Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T87675 | Target Info | |||
| Target Name | Aurora kinase A (AURKA) | ||||
| Synonyms |
hARK1; Serine/threonine-protein kinase aurora-A; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase 15; Serine/threonine kinase 15; STK6; STK15; IAK1; Breast tumor-amplified kinase; BTAK; Aurora/IPL1-related kinase 1; Aurora-related kinase 1; Aurora-A; Aurora 2; AYK1; AURA; ARK1; ARK-1; AIRK1; AIK
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| Target Type | Clinical trial Target | ||||
| Gene Name | AURKA | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 138 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Niclosamide
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Approved | Compound Info | ||
| Synonyms |
niclosamide; 50-65-7; Niclocide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; Tredemine; Bayluscid; Phenasal; Yomesan; Fenasal; Dichlosale; Helmiantin; Sagimid; Iomezan; Devermine; Atenase; Vermitid; Radeverm; Mansonil; Iomesan; Devermin; Cestocid; Sulqui; Lintex; Nasemo; Mato; Fedal-Telmin; Bayer 73; Radewerm; Zestocarp; Bayer 2353; 2',5-Dichloro-4'-nitrosalicylanilide; Chemagro 2353; BAY 2353; Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; nicolsamide; HL 2447; Niclosamidum [I
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| Activity |
IC50 = 54100 nM
|
[1] | |||
| Compound Name |
Milrinone
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Approved | Compound Info | ||
| Synonyms |
Corotrop; Corotrope; Milrila; Milrinona; Milrinonum; Primacor; Milrinona [Spanish]; Milrinonum [Latin]; M 4659; M1663; YM 018; MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER; Milrila (TN); PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER; Primacor (TN); WIN 47203-2; Win-47203; Milrinone [USAN:BAN:INN]; Win-47203-2; Milrinone (JAN/USAN/INN); 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile; 111GE027; 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile; 3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone; 6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile; 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
SB-743921
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Phase 2 | Compound Info | ||
| Synonyms |
N-[1-(3-benzyl-7-chloro-4-oxo-quinazolin-2-yl)propyl]-4-bromo-N-(3-dimethylaminopropyl)benzamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
7-bromoindirubin-3-acetoxime
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
7-iodoindirubin-3-oxime
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
7-chloroindirubin-3-oxime
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Investigative | Compound Info | ||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
1-(1H-Benzimidazol-2-yl)-N-methyl-2-oxo-3H-benzimidazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3903930; BDBM50198073
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Tert-butyl 6-(2-chloro-4-pyrimidin-5-ylanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109948; SCHEMBL17555287; BDBM50446449
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
6,6-Dimethyl-8-(1-(oxetan-3-yl)piperidin-4-yl)-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779202; SCHEMBL897210; BDBM50344664; 6,6-dimethyl-8-[1-(oxetan-3-yl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
(R)-6-(1-(2,6-Dichloro-3-fluorophenyl)ethoxy)quinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL600795; BDBM50306683
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
CID 49806721
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1823221; SCHEMBL896410; BDBM50352760; 9-ethyl-6,6-dimethyl-8-[4-(oxetan-3-yl)piperazin-1-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N-(4-Chlorophenyl)-3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965790; BDBM209965; US9249124, RK2-043
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
Bisanilinopyrimidine, 3k
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170600; BDBM92797; ZINC89469956; AKOS024459044; MCULE-1966023689
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
2-[3-[[4-[3-(Trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropane-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908823; BDBM209960; US9249124, RK2-013
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
2-[[2-Anilino-6-(dimethylamino)pyrimidin-4-yl]amino]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3916557; BDBM209968; US9249124, YL5-050
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-Phenyl-3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3903320; BDBM209966; US9249124, RK2-049
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
4-N,4-N-Dimethyl-2-N,6-N-diphenylpyrimidine-2,4,6-triamine
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL6791894; CHEMBL3970937; BDBM209967; ZINC148899822; US9249124, YL5-048
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-Cyclopropyl-2-methyl-4-(2-phenoxy-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)pyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3819210; CFI-401980; SCHEMBL15739891; BDBM50183019
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
Bisanilinopyrimidine, 4b
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2170426; SCHEMBL15487610; BDBM92807; 2-[[6-amino-2-(4-carboxyanilino)pyrimidin-4-yl]amino]benzoic acid
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-Benzyl-3-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-N,5-dimethyl-1H-pyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL451034; BDBM50479532
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
3-[(2E)-2-[(4-Methoxyphenyl)methylidene]hydrazinyl]-N,5-dimethyl-N-phenyl-1H-pyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL461955; BDBM50479523
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
4-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391127; SCHEMBL14603718; BDBM50435037
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| Activity |
IC50 = 50000 nM
|
[12] | |||
| Compound Name |
Unii-WF9CA8UL2V
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Investigative | Compound Info | ||
| Synonyms |
WF9CA8UL2V; GSK2646264 free base; CHEMBL4291402; 1398695-47-0 (free base); GSK2646264; SCHEMBL12100262; BDBM50467630; GSK-2646264
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| Activity |
IC50 ~ 50118.72 nM
|
[13] | |||
| Compound Name |
(5Z)-2-(2-Ethylphenyl)imino-3-methyl-5-(pyridin-4-ylmethylidene)-1,3-thiazolidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3929346; BDBM50198160
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| Activity |
IC50 = 52000 nM
|
[5] | |||
| Compound Name |
CID 66547759
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109939; SCHEMBL12492143; BDBM50446428
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| Activity |
IC50 = 53000 nM
|
[6] | |||
| Compound Name |
3-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391132; SCHEMBL14604396; BDBM50435031
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| Activity |
IC50 = 60000 nM
|
[12] | |||
| Compound Name |
N-[4-(5-Benzylsulfanyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391100; BDBM50435026
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| Activity |
IC50 = 60000 nM
|
[12] | |||
| Compound Name |
2-[[4-[3-(Trifluoromethyl)anilino]pyrimidin-2-yl]amino]benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3954884; BDBM209954; US9249124, RK2-015-03
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| Activity |
IC50 = 64000 nM
|
[9] | |||
| Compound Name |
Tert-butyl 6-[2-chloro-4-(4-methoxypiperidine-1-carbonyl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109937; SCHEMBL12526840; BDBM50446444
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| Activity |
IC50 = 65000 nM
|
[6] | |||
| Compound Name |
2,4,6,6'-Tetramethoxy-2'-hydroxy-trans-chalcone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3125820; (E)-1-(2-hydroxy-6-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one; BDBM50449313; (e)-1-(2-hydroxy-6-methoxyphenyl)-3-(2',4',6'-trimethoxyphenyl)prop-2-en-1-one
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| Activity |
IC50 = 66400 nM
|
[14] | |||
| Compound Name |
3-Amino-5-phenyl-1H-pyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1605269; SCHEMBL1392973; SCHEMBL21857207; BDBM50465487; NCGC00181388-01
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| Activity |
Ki = 66900 nM
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[2] | |||
| Compound Name |
3-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3893267; BDBM50198070
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| Activity |
IC50 ~ 70000 nM
|
[5] | |||
| Compound Name |
N-(2-Methoxyphenyl)-2-(3-methylimidazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109964; BDBM50446429
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| Activity |
IC50 = 72000 nM
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[6] | |||
| Compound Name |
Tert-Butyl 6-{[2-Chloro-4-(Dimethylcarbamoyl)phenyl]amino}-2-(1,3-Oxazol-5-Yl)-1h-Pyrrolo[3,2-C]pyridine-1-Carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109940; SCHEMBL12491465; BDBM50446435; Q27467412
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| Activity |
IC50 = 75000 nM
|
[6] | |||
| Compound Name |
2-(2-Aminopyridin-4-yl)-5-(4-ethylphenyl)imino-6-methyl-4-thia-6-azaspiro[2.4]heptan-7-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915641; CHEMBL3985380; BDBM50198158; BDBM50198161
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| Activity |
IC50 = 76000 nM
|
[5] | |||
| Compound Name |
6,7-Dimethoxy-4-(4-phenethylpiperazin-1-yl)quinazoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL236277; BDBM50224747
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| Activity |
IC50 = 76000 nM
|
[15] | |||
| Compound Name |
3-Amino-5-(quinolin-4-yl)pyridin-2(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4280308; BDBM50465484
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| Activity |
Ki = 76300 nM
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[2] | |||
| Compound Name |
N-(2-Cyclohexenylethyl)-2-(4-(6-methoxy-1H-indole-2-carbonyl)cyclohexyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1643142; BDBM50333661
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| Activity |
IC50 = 86150 nM
|
[16] | |||
| Compound Name |
Chembl4295011
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Investigative | Compound Info | ||
| Synonyms |
BDBM50465488
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| Activity |
Ki = 89600 nM
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[2] | |||
| Compound Name |
2-[(3S,9S,12R,17R,20S,23S,26S)-12-Amino-17-[(2-amino-2-oxoethyl)carbamoyl]-20,23-bis[3-(diaminomethylideneamino)propyl]-3-[(1R)-1-hydroxyethyl]-2,5,8,11,19,22,25-heptaoxo-14,15-dithia-1,4,7,10,18,21,24-heptazabicyclo[24.3.0]nonacosan-9-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950040; BDBM50363995
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| Activity |
IC50 = 91000 nM
|
[17] | |||
| Compound Name |
2-(4-(6,7-Dimethoxyquinazolin-4-yl)piperazin-1-yl)-1-(pyrrolidin-1-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL236279; BDBM50224744
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| Activity |
IC50 = 98000 nM
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[15] | |||
| Compound Name |
N-(4-Ethoxyphenyl)-2-(8-(4-ethoxyphenylamino)-3-methyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1643146; Oprea1_066364; Oprea1_856090; HMS1678M13; ZINC917027; BDBM50333665; AKOS000580726; MCULE-5318024071; BAS03571837; ST50272544; AB00685508-01
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| Activity |
IC50 = 98700 nM
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[16] | |||
| Compound Name |
5-Amino-1-methyl[3,4'-bipyridin]-6(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4282410; 5-amino-1-methyl-[3,4'-bipyridin]-6(1H)-one; SCHEMBL11448759; CTK2B3222; DTXSID30633103; BDBM50465480; 3-amino-1-methyl-5-pyridin-4-ylpyridin-2-one; [3,4'-Bipyridin]-6(1H)-one, 5-amino-1-methyl-; 3-Amino-1-methyl-5-(4-pyridinyl)-2(1H)-pyridinone
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| Activity |
Ki = 99500 nM
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[2] | |||
| Compound Name |
6-n-Hexylaminopurine
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Investigative | Compound Info | ||
| Synonyms |
N-hexyl-7H-purin-6-amine; N6-Hexylaminopurine; n-Hexyl-9H-purin-6-amine; CHEMBL449217; N-Hexyl-1H-adenine; adenine,N6-hexyl; Adenine, N-hexyl-; 1H-Purin-6-amine, N-hexyl-; 6-Hexylaminopurine; N6-n-hexyladenine; EINECS 238-282-4; Adenine, N6-hexyl; hexylpurin-6-ylamine; NERVONICCERAMIDE; 6-Hexylamino-9H-purine; 3-Oxo-2-phenylpiperazine; n-Hexyl-9H-purin-6-amine #; SCHEMBL5066424; DTXSID90876574; ZINC3871210; 5886AF; BDBM50251961; AKOS008631985; MCULE-7886697884; FT-0730104; ST51015018; A25724
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| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
Methyl 5-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397549; SCHEMBL13596390; BDBM50215755
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| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
CID 71578744
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391101; BDBM50435025; N-[4-[5-[(3-cyanophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]pyridin-2-yl]acetamide
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-(3,4-Dimethoxyphenyl)-N-(2,4-dimethylphenyl)-3-phenyl-1H-pyrazolo[3,4-b]pyridine-6-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1643137; BDBM50333659; ZINC20135002; MCULE-4993499987; 6-(3,4-dimethoxyphenyl)-N-(2,4-dimethylphenyl)-3-phenyl-2H-pyrazolo[3,4-b]pyridine-4-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
CID 68291184
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109971; SCHEMBL12492520; BDBM50446430
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(3,5-difluorophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391117; BDBM50435038
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
7-Iodoindirubin-3-acetoxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL395077; BDBM50218891
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
7-Chloroindirubin-3-acetoxime
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL397719; BDBM50218886
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
7-Bromoindirubin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL214173; CHEMBL397718; (2'Z)-7-bromoindirubin; (2''Z)-7-bromoindirubin; SCHEMBL22300869; cid_11845789; (3Z)-7-bromo-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; BDBM50191440; BDBM50218890; UNM-0000305768
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[[4-(4-Methoxyphenyl)phenyl]methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391131; SCHEMBL14604069; BDBM50435029
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
7-Iodoindirubin-3-methoxime
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL244191; BDBM50218903
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[[4-(3,5-Difluorophenyl)phenyl]methylsulfanyl]-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391124; SCHEMBL14604425; BDBM50435018
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Cyclapolin 9
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Cyclapolin-9; CHEMBL476124; 7-Nitro-5-(trifluoromethyl)-2-benzothiazolecarboxamide-3-oxide; 7-Nitro-3-oxy-5-trifluoromethyl-benzothiazole-2-carboxylic acid amide; SCHEMBL5055142; CTK8I6133; AOB5979; ZINC2577648; BDBM50263697; AKOS024457436; HY-15159; CS-0003792; 7-Nitro-5-(trifluoromethyl)-2-Benzothiazolecarboxamide 3-oxide; 2-(aminocarbonyl)-7-nitro-5-(trifluoromethyl)-1,3-benzothiazol-3-ium-3-olate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
N-(2,4-Dimethoxyphenyl)-2-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109960; BDBM50446466
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-methoxyethyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL517745; SCHEMBL13873522; BDBM50245409
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
3-[1-(4-Chlorobenzyl)-1h-indol-3-yl]-n-(4-nitrophenyl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1221633; BDBM50324796
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-phenylpyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461114; SCHEMBL3974260; BDBM50245363; 4-amino-6-(3-chloro-4-phenylmethoxyanilino)-N-phenylpyrimidine-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-(piperidin-1-yl)ethyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL462343; SCHEMBL13873521; BDBM50245364
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[21] | |||
| Compound Name |
CID 66548650
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109958; SCHEMBL12492059; BDBM50446455; N-(2-methoxyphenyl)-2-[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-[4-[5-[[4-(2-Cyanophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazol-2-yl]pyridin-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391102; BDBM50435024
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-Methoxy-N,N-dimethyl-4-[[2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl]amino]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109968; SCHEMBL12491567; BDBM50446461
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-(2-Methoxyphenyl)-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109957; SCHEMBL12492106; BDBM50446458; N-(2-methoxyphenyl)-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-(3,5-Dimethyl-1,2-oxazol-4-yl)-N-(2-methoxyphenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109963; BDBM50446433
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Tert-butyl 6-(2-chloroanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109934; SCHEMBL12492748; BDBM50446438
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-[(4-Phenylphenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391099; SCHEMBL14604409; BDBM50435027; AKOS000905896
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[2-Chloro-4-(1-methylpyrazol-4-yl)phenyl]-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109942; SCHEMBL17573340; BDBM50446434
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-(4-Benzyloxy-3-chloro-phenyl)-5-[5-(2-morpholin-4-yl-ethyl)-[1,3,4]oxadiazol-2-yl]-pyrimidine-4,6-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472545; SCHEMBL1096374; BDBM50245472
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064536; SCHEMBL14604399; BDBM50389082
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
TC-Mps1-12
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
TC Mps1 12; CHEMBL2089255; 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide; 4-[[4-Azanyl-6-(~{tert}-Butylamino)-5-Cyano-Pyridin-2-Yl]amino]benzamide; SCHEMBL18154878; BDBM50420401; ZINC84689624; AKOS024458325; NCGC00379193-01; HY-110115; CS-0032967; 4-(4-Amino-6-(tert-butylamino)-5-cyanopyridin-2-ylamino)benzamide; 2-(tert-Butylamino)-4-amino-6-(4-carbamoylanilino)pyridine-3-carbonitrile; 4-[[4-amino-6-(tert-butylamino)-5-cyanopyridin-2-yl]amino]benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
7-Bromoindirubin-3-methoxime
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243556; BDBM50218902
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[3,4'-Bipyridin]-6(1H)-one, 5-amino-2-methyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302219; SCHEMBL11235286; BDBM50226223; 5-Amino-2-methyl-3,4'-bipyridin-6(1H)-one; 3-amino-6-methyl-5-pyridin-4-yl-1H-pyridin-2-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(6-Oxo-1,6-dihydro-[3,4']bipyridinyl-5-yl)-benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4278218; SCHEMBL5240813; BDBM50465495; N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)benzenesulfonamide; N-(6-Oxo-1,6-dihydro-[3,4]bipyridinyl-5-yl)-benzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
Tert-butyl 2-(2-methyl-3-oxoisoindolin-4-yl)-1H-pyrrole-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491243; SCHEMBL5332117; BDBM50264549; tert-butyl 2-(2-methyl-3-oxo-1H-isoindol-4-yl)pyrrole-1-carboxylate; 2-(2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl)-pyrrole-1-carboxylic acid tert-butyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
7-Bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL373834; CHEMBL1092509; UNM-0000305775; 7-Bromoindirubin-3'-oxime; 7-Bromoindirubin-3'Oxime; 7-bromo-indirubin-3'-oxime; BDBM54685; CTK8F7254; cid_11846148; BDBM50012184; BDBM50191405; NSC737346; ZINC101329696; NSC-737346; (2''Z,3''E)-7-bromoindirubin-3''-oxime; 7-bromo-3-[3-(hydroxyamino)-1H-indol-2-yl]-2-indolone; 7-bromanyl-3-[3-(oxidanylamino)-1H-indol-2-yl]indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[4] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-5-[2-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]ethynyl]-6-methylpyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934626; BDBM50360453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(2-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391129; BDBM50435023
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N-(2-morpholinoethyl)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL518646; SCHEMBL13873523; BDBM50245407
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
3-Fluorobenzyl 4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472382; SCHEMBL3977223; BDBM50245442; (3-fluorophenyl)methyl 4-amino-6-(3-chloro-4-phenylmethoxyanilino)pyrimidine-5-carboxylate
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-({2-[(4-Carboxyphenyl)amino]pyrimidin-4-yl}amino)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Bisanilinopyrimidine, 1; ChemDiv3_004948; Oprea1_381491; CHEMBL2170592; BDBM87048; Bisanilinopyrimidine inhibitor, 2; HMS1487A20; CCG-23642; STK900123; MCULE-1749287938; IDI1_022858; EU-0082377; UNM000011036301; SR-01000085133; SR-01000085133-1; Q27451004
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[26] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N''-(3-morpholinopropanoyl)pyrimidine-5-carbohydrazide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472544; SCHEMBL1096489; BDBM50245471
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
7-Fluoroindirubin-3-methoxime
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397720; BDBM50218901
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-[2-Chloro-4-(1-methyl-1H-pyrazole-4-yl)anilino]-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109941; SCHEMBL17555251; BDBM50446450
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-(1,5-Dimethylpyrazol-4-yl)-N-(2-methoxyphenyl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109961; BDBM50446452
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2390958; SCHEMBL14604141; BDBM50435030
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
4-Amino-6-(4-(benzyloxy)-3-chlorophenylamino)-N,N-diethylpyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452727; SCHEMBL4090152; BDBM50245410; 4-amino-6-(3-chloro-4-phenylmethoxyanilino)-N,N-diethylpyrimidine-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
Chembl4280041
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465490
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
7-Chloroindirubin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243777; CHEMBL378191; (2'Z)-7-chloroindirubin; (2''Z)-7-chloroindirubin; SCHEMBL21440315; cid_11847137; (3Z)-7-chloro-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; BDBM50191445; BDBM50218889; UNM-0000305769
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-Oxoisoindoline-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXYLIC ACID; CHEMBL505379; MFCD11506114; 1H-Isoindole-4-carboxylic acid, 2,3-dihydro-3-oxo-; SCHEMBL5338831; CTK8B7220; DTXSID60659558; 3-Oxo-4-isoindolinecarboxylic acid; 5877AC; ANW-56758; BDBM50264659; ZINC40834475; AKOS006323136; DS-3664; SB40069; AK101028; SY235534; DB-079603; CS-0062203; FT-0712220; 3-oxo-1,2-dihydroisoindole-4-carboxylic acid; L-1815
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL185140; SCHEMBL21585709; BDBM50324797; 3-(1-(4-chlorobenzyl)-1H-indol-3-yl)-N-(pyridin-4-yl)propanamide; 3-[1-(4-Chloro-benzyl)-1H-indol-3-yl]-N-pyridin-4-yl-propionamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
3-Chloro-N,N-dimethyl-4-[[2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl]amino]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109969; SCHEMBL12492390; BDBM50446465
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-methoxybenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391125; SCHEMBL14604165; BDBM50435019
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Tert-butyl 6-(2-chloro-4-pyrazin-2-ylanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109947; SCHEMBL17555262; BDBM50446447
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(3-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391120; BDBM50435033
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
Tert-butyl 6-(2-chloro-4-pyridin-3-ylanilino)-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109946; SCHEMBL12524444; BDBM50446446
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-(2H-1,3-Benzodioxol-5-yl)-5-[({[1,1'-biphenyl]-4-yl}methyl)sulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064531; SCHEMBL14604056; ZINC5019100; BDBM50389086; AKOS000875105; MCULE-8962558919; Z19456538
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(2-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391122; BDBM50435035
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[2-Methoxy-5-(trifluoromethyl)phenyl]-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109965; BDBM50446456
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
CID 66547597
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109943; SCHEMBL12492177; BDBM50446440
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
CID 68290918
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109972; SCHEMBL12492104; BDBM50446464
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-[4-[[5-[(3R)-3-(Methoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064538; SCHEMBL14603965; BDBM50389084
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
6-[2-Chloro-4-(5-oxazolyl)anilino]-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109944; SCHEMBL17555308; BDBM50446448
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Chembl4281678
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465493
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-, 3-oxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Cyclapolin 1; 2-Benzothiazolecarboxamide, 7-nitro-5-[(trifluoromethyl)thio]-3-oxide; SCHEMBL5062617; CHEMBL1222044; CTK2H1083; DTXSID10429521; 7-nitro-3-oxido-5-(trifluoromethylsulfanyl)-1,3-benzothiazol-3-ium-2-carboxamide
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Chembl4292942
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465492
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
Methyl 3-oxoisoindoline-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-OXO-2,3-DIHYDRO-1H-ISOINDOLE-4-CARBOXYLIC ACID METHYL ESTER; CHEMBL473040; 1H-Isoindole-4-carboxylic acid, 2,3-dihydro-3-oxo-, methyl ester; Methyl 3-oxo-2,3-dihydro-1H-isoindole-4-carboxylate; SCHEMBL5333318; CTK8B8670; DTXSID00659557; 5875AC; ANW-61005; BDBM50264658; MFCD11506113; ZINC40411061; AKOS006323135; SB40068; DB-079602; AM20120450; FT-0736019; L-1817; methyl 3-oxo-1,2-dihydroisoindole-4-carboxylate; 2,3-Dihydro-3-oxo-1H-isoindole-4-carboxylic acid methyl ester
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
7-Fluoroindirubin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2'Z)-7-fluoroindirubin; CHEMBL210446; CHEMBL243986; (2''''Z)-7-Fluoroindirubin; SCHEMBL22300875; cid_11847138; (3Z)-7-fluoro-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one; BDBM50024791; BDBM50218896; UNM-0000305767
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(4-methoxyphenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391126; SCHEMBL14604054; BDBM50435020
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[4-[[5-[(3S)-3-(Methoxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064539; SCHEMBL14603830; BDBM50389078
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N1-(3-Acetamidophenyl)-N2-(2-(2-(4-chlorophenyl)-4-methylthiazol-5-yl)ethyl)oxalamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1643141; BDBM50333660; ZINC16992040; AKOS001564877; MCULE-3256945697; BRD-K20263515-001-01-1; F2053-0281; N-[3-(acetylamino)phenyl]-N'-{2-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]ethyl}ethanediamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
N-(4-Methoxyphenethyl)-4-amino-6-(4-(benzyloxy)-3-chlorophenylamino)pyrimidine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461115; SCHEMBL13873524; BDBM50245408
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
5-Fluoro-2-[4-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391098; BDBM50435028
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[2-Chloro-4-(4-methoxypiperidinocarbonyl)phenyl]-2-(1-methyl-1H-pyrazole-4-yl)-1H-pyrrolo[3,2-c]pyridine-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109970; SCHEMBL12492037; BDBM50446463
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064534; SCHEMBL14604288; BDBM50389081
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(3-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391128; SCHEMBL14603927; BDBM50435021
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-(4-Pyridin-4-yl-1,3-thiazol-2-yl)-2,3-dihydro-1,4-benzodioxine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CID-5056270; pyridine-thiazole, 1; Oprea1_440817; MLS000100920; CHEMBL510515; IFLab1_002379; BDBM25470; cid_5056270; HMS1418M03; HMS2256L23; KUC114266N; AKOS001082341; MCULE-5286256234; NCGC00080738-02; KSC-416-68-1; SMR000017746; MLS-0011428.0001; AB00429420-05; Z29461727; F0537-0683
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
Chembl4285109
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50465477
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391121; BDBM50435034
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
CID 68291016
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109936; SCHEMBL12492263; BDBM50446443
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
N-(5-Bromothiazol-2-yl)-2-(5-methoxybenzo[d]thiazol-2-ylthio)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1643148; BDBM50333667; BAS15364720
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Methyl 4-[[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064520; BDBM50389085
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(3Z)-7-Iodo-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL379160; 7-iodoindirubin; (2'Z)-7-iodoindirubin; (2''Z)-7-iodoindirubin; CHEMBL395078; SCHEMBL22300068; BDBM50191449
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-(2-Chlorophenyl)-2-(1-methylpyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109966; SCHEMBL12492860; BDBM50446457
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
7-Chloroindirubin-3-methoxime
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243776; BDBM50218887
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Methyl-6-oxo-1,6-dihydro-[3,4'-bipyridine]-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-Methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carboxamide; [3,4'-Bipyridine]-5-carboxamide, 1,6-dihydro-2-methyl-6-oxo-; 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carboxamide; Milrinone Related Compound A; UNII-75E39HK2X2; CHEMBL4278538; 75E39HK2X2; (3,4'-Bipyridine)-5-carboxamide, 1,6-dihydro-2-methyl-6-oxo-; MFCD09800601; POTASSIUMBENZENESULFONATE; SCHEMBL10704473; CTK5E7412; DTXSID30510182; KS-000002CI; 9920AE; BDBM50465491; SBB055744; WIN 47338; ZINC15021487; AKOS025116857; DS-3289; Milrinone related compound A [USP-RS]; AK468647; 6-Methyl-2-oxo-5-(4-pyridyl)-1H-pyridine-3-carboxamide; 6-methyl-2-oxo-5-(4-pyridyl)hydropyridine-3-carboxamide; 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carboxamide; 2-Methyl-6-oxo-1,6-dihydro[3,4'-bipyridine]-5-carboxamide; 6-Methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridine-3-carboxamide; 1,6-Dihydro-2-methyl-6-oxo-[3,4']bipyridin-5-ylcarboxylic acid amide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
N-Ethyl-5-(2-(3-(6-methoxy-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)nicotinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245966; SCHEMBL13596391; BDBM50215745
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Chembl4279867
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL10062845; BDBM50465494
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391130; SCHEMBL14603849; BDBM50435022
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[(4-phenylphenyl)methylsulfanyl]-1,3,4-oxadiazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391123; SCHEMBL14604095; BDBM50435036
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358966
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
Tert-butyl 6-[2-chloro-4-(dimethylsulfamoyl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3109935; SCHEMBL12492775; BDBM50446453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
4'-({[5-(2H-1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}methyl)-[1,1'-biphenyl]-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064533; BDBM50389087; ZINC22415373; AKOS033887643; MCULE-8760820046; Z237995644
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
5-Amino-[3,3'-bipyridin]-6(1H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1201292; 3-amino-5-pyridin-3-yl-1H-pyridin-2-one; [3,3'-Bipyridin]-6(1H)-one, 5-amino-; SCHEMBL11368332; CTK8C3782; DTXSID30276216; 2437AC; ANW-70535; BDBM50465489; ZINC31391078; 3-Amino-5-(pyridin-3-yl)pyridin-2-ol
Click to Show/Hide
|
||||
| Activity |
Ki = 125200 nM
|
[2] | |||
| Compound Name |
2-[(3S,6R,11R,14S,17S,23S,26S)-6-Amino-11-[(2-amino-2-oxoethyl)carbamoyl]-23-(3-amino-3-oxopropyl)-14-[(1R)-1-hydroxyethyl]-3-(1H-imidazol-5-ylmethyl)-2,5,13,16,19,22,25-heptaoxo-8,9-dithia-1,4,12,15,18,21,24-heptazabicyclo[24.3.0]nonacosan-17-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950041; BDBM50363996
Click to Show/Hide
|
||||
| Activity |
IC50 = 137000 nM
|
[17] | |||
| Compound Name |
3-[3-[[4-[3-(Trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3894354; BDBM209964; US9249124, RK2-052
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[9] | |||
| Compound Name |
2-Methoxy-5-(pyridine-4-yl)pyridine-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
[3,4'-Bipyridin]-5-amine, 6-methoxy-; CHEMBL4291350; ACMC-20ltv1; SCHEMBL2684595; CTK3G5501; DTXSID10552969; BDBM50465483; 6-Methoxy[3,4'-bipyridin]-5-amine; 6-Methoxy-[3,4'-bipyridin]-5-amine; 2-methoxy-5-pyridin-4-ylpyridin-3-amine; 2-METHOXY-5-(PYRIDIN-4-YL)PYRIDIN-3-AMINE; A1-32524
Click to Show/Hide
|
||||
| Activity |
Ki = 184700 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 16 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Inamrinone Lactate
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Amrinone; inamrinone; 60719-84-8; Wincoram; Inocor; Cordemcura; Cartonic; 5-Amino-[3,4'-bipyridin]-6(1H)-one; Amrinonum [INN-Latin]; Amrinonum; Amrinona; Amrinona [INN-Spanish]; 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone; Win-40680; Amcoral; 5-Amino-(3,4'-bipyridin)-6(1H)-one; WIN 40680; AWD 08-250; 3-amino-5-pyridin-4-yl-1H-pyridin-2-one; UNII-JUT23379TN; CCRIS 3794; Amrinone lactate; MLS000069829; EINECS 262-390-0; 5-amino-3,4'-bipyridin-6(1H)-one; BRN 0744819; 5-Amino(3,4'-bipyridin)-6(1H)-one; SMR000058850; CHEMBL12856; JUT23379TN; Amrinone Lactate
Click to Show/Hide
|
||||
| Activity |
Ki = 393900 nM
|
[2] | |||
| Compound Name |
AR-A014418
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
487021-52-3; GSK-3beta Inhibitor VIII; 1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea; A Inhibitor VIII; N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA; UNII-87KSH90Q6D; AR-AO 14418; SN 4521; AR-A 014418; CHEMBL259850; 87KSH90Q6D; N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea; AK175829; C12H12N4O4S; N-(4-Methoxybenzyl)-N& -(5-nitro-1,3-thiazol-2-yl)urea; AR 014418; GSK 3be
Click to Show/Hide
|
||||
| Activity |
IC50 > 100000000 nM
|
[29] | |||
| Compound Name |
3-(1H-Benzimidazol-2-yl)-6-chloro-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3912939; BDBM50198072
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
(5Z)-3-(Cyclohexylmethyl)-2-(4-ethylphenyl)imino-5-(pyridin-4-ylmethylidene)-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970952; BDBM50198026
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
(3S,6S,9S,15S,21R,26R,29S)-21-Amino-N-(2-amino-2-oxoethyl)-6-(3-amino-3-oxopropyl)-15-(1H-imidazol-5-ylmethyl)-2,5,8,14,17,20,28-heptaoxo-3-propan-2-yl-23,24-dithia-1,4,7,13,16,19,27-heptazatricyclo[27.3.0.09,13]dotriacontane-26-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950042; BDBM50363997
Click to Show/Hide
|
||||
| Activity |
IC50 = 234000 nM
|
[17] | |||
| Compound Name |
2-[(3S,9S,12R,17R,20S,23S,26S)-12-Amino-17-[(2-amino-2-oxoethyl)carbamoyl]-20-(1H-imidazol-5-ylmethyl)-23-(1H-indol-3-ylmethyl)-2,5,8,11,19,22,25-heptaoxo-3-propan-2-yl-14,15-dithia-1,4,7,10,18,21,24-heptazabicyclo[24.3.0]nonacosan-9-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1950039; BDBM50363994
Click to Show/Hide
|
||||
| Activity |
IC50 = 242000 nM
|
[17] | |||
| Compound Name |
3-Amino-2-hydroxypyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3-Amino-2-pyridinol; 3-aminopyridin-2-ol; 3-aminopyridin-2(1H)-one; 3-amino-1H-pyridin-2-one; 2(1H)-Pyridinone, 3-amino-; 2-Pyridinol, 3-amino-; 3-Amino-2-pyridone; 3-amino-pyridin-2-ol; 2-HYDROXY-3-AMINOPYRIDINE; 3-Amino-2-pyridinone; MFCD03411556; NSC279497; 3-aminohydropyridin-2-one; 3-Amino-2(1H)-pyridinone; CHEMBL4286709; 3-Amino-2-pyridinol, 97%; aminopyridinone; aminopyridone; Aminopyridinol; 2(1H)-Pyridinone,3-amino-; 3-aminopyrid-2-one; NSC 279497; PubChem1263; 3-Aminopyridine-2-ol; ACMC-1AJGZ; 3-amino-2-hydroxy pyridine; 3-amino-2-hydroxy-pyridine; SCHEMBL87697; 3-azanyl-1H-pyridin-2-one; KSC269G4B; Yttrium(III)OxalateNonahydrate; ACMC-209i21; SCHEMBL7834765; 3-Amino-2(1H)-pyridinone #; CTK1G9340; CTK7H0285; DTXSID70187317; Pyridin-2(1H)-one, 3-amino-; 3-amino-1,2-dihydropyridin-2-one; ACN-S003496; ACT01552; ALBB-027684; KS-00000PC2; KS-000010TU; ZINC8698104; AC-074; ANW-27671; ANW-51533; BBL100664; BDBM50465479; SBB051906; STK776258; STL554458; AKOS002670113; AKOS005618212; 3-amino-2-hydroxypyridine, AldrichCPR; CCG-325587; CS-W004662; MCULE-2705834056; NSC-279497; PB30752; PS-3655; VP11025; VP14460; AC-31846; AK-26159; AK-88485; AM807018; BR-26159; SC-03575; SC-51165; ST041905; SY008406; TS-01536; AB0015719; AB0068998; FT-0601494; FT-0649416; C-8187; K-7745; Z-4054; 630A998; A821885; AE-641/00363028; J-505326; J-511548
Click to Show/Hide
|
||||
| Activity |
Ki = 361000 nM
|
[2] | |||
| Compound Name |
N-[3-[3-[[2-Methyl-6-(2-morpholin-4-ylethylamino)pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807788; SCHEMBL12077782; BDBM50349021
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[30] | |||
| Compound Name |
N-[3-[3-[[6-[2-(Dimethylamino)ethylamino]-2-methylpyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807787; SCHEMBL12091967; BDBM50349020
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[30] | |||
| Compound Name |
CID 56659825
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807485; SCHEMBL12077735; BDBM50349017
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[30] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
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| Activity |
Ki > 1000000 nM
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[31] | |||
| Compound Name |
CID 56676977
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1807484; SCHEMBL12077993; BDBM50349016
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| Activity |
IC50 > 1000000 nM
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[30] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-[6-(2H-tetrazol-5-yl)-1,3-benzothiazol-2-yl]urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824332; BDBM50352494
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| Activity |
IC50 = 4800000 nM
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[29] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-[4-(2H-tetrazol-5-yl)pyridin-2-yl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824334; BDBM50352493
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||||
| Activity |
IC50 > 100000000 nM
|
[29] | |||
| Compound Name |
1-(4-Cyanopyridin-2-yl)-3-[(4-methoxyphenyl)methyl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824539; BDBM50352491
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||||
| Activity |
IC50 > 100000000 nM
|
[29] | |||
| Compound Name |
1-[(4-Methoxyphenyl)methyl]-3-(6-nitro-1,3-benzothiazol-2-yl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1824540; BDBM50352492
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| Activity |
IC50 > 100000000 nM
|
[29] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
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| REF 8 | Discovery of 6-benzyloxyquinolines as c-Met selective kinase inhibitors. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1405-9. | ||||
| REF 9 | US patent application no. 9249124B2, Aurora kinase inhibitors and methods of making and using thereof | ||||
| REF 10 | Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3562-6. | ||||
| REF 11 | Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity. J Med Chem. 2009 Feb 26;52(4):1050-62. | ||||
| REF 12 | Structure-based optimization of oxadiazole-based GSK-3 inhibitors. Eur J Med Chem. 2013 Mar;61:26-40. | ||||
| REF 13 | Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3458-62. | ||||
| REF 14 | Polyphenols bearing cinnamaldehyde scaffold showing cell growth inhibitory effects on the cisplatin-resistant A2780/Cis ovarian cancer cells. Bioorg Med Chem. 2014 Mar 15;22(6):1809-20. | ||||
| REF 15 | Hit generation and exploration: imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6567-71. | ||||
| REF 16 | Computational approach to the identification of novel Aurora-A inhibitors. Bioorg Med Chem. 2011 Jan 15;19(2):907-16. | ||||
| REF 17 | Selection of cyclic-peptide inhibitors targeting Aurora kinase A: problems and solutions. Bioorg Med Chem. 2011 Nov 15;19(22):6743-9. | ||||
| REF 18 | Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry. Bioorg Med Chem Lett. 2008 Jul 15;18(14):3978-81. | ||||
| REF 19 | Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4557-61. | ||||
| REF 20 | Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17. | ||||
| REF 21 | A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4896-9. | ||||
| REF 22 | Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5203-6. | ||||
| REF 23 | Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3alpha. J Med Chem. 2012 May 10;55(9):4407-24. | ||||
| REF 24 | 7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: design, synthesis, and biological activity. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5130-3. | ||||
| REF 25 | Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases. Bioorg Med Chem Lett. 2012 Jan 1;22(1):456-60. | ||||
| REF 26 | Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7392-7416. | ||||
| REF 27 | Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. | ||||
| REF 28 | Optimization of potent DFG-in inhibitors of platelet derived growth factor receptor (PDGF-R) guided by water thermodynamics. J Med Chem. 2015 Jan 8;58(1):170-82. | ||||
| REF 29 | Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5610-5. | ||||
| REF 30 | Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3). Bioorg Med Chem. 2011 Jul 15;19(14):4173-82. | ||||
| REF 31 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
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