Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T12119 | Target Info | |||
| Target Name | Voltage-gated sodium channel alpha Nav1.7 (SCN9A) | ||||
| Synonyms | hNE-Na; Voltage-gated sodium channel subunit alpha Nav1.7; Sodium channel proteintype IX subunit alpha; Sodium channel proteintype 9 subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel protein type 9 subunit alpha; Peripheral sodium channel 1; PN1; Neuroendocrine sodium channel; NENA | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | SCN9A | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol hemisuccinate | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C | ||||
| InChI | 1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1 | ||||
| InChIKey | WLNARFZDISHUGS-MIXBDBMTSA-N | ||||
| PubChem Compound ID | 65082 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7XVE Human Nav1.7 mutant class-I | ||||||
| Method | Electron microscopy | Resolution | 2.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVKYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNLGN209 VSALRTFRVL219 RALKTISVIP 229 GLKTIVGALI239 QSVKKLSDVM249 ILTVFCLSVF259 ALIGLQLFMG269 NLKHKCFRNS 279 LENNETLESI289 MNTLESEEDF299 RKYFYYLEGS309 KDALLCGFST319 DSGQCPEGYT 329 CVKIGRNPDY339 GYTSFDTFSW349 AFLALFRLMT359 QDYWENLYQQ369 TLRAAGKTYM 379 IFFVVVIFLG389 SFYLINLILA399 VVAMAYEEQN409 QANIEEAKQK419 ELEFQQMLCS 727 PYWIKFKKCI737 YFIVMDPFVD747 LAITICIVLN757 TLFMAMEHHP767 MTEEFKNVLA 777 IRNLVFTGIF787 AAEMVLKLIA797 MDPYEYFQVG807 WNIFDSLIVT817 LSLVELFGLS 832 VLRSFRLLRV842 FKLAKSWPTL852 NMLIKIIGNS862 VGAFGNLMLV872 LFIIVFIFAV 882 VGMQLFGKSY892 KECVCKINDD902 CTLPRWHMND912 FFHSFLIVFR922 VLCGEWIETM 932 WDCMEVAGQA942 MCLIFYMMVF952 FIGNLVVLNL962 FLALLLSSFS972 SDANNLQIAV 992 TRIKKGINYV1002 KQTLREFILK1012 AFGKIWWNIR1182 KTCYKIVEHS1192 WFESFIVLMI 1202 LLSSGALAFE1212 DIYIERKKTI1222 KIILEYADKI1232 FTYIFILEML1242 LKWIAYGYKT 1252 YFTNAWCWLD1262 FLIVDVSLVT1272 LVANTLGYSD1282 LGPIKSLRTL1292 RALRPLRALS 1302 RFEGMRVVVN1312 ALIGAIPSIM1322 NVLLVCLIFW1332 LIFSIMGVNL1342 FAGKFYECIN 1352 TTDGSRFPAS1362 QVPNRSECFA1372 LMNVSQNVRW1382 KNLKVNFDNV1392 GLGYLSLLQV 1402 ATFKGWTIIM1412 YAAVDSVNVD1422 KQPKYEYSLY1432 MYIYFIFFII1442 FGSFFTLNLF 1452 ICVIIDNFNQ1462 QKKKLGGQDI1472 FMTEEQKKYY1482 NAMKKLGSKK1492 PQKPIPRPGN 1502 KIQGCIFDLV1512 TNQAFDISIM1522 VLICLNMVTM1532 MVEKEGQSQH1542 MTEVLYWINV 1552 VFIILFTGEC1562 VLKLISLRHY1572 YFTVGWNIFD1582 FVVVIISIVG1592 MFLADLIETY 1602 FVSPTLFRVI1612 RLARIGRILR1622 LVKGAKGIRT1632 LLFALMMSLP1642 ALFNIGLLLF 1652 LVMFIYAIFG1662 MSNFAYVKKE1672 DGINDMFNFE1682 TFGNSMICLF1692 QITTSAGWDG 1702 LLAPILNSKP1712 PDCDPKKVHP1722 GSSVEGDCGN1732 PSVGIFYFVS1742 YIIISFLVVV 1752 NMYIAVILEN1762 FSVATE
|
|||||
|
|
||||||
| PDB ID: 7XVF Nav1.7 mutant class2 | ||||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVKYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNVSA212 LRTFRVLRAL222 KTISVIPGLK 232 TIVGALIQSV242 KKLSDVMILT252 VFCLSVFALI262 GLQLFMGNLK272 HKCFRNSLEN 282 NETLESIMNT292 LESEEDFRKY302 FYYLEGSKDA312 LLCGFSTDSG322 QCPEGYTCVK 332 IGRNPDYGYT342 SFDTFSWAFL352 ALFRLMTQDY362 WENLYQQTLR372 AAGKTYMIFF 382 VVVIFLGSFY392 LINLILAVVA402 MAYEEQNQAN412 IEEAKCSPYW730 IKFKKCIYFI 740 VMDPFVDLAI750 TICIVLNTLF760 MAMEHHPMTE770 EFKNVLAIRN780 LVFTGIFAAE 790 MVLKLIAMDP800 YEYFQVGWNI810 FDSLIVTLSL820 VELFGLSVLR835 SFRLLRVFKL 845 AKSWPTLNML855 IKIIGNSVGA865 FGNLMLVLFI875 IVFIFAVVGM885 QLFGKSYKEC 895 VCKINDDCTL905 PRWHMNDFFH915 SFLIVFRVLC925 GEWIETMWDC935 MEVAGQAMCL 945 IFYMMVFFIG955 NLVVLNLFLA965 LLLSSFSANN987 LQIAVTRIKK997 GINYVKQTLR 1007 EFILKAFGKI1177 WWNIRKTCYK1187 IVEHSWFESF1197 IVLMILLSSG1207 ALAFEDIYIE 1217 RKKTIKIILE1227 YADKIFTYIF1237 ILEMLLKWIA1247 YGYKTYFTNA1257 WCWLDFLIVD 1267 VSLVTLVANT1277 LGYSDLGPIK1287 SLRTLRALRP1297 LRALSRFEGM1307 RVVVNALIGA 1317 IPSIMNVLLV1327 CLIFWLIFSI1337 MGVNLFAGKF1347 YECINTTDGS1357 RFPASQVPNR 1367 SECFALMNVS1377 QNVRWKNLKV1387 NFDNVGLGYL1397 SLLQVATFKG1407 WTIIMYAAVD 1417 SVNVDKQPKY1427 EYSLYMYIYF1437 IFFIIFGSFF1447 TLNLFICVII1457 DNFNQQKKKL 1467 GGQDIFMTEE1477 QKKYYNAMKK1487 LGSKKPQKPI1497 PRPGNKIQGC1507 IFDLVTNQAF 1517 DISIMVLICL1527 NMVTMMVEKE1537 GQSQHMTEVL1547 YWINVVFIIL1557 FTGECVLKLI 1567 SLRHYYFTVG1577 WNIFDFVVVI1587 ISIVGMFLAD1597 LIETYFVSPT1607 LFRVIRLARI 1617 GRILRLVKGA1627 KGIRTLLFAL1637 MMSLPALFNI1647 GLLLFLVMFI1657 YAIFGMSNFA 1667 YVKKEDGIND1677 MFNFETFGNS1687 MICLFQITTS1697 AGWDGLLAPI1707 LNSKPPDCDP 1717 KKVHPGSSVE1727 GDCGNPSVGI1737 FYFVSYIIIS1747 FLVVVNMYIA1757 VILENFSVAT 1767 E
|
|||||
|
|
THR758
4.819
LEU759
4.184
ALA762
3.215
MET763
3.869
GLU764
4.970
HIS765
3.514
PRO767
3.425
GLY830
4.506
VAL833
4.715
PHE837
3.948
ASP912
4.578
TRP1245
3.202
TYR1250
3.530
LYS1251
3.910
PHE1254
3.790
THR1255
2.996
ASN1256
4.373
ALA1257
4.071
TRP1260
2.692
PHE1263
3.947
LEU1264
3.626
ASP1267
4.163
LEU1329
3.774
ILE1330
4.500
LEU1333
3.787
PHE1335
3.460
MET1338
3.612
LEU1342
4.700
ASN1391
3.987
VAL1392
4.277
GLY1393
3.827
TYR1396
3.603
GLU1428
2.758
TYR1429
2.898
SER1430
3.133
LEU1431
3.526
TYR1432
2.931
MET1433
2.325
ILE1435
2.983
TYR1436
3.635
PHE1439
2.958
PHE1443
4.348
|
|||||
| PDB ID: 7W9K Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution | ||||||
| Method | Electron microscopy | Resolution | 2.20 Å | Mutation | No | [2] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNNVS211 ALRTFRVLRA221 LKTISVIPGL 231 KTIVGALIQS241 VKKLSDVMIL251 TVFCLSVFAL261 IGLQLFMGNL271 KHKCFRNSLE 281 NNETLESIMN291 TLESEEDFRK301 YFYYLEGSKD311 ALLCGFSTDS321 GQCPEGYTCV 331 KIGRNPDYGY341 TSFDTFSWAF351 LALFRLMTQD361 YWENLYQQTL371 RAAGKTYMIF 381 FVVVIFLGSF391 YLINLILAVV401 AMAYEEQNQA411 NIEEAKQKEL421 EFQQMLDRLK 431 KEQEPYWIKF733 KKCIYFIVMD743 PFVDLAITIC753 IVLNTLFMAM763 EHHPMTEEFK 773 NVLAIGNLVF783 TGIFAAEMVL793 KLIAMDPYEY803 FQVGWNIFDS813 LIVTLSLVEL 823 FLLSVLRSFR838 LLRVFKLAKS848 WPTLNMLIKI858 IGNSVGALGN868 LTLVLAIIVF 878 IFAVVGMQLF888 GKSYKECVCK898 INDDCTLPRW908 HMNDFFHSFL918 IVFRVLCGEW 928 IETMWDCMEV938 AGQAMCLIVY948 MMVMVIGNLV958 VLNLFLALLL968 SSFSSDNLTA 978 IEEDPDANNL988 QIAVTRIKKG998 INYVKQTLRE1008 FILKAFGKIW1178 WNIRKTCYKI 1188 VEHSWFESFI1198 VLMILLSSGA1208 LAFEDIYIER1218 KKTIKIILEY1228 ADKIFTYIFI 1238 LEMLLKWIAY1248 GYKTYFTNAW1258 CWLDFLIVDV1268 SLVTLVANTL1278 GYSDLGPIKS 1288 LRTLRALRPL1298 RALSRFEGMR1308 VVVNALIGAI1318 PSIMNVLLVC1328 LIFWLIFSIM 1338 GVNLFAGKFY1348 ECINTTDGSR1358 FPASQVPNRS1368 ECFALMNVSQ1378 NVRWKNLKVN 1388 FDNVGLGYLS1398 LLQVATFKGW1408 TIIMYAAVDS1418 VNVDKQPKYE1428 YSLYMYIYFV 1438 VFIIFGSFFT1448 LNLFIGVIID1458 NFNQQKKKLG1468 GQDIFMTEEQ1478 KKYYNAMKKL 1488 GSKKPQKPIP1498 RPGNKIQGCI1508 FDLVTNQAFD1518 ISIMVLICLN1528 MVTMMVEKEG 1538 QSQHMTEVLY1548 WINVVFIILF1558 TGECVLKLIS1568 LRHYYFTVGW1578 NIFDFVVVII 1588 SIVGMFLADL1598 IETYFVSPTL1608 FRVIRLARIG1618 RILRLVKGAK1628 GIRTLLFALM 1638 MSLPALFNIG1648 LLLFLVMFIY1658 AIFGMSNFAY1668 VKKEDGINDM1678 FNFETFGNSM 1688 ICLFQITTSA1698 GWDGLLAPIL1708 NSKPPDCDPK1718 KVHPGSSVEG1728 DCGNPSVGIF 1738 YFVSYIIISF1748 LVVVNMYIAV1758 ILENFSVATE1768 ESTEPLSEDD1778 FEMFYEVWEK 1788 FDPDATQFIE1798 FSKLSDFAAA1808 LDPPLLIAKP1818 NKVQLIAMDL1828 PMVSGDRIHC 1838 LDILFAFTKR1848 VLGESGEMDS1858 LRSQMEERFM1868 SANPSKVSYE1878 PITTTLKRKQ 1888 EDV
|
|||||
|
|
ASN209
3.074
ALA212
3.400
THR215
3.500
PHE216
4.320
LEU219
3.986
LEU222
4.808
VAL755
3.678
THR758
3.583
LEU759
3.861
ALA762
3.185
MET763
4.127
HIS765
3.460
PRO767
3.849
VAL842
3.624
LEU845
3.298
SER848
3.786
TRP849
3.110
PRO850
3.532
ILE876
3.849
ILE879
3.403
PHE880
3.514
VAL883
3.808
LEU887
3.601
MET943
3.546
VAL947
4.481
MET950
2.869
ILE954
3.913
GLU981
2.299
LEU988
4.078
TYR1250
3.028
LYS1251
3.696
PHE1254
3.436
THR1255
3.237
ASN1256
4.727
ALA1257
4.244
TRP1260
3.014
LEU1264
4.141
LEU1326
3.899
LEU1329
3.883
ILE1330
3.609
LEU1333
3.603
ASN1391
3.982
VAL1392
4.152
GLY1393
3.900
TYR1396
2.694
TYR1429
4.566
TYR1432
3.207
|
|||||
| PDB ID: 7W9P Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV pi helix conformer) | ||||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | Yes | [2] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNLGN209 VSALRTFRVL219 RALKTISVIP 229 GLKTIVGALI239 QSVKKLSDVM249 ILTVFCLSVF259 ALIGLQLFMG269 NLKHKCFRNS 279 LENNETLESI289 MNTLESEEDF299 RKYFYYLEGS309 KDALLCGFST319 DSGQCPEGYT 329 CVKIGRNPDY339 GYTSFDTFSW349 AFLALFRLMT359 QDYWENLYQQ369 TLRAAGKTYM 379 IFFVVVIFLG389 SFYLINLILA399 VVAMAYKEQN409 QANIEEAKQK419 ELEFQQMLDP 728 YWIKFKKCIY738 FIVMDPFVDL748 AITICIVLNT758 LFMAMEHHPM768 TEEFKNVLAI 778 GNLVFTGIFA788 AEMVLKLIAM798 DPYEYFQVGW808 NIFDSLIVTL818 SLVELFLADV 828 EGLSVLRSFR838 LLRVFKLAKS848 WPTLNMLIKI858 IGNSVGALGN868 LTLVLAIIVF 878 IFAVVGMQLF888 GKSYKECVCK898 INDDCTLPRW908 HMNDFFHSFL918 IVFRVLCGEW 928 IETMWDCMEV938 AGQAMCLIVY948 MMVMVIGNLV958 VLNLFLALLL968 SSFSSDNLTA 978 IEEDPDANNL988 QIAVTRIKKG998 INYVKQTLRE1008 FILKAFGKIW1178 WNIRKTCYKI 1188 VEHSWFESFI1198 VLMILLSSGA1208 LAFEDIYIER1218 KKTIKIILEY1228 ADKIFTYIFI 1238 LEMLLKWIAY1248 GYKTYFTNAW1258 CWLDFLIVDV1268 SLVTLVANTL1278 GYSDLGPIKS 1288 LRTLRALRPL1298 RALSRFEGMR1308 VVVNALIGAI1318 PSIMNVLLVC1328 LIFWLIFSIM 1338 GVNLFAGKFY1348 ECINTTDGSR1358 FPASQVPNRS1368 ECFALMNVSQ1378 NVRWKNLKVN 1388 FDNVGLGYLS1398 LLQVATFKGW1408 TIIMYAAVDS1418 VNVDKQPKYE1428 YSLYMYIYFV 1438 VFIIFGSFFT1448 LNLFIGVIID1458 NFNQQKKKLG1468 GQDIFMTEEQ1478 KKYYNAMKKL 1488 GSKKPQKPIP1498 RPGNKIQGCI1508 FDLVTNQAFD1518 ISIMVLICLN1528 MVTMMVEKEG 1538 QSQHMTEVLY1548 WINVVFIILF1558 TGECVLKLIS1568 LRHYYFTVGW1578 NIFDFVVVII 1588 SIVGMFLADL1598 IETYFVSPTL1608 FRVIRLARIG1618 RILRLVKGAK1628 GIRTLLFALM 1638 MSLPALFNIG1648 LLLFLVMFIY1658 AIFGMSNFAY1668 VKKEDGINDM1678 FNFETFGNSM 1688 ICLFQITTSA1698 GWDGLLAPIL1708 NSKPPDCDPK1718 KVHPGSSVEG1728 DCGNPSVGIF 1738 YFVSYIIISF1748 LVVVNMYIAV1758 ILENFSVATE1768 ESTEPLSEDD1778 FEMFYEVWEK 1788 FDPDATQFIE1798 FSKLSDFAAA1808 LDPPLLIAKP1818 NKVQLIAMDL1828 PMVSGDRIHC 1838 LDILFAFTKR1848 VLGESGEMDS1858 LRSQMEERFM1868 SANPSKVSYE1878 PITTTLKRKQ 1888 EDV
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y01 or .Y012 or .Y013 or :3Y01;style chemicals stick;color identity;select .A:209 or .A:212 or .A:215 or .A:216 or .A:218 or .A:219 or .A:222 or .A:225 or .A:235 or .A:755 or .A:758 or .A:759 or .A:762 or .A:763 or .A:765 or .A:767 or .A:839 or .A:842 or .A:845 or .A:846 or .A:847 or .A:848 or .A:849 or .A:850 or .A:876 or .A:879 or .A:880 or .A:883 or .A:887 or .A:943 or .A:947 or .A:950 or .A:954 or .A:988 or .A:1250 or .A:1251 or .A:1254 or .A:1255 or .A:1256 or .A:1257 or .A:1260 or .A:1264 or .A:1326 or .A:1329 or .A:1330 or .A:1333 or .A:1391 or .A:1392 or .A:1393 or .A:1396 or .A:1429 or .A:1432; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASN209
2.603
ALA212
3.267
THR215
3.958
PHE216
3.827
VAL218
3.751
LEU219
3.532
LEU222
3.372
ILE225
4.957
VAL235
4.989
VAL755
3.791
THR758
4.022
LEU759
3.073
ALA762
4.145
MET763
4.037
HIS765
3.482
PRO767
4.027
LEU839
4.135
VAL842
4.982
LEU845
4.771
ALA846
4.012
LYS847
2.626
SER848
4.498
TRP849
3.979
PRO850
3.286
ILE876
4.827
ILE879
4.005
PHE880
4.227
VAL883
3.986
LEU887
3.990
MET943
4.321
VAL947
4.531
MET950
3.205
ILE954
4.946
LEU988
4.736
TYR1250
3.452
LYS1251
3.985
PHE1254
3.773
THR1255
3.803
ASN1256
3.640
ALA1257
4.156
TRP1260
3.058
LEU1264
3.827
LEU1326
3.357
LEU1329
4.179
ILE1330
2.925
LEU1333
2.874
ASN1391
3.685
VAL1392
4.352
GLY1393
3.567
TYR1396
4.232
TYR1429
3.975
TYR1432
3.530
|
|||||
| PDB ID: 7W9M Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (S6IV pi helix conformer) | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | Yes | [2] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNNVS211 ALRTFRVLRA221 LKTISVIPGL 231 KTIVGALIQS241 VKKLSDVMIL251 TVFCLSVFAL261 IGLQLFMGNL271 KHKCFRNSLE 281 NNETLESIMN291 TLESEEDFRK301 YFYYLEGSKD311 ALLCGFSTDS321 GQCPEGYTCV 331 KIGRNPDYGY341 TSFDTFSWAF351 LALFRLMTQD361 YWENLYQQTL371 RAAGKTYMIF 381 FVVVIFLGSF391 YLINLILAVV401 AMAYKEQNQA411 NIEEAKQKEL421 EFQQMLDRLK 431 KEQEPYWIKF733 KKCIYFIVMD743 PFVDLAITIC753 IVLNTLFMAM763 EHHPMTEEFK 773 NVLAIGNLVF783 TGIFAAEMVL793 KLIAMDPYEY803 FQVGWNIFDS813 LIVTLSLVEL 823 FLADVEGLSV833 LRSFRLLRVF843 KLAKSWPTLN853 MLIKIIGNSV863 GALGNLTLVL 873 AIIVFIFAVV883 GMQLFGKSYK893 ECVCKINDDC903 TLPRWHMNDF913 FHSFLIVFRV 923 LCGEWIETMW933 DCMEVAGQAM943 CLIVYMMVMV953 IGNLVVLNLF963 LALLLSSFSS 973 DNLTAIEEDP983 DANNLQIAVT993 RIKKGINYVK1003 QTLREFILKA1013 FGKIWWNIRK 1183 TCYKIVEHSW1193 FESFIVLMIL1203 LSSGALAFED1213 IYIERKKTIK1223 IILEYADKIF 1233 TYIFILEMLL1243 KWIAYGYKTY1253 FTNAWCWLDF1263 LIVDVSLVTL1273 VANTLGYSDL 1283 GPIKSLRTLR1293 ALRPLRALSR1303 FEGMRVVVNA1313 LIGAIPSIMN1323 VLLVCLIFWL 1333 IFSIMGVNLF1343 AGKFYECINT1353 TDGSRFPASQ1363 VPNRSECFAL1373 MNVSQNVRWK 1383 NLKVNFDNVG1393 LGYLSLLQVA1403 TFKGWTIIMY1413 AAVDSVNVDK1423 QPKYEYSLYM 1433 YIYFVVFIIF1443 GSFFTLNLFI1453 GVIIDNFNQQ1463 KKKLGGQDIF1473 MTEEQKKYYN 1483 AMKKLGSKKP1493 QKPIPRPGNK1503 IQGCIFDLVT1513 NQAFDISIMV1523 LICLNMVTMM 1533 VEKEGQSQHM1543 TEVLYWINVV1553 FIILFTGECV1563 LKLISLRHYY1573 FTVGWNIFDF 1583 VVVIISIVGM1593 FLADLIETYF1603 VSPTLFRVIR1613 LARIGRILRL1623 VKGAKGIRTL 1633 LFALMMSLPA1643 LFNIGLLLFL1653 VMFIYAIFGM1663 SNFAYVKKED1673 GINDMFNFET 1683 FGNSMICLFQ1693 ITTSAGWDGL1703 LAPILNSKPP1713 DCDPKKVHPG1723 SSVEGDCGNP 1733 SVGIFYFVSY1743 IIISFLVVVN1753 MYIAVILENF1763 SVATEESTEP1773 LSEDDFEMFY 1783 EVWEKFDPDA1793 TQFIEFSKLS1803 DFAAALDPPL1813 LIAKPNKVQL1823 IAMDLPMVSG 1833 DRIHCLDILF1843 AFTKRVLGES1853 GEMDSLRSQM1863 EERFMSANPS1873 KVSYEPITTT 1883 LKRKQEDV
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y01 or .Y012 or .Y013 or :3Y01;style chemicals stick;color identity;select .A:209 or .A:212 or .A:215 or .A:216 or .A:218 or .A:219 or .A:222 or .A:755 or .A:842 or .A:845 or .A:848 or .A:849 or .A:850 or .A:876 or .A:879 or .A:880 or .A:883 or .A:887 or .A:943 or .A:947 or .A:950 or .A:954 or .A:988 or .A:1250 or .A:1251 or .A:1254 or .A:1255 or .A:1256 or .A:1257 or .A:1260 or .A:1264 or .A:1323 or .A:1326 or .A:1330 or .A:1429 or .A:1432; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ASN209
2.484
ALA212
2.475
THR215
3.598
PHE216
3.407
VAL218
3.983
LEU219
4.291
LEU222
4.726
VAL755
4.590
VAL842
4.760
LEU845
3.948
SER848
4.207
TRP849
3.246
PRO850
4.818
ILE876
3.420
ILE879
3.866
PHE880
3.357
VAL883
3.713
LEU887
3.425
|
|||||
| PDB ID: 7W9T Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV alpha helix conformer) | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | Yes | [2] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNLGN209 VSALRTFRVL219 RALKTISVIP 229 GLKTIVGALI239 QSVKKLSDVM249 ILTVFCLSVF259 ALIGLQLFMG269 NLKHKCFRNS 279 LENNETLESI289 MNTLESEEDF299 RKYFYYLEGS309 KDALLCGFST319 DSGQCPEGYT 329 CVKIGRNPDY339 GYTSFDTFSW349 AFLALFRLMT359 QDYWENLYQQ369 TLRAAGKTYM 379 IFFVVVIFLG389 SFYLINLILA399 VVAMAYKEQN409 QANIEEAKQK419 ELEFQQMLDR 429 LKKPYWIKFK734 KCIYFIVMDP744 FVDLAITICI754 VLNTLFMAME764 HHPMTEEFKN 774 VLAIGNLVFT784 GIFAAEMVLK794 LIAMDPYEYF804 QVGWNIFDSL814 IVTLSLVELF 824 LADVEGLSVL834 RSFRLLRVFK844 LAKSWPTLNM854 LIKIIGNSVG864 ALGNLTLVLA 874 IIVFIFAVVG884 MQLFGKSYKE894 CVCKINDDCT904 LPRWHMNDFF914 HSFLIVFRVL 924 CGEWIETMWD934 CMEVAGQAMC944 LIVYMMVMVI954 GNLVVLNLFL964 ALLLSSFSSD 974 NLTAIEEDPD984 ANNLQIAVTR994 IKKGINYVKQ1004 TLREFILKAF1014 GKIWWNIRKT 1184 CYKIVEHSWF1194 ESFIVLMILL1204 SSGALAFEDI1214 YIERKKTIKI1224 ILEYADKIFT 1234 YIFILEMLLK1244 WIAYGYKTYF1254 TNAWCWLDFL1264 IVDVSLVTLV1274 ANTLGYSDLG 1284 PIKSLRTLRA1294 LRPLRALSRF1304 EGMRVVVNAL1314 IGAIPSIMNV1324 LLVCLIFWLI 1334 FSIMGVNLFA1344 GKFYECINTT1354 DGSRFPASQV1364 PNRSECFALM1374 NVSQNVRWKN 1384 LKVNFDNVGL1394 GYLSLLQVAT1404 FKGWTIIMYA1414 AVDSVNVDKQ1424 PKYEYSLYMY 1434 IYFVVFIIFG1444 SFFTLNLFIG1454 VIIDNFNQQK1464 KKLGGQDIFM1474 TEEQKKYYNA 1484 MKKLGSKKPQ1494 KPIPRPGNKI1504 QGCIFDLVTN1514 QAFDISIMVL1524 ICLNMVTMMV 1534 EKEGQSQHMT1544 EVLYWINVVF1554 IILFTGECVL1564 KLISLRHYYF1574 TVGWNIFDFV 1584 VVIISIVGMF1594 LADLIETYFV1604 SPTLFRVIRL1614 ARIGRILRLV1624 KGAKGIRTLL 1634 FALMMSLPAL1644 FNIGLLLFLV1654 MFIYAIFGMS1664 NFAYVKKEDG1674 INDMFNFETF 1684 GNSMICLFQI1694 TTSAGWDGLL1704 APILNSKPPD1714 CDPKKVHPGS1724 SVEGDCGNPS 1734 VGIFYFVSYI1744 IISFLVVVNM1754 YIAVILENFS1764 VATEESTEPL1774 SEDDFEMFYE 1784 VWEKFDPDAT1794 QFIEFSKLSD1804 FAAALDPPLL1814 IAKPNKVQLI1824 AMDLPMVSGD 1834 RIHCLDILFA1844 FTKRVLGESG1854 EMDSLRSQME1864 ERFMSANPSK1874 VSYEPITTTL 1884 KRKQEDV
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y01 or .Y012 or .Y013 or :3Y01;style chemicals stick;color identity;select .A:755 or .A:758 or .A:759 or .A:762 or .A:763 or .A:764 or .A:765 or .A:767 or .A:842 or .A:845 or .A:848 or .A:849 or .A:850 or .A:988 or .A:1250 or .A:1251 or .A:1254 or .A:1255 or .A:1256 or .A:1257 or .A:1260 or .A:1264 or .A:1323 or .A:1326 or .A:1329 or .A:1330 or .A:1333 or .A:1391 or .A:1392 or .A:1393 or .A:1396 or .A:1429 or .A:1432; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
VAL755
3.856
THR758
4.676
LEU759
3.750
ALA762
3.351
MET763
4.112
GLU764
4.569
HIS765
3.689
PRO767
4.178
VAL842
3.874
LEU845
4.080
SER848
3.162
TRP849
3.631
PRO850
3.780
LEU988
4.558
TYR1250
3.759
LYS1251
3.978
PHE1254
3.701
|
|||||
| PDB ID: 7W9L Cryo-EM structure of human Nav1.7(E406K)-beta1-beta2 complex | ||||||
| Method | Electron microscopy | Resolution | 3.50 Å | Mutation | Yes | [2] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNLGN209 VSALRTFRVL219 RALKTISVIP 229 GLKTIVGALI239 QSVKKLSDVM249 ILTVFCLSVF259 ALIGLQLFMG269 NLKHKCFRNS 279 LENNETLESI289 MNTLESEEDF299 RKYFYYLEGS309 KDALLCGFST319 DSGQCPEGYT 329 CVKIGRNPDY339 GYTSFDTFSW349 AFLALFRLMT359 QDYWENLYQQ369 TLRAAGKTYM 379 IFFVVVIFLG389 SFYLINLILA399 VVAMAYKEQN409 QANIEEAKQK419 ELEFQQMLDR 429 LKKEQEPYWI731 KFKKCIYFIV741 MDPFVDLAIT751 ICIVLNTLFM761 AMEHHPMTEE 771 FKNVLAIGNL781 VFTGIFAAEM791 VLKLIAMDPY801 EYFQVGWNIF811 DSLIVTLSLV 821 ELFLADVEGL831 SVLRSFRLLR841 VFKLAKSWPT851 LNMLIKIIGN861 SVGALGNLTL 871 VLAIIVFIFA881 VVGMQLFGKS891 YKECVCKIND901 DCTLPRWHMN911 DFFHSFLIVF 921 RVLCGEWIET931 MWDCMEVAGQ941 AMCLIVYMMV951 MVIGNLVVLN961 LFLALLLSSF 971 SSDNLTAIEE981 DPDANNLQIA991 VTRIKKGINY1001 VKQTLREFIL1011 KAFGKIWWNI 1181 RKTCYKIVEH1191 SWFESFIVLM1201 ILLSSGALAF1211 EDIYIERKKT1221 IKIILEYADK 1231 IFTYIFILEM1241 LLKWIAYGYK1251 TYFTNAWCWL1261 DFLIVDVSLV1271 TLVANTLGYS 1281 DLGPIKSLRT1291 LRALRPLRAL1301 SRFEGMRVVV1311 NALIGAIPSI1321 MNVLLVCLIF 1331 WLIFSIMGVN1341 LFAGKFYECI1351 NTTDGSRFPA1361 SQVPNRSECF1371 ALMNVSQNVR 1381 WKNLKVNFDN1391 VGLGYLSLLQ1401 VATFKGWTII1411 MYAAVDSVNV1421 DKQPKYEYSL 1431 YMYIYFVVFI1441 IFGSFFTLNL1451 FIGVIIDNFN1461 QQKKKLGGQD1471 IFMTEEQKKY 1481 YNAMKKLGSK1491 KPQKPIPRPG1501 NKIQGCIFDL1511 VTNQAFDISI1521 MVLICLNMVT 1531 MMVEKEGQSQ1541 HMTEVLYWIN1551 VVFIILFTGE1561 CVLKLISLRH1571 YYFTVGWNIF 1581 DFVVVIISIV1591 GMFLADLIET1601 YFVSPTLFRV1611 IRLARIGRIL1621 RLVKGAKGIR 1631 TLLFALMMSL1641 PALFNIGLLL1651 FLVMFIYAIF1661 GMSNFAYVKK1671 EDGINDMFNF 1681 ETFGNSMICL1691 FQITTSAGWD1701 GLLAPILNSK1711 PPDCDPKKVH1721 PGSSVEGDCG 1731 NPSVGIFYFV1741 SYIIISFLVV1751 VNMYIAVILE1761 NFSVATEEST1771 EPLSEDDFEM 1781 FYEVWEKFDP1791 DATQFIEFSK1801 LSDFAAALDP1811 PLLIAKPNKV1821 QLIAMDLPMV 1831 SGDRIHCLDI1841 LFAFTKRVLG1851 ESGEMDSLRS1861 QMEERFMSAN1871 PSKVSYEPIT 1881 TTLKRKQEDV1891
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y01 or .Y012 or .Y013 or :3Y01;style chemicals stick;color identity;select .A:208 or .A:209 or .A:212 or .A:213 or .A:215 or .A:216 or .A:218 or .A:219 or .A:222 or .A:755 or .A:758 or .A:759 or .A:762 or .A:763 or .A:764 or .A:765 or .A:767 or .A:829 or .A:842 or .A:845 or .A:848 or .A:849 or .A:850 or .A:876 or .A:879 or .A:880 or .A:883 or .A:887 or .A:950 or .A:954 or .A:986 or .A:988 or .A:989 or .A:1250 or .A:1251 or .A:1254 or .A:1255 or .A:1256 or .A:1257 or .A:1260 or .A:1264 or .A:1323 or .A:1326 or .A:1329 or .A:1330 or .A:1333 or .A:1391 or .A:1392 or .A:1393 or .A:1396 or .A:1429 or .A:1432 or .A:1435; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY208
4.981
ASN209
3.626
ALA212
2.234
LEU213
4.503
THR215
3.359
PHE216
3.750
VAL218
3.736
LEU219
3.108
LEU222
4.742
VAL755
3.058
THR758
3.449
LEU759
3.832
ALA762
3.224
MET763
3.919
GLU764
4.261
HIS765
3.415
PRO767
4.679
GLU829
3.573
VAL842
2.758
LEU845
2.962
SER848
4.114
TRP849
3.606
PRO850
3.334
ILE876
3.149
ILE879
4.037
PHE880
3.500
VAL883
3.758
LEU887
3.546
MET950
3.568
ILE954
4.478
ASN986
4.655
LEU988
4.682
GLN989
4.634
TYR1250
4.468
LYS1251
4.552
PHE1254
2.892
THR1255
2.594
ASN1256
4.169
ALA1257
3.381
TRP1260
3.482
LEU1264
3.315
ASN1323
4.605
LEU1326
3.839
LEU1329
3.780
ILE1330
2.557
LEU1333
3.201
ASN1391
3.641
VAL1392
4.170
GLY1393
3.916
TYR1396
3.101
TYR1429
3.931
TYR1432
3.476
ILE1435
4.681
|
|||||
| PDB ID: 6NT3 Cryo-EM structure of a human-cockroach hybrid Nav channel. | ||||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [3] |
| PDB Sequence |
ANKDRDGSAH
61 PDQALEQGSR71 LPARMRNIFP81 AELASNKKTF102 VVVTKASGEK118 SLWMLDPFTP 128 IRRVAISTMV138 QPIFSYFIMI148 TILIHCIFMI158 MPATQTTYIL168 ELVFLSIYTI 178 EVVVKVLARG188 FILHPFAYLR198 DPWNWLDFLV208 TLIGYITLVV218 DLGHLYALRA 228 FRVLRSWRTV238 TIVPGWRTIV248 DALSLSITSL258 KDLVLLLLFS268 LSVFALIGLQ 278 LFMGNLKHKC288 VKHFPADGSW298 GNFTDERWFN308 YTSNSSHWYI318 PDDWIEYPLC 328 GNSSGAGMCP338 PGYTCLQGYG348 GNPNYGYTSF358 DTFGWAFLSV368 FRLVTLDYWE 378 DLYQLALRSA388 GPWHILFFII398 VVFYGTFCFL408 NFILAVVVMS418 YTHMVKRADE 428 EKAAECVPWQ506 KLQGAIGAVV516 LSPFFELFIA526 VIIVLNITFM536 ALDHHDMNIE 546 FERILRTGNY556 IFTSIYIVEA566 VLKIIALSPK576 FYFKDSWNVF586 DFIIVVFAIL 596 ELGLEGVQGL606 SVFRSFRLLR616 VFRLAKFWPT626 LNNFMSVMTK636 SYGAFVNVMY 646 VMFLLLFIFA656 IIGMQLFGMN666 YIDNMERFPD676 GDLPRWNFTD686 FLHSFMIVFR 696 ALCGEWIESM706 WDCMLVGDWS716 CIPFFVAVFF726 VGNLVILNLL736 IALLLNNYGS 837 VQRMWSNIRR847 VCFLLAKNKY857 FQKFVTAVLV867 ITSVLLALED877 IYLPQRPVLV 887 NITLYVDYVL897 TAFFVIEMII907 MLFAVGFKKY917 FTSKWYWLDF927 IVVVAYLLNF 937 VLMCAGIEAL947 QTLRLLRVFR957 LFRPLSKVNG967 MQVVTSTLVE977 AVPHIFNVIL 987 VGIFFWLVFA997 IMGVQLFAGK1007 FYKCVDENST1017 VLSHEITMDR1027 NDCLHENYTW 1037 ENSPMNFDHV1047 GNAYLSLLQV1057 ATFKGWLQIM1067 NDAIDSREVH1077 KQPIRETNIY 1087 MYLYFIFFIV1097 FGSFFILKLF1107 VCILIDIFRQ1117 QRRKAEGLSA1127 TDSRTQLIYR 1137 RAVMRTMSAK1147 PVKRIPKPGN1157 KIQGCIFDLV1167 TNQAFDISIM1177 VLICLNMVTM 1187 MVEKEGQSQH1197 MTEVLYWINV1207 VFIILFTGEC1217 VLKLISLRHY1227 YFTVGWNIFD 1237 FVVVIISIVG1247 MFLADLIETY1257 FVSPTLFRVI1267 RLARIGRILR1277 LVKGAKGIRL 1287 LLLALRKALR1297 TLFNVSFLLF1307 VIMFVYAVFG1317 MEFFMHIRDA1327 GAIDDVYNFK 1337 TFGQSIILLF1347 QLATSAGWDG1357 VYFAIANEED1367 CRAPDHELGY1377 PGNCGSRALG 1387 IAYLVSYLII1397 TCLVVINMYA1407 AVILDYVLEV1417 YEDSKEGLTD1427 DDYDMFFEVW 1437 QQFDPEATQY1447 IRYDQLSELL1457 EALQPPLQVQ1467 KPNKYKILSM1477 NIPICKDDHI 1487 FYKDVLEALV1497 KDVFSRRG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y01 or .Y012 or .Y013 or :3Y01;style chemicals stick;color identity;select .A:332 or .A:390 or .A:391 or .A:393 or .A:394 or .A:397 or .A:1300 or .A:1303 or .A:1304 or .A:1307 or .A:1340 or .A:1343 or .A:1344; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| PDB ID: 6NT4 Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2. | ||||||
| Method | Electron microscopy | Resolution | 3.50 Å | Mutation | Yes | [4] |
| PDB Sequence |
ANKDRDGSAH
61 PDQALEQGSR71 LPARMRNIFP81 AELASKKTFV103 VVTKAGDFSG116 EKSLWMLDPF 126 TPIRRVAIST136 MVQPIFSYFI146 MITILIHCIF156 MIMPATQTTY166 ILELVFLSIY 176 TIEVVVKVLA186 RGFILHPFAY196 LRDPWNWLDF206 LVTLIGYITL216 VVDLGHLYAL 226 RAFRVLRSWR236 TVTIVPGWRT246 IVDALSLSIT256 SLKDLVLLLL266 FSLSVFALIG 276 LQLFMGNLKH286 KCVKHFPADG296 SWGNFTDERW306 FNYTSNSSHW316 YIPDDWIEYP 326 LCGNSSGAGM336 CPPGYTCLQG346 YGGNPNYGYT356 SFDTFGWAFL366 SVFRLVTLDY 376 WEDLYQLALR386 SAGPWHILFF396 IIVVFYGTFC406 FLNFILAVVV416 MSYTHMVKRA 426 DEEKAAECVP504 WQKLQGAIGA514 VVLSPFFELF524 IAVIIVLNIT534 FMALDHHDMN 544 IEFERILRTG554 NYIFTSIYIV564 EAVLKIIALS574 PKFYFKDSWN584 VFDFIIVVFA 594 ILELGLEGVQ604 SVFRSFRLLR616 VFRLAKFWPT626 LNNFMSVMTK636 SYGAFVNVMY 646 VMFLLLFIFA656 IIGMQLFGMN666 YIDNMERFPD676 GDLPRWNFTD686 FLHSFMIVFR 696 ALCGEWIESM706 WDCMLVGDWS716 CIPFFVAVFF726 VGNLVILNLL736 IALLLNNYGS 837 VQRMWSNIRR847 VCFLLAKNKY857 FQKFVTAVLV867 ITSVLLALED877 IYLPQRPVLV 887 NITLYVDYVL897 TAFFVIEMII907 MLFAVGFKKY917 FTSKWYWLDF927 IVVVAYLLNF 937 VLMCAGIEAL947 QTLRLLRVFR957 LFRPLSKVNG967 MQVVTSTLVE977 AVPHIFNVIL 987 VGIFFWLVFA997 IMGVQLFAGK1007 FYKCVDENST1017 VLSHEITMDR1027 NDCLHENYTW 1037 ENSPMNFDHV1047 GNAYLSLLQV1057 ATFKGWLQIM1067 NDAIDSREVH1077 KQPIRETNIY 1087 MYLYFIFFIV1097 FGSFFILKLF1107 VCILIDIFRQ1117 QRRKAEGLSA1127 TDSRTQLIYR 1137 RAVMRTMSAK1147 PVKRIPKPGN1157 KIQGCIFDLV1167 TNQAFDISIM1177 VLICLNMVTM 1187 MVEKEGQSQH1197 MTEVLYWINV1207 VFIILFTGEC1217 VLKLISLRHY1227 YFTVGWNIFD 1237 FVVVIISIVG1247 MFLADLIETY1257 FVSPTLFRVI1267 RLARIGRILR1277 LVKGAKGIRL 1287 LLLALRKALR1297 TLFNVSFLLF1307 VIMFVYAVFG1317 MEFFMHIRDA1327 GAIDDVYNFK 1337 TFGQSIILLF1347 QLATSAGWDG1357 VYFAIANEED1367 CRAPDHELGY1377 PGNCGSRALG 1387 IAYLVSYLII1397 TCLVVINMYA1407 AVILDYVLEV1417 YEDSKEGLTD1427 DDYDMFFEVW 1437 QQFDPEATQY1447 IRYDQLSELL1457 EALQPPLQVQ1467 KPNKYKILSM1477 NIPICKDDHI 1487 FYKDVLEALV1497 KDVFSRRG
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .Y01 or .Y012 or .Y013 or :3Y01;style chemicals stick;color identity;select .A:332 or .A:390 or .A:391 or .A:393 or .A:394 or .A:397 or .A:1300 or .A:1303 or .A:1304 or .A:1307 or .A:1339 or .A:1340 or .A:1343 or .A:1344; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
||||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na(v)1.7. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2209164119. | ||||
| REF 2 | High-resolution structures of human Na(v)1.7 reveal gating modulation through Alpha-Pi helical transition of S6(IV). Cell Rep. 2022 Apr 26;39(4):110735. | ||||
| REF 3 | Cryo-EM structures of a human-cockroach hybrid Nav channel in the presence and absence of the alpha-scorpion toxin AaH2. | ||||
| REF 4 | Structural basis of Alpha-scorpion toxin action on Na(v) channels. Science. 2019 Mar 22;363(6433):eaav8573. | ||||
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