Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T08029 | Target Info | |||
| Target Name | Complement factor P (CFP) | ||||
| Synonyms | Properdin; CFP | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CFP | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | alpha-L-Fucose | Ligand Info | |||
| Canonical SMILES | CC1C(C(C(C(O1)O)O)O)O | ||||
| InChI | 1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1 | ||||
| InChIKey | SHZGCJCMOBCMKK-SXUWKVJYSA-N | ||||
| PubChem Compound ID | 439554 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6S08 Crystal Structure of Properdin (TSR domains N1 & 456) | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [1] |
| PDB Sequence |
DPVLCFTQYE
37 ESSGKCKGLL47 GGGVSVEDCC57 LNTAFAYQKR67 SGGLCQPCRS77 PRWSLWSTWA 87 PCSVTCSEGS97 QLRYRRCVGW107 NGQCSGKVAP117 GTLEWQLQAC127 EDQQC |
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| PDB ID: 6S0A Crystal Structure of Properdin (TSR domains N12 & 456) | ||||||
| Method | X-ray diffraction | Resolution | 2.52 Å | Mutation | No | [1] |
| PDB Sequence |
SDPVLCFTQY
36 EESSGKCKGL46 LGGGVSVEDC56 CLNTAFAYQK66 RSGGLCQPCR76 SPRWSLWSTW 86 APCSVTCSEG96 SQLRYRRCVG106 WNGQCSGKVA116 PGTLEWQLQA126 CEDQQCCPEM 136 GGWSGWGPWE146 PCSVTCSKGT156 RTRRRACNHP166 APKCGGHCPG176 QAQESEACDT 186
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b. Front Immunol. 2019 Sep 4;10:2097. | ||||
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