Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T08029 | Target Info | |||
| Target Name | Complement factor P (CFP) | ||||
| Synonyms | Properdin; CFP | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | CFP | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Alpha-D-Mannose | Ligand Info | |||
| Canonical SMILES | C(C1C(C(C(C(O1)O)O)O)O)O | ||||
| InChI | 1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1 | ||||
| InChIKey | WQZGKKKJIJFFOK-PQMKYFCFSA-N | ||||
| PubChem Compound ID | 185698 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7B26 CirpA1 in complex with pseudo-monomeric Properdin lacking TSR2-3 | ||||||
| Method | X-ray diffraction | Resolution | 3.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
> Chain A
DPVLCFTQYE 37 ESSGKCKGLL47 GGGVSVEDCC57 LNTAFAYQKR67 SGGLCQPCRS77 PRWSLWSTWA 87 PCSVTCSEGS97 QLRYRRCVGW107 NGQCSGKVAP117 GTLEWQLQAC127 EDQQAC > Chain B WGPWGPVSPC 269 PVTCGLGQTM279 EQRTCNCAGD299 ATRTHICNTA309 VPCPVDGEWD319 SWGEWSPCIR 329 RNMKSISCQE339 IPGQQSRGRT349 CRGRKFDGHR359 CAGQQQDIRH369 CYSIQHCPLK 379 GSWSEWSTWG389 LCMPPCGPNP399 TRARQRLCTP409 LLPKYPPTVS419 GEKNVTFWGR 434 PLPRCEELQG444 QKLVVEEKRP454 CLHVPACKDP464 E
|
|||||
|
|
ALA126[A]
4.210
GLU128[A]
4.281
SER81[A]
4.083
LEU82[A]
3.468
TRP83[A]
1.492
SER84[A]
4.020
THR85[A]
3.387
TRP86[A]
1.492
ARG100[A]
2.995
ARG102[A]
4.826
GLN125[A]
4.839
TRP260[B]
1.490
ARG282[B]
3.395
CYS296[B]
4.251
ALA297[B]
3.977
ASP319[B]
3.879
SER320[B]
3.204
TRP321[B]
1.491
GLY322[B]
3.473
GLU323[B]
2.678
TRP324[B]
1.491
ARG346[B]
3.040
ARG368[B]
2.639
LYS379[B]
4.401
GLY380[B]
3.025
SER381[B]
3.593
TRP382[B]
1.492
SER383[B]
4.981
GLU384[B]
2.535
TRP385[B]
1.492
SER386[B]
3.976
THR387[B]
3.290
TRP388[B]
1.491
ARG401[B]
3.050
ARG403[B]
3.637
ARG405[B]
3.183
PHE431[B]
4.433
TRP432[B]
3.347
GLY433[B]
4.371
CYS439[B]
3.711
GLU440[B]
3.545
GLU441[B]
4.701
LEU442[B]
3.921
|
|||||
| PDB ID: 6RUS Structure of a functional properdin monomer | ||||||
| Method | X-ray diffraction | Resolution | 2.80 Å | Mutation | No | [2] |
| PDB Sequence |
> Chain A
DPVLCFTQYE 37 ESSGKCKGLL47 GGGVSVEDCC57 LNTAFAYQKR67 SGGLCQPCRS77 PRWSLWSTWA 87 PCSVTCSEGS97 QLRYRRCVGW107 NGQCSGKVAP117 GTLEWQLQAC127 EDQQCCPEMG 137 GWSGWGPWEP147 CSVTCSKGTR157 TRRRACNHPA167 PKCGGHCPGQ177 AQESEACDTQ 187 QVCPTHGAWA197 TWGPWTPCSA207 SCHGGPHEPK217 ETRSRKCSAP227 EPSQKPPGKP 237 CPGLAYEQRR247 CTGLPPCPEN257 LYFQ> Chain B GVAGGWGPWG 264 PVSPCPVTCG274 LGQTMEQRTC284 NHPVPQHGGP294 FCAGDATRTH304 ICNTAVPCPV 314 DGEWDSWGEW324 SPCIRRNMKS334 ISCQEIPGQQ344 SRGRTCRGRK354 FDGHRCAGQQ 364 QDIRHCYSIQ374 HCPLKGSWSE384 WSTWGLCMPP394 CGPNPTRARQ404 RLCTPLLPKY 414 PPTVSMVEGQ424 GEKNVTFWGR434 PLPRCEELQG444 QKLVVEEKRP454 CLHVPACKDP 464 EEEELENLYF474
|
|||||
|
|
SER81[A]
4.312
LEU82[A]
3.315
TRP83[A]
1.514
SER84[A]
4.958
THR85[A]
2.486
TRP86[A]
1.530
ARG100[A]
3.282
ARG102[A]
4.902
GLY137[A]
4.482
GLY138[A]
3.342
TRP139[A]
1.510
SER140[A]
4.334
GLY141[A]
3.792
TRP142[A]
1.516
GLY143[A]
4.079
PRO144[A]
3.427
TRP145[A]
1.514
ARG157[A]
3.352
ARG159[A]
2.616
ARG161[A]
3.034
CYS174[A]
4.996
PRO175[A]
3.981
GLY194[A]
4.926
ALA195[A]
3.427
TRP196[A]
1.515
ALA197[A]
4.087
THR198[A]
3.774
TRP199[A]
1.513
GLY200[A]
3.485
PRO201[A]
3.320
TRP202[A]
1.525
ARG220[A]
3.453
ARG222[A]
3.381
PRO239[A]
3.712
ARG246[A]
4.049
ALA126[A]
4.176
GLY259[B]
4.170
TRP260[B]
1.544
GLY261[B]
4.502
PRO262[B]
3.979
TRP263[B]
1.517
GLU280[B]
4.968
ARG282[B]
3.647
CYS296[B]
4.089
ALA297[B]
3.184
ARG302[B]
3.861
ASP319[B]
4.187
SER320[B]
3.346
TRP321[B]
1.522
GLY322[B]
3.417
GLU323[B]
3.352
TRP324[B]
1.524
ARG346[B]
3.071
ARG348[B]
4.625
ARG368[B]
3.171
GLY380[B]
4.140
SER381[B]
3.565
TRP382[B]
1.517
GLU384[B]
2.780
TRP385[B]
1.510
SER386[B]
3.798
THR387[B]
3.343
TRP388[B]
1.516
ARG401[B]
2.842
ARG403[B]
3.054
ARG405[B]
3.874
PHE431[B]
4.784
TRP432[B]
3.197
GLY433[B]
4.424
CYS439[B]
4.470
GLU440[B]
3.333
GLU441[B]
4.011
LEU442[B]
3.306
|
|||||
| PDB ID: 6S08 Crystal Structure of Properdin (TSR domains N1 & 456) | ||||||
| Method | X-ray diffraction | Resolution | 2.03 Å | Mutation | No | [3] |
| PDB Sequence |
> Chain A
SVAGGWGPWG 264 PVSPCPVTCG274 LGQTMEQRTC284 NHPVPQHGGP294 FCAGDATRTH304 ICNTAVPCPV 314 DGEWDSWGEW324 SPCIRRNMKS334 ISCQEIPGQQ344 SRGRTCRGRK354 FDGHRCAGQQ 364 QDIRHCYSIQ374 HCPLKGSWSE384 WSTWGLCMPP394 CGPNPTRARQ404 RLCTPLLPKY 414 PPTVGEKNVT430 FWGRPLPRCE440 ELQGQKLVVE450 EKRPCLHVPA460 CKDPEE > Chain B DPVLCFTQYE 37 ESSGKCKGLL47 GGGVSVEDCC57 LNTAFAYQKR67 SGGLCQPCRS77 PRWSLWSTWA 87 PCSVTCSEGS97 QLRYRRCVGW107 NGQCSGKVAP117 GTLEWQLQAC127 EDQQC |
|||||
|
|
GLY258[A]
4.305
GLY259[A]
3.733
TRP260[A]
1.509
GLY261[A]
4.121
PRO262[A]
3.617
TRP263[A]
1.511
ARG282[A]
3.016
CYS296[A]
3.520
ALA297[A]
2.790
GLY298[A]
4.765
ARG302[A]
3.151
ASP319[A]
4.314
SER320[A]
3.058
TRP321[A]
1.510
GLY322[A]
3.904
GLU323[A]
2.483
TRP324[A]
1.514
ARG346[A]
2.989
ARG368[A]
3.193
GLY380[A]
4.459
SER381[A]
3.826
TRP382[A]
1.512
GLU384[A]
2.356
TRP385[A]
1.503
SER386[A]
3.688
THR387[A]
2.851
TRP388[A]
1.513
ARG401[A]
3.179
ARG403[A]
2.912
ARG405[A]
4.264
PHE431[A]
4.498
TRP432[A]
3.150
GLY433[A]
4.709
CYS439[A]
4.071
GLU440[A]
3.126
LEU442[A]
3.869
SER81[B]
3.923
LEU82[B]
3.080
TRP83[B]
1.518
ARG100[B]
2.726
ARG102[B]
4.881
|
|||||
| PDB ID: 6S0B Crystal Structure of Properdin in complex with the CTC domain of C3/C3b | ||||||
| Method | X-ray diffraction | Resolution | 2.31 Å | Mutation | No | [3] |
| PDB Sequence |
> Chain A
GSVAGGWGPW 263 GPVSPCPVTC273 GLGQTMEQRT283 CNHPVPQHGG293 PFCAGDATRT303 HICNTAVPCP 313 VDGEWDSWGE323 WSPCIRRNMK333 SISCQEIPGQ343 QSRGRTCRGR353 KFDGHRCAGQ 363 QQDIRHCYSI373 QHCPLKGSWS383 EWSTWGLCMP393 PCGPNPTRAR403 QRLCTPLLPK 413 YPPTVSMVEG423 QGEKNVTFWG433 RPLPRCEELQ443 GQKLVVEEKR453 PCLHVPACKD 463 PEEEELAAA> Chain B DPVLCFTQYE 37 ESSGKCKGLL47 GGGVSVEDCC57 LNTAFAYQKR67 SGGLCQPCRS77 PRWSLWSTWA 87 PCSCSEGSQL99 RYRRCVGWNG109 QCSGKVAPGT119 LEWQLQACED129 QQC |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MAN or .MAN2 or .MAN3 or :3MAN;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:261 or .A:262 or .A:263 or .A:282 or .A:296 or .A:297 or .A:302 or .A:319 or .A:320 or .A:321 or .A:322 or .A:323 or .A:324 or .A:346 or .A:348 or .A:368 or .A:380 or .A:381 or .A:382 or .A:384 or .A:385 or .A:386 or .A:387 or .A:388 or .A:401 or .A:403 or .A:405 or .A:431 or .A:432 or .A:433 or .A:439 or .A:440 or .A:441 or .A:442 or .B:126 or .B:81 or .B:82 or .B:83 or .B:100 or .B:102; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY258[A]
4.217
GLY259[A]
3.750
TRP260[A]
1.500
GLY261[A]
4.214
PRO262[A]
3.331
TRP263[A]
1.511
ARG282[A]
3.148
CYS296[A]
3.955
ALA297[A]
3.664
ARG302[A]
2.866
ASP319[A]
4.485
SER320[A]
3.270
TRP321[A]
1.512
GLY322[A]
4.028
GLU323[A]
2.819
TRP324[A]
1.508
ARG346[A]
3.187
ARG348[A]
4.782
ARG368[A]
2.976
GLY380[A]
4.874
SER381[A]
4.509
TRP382[A]
1.514
GLU384[A]
3.316
TRP385[A]
1.510
SER386[A]
3.941
THR387[A]
3.213
TRP388[A]
1.516
ARG401[A]
3.456
ARG403[A]
3.521
ARG405[A]
2.814
PHE431[A]
4.954
TRP432[A]
3.370
GLY433[A]
4.866
CYS439[A]
4.339
GLU440[A]
3.098
GLU441[A]
3.305
LEU442[A]
3.535
ALA126[B]
4.256
SER81[B]
4.051
LEU82[B]
3.304
TRP83[B]
1.513
ARG100[B]
2.790
ARG102[B]
4.736
|
|||||
| PDB ID: 6S0A Crystal Structure of Properdin (TSR domains N12 & 456) | ||||||
| Method | X-ray diffraction | Resolution | 2.52 Å | Mutation | No | [3] |
| PDB Sequence |
> Chain A
SVAGGWGPWG 264 PVSPCPVTCG274 LGQTMEQRTC284 NHPVPQHGGP294 FCAGDATRTH304 ICNTAVPCPV 314 DGEWDSWGEW324 SPCIRRNMKS334 ISCQEIPGQQ344 SRGRTCRGRK354 FDGHRCAGQQ 364 QDIRHCYSIQ374 HCPLKGSWSE384 WSTWGLCMPP394 CGPNPTRARQ404 RLCTPLLPKY 414 PPTVSMVEKN428 VTFWGRPLPR438 CEELQGQKLV448 VEEKRPCLHV458 PACKDPEE > Chain B SDPVLCFTQY 36 EESSGKCKGL46 LGGGVSVEDC56 CLNTAFAYQK66 RSGGLCQPCR76 SPRWSLWSTW 86 APCSVTCSEG96 SQLRYRRCVG106 WNGQCSGKVA116 PGTLEWQLQA126 CEDQQCCPEM 136 GGWSGWGPWE146 PCSVTCSKGT156 RTRRRACNHP166 APKCGGHCPG176 QAQESEACDT 186
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MAN or .MAN2 or .MAN3 or :3MAN;style chemicals stick;color identity;select .A:258 or .A:259 or .A:260 or .A:261 or .A:262 or .A:263 or .A:282 or .A:296 or .A:297 or .A:302 or .A:319 or .A:320 or .A:321 or .A:322 or .A:323 or .A:324 or .A:346 or .A:368 or .A:380 or .A:381 or .A:382 or .A:384 or .A:385 or .A:386 or .A:387 or .A:388 or .A:401 or .A:403 or .A:405 or .A:431 or .A:432 or .A:433 or .A:439 or .A:440 or .A:441 or .A:442 or .B:126 or .B:82 or .B:83 or .B:100 or .B:137 or .B:138 or .B:139 or .B:141 or .B:142 or .B:159 or .B:161 or .B:175 or .B:176; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
GLY258[A]
4.659
GLY259[A]
3.595
TRP260[A]
1.502
GLY261[A]
4.150
PRO262[A]
3.644
TRP263[A]
1.510
ARG282[A]
3.037
CYS296[A]
4.056
ALA297[A]
3.232
ARG302[A]
2.920
ASP319[A]
4.483
SER320[A]
3.565
TRP321[A]
1.519
GLY322[A]
4.174
GLU323[A]
2.576
TRP324[A]
1.508
ARG346[A]
2.770
ARG368[A]
2.901
GLY380[A]
3.972
SER381[A]
3.828
TRP382[A]
1.507
GLU384[A]
3.036
TRP385[A]
1.510
SER386[A]
4.307
THR387[A]
2.851
TRP388[A]
1.520
ARG401[A]
3.022
ARG403[A]
2.827
ARG405[A]
3.339
PHE431[A]
4.375
TRP432[A]
3.284
GLY433[A]
4.989
CYS439[A]
3.742
GLU440[A]
3.121
GLU441[A]
4.427
LEU442[A]
4.424
ALA126[B]
4.322
LEU82[B]
3.817
TRP83[B]
1.519
ARG100[B]
2.980
GLY137[B]
4.445
GLY138[B]
3.411
TRP139[B]
1.512
GLY141[B]
3.367
TRP142[B]
1.520
ARG159[B]
2.564
ARG161[B]
3.574
PRO175[B]
3.275
GLY176[B]
4.818
|
|||||
| PDB ID: 6SEJ Structure of a functional monomeric properdin lacking TSR3 | ||||||
| Method | X-ray diffraction | Resolution | 3.50 Å | Mutation | No | [2] |
| PDB Sequence |
> Chain A
DPVLCFTQYE 37 ESSGKCKGLL47 GGGVSVEDCC57 LNTAFAYQKR67 SGGLCQPCRS77 PRWSLWSTWA 87 PCSVTCSEGS97 QLRYRRCVGW107 NGQCSGKVAP117 GTLEWQLQAC127 EDQQCCPEMG 137 GWSGWGPWEP147 CSVTCSKGTR157 TRRRACNHPA167 PKCGGHCPGQ177 AQESEACDTQ 187 QVCPE> Chain B GVAGGWGPWG 264 PVSPCPVTCG274 LGQTMEQRTC284 NHPVPQHGGP294 FCAGDATRTH304 ICNTAVPCPV 314 DGEWDSWGEW324 SPCIRRNMKS334 ISCQEIPGQQ344 SRGRTCRGRK354 FDGHRCAGQQ 364 QDIRHCYSIQ374 HCPLKGSWSE384 WSTWGLCMPP394 CGPNPTRARQ404 RLCTPLLPKY 414 PPTVSMVEGQ424 GEKNVTFWGR434 PLPRCEELQG444 QKLVVEEKRP454 CLHVPACKDP 464 EEEELENLYF474
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MAN or .MAN2 or .MAN3 or :3MAN;style chemicals stick;color identity;select .A:81 or .A:82 or .A:83 or .A:84 or .A:85 or .A:86 or .A:100 or .A:102 or .A:137 or .A:138 or .A:139 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:157 or .A:159 or .A:161 or .A:175 or .B:258 or .B:259 or .B:260 or .B:261 or .B:262 or .B:263 or .B:280 or .B:282 or .B:297 or .B:298 or .B:302 or .B:319 or .B:320 or .B:321 or .B:322 or .B:323 or .B:324 or .B:346 or .B:348 or .B:368 or .B:380 or .B:381 or .B:382 or .B:384 or .B:385 or .B:386 or .B:387 or .B:388 or .B:401 or .B:403 or .B:405 or .B:432 or .B:433 or .B:439 or .B:440 or .B:441 or .B:442; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER81[A]
3.785
LEU82[A]
3.272
TRP83[A]
1.520
SER84[A]
4.994
THR85[A]
2.535
TRP86[A]
1.533
ARG100[A]
3.569
ARG102[A]
4.542
GLY137[A]
4.199
GLY138[A]
3.331
TRP139[A]
1.523
SER140[A]
3.850
GLY141[A]
3.994
TRP142[A]
1.517
GLY143[A]
4.323
PRO144[A]
3.268
TRP145[A]
1.515
ARG157[A]
3.315
ARG159[A]
3.341
ARG161[A]
3.610
PRO175[A]
3.851
GLY258[B]
4.347
GLY259[B]
3.589
TRP260[B]
1.520
GLY261[B]
3.280
PRO262[B]
3.641
TRP263[B]
1.527
GLU280[B]
4.804
ARG282[B]
2.816
ALA297[B]
4.212
GLY298[B]
4.852
ARG302[B]
4.377
ASP319[B]
3.685
SER320[B]
3.369
TRP321[B]
1.521
GLY322[B]
3.329
GLU323[B]
2.640
TRP324[B]
1.528
ARG346[B]
3.966
ARG348[B]
4.534
ARG368[B]
3.215
GLY380[B]
3.721
SER381[B]
3.958
TRP382[B]
1.535
GLU384[B]
3.021
TRP385[B]
1.525
SER386[B]
3.693
THR387[B]
3.362
TRP388[B]
1.528
ARG401[B]
4.015
ARG403[B]
3.496
ARG405[B]
4.301
TRP432[B]
3.279
GLY433[B]
4.720
CYS439[B]
4.771
GLU440[B]
3.733
GLU441[B]
4.131
LEU442[B]
3.764
|
|||||
| PDB ID: 6RV6 Structure of properdin lacking TSR3 based on anomalous data | ||||||
| Method | X-ray diffraction | Resolution | 3.51 Å | Mutation | No | [2] |
| PDB Sequence |
> Chain A
DPVLCFTQYE 37 ESSGKCKGLL47 GGGVSVEDCC57 LNTAFAYQKR67 SGGLCQPCRS77 PRWSLWSTWA 87 PCSVTCSEGS97 QLRYRRCVGW107 NGQCSGKVAP117 GTLEWQLQAC127 EDQQCCPEMG 137 GWSGWGPWEP147 CSVTCSKGTR157 TRRRACNHPA167 PKCGGHCPGQ177 AQESEACDTQ 187 QVCPE> Chain B GVAGGWGPWG 264 PVSPCPVTCG274 LGQTMEQRTC284 NHPVPQHGGP294 FCAGDATRTH304 ICNTAVPCPV 314 DGEWDSWGEW324 SPCIRRNMKS334 ISCQEIPGQQ344 SRGRTCRGRK354 FDGHRCAGQQ 364 QDIRHCYSIQ374 HCPLKGSWSE384 WSTWGLCMPP394 CGPNPTRARQ404 RLCTPLLPKY 414 PPTVSMVEGQ424 GEKNVTFWGR434 PLPRCEELQG444 QKLVVEEKRP454 CLHVPACKDP 464 EEEELENLYF474
|
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MAN or .MAN2 or .MAN3 or :3MAN;style chemicals stick;color identity;select .A:81 or .A:82 or .A:83 or .A:84 or .A:85 or .A:86 or .A:100 or .A:102 or .A:137 or .A:138 or .A:139 or .A:140 or .A:141 or .A:142 or .A:143 or .A:144 or .A:145 or .A:157 or .A:159 or .A:161 or .A:175 or .B:258 or .B:259 or .B:260 or .B:261 or .B:262 or .B:263 or .B:280 or .B:282 or .B:297 or .B:298 or .B:302 or .B:319 or .B:320 or .B:321 or .B:322 or .B:323 or .B:324 or .B:346 or .B:348 or .B:368 or .B:380 or .B:381 or .B:382 or .B:384 or .B:385 or .B:386 or .B:387 or .B:388 or .B:401 or .B:403 or .B:405 or .B:431 or .B:432 or .B:433 or .B:439 or .B:440 or .B:441 or .B:442; color #00ffc7; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER81[A]
3.835
LEU82[A]
3.232
TRP83[A]
1.519
SER84[A]
4.905
THR85[A]
2.513
TRP86[A]
1.530
ARG100[A]
3.524
ARG102[A]
4.665
GLY137[A]
4.154
GLY138[A]
3.319
TRP139[A]
1.522
SER140[A]
4.048
GLY141[A]
3.803
TRP142[A]
1.519
GLY143[A]
3.822
PRO144[A]
3.273
TRP145[A]
1.523
ARG157[A]
3.456
ARG159[A]
3.306
ARG161[A]
3.526
PRO175[A]
3.688
GLY258[B]
4.587
GLY259[B]
3.215
TRP260[B]
1.523
GLY261[B]
3.287
PRO262[B]
3.534
TRP263[B]
1.517
GLU280[B]
4.928
ARG282[B]
2.815
ALA297[B]
3.479
GLY298[B]
4.900
ARG302[B]
4.569
ASP319[B]
3.859
SER320[B]
3.291
TRP321[B]
1.521
GLY322[B]
3.351
GLU323[B]
2.839
TRP324[B]
1.520
ARG346[B]
3.931
ARG348[B]
4.647
ARG368[B]
3.393
GLY380[B]
3.484
SER381[B]
3.802
TRP382[B]
1.530
GLU384[B]
2.905
TRP385[B]
1.520
SER386[B]
3.783
THR387[B]
3.371
TRP388[B]
1.521
ARG401[B]
3.721
ARG403[B]
3.493
ARG405[B]
4.576
PHE431[B]
4.627
TRP432[B]
3.279
GLY433[B]
4.535
CYS439[B]
4.623
GLU440[B]
3.935
GLU441[B]
3.775
LEU442[B]
3.603
|
|||||
| PDB ID: 7NOZ Structure of the nanobody stablized properdin bound alternative pathway proconvertase C3b:FB:FP | ||||||
| Method | X-ray diffraction | Resolution | 3.90 Å | Mutation | Yes | [4] |
| PDB Sequence |
> Chain C
DPVLCFTQYE 37 ESSGKCKGLL47 GGGVSVEDCC57 LNTAFAYQKR67 SGGLCQPCRS77 PRWSLWSTWA 87 PCSVTCSEGS97 QLRYRRCVGW107 NGQCSGKVAP117 GTLEWQLQAC127 EDQQCCPEMG 137 GWSGWGPWEP147 CSVTCSKGTR157 TRRRACNHPA167 PKCGGHCPGQ177 AQESEACDTQ 187 QVC> Chain D GVAGGWGPWG 264 PVSPCPVTCG274 LGQTMEQRTC284 NHPVPQHGGP294 FCAGDATRTH304 ICNTAVPCPV 314 DGEWDSWGEW324 SPCIRRNMKS334 ISCQEIPGQQ344 SRGRTCRGRK354 FDGHRCAGQQ 364 QDIRHCYSIQ374 HCPLKGSWSE384 WSTWGLCMPP394 CGPNPTRARQ404 RLCTPLLPKY 414 PPTVSMVEGQ424 GEKNVTFWGR434 PLPRCEELQG444 QKLVVEEKRP454 CLHVPAC |
|||||
|
Click to Show 3D Structure of This Binding Site
set background white;style ions nothing; color 8e8e8e;style chemicals nothing; select .MAN or .MAN2 or .MAN3 or :3MAN;style chemicals stick;color identity;select .C:81 or .C:82 or .C:83 or .C:84 or .C:85 or .C:86 or .C:98 or .C:100 or .C:102 or .C:143 or .C:144 or .C:145 or .C:157 or .C:159 or .D:319 or .D:320 or .D:321 or .D:322 or .D:323 or .D:324 or .D:346 or .D:348 or .D:368 or .D:380 or .D:381 or .D:382 or .D:431 or .D:432 or .D:433 or .D:440 or .D:441 or .D:442; color #f3c393; zoom selection;set surface opacity 0.5;set surface Van der Waals surface;set mode all
|
SER81[C]
3.721
LEU82[C]
3.372
TRP83[C]
1.520
SER84[C]
4.576
THR85[C]
3.427
TRP86[C]
1.522
GLN98[C]
4.470
ARG100[C]
3.433
ARG102[C]
4.706
GLY143[C]
4.489
PRO144[C]
3.870
TRP145[C]
1.520
ARG157[C]
4.441
ARG159[C]
2.874
ASP319[D]
3.806
SER320[D]
3.419
|
|||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure and function of a family of tick-derived complement inhibitors targeting properdin. Nat Commun. 2022 Jan 14;13(1):317. | ||||
| REF 2 | Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. Front Immunol. 2019 Aug 22;10:2007. | ||||
| REF 3 | Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b. Front Immunol. 2019 Sep 4;10:2097. | ||||
| REF 4 | Structure determination of an unstable macromolecular complex enabled by nanobody-peptide bridging. Protein Sci. 2022 Oct;31(10):e4432. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.