Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T12119 | Target Info | |||
| Target Name | Voltage-gated sodium channel alpha Nav1.7 (SCN9A) | ||||
| Synonyms | hNE-Na; Voltage-gated sodium channel subunit alpha Nav1.7; Sodium channel proteintype IX subunit alpha; Sodium channel proteintype 9 subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel protein type 9 subunit alpha; Peripheral sodium channel 1; PN1; Neuroendocrine sodium channel; NENA | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | SCN9A | ||||
| Biochemical Class | Voltage-gated ion channel | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Lpc-Ether | Ligand Info | |||
| Canonical SMILES | CCCCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)O | ||||
| InChI | 1S/C26H56NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-31-24-26(28)25-33-34(29,30)32-23-21-27(2,3)4/h26,28H,5-25H2,1-4H3/t26-/m1/s1 | ||||
| InChIKey | XKBJVQHMEXMFDZ-AREMUKBSSA-N | ||||
| PubChem Compound ID | 2733532 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7XVE Human Nav1.7 mutant class-I | ||||||
| Method | Electron microscopy | Resolution | 2.70 Å | Mutation | Yes | [1] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVKYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNLGN209 VSALRTFRVL219 RALKTISVIP 229 GLKTIVGALI239 QSVKKLSDVM249 ILTVFCLSVF259 ALIGLQLFMG269 NLKHKCFRNS 279 LENNETLESI289 MNTLESEEDF299 RKYFYYLEGS309 KDALLCGFST319 DSGQCPEGYT 329 CVKIGRNPDY339 GYTSFDTFSW349 AFLALFRLMT359 QDYWENLYQQ369 TLRAAGKTYM 379 IFFVVVIFLG389 SFYLINLILA399 VVAMAYEEQN409 QANIEEAKQK419 ELEFQQMLCS 727 PYWIKFKKCI737 YFIVMDPFVD747 LAITICIVLN757 TLFMAMEHHP767 MTEEFKNVLA 777 IRNLVFTGIF787 AAEMVLKLIA797 MDPYEYFQVG807 WNIFDSLIVT817 LSLVELFGLS 832 VLRSFRLLRV842 FKLAKSWPTL852 NMLIKIIGNS862 VGAFGNLMLV872 LFIIVFIFAV 882 VGMQLFGKSY892 KECVCKINDD902 CTLPRWHMND912 FFHSFLIVFR922 VLCGEWIETM 932 WDCMEVAGQA942 MCLIFYMMVF952 FIGNLVVLNL962 FLALLLSSFS972 SDANNLQIAV 992 TRIKKGINYV1002 KQTLREFILK1012 AFGKIWWNIR1182 KTCYKIVEHS1192 WFESFIVLMI 1202 LLSSGALAFE1212 DIYIERKKTI1222 KIILEYADKI1232 FTYIFILEML1242 LKWIAYGYKT 1252 YFTNAWCWLD1262 FLIVDVSLVT1272 LVANTLGYSD1282 LGPIKSLRTL1292 RALRPLRALS 1302 RFEGMRVVVN1312 ALIGAIPSIM1322 NVLLVCLIFW1332 LIFSIMGVNL1342 FAGKFYECIN 1352 TTDGSRFPAS1362 QVPNRSECFA1372 LMNVSQNVRW1382 KNLKVNFDNV1392 GLGYLSLLQV 1402 ATFKGWTIIM1412 YAAVDSVNVD1422 KQPKYEYSLY1432 MYIYFIFFII1442 FGSFFTLNLF 1452 ICVIIDNFNQ1462 QKKKLGGQDI1472 FMTEEQKKYY1482 NAMKKLGSKK1492 PQKPIPRPGN 1502 KIQGCIFDLV1512 TNQAFDISIM1522 VLICLNMVTM1532 MVEKEGQSQH1542 MTEVLYWINV 1552 VFIILFTGEC1562 VLKLISLRHY1572 YFTVGWNIFD1582 FVVVIISIVG1592 MFLADLIETY 1602 FVSPTLFRVI1612 RLARIGRILR1622 LVKGAKGIRT1632 LLFALMMSLP1642 ALFNIGLLLF 1652 LVMFIYAIFG1662 MSNFAYVKKE1672 DGINDMFNFE1682 TFGNSMICLF1692 QITTSAGWDG 1702 LLAPILNSKP1712 PDCDPKKVHP1722 GSSVEGDCGN1732 PSVGIFYFVS1742 YIIISFLVVV 1752 NMYIAVILEN1762 FSVATE
|
|||||
|
|
LEU131
4.503
ASN154
3.566
TYR157
3.099
THR158
3.706
THR160
4.186
GLY161
3.794
ILE162
2.787
PHE165
3.764
GLU203
4.935
ILE250
3.760
VAL253
3.769
PHE254
3.229
SER257
3.449
THR319
4.607
ASP320
3.617
PHE347
3.704
SER348
3.863
PHE351
3.903
LYS376
3.148
THR377
4.342
MET379
3.901
VAL383
4.109
PHE387
3.883
LEU759
4.061
MET763
3.188
HIS765
3.974
PHE772
3.355
LYS1176
3.973
TRP1178
2.995
TRP1179
3.277
ARG1182
3.067
LYS1183
4.041
TYR1186
3.566
LYS1187
3.696
ILE1188
3.449
HIS1191
3.314
TRP1193
3.679
PHE1194
3.137
PHE1197
3.613
LEU1203
3.620
SER1206
3.611
GLY1207
4.033
ALA1210
3.354
PHE1211
3.661
ASP1213
3.362
TYR1215
3.020
ARG1218
3.729
LYS1219
3.945
LEU1239
4.211
LEU1242
4.496
TRP1245
3.326
ILE1246
3.705
ALA1247
3.183
TYR1248
2.725
GLY1249
3.635
TYR1250
3.428
LYS1251
3.825
THR1252
4.535
ASN1256
4.762
ALA1257
3.688
TRP1258
3.409
LEU1261
3.860
LYS1287
4.094
SER1288
3.476
THR1291
3.058
LEU1292
4.230
LEU1295
3.788
PRO1297
4.685
LEU1298
4.032
ALA1300
4.147
LEU1301
3.949
PHE1304
3.691
GLU1305
3.568
GLY1306
4.983
ARG1308
4.865
VAL1311
3.512
ASN1312
3.395
ILE1315
3.536
THR1475
3.266
GLU1476
4.731
GLU1477
3.725
GLN1478
3.528
TYR1481
3.343
ALA1484
3.542
MET1485
4.116
LEU1488
4.047
CYS1526
4.871
MET1529
4.162
MET1533
3.993
LEU1623
3.743
GLY1626
3.532
ALA1627
3.848
LYS1628
4.459
ILE1630
3.773
MET1638
4.368
LEU1641
3.720
PRO1642
3.929
LEU1644
3.515
PHE1645
3.789
GLY1648
3.822
LEU1649
3.756
LEU1650
3.971
LEU1651
4.025
PHE1652
3.585
LEU1653
3.593
VAL1654
3.953
MET1655
4.002
PHE1656
3.113
ILE1657
3.864
TYR1658
3.594
PHE1661
3.632
ASN1665
2.767
THR1683
3.613
PHE1684
3.708
GLY1685
3.356
ASN1686
4.465
MET1688
3.880
ILE1689
3.488
PHE1692
4.603
ASN1732
2.808
PRO1733
3.199
SER1734
3.257
VAL1735
3.461
ILE1737
3.234
PHE1738
3.629
TYR1739
3.792
VAL1741
3.720
SER1742
4.067
ILE1745
3.964
ILE1746
4.081
ILE1177
3.961
ILE1181
3.591
|
|||||
| PDB ID: 7XVF Nav1.7 mutant class2 | ||||||
| Method | Electron microscopy | Resolution | 2.80 Å | Mutation | Yes | [1] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVKYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNVSA212 LRTFRVLRAL222 KTISVIPGLK 232 TIVGALIQSV242 KKLSDVMILT252 VFCLSVFALI262 GLQLFMGNLK272 HKCFRNSLEN 282 NETLESIMNT292 LESEEDFRKY302 FYYLEGSKDA312 LLCGFSTDSG322 QCPEGYTCVK 332 IGRNPDYGYT342 SFDTFSWAFL352 ALFRLMTQDY362 WENLYQQTLR372 AAGKTYMIFF 382 VVVIFLGSFY392 LINLILAVVA402 MAYEEQNQAN412 IEEAKCSPYW730 IKFKKCIYFI 740 VMDPFVDLAI750 TICIVLNTLF760 MAMEHHPMTE770 EFKNVLAIRN780 LVFTGIFAAE 790 MVLKLIAMDP800 YEYFQVGWNI810 FDSLIVTLSL820 VELFGLSVLR835 SFRLLRVFKL 845 AKSWPTLNML855 IKIIGNSVGA865 FGNLMLVLFI875 IVFIFAVVGM885 QLFGKSYKEC 895 VCKINDDCTL905 PRWHMNDFFH915 SFLIVFRVLC925 GEWIETMWDC935 MEVAGQAMCL 945 IFYMMVFFIG955 NLVVLNLFLA965 LLLSSFSANN987 LQIAVTRIKK997 GINYVKQTLR 1007 EFILKAFGKI1177 WWNIRKTCYK1187 IVEHSWFESF1197 IVLMILLSSG1207 ALAFEDIYIE 1217 RKKTIKIILE1227 YADKIFTYIF1237 ILEMLLKWIA1247 YGYKTYFTNA1257 WCWLDFLIVD 1267 VSLVTLVANT1277 LGYSDLGPIK1287 SLRTLRALRP1297 LRALSRFEGM1307 RVVVNALIGA 1317 IPSIMNVLLV1327 CLIFWLIFSI1337 MGVNLFAGKF1347 YECINTTDGS1357 RFPASQVPNR 1367 SECFALMNVS1377 QNVRWKNLKV1387 NFDNVGLGYL1397 SLLQVATFKG1407 WTIIMYAAVD 1417 SVNVDKQPKY1427 EYSLYMYIYF1437 IFFIIFGSFF1447 TLNLFICVII1457 DNFNQQKKKL 1467 GGQDIFMTEE1477 QKKYYNAMKK1487 LGSKKPQKPI1497 PRPGNKIQGC1507 IFDLVTNQAF 1517 DISIMVLICL1527 NMVTMMVEKE1537 GQSQHMTEVL1547 YWINVVFIIL1557 FTGECVLKLI 1567 SLRHYYFTVG1577 WNIFDFVVVI1587 ISIVGMFLAD1597 LIETYFVSPT1607 LFRVIRLARI 1617 GRILRLVKGA1627 KGIRTLLFAL1637 MMSLPALFNI1647 GLLLFLVMFI1657 YAIFGMSNFA 1667 YVKKEDGIND1677 MFNFETFGNS1687 MICLFQITTS1697 AGWDGLLAPI1707 LNSKPPDCDP 1717 KKVHPGSSVE1727 GDCGNPSVGI1737 FYFVSYIIIS1747 FLVVVNMYIA1757 VILENFSVAT 1767 E
|
|||||
|
|
ILE250
3.943
VAL253
3.939
PHE254
4.020
SER257
3.671
THR319
4.036
ASP320
3.567
PHE347
4.097
PHE351
4.186
LYS376
3.394
THR377
3.586
MET379
3.738
VAL383
4.251
PHE387
4.158
LEU388
3.983
LEU759
3.333
MET763
3.488
HIS765
4.117
PHE772
3.209
GLY1175
3.583
TRP1178
3.426
TRP1179
3.371
ARG1182
2.677
LYS1183
4.057
TYR1186
3.890
LYS1187
4.085
ILE1188
3.389
HIS1191
3.127
TRP1193
3.914
PHE1194
3.328
PHE1197
3.920
LEU1203
4.315
SER1206
3.719
GLY1207
4.173
ALA1210
3.895
PHE1211
3.482
ASP1213
3.449
TYR1215
3.855
ARG1218
4.762
LYS1219
3.997
TRP1245
2.983
ILE1246
3.750
ALA1247
3.060
TYR1248
2.537
GLY1249
3.739
TYR1250
3.090
LYS1251
3.484
THR1252
4.287
ASN1256
4.818
ALA1257
3.493
TRP1258
3.064
LEU1261
4.155
LYS1287
4.708
SER1288
3.287
THR1291
3.881
LEU1292
3.449
LEU1295
4.064
PRO1297
4.995
LEU1298
4.240
ALA1300
4.178
LEU1301
4.851
PHE1304
3.968
GLU1305
4.108
VAL1311
3.684
ASN1312
3.667
ILE1315
4.505
THR1475
3.216
GLU1477
3.997
GLN1478
3.167
TYR1481
3.185
ALA1484
3.980
MET1485
3.841
MET1522
4.052
CYS1526
4.201
MET1529
3.717
MET1533
4.050
LEU1623
4.185
GLY1626
4.330
ALA1627
4.084
ILE1630
3.879
MET1638
4.745
LEU1641
4.135
PRO1642
4.173
LEU1644
3.937
PHE1645
4.072
GLY1648
3.746
LEU1649
4.893
LEU1650
4.870
LEU1651
4.207
PHE1652
3.484
LEU1653
3.975
VAL1654
3.965
MET1655
4.662
PHE1656
3.697
ILE1657
4.230
TYR1658
3.780
PHE1661
3.298
ASN1665
2.648
THR1683
3.313
PHE1684
3.479
GLY1685
2.234
ASN1686
3.883
MET1688
3.888
ILE1689
3.922
SER1710
4.505
ASN1732
2.397
PRO1733
3.067
SER1734
2.596
VAL1735
3.939
ILE1737
4.270
PHE1738
3.607
TYR1739
4.137
VAL1741
3.945
SER1742
4.290
ILE1745
3.396
ILE1746
4.592
TYR1755
4.839
ILE1177
3.811
ILE1181
4.669
THR1184
4.885
|
|||||
| PDB ID: 7W9K Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution | ||||||
| Method | Electron microscopy | Resolution | 2.20 Å | Mutation | No | [2] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNNVS211 ALRTFRVLRA221 LKTISVIPGL 231 KTIVGALIQS241 VKKLSDVMIL251 TVFCLSVFAL261 IGLQLFMGNL271 KHKCFRNSLE 281 NNETLESIMN291 TLESEEDFRK301 YFYYLEGSKD311 ALLCGFSTDS321 GQCPEGYTCV 331 KIGRNPDYGY341 TSFDTFSWAF351 LALFRLMTQD361 YWENLYQQTL371 RAAGKTYMIF 381 FVVVIFLGSF391 YLINLILAVV401 AMAYEEQNQA411 NIEEAKQKEL421 EFQQMLDRLK 431 KEQEPYWIKF733 KKCIYFIVMD743 PFVDLAITIC753 IVLNTLFMAM763 EHHPMTEEFK 773 NVLAIGNLVF783 TGIFAAEMVL793 KLIAMDPYEY803 FQVGWNIFDS813 LIVTLSLVEL 823 FLLSVLRSFR838 LLRVFKLAKS848 WPTLNMLIKI858 IGNSVGALGN868 LTLVLAIIVF 878 IFAVVGMQLF888 GKSYKECVCK898 INDDCTLPRW908 HMNDFFHSFL918 IVFRVLCGEW 928 IETMWDCMEV938 AGQAMCLIVY948 MMVMVIGNLV958 VLNLFLALLL968 SSFSSDNLTA 978 IEEDPDANNL988 QIAVTRIKKG998 INYVKQTLRE1008 FILKAFGKIW1178 WNIRKTCYKI 1188 VEHSWFESFI1198 VLMILLSSGA1208 LAFEDIYIER1218 KKTIKIILEY1228 ADKIFTYIFI 1238 LEMLLKWIAY1248 GYKTYFTNAW1258 CWLDFLIVDV1268 SLVTLVANTL1278 GYSDLGPIKS 1288 LRTLRALRPL1298 RALSRFEGMR1308 VVVNALIGAI1318 PSIMNVLLVC1328 LIFWLIFSIM 1338 GVNLFAGKFY1348 ECINTTDGSR1358 FPASQVPNRS1368 ECFALMNVSQ1378 NVRWKNLKVN 1388 FDNVGLGYLS1398 LLQVATFKGW1408 TIIMYAAVDS1418 VNVDKQPKYE1428 YSLYMYIYFV 1438 VFIIFGSFFT1448 LNLFIGVIID1458 NFNQQKKKLG1468 GQDIFMTEEQ1478 KKYYNAMKKL 1488 GSKKPQKPIP1498 RPGNKIQGCI1508 FDLVTNQAFD1518 ISIMVLICLN1528 MVTMMVEKEG 1538 QSQHMTEVLY1548 WINVVFIILF1558 TGECVLKLIS1568 LRHYYFTVGW1578 NIFDFVVVII 1588 SIVGMFLADL1598 IETYFVSPTL1608 FRVIRLARIG1618 RILRLVKGAK1628 GIRTLLFALM 1638 MSLPALFNIG1648 LLLFLVMFIY1658 AIFGMSNFAY1668 VKKEDGINDM1678 FNFETFGNSM 1688 ICLFQITTSA1698 GWDGLLAPIL1708 NSKPPDCDPK1718 KVHPGSSVEG1728 DCGNPSVGIF 1738 YFVSYIIISF1748 LVVVNMYIAV1758 ILENFSVATE1768 ESTEPLSEDD1778 FEMFYEVWEK 1788 FDPDATQFIE1798 FSKLSDFAAA1808 LDPPLLIAKP1818 NKVQLIAMDL1828 PMVSGDRIHC 1838 LDILFAFTKR1848 VLGESGEMDS1858 LRSQMEERFM1868 SANPSKVSYE1878 PITTTLKRKQ 1888 EDV
|
|||||
|
|
ILE250
3.867
VAL253
3.624
PHE254
4.014
SER257
3.565
THR319
4.291
ASP320
2.861
PHE347
3.838
SER348
4.399
PHE351
3.716
LYS376
3.421
THR377
3.131
MET379
3.629
ILE380
4.325
VAL383
3.893
PHE387
3.597
LEU759
4.875
MET763
3.682
HIS765
3.613
PHE772
3.224
TRP1178
3.411
TRP1179
2.856
ARG1182
2.927
LYS1187
3.636
ILE1188
3.373
HIS1191
3.579
TRP1193
3.450
PHE1194
2.754
PHE1197
3.966
LEU1203
3.663
SER1206
3.739
GLY1207
3.852
ALA1210
3.059
PHE1211
3.515
ASP1213
2.921
TYR1215
3.341
ARG1218
3.624
LYS1219
4.265
LEU1239
4.805
TRP1245
4.359
TYR1250
3.102
LYS1251
3.932
ASN1256
4.794
ALA1257
3.400
TRP1258
3.273
LEU1261
4.106
LEU1292
3.415
LEU1295
3.733
LEU1298
3.511
ALA1300
4.009
LEU1301
3.268
PHE1304
3.920
MET1307
3.863
VAL1311
3.309
ASN1312
3.368
ILE1315
3.430
LEU1329
4.770
GLU1477
3.518
GLN1478
2.807
TYR1481
3.401
ALA1484
3.352
MET1485
3.724
LEU1488
3.918
CYS1526
4.560
MET1529
3.799
MET1533
3.292
LEU1623
3.405
GLY1626
3.375
ALA1627
3.316
LYS1628
4.131
MET1638
4.123
LEU1641
3.568
PRO1642
3.282
LEU1644
4.095
PHE1645
3.607
ASN1646
4.349
GLY1648
4.571
LEU1650
3.711
PHE1652
3.608
LEU1653
3.316
VAL1654
3.486
MET1655
3.783
PHE1656
3.769
ILE1657
3.521
TYR1658
3.006
PHE1661
3.098
THR1683
3.478
PHE1684
3.265
GLY1685
3.784
ASN1686
4.065
MET1688
3.902
ILE1689
4.593
PHE1692
4.048
SER1710
3.715
ASN1732
4.418
PRO1733
3.690
SER1734
3.480
VAL1735
4.026
ILE1737
3.623
PHE1738
3.624
TYR1739
3.828
VAL1741
4.060
SER1742
3.935
ILE1745
4.339
ILE1746
4.069
MET1754
4.249
ILE1181
3.854
|
|||||
| PDB ID: 7W9P Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV pi helix conformer) | ||||||
| Method | Electron microscopy | Resolution | 2.90 Å | Mutation | Yes | [2] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNLGN209 VSALRTFRVL219 RALKTISVIP 229 GLKTIVGALI239 QSVKKLSDVM249 ILTVFCLSVF259 ALIGLQLFMG269 NLKHKCFRNS 279 LENNETLESI289 MNTLESEEDF299 RKYFYYLEGS309 KDALLCGFST319 DSGQCPEGYT 329 CVKIGRNPDY339 GYTSFDTFSW349 AFLALFRLMT359 QDYWENLYQQ369 TLRAAGKTYM 379 IFFVVVIFLG389 SFYLINLILA399 VVAMAYKEQN409 QANIEEAKQK419 ELEFQQMLDP 728 YWIKFKKCIY738 FIVMDPFVDL748 AITICIVLNT758 LFMAMEHHPM768 TEEFKNVLAI 778 GNLVFTGIFA788 AEMVLKLIAM798 DPYEYFQVGW808 NIFDSLIVTL818 SLVELFLADV 828 EGLSVLRSFR838 LLRVFKLAKS848 WPTLNMLIKI858 IGNSVGALGN868 LTLVLAIIVF 878 IFAVVGMQLF888 GKSYKECVCK898 INDDCTLPRW908 HMNDFFHSFL918 IVFRVLCGEW 928 IETMWDCMEV938 AGQAMCLIVY948 MMVMVIGNLV958 VLNLFLALLL968 SSFSSDNLTA 978 IEEDPDANNL988 QIAVTRIKKG998 INYVKQTLRE1008 FILKAFGKIW1178 WNIRKTCYKI 1188 VEHSWFESFI1198 VLMILLSSGA1208 LAFEDIYIER1218 KKTIKIILEY1228 ADKIFTYIFI 1238 LEMLLKWIAY1248 GYKTYFTNAW1258 CWLDFLIVDV1268 SLVTLVANTL1278 GYSDLGPIKS 1288 LRTLRALRPL1298 RALSRFEGMR1308 VVVNALIGAI1318 PSIMNVLLVC1328 LIFWLIFSIM 1338 GVNLFAGKFY1348 ECINTTDGSR1358 FPASQVPNRS1368 ECFALMNVSQ1378 NVRWKNLKVN 1388 FDNVGLGYLS1398 LLQVATFKGW1408 TIIMYAAVDS1418 VNVDKQPKYE1428 YSLYMYIYFV 1438 VFIIFGSFFT1448 LNLFIGVIID1458 NFNQQKKKLG1468 GQDIFMTEEQ1478 KKYYNAMKKL 1488 GSKKPQKPIP1498 RPGNKIQGCI1508 FDLVTNQAFD1518 ISIMVLICLN1528 MVTMMVEKEG 1538 QSQHMTEVLY1548 WINVVFIILF1558 TGECVLKLIS1568 LRHYYFTVGW1578 NIFDFVVVII 1588 SIVGMFLADL1598 IETYFVSPTL1608 FRVIRLARIG1618 RILRLVKGAK1628 GIRTLLFALM 1638 MSLPALFNIG1648 LLLFLVMFIY1658 AIFGMSNFAY1668 VKKEDGINDM1678 FNFETFGNSM 1688 ICLFQITTSA1698 GWDGLLAPIL1708 NSKPPDCDPK1718 KVHPGSSVEG1728 DCGNPSVGIF 1738 YFVSYIIISF1748 LVVVNMYIAV1758 ILENFSVATE1768 ESTEPLSEDD1778 FEMFYEVWEK 1788 FDPDATQFIE1798 FSKLSDFAAA1808 LDPPLLIAKP1818 NKVQLIAMDL1828 PMVSGDRIHC 1838 LDILFAFTKR1848 VLGESGEMDS1858 LRSQMEERFM1868 SANPSKVSYE1878 PITTTLKRKQ 1888 EDV
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LPE or .LPE2 or .LPE3 or :3LPE;style chemicals stick;color identity;select .A:250 or .A:253 or .A:254 or .A:257 or .A:319 or .A:320 or .A:347 or .A:348 or .A:351 or .A:376 or .A:377 or .A:379 or .A:383 or .A:387 or .A:1178 or .A:1179 or .A:1182 or .A:1203 or .A:1206 or .A:1207 or .A:1210 or .A:1211 or .A:1213 or .A:1215 or .A:1218 or .A:1219 or .A:1245 or .A:1250 or .A:1251 or .A:1257 or .A:1258 or .A:1261 or .A:1292 or .A:1295 or .A:1297 or .A:1298 or .A:1300 or .A:1301 or .A:1304 or .A:1307 or .A:1311 or .A:1312 or .A:1315 or .A:1329 or .A:1477 or .A:1478 or .A:1481 or .A:1484 or .A:1485 or .A:1488 or .A:1526 or .A:1529 or .A:1533 or .A:1623 or .A:1626 or .A:1627 or .A:1628 or .A:1630 or .A:1638 or .A:1641 or .A:1642 or .A:1644 or .A:1645 or .A:1646 or .A:1648 or .A:1649 or .A:1650 or .A:1652 or .A:1653 or .A:1654 or .A:1655 or .A:1656 or .A:1657 or .A:1658 or .A:1661 or .A:1683 or .A:1684 or .A:1685 or .A:1686 or .A:1688 or .A:1689 or .A:1692 or .A:1710 or .A:1711 or .A:1733 or .A:1734 or .A:1735 or .A:1737 or .A:1738 or .A:1739 or .A:1741 or .A:1742 or .A:1745 or .A:1746 or .A:1755 or .A:1177 or .A:1181; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE250
3.940
VAL253
4.174
PHE254
4.458
SER257
3.981
THR319
4.469
ASP320
3.078
PHE347
3.949
SER348
4.633
PHE351
3.740
LYS376
2.879
THR377
3.124
MET379
3.308
VAL383
3.970
PHE387
3.384
TRP1178
3.483
TRP1179
3.009
ARG1182
3.555
LEU1203
4.489
SER1206
3.968
GLY1207
4.297
ALA1210
3.102
PHE1211
3.137
ASP1213
3.782
TYR1215
3.329
ARG1218
3.513
LYS1219
2.970
TRP1245
4.367
TYR1250
3.240
LYS1251
3.758
ALA1257
3.434
TRP1258
3.158
LEU1261
4.452
LEU1292
4.191
LEU1295
4.236
PRO1297
4.975
LEU1298
3.233
ALA1300
4.858
LEU1301
2.934
PHE1304
4.221
MET1307
2.758
VAL1311
3.439
ASN1312
2.939
ILE1315
4.078
LEU1329
4.306
GLU1477
3.896
GLN1478
3.615
TYR1481
3.168
ALA1484
3.753
MET1485
3.357
LEU1488
3.062
CYS1526
4.968
MET1529
4.132
MET1533
3.619
LEU1623
4.202
GLY1626
4.154
ALA1627
3.531
LYS1628
4.062
ILE1630
4.875
MET1638
4.529
LEU1641
3.461
PRO1642
3.831
LEU1644
3.951
PHE1645
2.954
ASN1646
4.097
GLY1648
4.563
LEU1649
4.388
LEU1650
3.900
PHE1652
3.699
LEU1653
2.441
VAL1654
3.857
MET1655
3.301
PHE1656
4.084
ILE1657
3.280
TYR1658
3.164
PHE1661
3.284
THR1683
3.546
PHE1684
3.114
GLY1685
3.639
ASN1686
4.734
MET1688
3.900
ILE1689
4.686
PHE1692
3.755
SER1710
3.650
LYS1711
3.963
PRO1733
3.929
SER1734
3.671
VAL1735
4.264
ILE1737
3.974
PHE1738
2.092
TYR1739
3.994
VAL1741
3.858
SER1742
3.678
ILE1745
4.004
ILE1746
3.888
TYR1755
4.368
ILE1177
4.499
ILE1181
3.908
|
|||||
| PDB ID: 7W9M Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (S6IV pi helix conformer) | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | Yes | [2] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNNVS211 ALRTFRVLRA221 LKTISVIPGL 231 KTIVGALIQS241 VKKLSDVMIL251 TVFCLSVFAL261 IGLQLFMGNL271 KHKCFRNSLE 281 NNETLESIMN291 TLESEEDFRK301 YFYYLEGSKD311 ALLCGFSTDS321 GQCPEGYTCV 331 KIGRNPDYGY341 TSFDTFSWAF351 LALFRLMTQD361 YWENLYQQTL371 RAAGKTYMIF 381 FVVVIFLGSF391 YLINLILAVV401 AMAYKEQNQA411 NIEEAKQKEL421 EFQQMLDRLK 431 KEQEPYWIKF733 KKCIYFIVMD743 PFVDLAITIC753 IVLNTLFMAM763 EHHPMTEEFK 773 NVLAIGNLVF783 TGIFAAEMVL793 KLIAMDPYEY803 FQVGWNIFDS813 LIVTLSLVEL 823 FLADVEGLSV833 LRSFRLLRVF843 KLAKSWPTLN853 MLIKIIGNSV863 GALGNLTLVL 873 AIIVFIFAVV883 GMQLFGKSYK893 ECVCKINDDC903 TLPRWHMNDF913 FHSFLIVFRV 923 LCGEWIETMW933 DCMEVAGQAM943 CLIVYMMVMV953 IGNLVVLNLF963 LALLLSSFSS 973 DNLTAIEEDP983 DANNLQIAVT993 RIKKGINYVK1003 QTLREFILKA1013 FGKIWWNIRK 1183 TCYKIVEHSW1193 FESFIVLMIL1203 LSSGALAFED1213 IYIERKKTIK1223 IILEYADKIF 1233 TYIFILEMLL1243 KWIAYGYKTY1253 FTNAWCWLDF1263 LIVDVSLVTL1273 VANTLGYSDL 1283 GPIKSLRTLR1293 ALRPLRALSR1303 FEGMRVVVNA1313 LIGAIPSIMN1323 VLLVCLIFWL 1333 IFSIMGVNLF1343 AGKFYECINT1353 TDGSRFPASQ1363 VPNRSECFAL1373 MNVSQNVRWK 1383 NLKVNFDNVG1393 LGYLSLLQVA1403 TFKGWTIIMY1413 AAVDSVNVDK1423 QPKYEYSLYM 1433 YIYFVVFIIF1443 GSFFTLNLFI1453 GVIIDNFNQQ1463 KKKLGGQDIF1473 MTEEQKKYYN 1483 AMKKLGSKKP1493 QKPIPRPGNK1503 IQGCIFDLVT1513 NQAFDISIMV1523 LICLNMVTMM 1533 VEKEGQSQHM1543 TEVLYWINVV1553 FIILFTGECV1563 LKLISLRHYY1573 FTVGWNIFDF 1583 VVVIISIVGM1593 FLADLIETYF1603 VSPTLFRVIR1613 LARIGRILRL1623 VKGAKGIRTL 1633 LFALMMSLPA1643 LFNIGLLLFL1653 VMFIYAIFGM1663 SNFAYVKKED1673 GINDMFNFET 1683 FGNSMICLFQ1693 ITTSAGWDGL1703 LAPILNSKPP1713 DCDPKKVHPG1723 SSVEGDCGNP 1733 SVGIFYFVSY1743 IIISFLVVVN1753 MYIAVILENF1763 SVATEESTEP1773 LSEDDFEMFY 1783 EVWEKFDPDA1793 TQFIEFSKLS1803 DFAAALDPPL1813 LIAKPNKVQL1823 IAMDLPMVSG 1833 DRIHCLDILF1843 AFTKRVLGES1853 GEMDSLRSQM1863 EERFMSANPS1873 KVSYEPITTT 1883 LKRKQEDV
|
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|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LPE or .LPE2 or .LPE3 or :3LPE;style chemicals stick;color identity;select .A:1181; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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| PDB ID: 7W9T Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV alpha helix conformer) | ||||||
| Method | Electron microscopy | Resolution | 3.00 Å | Mutation | Yes | [2] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNLGN209 VSALRTFRVL219 RALKTISVIP 229 GLKTIVGALI239 QSVKKLSDVM249 ILTVFCLSVF259 ALIGLQLFMG269 NLKHKCFRNS 279 LENNETLESI289 MNTLESEEDF299 RKYFYYLEGS309 KDALLCGFST319 DSGQCPEGYT 329 CVKIGRNPDY339 GYTSFDTFSW349 AFLALFRLMT359 QDYWENLYQQ369 TLRAAGKTYM 379 IFFVVVIFLG389 SFYLINLILA399 VVAMAYKEQN409 QANIEEAKQK419 ELEFQQMLDR 429 LKKPYWIKFK734 KCIYFIVMDP744 FVDLAITICI754 VLNTLFMAME764 HHPMTEEFKN 774 VLAIGNLVFT784 GIFAAEMVLK794 LIAMDPYEYF804 QVGWNIFDSL814 IVTLSLVELF 824 LADVEGLSVL834 RSFRLLRVFK844 LAKSWPTLNM854 LIKIIGNSVG864 ALGNLTLVLA 874 IIVFIFAVVG884 MQLFGKSYKE894 CVCKINDDCT904 LPRWHMNDFF914 HSFLIVFRVL 924 CGEWIETMWD934 CMEVAGQAMC944 LIVYMMVMVI954 GNLVVLNLFL964 ALLLSSFSSD 974 NLTAIEEDPD984 ANNLQIAVTR994 IKKGINYVKQ1004 TLREFILKAF1014 GKIWWNIRKT 1184 CYKIVEHSWF1194 ESFIVLMILL1204 SSGALAFEDI1214 YIERKKTIKI1224 ILEYADKIFT 1234 YIFILEMLLK1244 WIAYGYKTYF1254 TNAWCWLDFL1264 IVDVSLVTLV1274 ANTLGYSDLG 1284 PIKSLRTLRA1294 LRPLRALSRF1304 EGMRVVVNAL1314 IGAIPSIMNV1324 LLVCLIFWLI 1334 FSIMGVNLFA1344 GKFYECINTT1354 DGSRFPASQV1364 PNRSECFALM1374 NVSQNVRWKN 1384 LKVNFDNVGL1394 GYLSLLQVAT1404 FKGWTIIMYA1414 AVDSVNVDKQ1424 PKYEYSLYMY 1434 IYFVVFIIFG1444 SFFTLNLFIG1454 VIIDNFNQQK1464 KKLGGQDIFM1474 TEEQKKYYNA 1484 MKKLGSKKPQ1494 KPIPRPGNKI1504 QGCIFDLVTN1514 QAFDISIMVL1524 ICLNMVTMMV 1534 EKEGQSQHMT1544 EVLYWINVVF1554 IILFTGECVL1564 KLISLRHYYF1574 TVGWNIFDFV 1584 VVIISIVGMF1594 LADLIETYFV1604 SPTLFRVIRL1614 ARIGRILRLV1624 KGAKGIRTLL 1634 FALMMSLPAL1644 FNIGLLLFLV1654 MFIYAIFGMS1664 NFAYVKKEDG1674 INDMFNFETF 1684 GNSMICLFQI1694 TTSAGWDGLL1704 APILNSKPPD1714 CDPKKVHPGS1724 SVEGDCGNPS 1734 VGIFYFVSYI1744 IISFLVVVNM1754 YIAVILENFS1764 VATEESTEPL1774 SEDDFEMFYE 1784 VWEKFDPDAT1794 QFIEFSKLSD1804 FAAALDPPLL1814 IAKPNKVQLI1824 AMDLPMVSGD 1834 RIHCLDILFA1844 FTKRVLGESG1854 EMDSLRSQME1864 ERFMSANPSK1874 VSYEPITTTL 1884 KRKQEDV
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LPE or .LPE2 or .LPE3 or :3LPE;style chemicals stick;color identity;select .A:250 or .A:253 or .A:254 or .A:257 or .A:319 or .A:320 or .A:347 or .A:351 or .A:376 or .A:377 or .A:379 or .A:380 or .A:383 or .A:387 or .A:759 or .A:763 or .A:765 or .A:772 or .A:1178 or .A:1179 or .A:1182 or .A:1203 or .A:1206 or .A:1207 or .A:1210 or .A:1211 or .A:1213 or .A:1215 or .A:1219 or .A:1245 or .A:1250 or .A:1251 or .A:1256 or .A:1257 or .A:1258 or .A:1261 or .A:1292 or .A:1295 or .A:1298 or .A:1300 or .A:1301 or .A:1304 or .A:1307 or .A:1311 or .A:1312 or .A:1315 or .A:1477 or .A:1478 or .A:1480 or .A:1481 or .A:1484 or .A:1485 or .A:1488 or .A:1526 or .A:1529 or .A:1533 or .A:1623 or .A:1626 or .A:1627 or .A:1638 or .A:1641 or .A:1642 or .A:1644 or .A:1645 or .A:1646 or .A:1648 or .A:1649 or .A:1650 or .A:1652 or .A:1653 or .A:1654 or .A:1655 or .A:1656 or .A:1657 or .A:1658 or .A:1661 or .A:1665 or .A:1683 or .A:1684 or .A:1685 or .A:1686 or .A:1688 or .A:1689 or .A:1692 or .A:1710 or .A:1711 or .A:1732 or .A:1733 or .A:1734 or .A:1735 or .A:1737 or .A:1738 or .A:1739 or .A:1741 or .A:1742 or .A:1745 or .A:1746 or .A:1754 or .A:1181; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
ILE250
4.283
VAL253
3.332
PHE254
4.190
SER257
4.135
THR319
4.418
ASP320
2.747
PHE347
4.612
PHE351
4.197
LYS376
3.173
THR377
3.318
MET379
3.257
ILE380
4.820
VAL383
3.774
PHE387
3.881
LEU759
4.557
MET763
3.502
HIS765
4.010
PHE772
2.945
TRP1178
3.082
TRP1179
2.777
ARG1182
2.592
LEU1203
4.286
SER1206
3.930
GLY1207
4.044
ALA1210
3.045
PHE1211
3.781
ASP1213
3.736
TYR1215
4.350
LYS1219
2.967
TRP1245
4.034
TYR1250
2.838
LYS1251
2.923
ASN1256
4.951
ALA1257
2.720
TRP1258
2.804
LEU1261
4.484
LEU1292
4.643
LEU1295
4.507
LEU1298
2.934
ALA1300
4.472
LEU1301
3.061
PHE1304
2.869
MET1307
2.460
VAL1311
3.731
ASN1312
3.928
ILE1315
3.109
GLU1477
2.975
GLN1478
3.093
LYS1480
4.215
TYR1481
3.503
ALA1484
2.944
MET1485
3.536
LEU1488
3.677
CYS1526
4.299
MET1529
4.131
MET1533
3.727
LEU1623
3.265
GLY1626
4.179
ALA1627
3.993
MET1638
4.065
LEU1641
3.616
PRO1642
3.247
LEU1644
3.749
PHE1645
3.521
ASN1646
4.210
GLY1648
4.408
LEU1649
3.958
LEU1650
4.517
PHE1652
3.999
LEU1653
2.738
VAL1654
3.871
MET1655
3.138
PHE1656
3.929
ILE1657
3.153
TYR1658
3.230
PHE1661
3.397
ASN1665
4.603
THR1683
3.284
PHE1684
3.257
GLY1685
3.946
ASN1686
3.595
MET1688
3.898
ILE1689
4.641
PHE1692
3.777
SER1710
4.073
LYS1711
4.810
ASN1732
4.448
PRO1733
3.629
SER1734
3.472
VAL1735
2.947
ILE1737
3.832
PHE1738
2.556
TYR1739
3.534
VAL1741
3.208
SER1742
3.825
ILE1745
4.259
ILE1746
3.473
MET1754
3.360
ILE1181
3.303
|
|||||
| PDB ID: 7W9L Cryo-EM structure of human Nav1.7(E406K)-beta1-beta2 complex | ||||||
| Method | Electron microscopy | Resolution | 3.50 Å | Mutation | Yes | [2] |
| PDB Sequence |
GPQSFVHFTK
17 QSLALIEQRI27 AERKSKEPKP49 SSDLEAGKQL59 PFIYGDIPPG69 MVSEPLEDLD 79 PYYADKKTFI89 VLNKGKTIFR99 FNATPALYML109 SPFSPLRRIS119 IKILVHSLFS 129 MLIMCTILTN139 CIFMTMNNPP149 DWTKNVEYTF159 TGIYTFESLV169 KILARGFCVG 179 EFTFLRDPWN189 WLDFVVIVFA199 YLTEFVNLGN209 VSALRTFRVL219 RALKTISVIP 229 GLKTIVGALI239 QSVKKLSDVM249 ILTVFCLSVF259 ALIGLQLFMG269 NLKHKCFRNS 279 LENNETLESI289 MNTLESEEDF299 RKYFYYLEGS309 KDALLCGFST319 DSGQCPEGYT 329 CVKIGRNPDY339 GYTSFDTFSW349 AFLALFRLMT359 QDYWENLYQQ369 TLRAAGKTYM 379 IFFVVVIFLG389 SFYLINLILA399 VVAMAYKEQN409 QANIEEAKQK419 ELEFQQMLDR 429 LKKEQEPYWI731 KFKKCIYFIV741 MDPFVDLAIT751 ICIVLNTLFM761 AMEHHPMTEE 771 FKNVLAIGNL781 VFTGIFAAEM791 VLKLIAMDPY801 EYFQVGWNIF811 DSLIVTLSLV 821 ELFLADVEGL831 SVLRSFRLLR841 VFKLAKSWPT851 LNMLIKIIGN861 SVGALGNLTL 871 VLAIIVFIFA881 VVGMQLFGKS891 YKECVCKIND901 DCTLPRWHMN911 DFFHSFLIVF 921 RVLCGEWIET931 MWDCMEVAGQ941 AMCLIVYMMV951 MVIGNLVVLN961 LFLALLLSSF 971 SSDNLTAIEE981 DPDANNLQIA991 VTRIKKGINY1001 VKQTLREFIL1011 KAFGKIWWNI 1181 RKTCYKIVEH1191 SWFESFIVLM1201 ILLSSGALAF1211 EDIYIERKKT1221 IKIILEYADK 1231 IFTYIFILEM1241 LLKWIAYGYK1251 TYFTNAWCWL1261 DFLIVDVSLV1271 TLVANTLGYS 1281 DLGPIKSLRT1291 LRALRPLRAL1301 SRFEGMRVVV1311 NALIGAIPSI1321 MNVLLVCLIF 1331 WLIFSIMGVN1341 LFAGKFYECI1351 NTTDGSRFPA1361 SQVPNRSECF1371 ALMNVSQNVR 1381 WKNLKVNFDN1391 VGLGYLSLLQ1401 VATFKGWTII1411 MYAAVDSVNV1421 DKQPKYEYSL 1431 YMYIYFVVFI1441 IFGSFFTLNL1451 FIGVIIDNFN1461 QQKKKLGGQD1471 IFMTEEQKKY 1481 YNAMKKLGSK1491 KPQKPIPRPG1501 NKIQGCIFDL1511 VTNQAFDISI1521 MVLICLNMVT 1531 MMVEKEGQSQ1541 HMTEVLYWIN1551 VVFIILFTGE1561 CVLKLISLRH1571 YYFTVGWNIF 1581 DFVVVIISIV1591 GMFLADLIET1601 YFVSPTLFRV1611 IRLARIGRIL1621 RLVKGAKGIR 1631 TLLFALMMSL1641 PALFNIGLLL1651 FLVMFIYAIF1661 GMSNFAYVKK1671 EDGINDMFNF 1681 ETFGNSMICL1691 FQITTSAGWD1701 GLLAPILNSK1711 PPDCDPKKVH1721 PGSSVEGDCG 1731 NPSVGIFYFV1741 SYIIISFLVV1751 VNMYIAVILE1761 NFSVATEEST1771 EPLSEDDFEM 1781 FYEVWEKFDP1791 DATQFIEFSK1801 LSDFAAALDP1811 PLLIAKPNKV1821 QLIAMDLPMV 1831 SGDRIHCLDI1841 LFAFTKRVLG1851 ESGEMDSLRS1861 QMEERFMSAN1871 PSKVSYEPIT 1881 TTLKRKQEDV1891
|
|||||
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Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .LPE or .LPE2 or .LPE3 or :3LPE;style chemicals stick;color identity;select .A:1177 or .A:1181 or .A:250 or .A:253 or .A:254 or .A:257 or .A:319 or .A:320 or .A:347 or .A:351 or .A:376 or .A:377 or .A:379 or .A:380 or .A:383 or .A:387 or .A:759 or .A:763 or .A:765 or .A:769 or .A:772 or .A:1178 or .A:1179 or .A:1182 or .A:1203 or .A:1206 or .A:1207 or .A:1210 or .A:1211 or .A:1213 or .A:1215 or .A:1218 or .A:1219 or .A:1245 or .A:1250 or .A:1251 or .A:1256 or .A:1257 or .A:1258 or .A:1261 or .A:1292 or .A:1295 or .A:1298 or .A:1300 or .A:1301 or .A:1304 or .A:1305 or .A:1306 or .A:1307 or .A:1308 or .A:1311 or .A:1312 or .A:1315 or .A:1329 or .A:1475 or .A:1477 or .A:1478 or .A:1481 or .A:1484 or .A:1485 or .A:1519 or .A:1522 or .A:1529 or .A:1533 or .A:1623 or .A:1626 or .A:1627 or .A:1638 or .A:1641 or .A:1642 or .A:1644 or .A:1645 or .A:1648 or .A:1649 or .A:1650 or .A:1652 or .A:1653 or .A:1654 or .A:1655 or .A:1656 or .A:1657 or .A:1658 or .A:1661 or .A:1683 or .A:1684 or .A:1685 or .A:1686 or .A:1688 or .A:1692 or .A:1710 or .A:1732 or .A:1733 or .A:1734 or .A:1735 or .A:1737 or .A:1738 or .A:1739 or .A:1741 or .A:1742 or .A:1745 or .A:1746 or .A:1754; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
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ILE1177
4.965
ILE1181
3.548
ILE250
4.286
VAL253
3.656
PHE254
4.456
SER257
3.053
THR319
4.786
ASP320
3.379
PHE347
4.501
PHE351
4.529
LYS376
3.412
THR377
3.085
MET379
3.398
ILE380
4.643
VAL383
4.208
PHE387
3.559
LEU759
3.924
MET763
3.407
HIS765
3.580
THR769
4.600
PHE772
4.177
TRP1178
3.353
TRP1179
3.932
ARG1182
3.943
LEU1203
3.546
SER1206
3.233
GLY1207
4.017
ALA1210
3.559
PHE1211
2.951
ASP1213
4.358
TYR1215
3.641
ARG1218
2.752
LYS1219
2.655
TRP1245
4.650
TYR1250
3.410
LYS1251
3.638
ASN1256
3.387
ALA1257
3.244
TRP1258
2.678
LEU1261
3.259
LEU1292
3.300
LEU1295
3.424
LEU1298
3.160
ALA1300
4.159
LEU1301
2.971
PHE1304
2.651
GLU1305
4.152
GLY1306
4.614
MET1307
2.465
ARG1308
4.391
VAL1311
3.673
ASN1312
3.969
ILE1315
4.570
LEU1329
4.841
THR1475
3.389
GLU1477
3.754
GLN1478
4.039
TYR1481
3.344
ALA1484
3.813
MET1485
3.734
ILE1519
4.686
MET1522
4.232
MET1529
3.403
MET1533
4.715
LEU1623
3.203
GLY1626
4.362
ALA1627
4.692
MET1638
3.321
LEU1641
3.575
PRO1642
3.981
LEU1644
4.170
PHE1645
3.853
GLY1648
4.467
LEU1649
4.333
LEU1650
3.435
PHE1652
3.423
LEU1653
2.214
VAL1654
3.534
MET1655
3.654
PHE1656
4.506
ILE1657
3.226
TYR1658
2.973
PHE1661
3.062
THR1683
3.815
PHE1684
3.077
GLY1685
3.946
ASN1686
4.144
MET1688
3.836
PHE1692
3.931
SER1710
3.891
ASN1732
4.989
PRO1733
3.787
SER1734
3.396
VAL1735
3.731
ILE1737
2.843
PHE1738
3.259
TYR1739
3.858
VAL1741
4.180
SER1742
3.833
ILE1745
4.111
ILE1746
4.374
MET1754
4.355
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Unwinding and spiral sliding of S4 and domain rotation of VSD during the electromechanical coupling in Na(v)1.7. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2209164119. | ||||
| REF 2 | High-resolution structures of human Na(v)1.7 reveal gating modulation through Alpha-Pi helical transition of S6(IV). Cell Rep. 2022 Apr 26;39(4):110735. | ||||
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