Drug Information
Drug General Information | Top | |||
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Drug ID |
D0K6VW
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Former ID |
DNC007557
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Drug Name |
7-iodoindirubin-3-oxime
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Drug Type |
Small molecular drug
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Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
Structure |
Download2D MOL |
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Canonical SMILES |
C1=CC=C2C(=C1)C(=C(N2)C3=C4C=CC=C(C4=NC3=O)I)NO
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Aurora B messenger RNA (AURKB mRNA) | Target Info | Inhibitor | [1] |
Aurora kinase C (AURKC) | Target Info | Inhibitor | [1] | |
KEGG Pathway | Oocyte meiosis | |||
Pathway Interaction Database | Aurora B signaling | |||
Signaling by Aurora kinases | ||||
Aurora C signaling | ||||
FOXM1 transcription factor network | ||||
Aurora A signaling | ||||
Reactome | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | |||
Separation of Sister Chromatids | ||||
Resolution of Sister Chromatid Cohesion | ||||
RHO GTPases Activate Formins | ||||
Mitotic Prometaphase | ||||
WikiPathways | EGF/EGFR Signaling Pathway | |||
JAK/STAT | ||||
Gastric Cancer Network 1 | ||||
Integrated Breast Cancer Pathway | ||||
APC/C-mediated degradation of cell cycle proteins | ||||
Mitotic Metaphase and Anaphase | ||||
Mitotic Prometaphase | ||||
Regulation of Microtubule Cytoskeleton | ||||
miR-targeted genes in lymphocytes - TarBase | ||||
miR-targeted genes in epithelium - TarBase |
References | Top | |||
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REF 1 | An integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases B and C by a series of 7-substituted in... J Med Chem. 2007 Aug 23;50(17):4027-37. |
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