDF299 RKYFYYLEGS309 KDALLCGFST319 DSGQCPEGYT 329 CVKIGRNPDY339 GYTSFDTFSW349 AFLALFRLMT359 QDYWENLYQQ369 TLRAAGKTYM 379 IFFVVVIFLG389 SFYLINLILA399 VVAMAYKEQN409 QANIEEAKQK419 ELEFQQMLDP 728 YWIKFKKCIY738 FIVMDPFVDL748 AITICIVLNT758 LFMAMEHHPM768 TEEFKNVLAI 778 GNLVFTGIFA788 AEMVLKLIAM798 DPYEYFQVGW808 NIFDSLIVTL818 SLVELFLADV 828 EGLSVLRSFR838 LLRVFKLAKS848 WPTLNMLIKI858 IGNSVGALGN868 LTLVLAIIVF 878 IFAVVGMQLF888 GKSYKECVCK898 INDDCTLPRW908 HMNDFFHSFL918 IVFRVLCGEW 928 IETMWDCMEV938 AGQAMCLIVY948 MMVMVIGNLV958 VLNLFLALLL968 SSFSSDNLTA 978 IEEDPDANNL988 QIAVTRIKKG998 INYVKQTLRE1008 FILKAFGKIW1178 WNIRKTCYKI 1188 VEHSWFESFI1198 VLMILLSSGA1208 LAFEDIYIER1218 KKTIKIILEY1228 ADKIFTYIFI 1238 LEMLLKWIAY1248 GYKTYFTNAW1258 CWLDFLIVDV1268 SLVTLVANTL1278 GYSDLGPIKS 1288 LRTLRALRPL1298 RALSRFEGMR1308 VVVNALIGAI1318 PSIMNVLLVC1328 LIFWLIFSIM 1338 GVNLFAGKFY1348 ECINTTDGSR1358 FPASQVPNRS1368 ECFALMNVSQ1378 NVRWKNLKVN 1388 FDNVGLGYLS1398 LLQVATFKGW1408 TIIMYAAVDS1418 VNVDKQPKYE1428 YSLYMYIYFV 1438 VFIIFGSFFT1448 LNLFIGVIID1458 NFNQQKKKLG1468 GQDIFMTEEQ1478 KKYYNAMKKL 1488 GSKKPQKPIP1498 RPGNKIQGCI1508 FDLVTNQAFD1518 ISIMVLICLN1528 MVTMMVEKEG 1538 QSQHMTEVLY1548 WINVVFIILF1558 TGECVLKLIS1568 LRHYYFTVGW1578 NIFDFVVVII 1588 SIVGMFLADL1598 IETYFVSPTL1608 FRVIRLARIG1618 RILRLVKGAK1628 GIRTLLFALM 1638 MSLPALFNIG1648 LLLFLVMFIY1658 AIFGMSNFAY1668 VKKEDGINDM1678 FNFETFGNSM 1688 ICLFQITTSA1698 GWDGLLAPIL1708 NSKPPDCDPK1718 KVHPGSSVEG1728 DCGNPSVGIF 1738 YFVSYIIISF1748 LVVVNMYIAV1758 ILENFSVATE1768 ESTEPLSEDD1778 FEMFYEVWEK 1788 FDPDATQFIE1798 FSKLSDFAAA1808 LDPPLLIAKP1818 NKVQLIAMDL1828 PMVSGDRIHC 1838 LDILFAFTKR1848 VLGESGEMDS1858 LRSQMEERFM1868 SANPSKVSYE1878 PITTTLKRKQ 1888 EDV
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .9SL or .9SL2 or .9SL3 or :39SL;style chemicals stick;color identity;select .A:362 or .A:363 or .A:364 or .A:922 or .A:927 or .A:930 or .A:1405 or .A:1406 or .A:1407 or .A:1408 or .A:1409 or .A:1410 or .A:1698 or .A:1699 or .A:1700 or .A:1701; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | High-resolution structures of human Na(v)1.7 reveal gating modulation through Alpha-Pi helical transition of S6(IV). Cell Rep. 2022 Apr 26;39(4):110735. | ||||
| REF 2 | Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na(v)1.7. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2209164119. | ||||
| REF 3 | Cryo-EM structures of a human-cockroach hybrid Nav channel in the presence and absence of the alpha-scorpion toxin AaH2. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.