Binding Site Information of Target
Target General Information | Top | ||||
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Target ID | T08029 | Target Info | |||
Target Name | Complement factor P (CFP) | ||||
Synonyms | Properdin; CFP | ||||
Target Type | Clinical trial Target | ||||
Gene Name | CFP | ||||
UniProt ID |
Drug Binding Sites of Target | Top | |||||
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Ligand Name: Beta-D-Mannose | Ligand Info | |||||
Structure Description | CirpA1 in complex with pseudo-monomeric Properdin lacking TSR2-3 | PDB:7B26 | ||||
Method | X-ray diffraction | Resolution | 3.40 Å | Mutation | Yes | [1] |
PDB Sequence |
WGPWGPVSPC
269 PVTCGLGQTM279 EQRTCNCAGD299 ATRTHICNTA309 VPCPVDGEWD319 SWGEWSPCIR 329 RNMKSISCQE339 IPGQQSRGRT349 CRGRKFDGHR359 CAGQQQDIRH369 CYSIQHCPLK 379 GSWSEWSTWG389 LCMPPCGPNP399 TRARQRLCTP409 LLPKYPPTVS419 GEKNVTFWGR 434 PLPRCEELQG444 QKLVVEEKRP454 CLHVPACKDP464 E
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Ligand Name: Alpha-D-Mannose | Ligand Info | |||||
Structure Description | Crystal Structure of Properdin (TSR domains N1 & 456) | PDB:6S08 | ||||
Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [2] |
PDB Sequence |
> Chain A
SVAGGWGPWG 264 PVSPCPVTCG274 LGQTMEQRTC284 NHPVPQHGGP294 FCAGDATRTH304 ICNTAVPCPV 314 DGEWDSWGEW324 SPCIRRNMKS334 ISCQEIPGQQ344 SRGRTCRGRK354 FDGHRCAGQQ 364 QDIRHCYSIQ374 HCPLKGSWSE384 WSTWGLCMPP394 CGPNPTRARQ404 RLCTPLLPKY 414 PPTVGEKNVT430 FWGRPLPRCE440 ELQGQKLVVE450 EKRPCLHVPA460 CKDPEE > Chain B DPVLCFTQYE 37 ESSGKCKGLL47 GGGVSVEDCC57 LNTAFAYQKR67 SGGLCQPCRS77 PRWSLWSTWA 87 PCSVTCSEGS97 QLRYRRCVGW107 NGQCSGKVAP117 GTLEWQLQAC127 EDQQC |
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GLY258[A]
4.305
GLY259[A]
3.733
TRP260[A]
1.509
GLY261[A]
4.121
PRO262[A]
3.617
TRP263[A]
1.511
ARG282[A]
3.016
CYS296[A]
3.520
ALA297[A]
2.790
GLY298[A]
4.765
ARG302[A]
3.151
ASP319[A]
4.314
SER320[A]
3.058
TRP321[A]
1.510
GLY322[A]
3.904
GLU323[A]
2.483
TRP324[A]
1.514
ARG346[A]
2.989
ARG368[A]
3.193
GLY380[A]
4.459
SER381[A]
3.826
TRP382[A]
1.512
GLU384[A]
2.356
TRP385[A]
1.503
SER386[A]
3.688
THR387[A]
2.851
TRP388[A]
1.513
ARG401[A]
3.179
ARG403[A]
2.912
ARG405[A]
4.264
PHE431[A]
4.498
TRP432[A]
3.150
GLY433[A]
4.709
CYS439[A]
4.071
GLU440[A]
3.126
LEU442[A]
3.869
SER81[B]
3.923
LEU82[B]
3.080
TRP83[B]
1.518
ARG100[B]
2.726
ARG102[B]
4.881
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Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
Ligand Name: alpha-L-Fucose | Ligand Info | |||||
Structure Description | Crystal Structure of Properdin (TSR domains N1 & 456) | PDB:6S08 | ||||
Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [2] |
PDB Sequence |
DPVLCFTQYE
37 ESSGKCKGLL47 GGGVSVEDCC57 LNTAFAYQKR67 SGGLCQPCRS77 PRWSLWSTWA 87 PCSVTCSEGS97 QLRYRRCVGW107 NGQCSGKVAP117 GTLEWQLQAC127 EDQQC |
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Click to View More Binding Site Information of This Target and Ligand Pair |
References | Top | ||||
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REF 1 | Structure and function of a family of tick-derived complement inhibitors targeting properdin. Nat Commun. 2022 Jan 14;13(1):317. | ||||
REF 2 | Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b. Front Immunol. 2019 Sep 4;10:2097. |
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