Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T84173 | Target Info | |||
| Target Name | Glucosylceramidase (GBA) | ||||
| Synonyms |
SGTase; Lysosomal acid glucosylceramidase; Lysosomal acid GCase; Imiglucerase; GLUC; GC; D-glucosyl-N-acylsphingosine glucohydrolase; Cholesteryl-beta-glucosidase; Cholesterol glucosyltransferase; Beta-glucocerebrosidase; Beta-GC; Alglucerase; Acid beta-glucosidase
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| Target Type | Successful Target | ||||
| Gene Name | GBA | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 65 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Miglitol
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|
Approved | Compound Info | ||
| Synonyms |
Diastabol; Glyset; Plumarol; Seibule; Glyset (TN); SK-983; Bay-m-1099; Miglitol (JAN/USAN/INN); (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
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| Activity |
IC50 = 84000 nM
|
[1] | |||
| Compound Name |
Deoxynojirimycin
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|
Phase 3 | Compound Info | ||
| Synonyms |
1-DEOXYNOJIRIMYCIN; 19130-96-2; DUVOGLUSTAT; deoxynojirimycin; Moranoline; (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Deoxy-1,5-imino-D-mannitol; Moranolin; UNII-FZ56898FLE; D-1-deoxynojirimycin; 1,5-Dideoxy-1,5-imino-D-glucitol; CHEMBL307429; C6H13NO4; FZ56898FLE; CHEBI:44369; 1-Deoxy-Nojirimycin; 5-Amino-1,5-dideoxy-D-glucopyranose; DNJ; AK151410; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R-(2alpha,3beta,4alpha,5beta))-
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| Activity |
Ki = 79000 nM
|
[2] | |||
| Compound Name |
D-Gluconhydroximo-1,5-Lactam
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Investigative | Compound Info | ||
| Synonyms |
D-GLUCONHYDROXIMO-1,5-LACTAM; CHEMBL1213470; (Z)-D-Gluconhydroximo-1,5-lactam; GOX; (2S,3S,4R,5R)-6-(HYDROXYAMINO)-2-(HYDROXYMETHYL)-2,3,4,5-TETRAHYDROPYRIDINE-3,4,5-TRIOL; CID445248; GHIL; 1e6s; AC1L9HO3; BDBM36390; 3d51; 2j78; BDBM50120840; DB02376; (Z)-D-Gluconhydroximo-1,5-lactam, 15; (2Z,3S,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)piperidin-2-one oxime
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| Activity |
IC50 = 65810 nM
|
[3] | |||
| Compound Name |
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienoxy]pentyl]piperidine-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354033; BDBM50028259
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|
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-(naphthalen-2-ylmethoxy)pentyl]piperidine-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354035; BDBM50028215
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
N-Nonyl-L-ido-1-deoxynojirimycin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651627; BDBM50335393; ZINC66156319; (2S,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol
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| Activity |
IC50 = 50000 nM
|
[5] | |||
| Compound Name |
4-Benzenesulfonamido-N-benzylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
Sulfonamide analogue, 26; CHEMBL259848; BDBM18446; ZINC1049409; STL119122; AKOS000394516; MCULE-4653437804; NCGC00093491-01; N-benzyl-4-[(phenylsulfonyl)amino]benzamide; Z31477320
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| Activity |
Ki = 50600 nM
|
[6] | |||
| Compound Name |
(1S,2R,4S,5R)-6-(Nonylamino)cyclohexane-1,2,3,4,5-pentol;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163840; CHEMBL2163841
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|
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| Activity |
IC50 = 52600 nM
|
[7] | |||
| Compound Name |
(1S,2R,3R,4S,5R,6S)-5,6-Diaminocyclohexane-1,2,3,4-tetrol;dihydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216992
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|
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| Activity |
IC50 = 53400 nM
|
[8] | |||
| Compound Name |
(2R,3R,4R)-2-(Hydroxymethyl)-1-[(4-methylphenyl)methyl]piperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3669166; BDBM175508; US9119845, 9
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|
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| Activity |
Ki = 53720 nM
|
[9] | |||
| Compound Name |
(3R,4R,5R)-5-(Hydroxymethyl)-1-[(4-methylphenyl)methyl]piperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2714366; CHEMBL3943462; BDBM238205; US9402837, 9
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|
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| Activity |
Ki = 53720 nM
|
[10] | |||
| Compound Name |
D-Galacto-Isofagomine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1818433; (3R,4S,5R)-5-(Hydroxymethyl)piperidine-3,4-diol; 4-epi-Isofagomine; SCHEMBL12232220; CTK0E4850; DTXSID30437108; BDBM50350758; Q27460740; 3,4-Piperidinediol, 5-(hydroxymethyl)-, (3R,4S,5R)-
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| Activity |
IC50 = 54000 nM
|
[11] | |||
| Compound Name |
(1S,2S,3S,4R,5R)-4-(6-Aminohexylamino)-5-(hydroxymethyl)cyclopentane-1,2,3-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090899; BDBM50254118
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|
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| Activity |
Ki = 54200 nM
|
[12] | |||
| Compound Name |
(6R,7S,7As)-3-(16-hydroxyhexadecylimino)-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole-6,7-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3974420; BDBM50197873
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|
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| Activity |
IC50 = 55000 nM
|
[13] | |||
| Compound Name |
(1R,2S,3r,4R,5S,6s)-6-[2-(1-Octyl-1H-1,2,3-triazol-4-yl)ethylamino]cyclohexane-1,2,3,4,5-pentaol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1085631; BDBM50318552
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|
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| Activity |
IC50 = 55900 nM
|
[14] | |||
| Compound Name |
(7R,8R,8As)-3-(16-hydroxyhexadecylimino)-1,5,6,7,8,8a-hexahydro-[1,3]thiazolo[3,4-a]pyridine-7,8-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3909220; BDBM50197869
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|
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| Activity |
IC50 = 56000 nM
|
[13] | |||
| Compound Name |
3-Deoxy-3-[[3-(1-adamantylcarbamoyl)propyl]amino]-scyllo-inositol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3220376
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|
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| Activity |
IC50 = 58000 nM
|
[15] | |||
| Compound Name |
(1R,2S,3R,4R,5R)-4-(Hydroxymethyl)-8-nonyl-8-azabicyclo[3.2.1]octane-1,2,3-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682495; N-nonyl noeurostegine; BDBM50337388
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|
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| Activity |
IC50 = 60000 nM
|
[16] | |||
| Compound Name |
(2S,3R,4R,5S)-1-[5-(Cyclohexylmethoxy)pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354026; BDBM50028208
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|
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| Activity |
IC50 = 60000 nM
|
[4] | |||
| Compound Name |
(2R,3R,4R)-2-(Hydroxymethyl)-1-(2-methoxyethyl)piperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3669162; SCHEMBL17189555; BDBM175504; US9119845, 5
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|
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| Activity |
EC50 = 60700 nM
|
[9] | |||
| Compound Name |
(2R,3R,4R)-2-(Hydroxymethyl)-1-(3-methylbut-2-enyl)piperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3669161; BDBM175503; US9119845, 4
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|
||||
| Activity |
EC50 = 63000 nM
|
[9] | |||
| Compound Name |
Schembl20726290
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3669172; BDBM175516; US9119845, 17
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|
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| Activity |
EC50 = 65600 nM
|
[9] | |||
| Compound Name |
(2R,3R,4R)-2-(Hydroxymethyl)-1-propylpiperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3669158; SCHEMBL20726258; CTK3G2160; DTXSID60678527; BDBM175500; US9119845, 1; 3,4-Piperidinediol, 2-(hydroxymethyl)-1-propyl-, (2R,3R,4R)-
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|
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| Activity |
EC50 = 65900 nM
|
[9] | |||
| Compound Name |
2,5-Bis-hydroxymethyl-piperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350915; CHEMBL157578; BDBM50075409
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|
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| Activity |
Ki = 66000 nM
|
[17] | |||
| Compound Name |
(1R,2S,4R,5S)-6-[[1-[[3-[(4-Methylpiperazin-1-yl)methyl]phenyl]methyl]triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1766469; BDBM50341337
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|
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| Activity |
IC50 = 66500 nM
|
[18] | |||
| Compound Name |
(2R,3R,4R)-2-(Hydroxymethyl)-1-(oxan-4-ylmethyl)piperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3669170; BDBM175514; US9119845, 15
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|
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| Activity |
EC50 = 68300 nM
|
[9] | |||
| Compound Name |
(3R,4R,5R)-5-(Hydroxymethyl)-1-[(2-methylphenyl)methyl]piperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2713931; CHEMBL3987011; BDBM238203; US9402837, 7
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|
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| Activity |
IC50 = 69470 nM
|
[10] | |||
| Compound Name |
(2R,3R,4R)-2-(Hydroxymethyl)-1-[(2-methylphenyl)methyl]piperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3669164; BDBM175506; US9119845, 7
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|
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| Activity |
IC50 = 69470 nM
|
[9] | |||
| Compound Name |
(2R,3S,4R,5R,6R)-2-Butyl-6-(hydroxymethyl)piperidine-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
alpha-1-C-Butyl-DNJ; CHEMBL1088892; SCHEMBL17189493; BDBM18361; 1-Butyl-1-deoxy-5-O-aza-alpha-D-glucopyranose
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| Activity |
IC50 = 70000 nM
|
[19] | |||
| Compound Name |
(2R,3R,4R)-1-[(4-Fluorophenyl)methyl]-2-(hydroxymethyl)piperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3669167; BDBM175509; US9119845, 10
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| Activity |
EC50 = 70600 nM
|
[9] | |||
| Compound Name |
(6R,7S,7As)-3-octylimino-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole-6,7-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3980439; BDBM50197867
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| Activity |
IC50 = 76000 nM
|
[13] | |||
| Compound Name |
1-Butyl-5-methyl-piperidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL356023; BDBM50288853
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|
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| Activity |
IC50 = 80000 nM
|
[20] | |||
| Compound Name |
4,4,5,5,6,6,7,7,7-Nonafluoro-N-[9-[[(1R,2R,3S,4R,5S)-2,3,4-trihydroxy-6-oxa-8-azabicyclo[3.2.1]octane-8-carbothioyl]amino]nonyl]heptanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076141; BDBM50236281
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|
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| Activity |
Ki = 80000 nM
|
[21] | |||
| Compound Name |
(2R,3R,4R,5S)-1-Hexyl-2-(hydroxymethyl)piperidine-3,4,5-triol
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Investigative | Compound Info | ||
| Synonyms |
N-Hexyl-DNJ; SCHEMBL2789051; CHEMBL1651550; BDBM18356; (2R)-1-Hexyl-2alpha-(hydroxymethyl)piperidine-3beta,4alpha,5beta-triol
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| Activity |
IC50 = 80000 nM
|
[5] | |||
| Compound Name |
(2R,3R,4R)-1-Benzyl-2-(hydroxymethyl)piperidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3669163; BDBM175505; US9119845, 6
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|
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| Activity |
Ki = 82990 nM
|
[9] | |||
| Compound Name |
(3r,4r,5r)-1-Benzyl-5-(hydroxymethyl)piperidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2713933; CHEMBL3906523; BDBM238202; US9402837, 6
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| Activity |
Ki = 82990 nM
|
[10] | |||
| Compound Name |
(1s,2s,3s,6r)-4-(Hydroxymethyl)-6-(Octylamino)cyclohex-4-Ene-1,2,3-Triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1922581; CHEMBL1922579; N-Octyl-4-epi-beta-Valienamine; BDBM50358321; Q27463709
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| Activity |
Ki = 83000 nM
|
[12] | |||
| Compound Name |
5-Aminocyclopentane-1,2,3,4-tetrol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL87120; SCHEMBL10824967; BDBM50283600; AKOS006338476; 5-Amino-cyclopentane-1,2,3,4-tetraol
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| Activity |
IC50 = 83800 nM
|
[22] | |||
| Compound Name |
4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluoro-N-[4-[[(1R,2R,3S,4R,5S)-2,3,4-trihydroxy-6-oxa-8-azabicyclo[3.2.1]octane-8-carbothioyl]amino]butyl]nonanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100971; BDBM50236280
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| Activity |
Ki = 90000 nM
|
[21] | |||
| Compound Name |
(6S,7S,7Ar)-3-octylimino-5,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole-6,7-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3950752; BDBM50197870
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| Activity |
IC50 = 92000 nM
|
[13] | |||
| Compound Name |
N-(Adamantan-1-yl)-6-[(3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)piperidin-1-yl]hexanamide
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Investigative | Compound Info | ||
| Synonyms |
isofagomine-based compound, 5; CHEMBL375376; BDBM18371
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| Activity |
IC50 = 94000 nM
|
[23] | |||
| Compound Name |
N-Hexoxypentyl-L-ido-1-deoxynojirimycin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651636; SCHEMBL17132911; BDBM50335384
Click to Show/Hide
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| Activity |
IC50 = 95000 nM
|
[5] | |||
| Compound Name |
Calystegine B4
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233945; (1R,2S,3R,4R,5R)-8-azabicyclo[3.2.1]octane-1,2,3,4-tetrol; BDBM50002909; (1R,2R,3R,4S,5R)-8-azabicyclo[3.2.1]octane-2,3,4,5-tetrol; 8-Azabicyclo(3.2.1)octane-1,2,3,4-tetrol, (1R,2S,3R,4R,5R)-
Click to Show/Hide
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| Activity |
Ki = 98000 nM
|
[24] | |||
| Compound Name |
(1R,2S,3R,4R,5R)-8-Butyl-4-(hydroxymethyl)-8-azabicyclo[3.2.1]octane-1,2,3-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682494; N-Butyl noeurostegine; BDBM50337387
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| Activity |
IC50 = 100000 nM
|
[16] | |||
| Compound Name |
N-Pentoxypentyl-L-ido-1-deoxynojirimycin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651635; BDBM50335385
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|
||||
| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
(3S,4R,5R)-3,4,5-Trihydroxy-1-nonylpiperidin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL444504; BDBM50413910
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|
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| Activity |
IC50 = 102000 nM
|
[25] | |||
| Compound Name |
(3R,4R,5R)-1-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)piperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2717187; CHEMBL3977796; BDBM238206; US9402837, 10
Click to Show/Hide
|
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| Activity |
Ki = 111800 nM
|
[10] | |||
| Compound Name |
(3S,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1818321; 3-epi-Isofagomine; BDBM50350761
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|
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| Activity |
IC50 = 113000 nM
|
[11] | |||
| Compound Name |
Rel-(1R,2S,4R,5S)-6-((1-((1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)methyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1766478; BDBM50341320
Click to Show/Hide
|
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| Activity |
IC50 = 114000 nM
|
[18] | |||
| Compound Name |
(7R,8R,8As)-3-octylimino-1,5,6,7,8,8a-hexahydro-[1,3]thiazolo[3,4-a]pyridine-7,8-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3937138; BDBM50197866
Click to Show/Hide
|
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| Activity |
IC50 = 115000 nM
|
[13] | |||
| Compound Name |
(3R,4R,5R)-1-(Furan-2-ylmethyl)-5-(hydroxymethyl)piperidine-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2715520; CHEMBL3902412; BDBM238211; US9402837, 17
Click to Show/Hide
|
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| Activity |
Ki = 116390 nM
|
[10] | |||
| Compound Name |
(2S,3S,4S)-3,4-Dihydroxy-2-(hydroxymethyl)-N-octylpyrrolidine-1-carbothioamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3933048; BDBM50197874
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|
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| Activity |
IC50 = 121000 nM
|
[13] | |||
| Compound Name |
N-{2-[(3-Chlorophenyl)amino]-4-methylquinolin-6-yl}-4-methylcyclohexanecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
Aminoquinoline compound, 22; CHEMBL448107; BDBM18437; ZINC6899663; NCGC00092414-01; NCGC00092414-02; NCGC00092414-03; NCGC00092414-04; AB01316400-02
Click to Show/Hide
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| Activity |
Ki = 122000 nM
|
[6] | |||
| Compound Name |
(1S,2S,3S,4R,5R)-4-(Hydroxymethyl)-5-pyrrolidin-1-ylcyclopentane-1,2,3-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098625; BDBM50254119
Click to Show/Hide
|
||||
| Activity |
Ki = 123000 nM
|
[12] | |||
| Compound Name |
(3S,4R,5R)-3,4,5-Trihydroxy-1-(6-propoxyhexyl)piperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490715; BDBM50413909
Click to Show/Hide
|
||||
| Activity |
IC50 = 127000 nM
|
[25] | |||
| Compound Name |
Rel-(1R,2S,4R,5S)-6-((1-(3-hydroxy-2,2-dimethylpropyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1766481; BDBM50341323
Click to Show/Hide
|
||||
| Activity |
IC50 = 134000 nM
|
[18] | |||
| Compound Name |
(2R,3R,4R)-2-(Hydroxymethyl)-1-(thiophen-2-ylmethyl)piperidine-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3669173; BDBM175517; US9119845, 18
Click to Show/Hide
|
||||
| Activity |
EC50 = 139000 nM
|
[9] | |||
| Compound Name |
CID 70681086
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012659; BDBM50379104; (1R,2S,3S,4R,5R,6S)-5,6-di(nonoxy)cyclohexane-1,2,3,4-tetrol
Click to Show/Hide
|
||||
| Activity |
IC50 = 144000 nM
|
[8] | |||
| Compound Name |
(2S,3S,4R,5R,6S)-2-Butyl-6-(hydroxymethyl)piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1088891; SCHEMBL19831653; BDBM50315253
Click to Show/Hide
|
||||
| Activity |
IC50 = 147000 nM
|
[26] | |||
| Compound Name |
(3S,4R,5R)-3,4,5-Trihydroxy-1-octylpiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491718; BDBM50413904
Click to Show/Hide
|
||||
| Activity |
IC50 = 175000 nM
|
[25] | |||
| Compound Name |
(1R,2S,3r,4R,5S,6s)-6-[(1-Butyl-1H-1,2,3-triazol-4-yl)methylamino]cyclohexane-1,2,3,4,5-pentaol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1085391; BDBM50318551
Click to Show/Hide
|
||||
| Activity |
IC50 = 177827.94 nM
|
[14] | |||
| Compound Name |
Rel-(1R,2S,4R,5S)-6-((1-(3-(3-butoxypropoxy)propyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1766484; BDBM50341326
Click to Show/Hide
|
||||
| Activity |
IC50 = 181000 nM
|
[18] | |||
| Compound Name |
Chembl4209809
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456587
Click to Show/Hide
|
||||
| Activity |
IC50 = 187000 nM
|
[27] | |||
| Compound Name |
8-Azabicyclo[3.2.1]octane-1,2,3,4-tetrol, (1R,2R,3R,4S,5R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233944; BDBM50002857; AKOS006345680; (1R,2S,3R,4R,5R)-8-azabicyclo[3.2.1]octane-2,3,4,5-tetrol; (1R,5R)-8-Azabicyclo[3.2.1]octane-1,2alpha,3alpha,4beta-tetrol
Click to Show/Hide
|
||||
| Activity |
Ki = 199000 nM
|
[24] | |||
| Compound Name |
(2R,3S,4R,5S)-2-(Hydroxymethyl)-1-[5-[(4-phenylphenyl)methoxy]pentyl]piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354638; SCHEMBL17132914; BDBM50028258
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 101 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Miglustat
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
BuDNJ; Butyldeoxynojirimycin; Miglustatum; NBV; Vevesca; Zavesca; Miglustat [USAN]; OGT 918; SC 48334; SC48334; Miglustat, Hydrochloride; N-Butyl deoxynojirimycin; N-Butyl dnj; N-Butyldeoxynojirimycin; N-Butylmoranoline; NB-DNJ; OGT-918; SC-48334; Zavesca (TN); Miglustat (USAN/INN); N-Bu-DNJ; N-Butyl-DNJ; N-Butyl-deoxynojirimycin; N-(n-Butyl)deoxynojirimycin; N-butyl-1-deoxynojirimycin; N-(n-butyl)-1,5-dideoxy-1,5-imino-D-glucitol; (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Dideoxy-1,5-N-butylimino-D-glucitol
Click to Show/Hide
|
||||
| Activity |
IC50 = 259000 nM
|
[25] | |||
| Compound Name |
Lucerastat
Click to Show/Hide
|
Phase 3 | Compound Info | ||
| Synonyms |
141206-42-0; UNII-GVS3YDM418; N-Butyldeoxygalactonojirimycin; GVS3YDM418; CHEMBL1086997; N-(n-Butyl)deoxygalactonojirimycin; (2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol; Lucerastat [INN]; N-Butyl-DGJ; NB-DGJ; N-Bu-DGJ; AC1L9UXN; N- Butyldeoxygalactonojirimycin; SCHEMBL6821044; N-Butyl-deoxy-galactonojirimycin; CDP-923; N-N-Butyl Deoxygalactonojirimycin; OGT-923; DTXSID60161601; MolPort-039-015-418; ZX-AT009021; ZINC13719785; BDBM50312528; N-Butyl-D-galacto-1-deoxynojirimycin; AKOS027384398; NCGC00181326
Click to Show/Hide
|
||||
| Activity |
IC50 = 320000 nM
|
[4] | |||
| Compound Name |
2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11516; 63586-13-0; 2-Benzyl-4,5,6,7-tetrachloro-isoindole-1,3-dione; 2-benzyl-4,5,6,7-tetrachloro-1H-isoindole-1,3(2H)-dione; AC1LK1ZO; Oprea1_023833; 2-benzyl-4,5,6,7-tetrachloroisoindole-1,3-dione; 2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione; SCHEMBL10675358; CTK2A8819; DTXSID60359687; MolPort-001-020-850; ZINC630019; STK246502; BDBM50088678; AKOS003243470; MCULE-7798575308; N-Benzyl-3,4,5,6-tetrachlorophthalimide; ST50854964; AK-918/11423009; 4,5,6,7-tetrachloro-2-benzylbenzo[c]azolidine-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
5-hydroxy-2-phenylisoindoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL276030; 4-Hydroxy-N-phenylphthalimide; 3975-50-6; 5-hydroxy-2-phenylisoindoline-1,3-dione; 5-hydroxy-2-phenyl-isoindole-1,3-dione; SCHEMBL8615277; CTK1B3719; DTXSID80445430; HCUAWJNHCZEMJS-UHFFFAOYSA-N; ZINC26020837; BDBM50088673; 5-hydroxy-2-phenyl-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 5-hydroxy-2-phenyl-
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
N-Hexoxypentyl-1-deoxynojirimycin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651630; SCHEMBL17132910; BDBM50335390
Click to Show/Hide
|
||||
| Activity |
IC50 = 205000 nM
|
[5] | |||
| Compound Name |
3-Anilino-5,7a-bis(hydroxymethyl)-2,4a,6,7-tetrahydrocyclopenta[b][1,4]oxazine-5,6,7-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314403; BDBM50283599; 5,7a-Bis-hydroxymethyl-3-phenylamino-2,4a,5,6,7,7a-hexahydro-cyclopenta[1,4]oxazine-5,6,7-triol
Click to Show/Hide
|
||||
| Activity |
IC50 = 211000 nM
|
[22] | |||
| Compound Name |
(3As,5R,6S,7S,7aR)-5-(hydroxymethyl)-2-(16-iodohexadecylsulfanyl)-5,6,7,7a-tetrahydro-3aH-pyrano[2,3-d][1,3]oxazole-6,7-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393928; BDBM50101401
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[29] | |||
| Compound Name |
(1R,2S,4R,5S)-6-[[1-[(2-Butyl-1H-imidazol-5-yl)methyl]triazol-4-yl]methylamino]cyclohexane-1,2,3,4,5-pentol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1766468; BDBM50341336
Click to Show/Hide
|
||||
| Activity |
IC50 = 237000 nM
|
[18] | |||
| Compound Name |
(3S,4R,5R)-1-[2-(Dipropylamino)ethyl]-3,4,5-trihydroxypiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL488314; BDBM50413908
Click to Show/Hide
|
||||
| Activity |
IC50 = 253000 nM
|
[25] | |||
| Compound Name |
(1R,2S,3r,4R,5S,6s)-6-(3-(1-Hexyl-1H-1,2,3-triazol-4-yl)propylamino)cyclohexane-1,2,3,4,5-pentaol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1085859; BDBM50318550
Click to Show/Hide
|
||||
| Activity |
IC50 = 257000 nM
|
[14] | |||
| Compound Name |
(1R,2R,3R)-3-(Hydroxymethyl)-4-pentylcyclohexane-1,2-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3669159; BDBM175501; US9119845, 2
Click to Show/Hide
|
||||
| Activity |
EC50 = 266100 nM
|
[9] | |||
| Compound Name |
(3R,4R)-1-Decyl-3,4-dihydroxypyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491744; BDBM50413902
Click to Show/Hide
|
||||
| Activity |
IC50 = 285000 nM
|
[25] | |||
| Compound Name |
(3S,4R,5S)-1-Decyl-3,4,5-trihydroxypiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492080; BDBM50413914
Click to Show/Hide
|
||||
| Activity |
IC50 = 295000 nM
|
[25] | |||
| Compound Name |
Methyl 16-[[(3aS,5R,6S,7S,7aR)-6,7-dihydroxy-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[2,3-d][1,3]oxazol-2-yl]sulfanyl]hexadecanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393927; BDBM50101402
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[29] | |||
| Compound Name |
2-Phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86865; BDBM50283601; 2-anilino-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]oxazole-4,5,6-triol
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[22] | |||
| Compound Name |
2-Anilino-6a-(hydroxymethyl)-3a,4,5,6-tetrahydrocyclopenta[d][1,3]oxazole-4,5,6-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86772; BDBM50283602; 6a-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[22] | |||
| Compound Name |
2-Anilino-4-(hydroxymethyl)-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]oxazole-5,6-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313375; BDBM50283603; 4-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-5,6-diol
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[22] | |||
| Compound Name |
2-Anilino-6-(hydroxymethyl)-3a,4,5,6a-tetrahydrocyclopenta[d][1,3]oxazole-4,5,6-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88408; BDBM50283604; 6-Hydroxymethyl-2-phenylamino-4,5,6,6a-tetrahydro-3aH-cyclopentaoxazole-4,5,6-triol
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[22] | |||
| Compound Name |
5-Amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetrol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL88413; 5-amino-1-C-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol; SCHEMBL7109677; BDBM50283598; 5-amino-1-(hydroxymethyl)cyclopentane-1,2,3,4-tetraol; 5-Amino-1-hydroxymethyl-cyclopentane-1,2,3,4-tetraol; 5-amino-1 -(hydroxymethyl)cyclopentane-1,2,3,4-tetraol
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[22] | |||
| Compound Name |
Rel-(1R,2S,4R,5S)-6-((1-(3-(3-tert-butoxypropoxy)propyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1766487; BDBM50341329
Click to Show/Hide
|
||||
| Activity |
IC50 = 325000 nM
|
[18] | |||
| Compound Name |
(2S,3R,4R,5S)-2-Fluoromethyl-piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL111326; SCHEMBL15599039; BDBM50280030; ZINC13687199; (2S,3R,4R,5S)-2-(fluoromethyl)piperidine-3,4,5-triol; Hexahydro-6beta-(fluoromethyl)pyridine-3alpha,4beta,5alpha-triol
Click to Show/Hide
|
||||
| Activity |
Ki = 380000 nM
|
[30] | |||
| Compound Name |
N-(Adamantan-1-yl)-5-[(2S,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)pyrrolidin-1-yl]pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219813; BDBM18368; 2,5-anhydro-2,5-imino-D-glucitol based compound, 2
Click to Show/Hide
|
||||
| Activity |
IC50 = 393000 nM
|
[23] | |||
| Compound Name |
alpha-1-C-Propyl-DNJ
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089184; BDBM18360; CTK0A1375; DTXSID50448812; (2R,3R,4R,5S,6R)-2-(hydroxymethyl)-6-propylpiperidine-3,4,5-triol; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-6-propyl-, (2R,3R,4R,5S,6R)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[26] | |||
| Compound Name |
(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-[(1S)-1-(4-phenylphenyl)ethoxy]pentyl]piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354622; SCHEMBL19224247; BDBM50028177
Click to Show/Hide
|
||||
| Activity |
IC50 = 400000 nM
|
[4] | |||
| Compound Name |
(3R,4R,5R)-5-(Hydroxymethyl)-1-pentylpiperidine-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2713123; CHEMBL3902719; BDBM238198; US9402837, 2
Click to Show/Hide
|
||||
| Activity |
Ki = 406060 nM
|
[10] | |||
| Compound Name |
16-[[(3As,5R,6S,7S,7aR)-6,7-dihydroxy-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[2,3-d][1,3]oxazol-2-yl]sulfanyl]hexadecanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3393932; BDBM50101403
Click to Show/Hide
|
||||
| Activity |
IC50 = 420000 nM
|
[29] | |||
| Compound Name |
Rel-(1R,2S,4R,5S)-6-((1-(3-(3-(3-methoxypropoxy)propoxy)propyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1766486; BDBM50341328
Click to Show/Hide
|
||||
| Activity |
IC50 = 453000 nM
|
[18] | |||
| Compound Name |
(3R,4R,5R)-1-Decyl-3,4,5-trihydroxypiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL486065; BDBM50413907
Click to Show/Hide
|
||||
| Activity |
IC50 = 463000 nM
|
[25] | |||
| Compound Name |
Rel-(1R,2S,4R,5S)-6-((1-(3-(3-methoxypropoxy)propyl)-1H-1,2,3-triazol-4-yl)methylamino)cyclohexane-1,2,3,4,5-pentaol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1766483; BDBM50341325
Click to Show/Hide
|
||||
| Activity |
IC50 = 466000 nM
|
[18] | |||
| Compound Name |
(2S,3R,4R,5S,6S)-2-(Hydroxymethyl)-6-propylpiperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089183; SCHEMBL19831664; BDBM50315251
Click to Show/Hide
|
||||
| Activity |
IC50 = 487000 nM
|
[26] | |||
| Compound Name |
1-Octylpiperidine-3beta,4beta,5alpha-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490751; BDBM50413900
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
(3R,4R,5R)-3,4,5-Trihydroxy-1-(6-hydroxyhexyl)piperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491745; BDBM50413896
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
4,5,6,7-Tetrachloro-2-(5-phenylpentyl)isoindoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL276643; BDBM50088683; N-(5-Phenylpentyl)-3,4,5,6-tetrachlorophthalimide; 4,5,6,7-Tetrachloro-2-(5-phenyl-pentyl)-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
N-Phenylphthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-phenylisoindole-1,3-dione; 2-Phenyl-isoindole-1,3-Dione; Phthalanil; 1H-Isoindole-1,3(2H)-dione, 2-phenyl-; Phthalimide, N-phenyl-; 2-phenylisoindoline-1,3-dione; 2-Phenyl-1H-isoindole-1,3(2H)-dione; N-Phenylphtalimide; CHEMBL9020; UNII-LA29QA196M; MLS002637643; LA29QA196M; 2-phenyl-2,3-dihydro-1H-isoindole-1,3-dione; Phthalimidobenzene; NSC 2769; EINECS 208-282-9; BRN 0010683; AI3-03744; N-phenyl phthalimide; N-(phenyl) phthalimide; ACMC-1AVL8; N-Phenylphthalic acid imide; N-Phenylphthalimide, 98%; Oprea1_380408; Oprea1_603933; 5-21-10-00292 (Beilstein Handbook Reference); SCHEMBL123618; 1H-Isoindole-1, 2-phenyl-; DTXSID3060166; NSC2769; HMS1578O16; ZINC133969; BCP14277; NSC-2769; ANW-59825; BDBM50088679; MFCD00023044; STK174445; 2-phenylbenzo[c]azolidine-1,3-dione; AKOS001268564; MCULE-8546738195; NE32034; NCGC00246780-01; AC-26721; AS-59263; SC-90667; SMR001547169; 2-Phenyl-1H-isoindole-1,3(2H)-dione #; DB-026841; FT-0632274; ST50171260; EN300-56140; SR-01000197336; SR-01000197336-1
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
(3S,4R,5S)-3,4,5-Trihydroxy-1-(6-hydroxyhexyl)piperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491915; BDBM50413901
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
5-Methylpiperidine-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL357108; SCHEMBL6432951; AKOS006378114
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[20] | |||
| Compound Name |
4,5,6,7-Tetrachloro-2-(6-phenyl-hexyl)-isoindole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL275509; BDBM50088672; N-(6-Phenylhexyl)-3,4,5,6-tetrachlorophthalimide
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
3beta,4alpha,5alpha-Trihydroxypiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491731; BDBM50413903; AKOS006359465
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
(3S,4R,5R)-3,4,5-Trihydroxy-1-(2-hydroxyethyl)piperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499827; BDBM50413899
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
2-(3-Phenylpropyl)isoindole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11322; 2-(3-Phenyl-propyl)-isoindole-1,3-dione; 3-phthalimidopropyl-benzene; SCHEMBL45050; N-(3-Phenylpropyl)phthalimide; BDBM50088669; AKOS008333088
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
4,5,6,7-Tetrachloro-2-(3-phenylpropyl)isoindoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11216; BDBM50088677; N-(3-Phenylpropyl)-3,4,5,6-tetrachlorophthalimide; 4,5,6,7-Tetrachloro-2-(3-phenyl-propyl)-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
(2S,3R,4R,5S)-1-[2,2-Difluoro-5-[(4-phenylphenyl)methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354632; SCHEMBL19224269; BDBM50028252
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[4] | |||
| Compound Name |
4-Amino-2-phenyl-1H-isoindole-1,3(2H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-amino-2-phenylisoindole-1,3-dione; 3-Amino-N-phenylphthalimide; MLS000104009; CHEMBL269410; SMR000015725; ChemDiv2_000234; 3-Amino-N-phenylphthalimid; 1H-Isoindole-1,3(2H)-dione,4-amino-2-phenyl-; Oprea1_304317; SCHEMBL11513204; BDBM31709; cid_3448473; HMS1369K14; ZINC241267; BBL002251; MFCD00441119; STK894867; AKOS000291407; MCULE-1835690051; 4-Amino-2-phenyl-isoindole-1,3-dione; 4-azanyl-2-phenyl-isoindole-1,3-dione; 4-amino-2-phenyl-isoindoline-1,3-quinone; BB 0244050; H3249; SR-01000393466; SR-01000393466-1
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
(3S,4R,5R)-3,4,5-Trihydroxy-1-(2-propoxyethyl)piperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490716; BDBM50413913
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
1h-Isoindole-1,3(2h)-dione, 4-nitro-2-phenyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Phenyl-3-nitrophthalimide; CHEMBL11614; 4-nitro-2-phenyl-1H-isoindole-1,3(2H)-dione; NSC117486; 4-nitro-2-phenylisoindole-1,3-dione; Oprea1_549994; MLS000584160; cid_272783; SCHEMBL5151001; CTK4E0446; DTXSID80297714; HMS2603P21; ZINC262369; BDBM50088682; STK388344; AKOS001483638; MCULE-1941734038; NSC-117486; 4-Nitro-2-phenyl-isoindole-1,3-dione; 4-Nitro-2-phenylisoindoline-1,3-dione; SMR000203323; 4-nitro-2-phenylbenzo[c]azoline-1,3-dione; ST51060619; SR-01000390627; SR-01000390627-1
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
(3S,4R,5R)-3,4,5-Trihydroxy-1-(6-hydroxyhexyl)piperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL448517; BDBM50413898
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
(3S,4R,5R)-1-Benzyl-3,4,5-trihydroxypiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490661; BDBM50413897
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
4-Hydroxy-2-phenyl-isoindole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11566; 4-hydroxy-2-phenylisoindoline-1,3-dione; 3-Hydroxy-N-phenylphthalimide; CTK1F2661; DTXSID70444417; BDBM50088680; 4-HYDROXY-2-PHENYLISOINDOLE-1,3-DIONE; 1H-Isoindole-1,3(2H)-dione, 4-hydroxy-2-phenyl-
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
(3S,4R,5R)-1-Butyl-3,4,5-trihydroxypiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490714; BDBM50413905
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
4,5,6,7-Tetrachloro-2-(4-phenylbutyl)isoindoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL275285; CP4P; BDBM50088675; 4,5,6,7-Tetrachloro-2-(4-phenyl-butyl)-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
4,5,6,7-Tetrachloro-2-phenethyl-isoindole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL11766; BDBM50088670; 3,4,5,6-Tetrachloro-N-phenethylphthalimide; 4,5,6,7-tetrachloro-2-phenethylisoindoline-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
4-Nitro-N-phenylphthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-Nitro-2-phenylisoindoline-1,3-dione; 5-nitro-2-phenylisoindole-1,3-dione; 5-Nitro-2-phenyl-isoindole-1,3-dione; CHEMBL273605; ACMC-1AM9K; N-Phenyl-4-nitrophthalimid; 5-Nitro-N-phenylphthalimide; Oprea1_288736; Oprea1_853070; SCHEMBL406359; 5-nitro-2-phenyl-2,3-dihydro-1H-isoindole-1,3-dione; CTK1D4595; DTXSID10354041; ZINC235609; KS-000013CE; ANW-29391; BDBM50088676; MFCD00191559; STK391465; AKOS000520535; CCG-353873; MCULE-1373452400; AS-63209; DA-37054; 5-nitro-2-phenylbenzo[c]azoline-1,3-dione; EU-0033650; FT-0751073; N0574; ST50225021; 5-nitro-2-phenyl-1H-isoindole-1,3(2H)-dione; SR-01000391092; 1H-Isoindole-1,3(2H)-dione, 5-nitro-2-phenyl-; SR-01000391092-1
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
N-Phenethyl phthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
n-phenethylphthalimide; 2-(2-phenylethyl)-1H-isoindole-1,3(2H)-dione; CHEMBL11452; 2-phenethylisoindoline-1,3-dione; 2-phenethylisoindole-1,3-dione; NSC408070; Cambridge id 5361606; N-(2-phenethyl)phthalimide; Oprea1_118998; MLS001180164; SCHEMBL1142116; CTK7H5069; 2-phenethyl isoindole-1,3-dione; DTXSID40324959; 2-Phenethyl-isoindole-1,3-dione; HMS1583L05; HMS2792N20; ZINC246806; BDBM50088674; SBB100959; STK058588; AKOS003435335; CCG-342470; MCULE-6181114117; NSC-408070; SMR000476103; ST078781; 2-(2-phenylethyl)benzo[c]azoline-1,3-dione; 2-(2-phenylethyl)benzo[c]azolidine-1,3-dione; 2-(2-PHENYLETHYL)ISOINDOLE-1,3-DIONE; AB00082991-01; AG-205/04527031; SR-01000207053; SR-01000207053-1
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
Pentyldnm
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Pentyl-1-deoxynojirimycin; CHEMBL1651549; (2R,3R,4R,5S)-2-(hydroxymethyl)-1-pentylpiperidine-3,4,5-triol; 2-(hydroxymethyl)-1-pentylpiperidine-3,4,5-triol; SCHEMBL9798003; DTXSID50923694; BDBM50335399; (2R)-1-Pentyl-2alpha-(hydroxymethyl)piperidine-3beta,4alpha,5beta-triol
Click to Show/Hide
|
||||
| Activity |
IC50 = 500000 nM
|
[5] | |||
| Compound Name |
N-[(3S,4R,5R)-1-Decyl-4,5-dihydroxy-6-oxopiperidin-3-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL491743; BDBM50413906
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
N-[(3S,4R,5R)-4,5-Dihydroxy-1-(6-hydroxyhexyl)-6-oxopiperidin-3-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL526183; BDBM50413895
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
(3R,4R)-3,4-Dihydroxy-1-(6-hydroxyhexyl)pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL470943; BDBM50413912
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[25] | |||
| Compound Name |
N-Benzylphthalimide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-benzylisoindoline-1,3-dione; benzylphthalimide; 2-Benzylisoindole-1,3-dione; n-benzylphtalimide; 1H-Isoindole-1,3(2H)-dione, 2-(phenylmethyl)-; 2-Benzyl-1H-isoindole-1,3(2H)-dione; CHEMBL416887; UNII-3G2A77460J; NSC2771; 2-benzyl-2,3-dihydro-1H-isoindole-1,3-dione; 3G2A77460J; Phthalimide, N-benzyl-; N-benzylpthalimide; ACMC-1CKGK; Maybridge1_007213; ChemDiv2_000151; C14263; N-Benzylphthalimide, 99%; Cambridge id 5100224; Oprea1_454921; CBDivE_000093; SCHEMBL326305; 2-Benzyl-isoindole-1,3-dione; DTXSID4036647; CTK8B1186; HMS561P19; WITXFYCLPDFRNM-UHFFFAOYSA-; ZINC96893; HMS1369G19; NSC 2771; NSC-2771; EINECS 218-395-5; 6264AF; ANW-24427; BDBM50088671; MFCD00023077; STK048584; 2-(phenylmethyl)isoindole-1,3-dione; 2-benzylbenzo[c]azolidine-1,3-dione; AKOS001483563; 2-(Phenylmethyl)-1,3-isoindolinedione; MCULE-6634249322; NCGC00186534-01; AS-59839; 2-(Phenylmethyl)isoindole-1,3(2H)-dione; 2-BENZYL-1,3-DIOXO-2H-ISOINDOLE; 2-Benzyl-1H-isoindole-1,3(2H)-dione #; AI3-02617; DB-045575; FT-0634060; FT-0657008; ST45186322; AZ0001-0027; 10.14272/WITXFYCLPDFRNM-UHFFFAOYSA-N.1; AE-848/30539055; SR-01000390068; doi:10.14272/WITXFYCLPDFRNM-UHFFFAOYSA-N.1; J-014043; SR-01000390068-1; Q27116303; Z18271714; F0405-0287
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
5-Amino-2-phenylisoindole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Amino-N-phenylphthalimide; CHEMBL11477; 5-amino-2-phenyl-1H-isoindole-1,3(2H)-dione; CBMicro_012312; 4-Amino-N-phenylphthalimid; Oprea1_179775; Oprea1_225268; SCHEMBL4782142; ZINC285195; SMSF0003994; BDBM50088681; STK295612; AKOS003243899; CB15811; MCULE-1164548304; 5-Amino-2-phenyl-isoindole-1,3-dione; 5-amino-2-phenylisoindoline-1,3-dione; BIM-0012403.P001; SR-01000197351; SR-01000197351-1; 5-amino-2-phenyl-2,3-dihydro-1H-isoindole-1,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[28] | |||
| Compound Name |
N-(Adamantan-1-yl)-4-[(2S,3R,4R,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)pyrrolidin-1-yl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219651; BDBM18367; 2,5-anhydro-2,5-imino-D-glucitol based compound, 1
Click to Show/Hide
|
||||
| Activity |
IC50 = 507000 nM
|
[23] | |||
| Compound Name |
1-Butyl-piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL152232; SCHEMBL3378984; 1-butylpiperidine-3,4,5-triol; BDBM50288855
Click to Show/Hide
|
||||
| Activity |
IC50 = 530000 nM
|
[20] | |||
| Compound Name |
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-[5-(phenanthren-9-ylmethoxy)pentyl]piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3354036; BDBM50028216
Click to Show/Hide
|
||||
| Activity |
IC50 = 600000 nM
|
[4] | |||
| Compound Name |
2-Morpholinoethanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-(2-Hydroxyethyl)morpholine; 4-MORPHOLINEETHANOL; N-(2-Hydroxyethyl)morpholine; 2-(4-Morpholinyl)ethanol; 2-morpholin-4-ylethanol; Morpholine ethanol; 2-(morpholin-4-yl)ethanol; Morpholineethanol; Hydroxyethylmorpholine; Ethanol, 2-morpholino-; beta-Morpholinoethanol; Ethanol, 2-(morpholinyl)-; N-beta-Hydroxyethylmorpholine; 2-(Morpholin-4-Yl)Ethan-1-Ol; .beta.-Morpholinoethanol; 2-morpholin-4-yl-ethanol; UNII-LY5IL94D3K; NSC 1946; N-(2-Hydroxyethyl)morfolin; MFCD00006180; .beta.-Oxyaethyl-morpholin; N(2-hydroxyethyl)morpholine; LY5IL94D3K; N-(2-hydroxyethyl)-morpholine; 4-(2-hydroxyethyl)-morpholine; 2-(4-Morpholinyl)-1-ethanol; N-.beta.-Hydroxyethylmorpholine; CHEMBL1821739; 2-morpholin-4-ylethan-1-ol; N-(2-Hydroxyethyl)morpholine, 99%; beta-Oxyaethyl-morpholin [German]; beta-Oxyaethyl-morpholin; EINECS 210-734-5; N-(2-Hydroxyethyl)morfolin [Czech]; BRN 0104375; AI3-03872; beta-Oxyaethyl-morpholin [German]; 2-morpholino ethanol; 2-morpholino-ethanol; morpholino-2-ethanol; 2-morpholinyl-ethanol; hydroxyethyl morpholine; beta-morpholino-ethanol; N-hydroxyethylmorpholine; 2-hydroxyethylmorpholine; hydroxy ethyl morpholine; 2-morpholino-1-ethanol; 2-hydroxylethylmorpholine; 2-Morpholinoethan-1-ol; N-hydroxyethyl-morpholine; ACMC-1BB7X; DSSTox_CID_2090; 2-morpholin-4-yl ethanol; 4-(Hydroxyethyl)morpholine; EC 210-734-5; 4(2-hydroxyethyl)morpholine; DSSTox_RID_76485; 4-(2-hyroxyethyl)morpholine; DSSTox_GSID_22090; Oprea1_169224; SCHEMBL11300; WLN: T6N DOTJ A2Q; 4(2-hydroxyethyl)-morpholine; 4-27-00-00056 (Beilstein Handbook Reference); KSC352S1D; 4-(2-hydroxyethyl)-morphline; N-(2-hydroxy ethyl)morpholine; N-(2-hydroxyethyl) morpholine; N-(2-hydroxyethyl)morpholine-; 4-(2-hydroxy-ethyl)morpholine; 4-(2-hydroxyethyl) morpholine; 4-(2-hydroxylethyl)-morpholine; DTXSID2022090; CTK2F2911; KS-00000GOU; NSC1946; BCP27473; NSC-1946; Tox21_302022; ANW-34116; BBL019032; BDBM50353062; SBB004221; STK803089; ZINC19230121; AKOS000119835; CS-W011103; MCULE-4008383485; NCGC00255398-01; AK-72501; BR-72501; SC-27241; DB-030070; FT-0629143; FT-0672530; ST50214488; W-2914; 42963-EP2295432A1; 42963-EP2311829A1; 69249-EP2270002A1; 69249-EP2308861A1; N-(2-Hydroxyethyl)morpholine 2-Morpholinoethanol; A800245; Q-101430; 4-(2-Hydroxyethyl)morpholine, ReagentPlus(R), 99%; Q23648402; F1993-0061; Z149158414
Click to Show/Hide
|
||||
| Activity |
Ki = 620000 nM
|
[31] | |||
| Compound Name |
(2R,3R,4R,5S)-2-(1-Hydroxy-propyl)-piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL108656; BDBM50280029
Click to Show/Hide
|
||||
| Activity |
Ki = 630000 nM
|
[30] | |||
| Compound Name |
4-Morpholin-4-ylbutane-1,3-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1822915; SCHEMBL18463978; BDBM50353063
Click to Show/Hide
|
||||
| Activity |
Ki = 640000 nM
|
[31] | |||
| Compound Name |
N-Heptyl-L-ido-1-deoxynojirimycin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651555; BDBM50335395; (2S,3R,4R,5S)-1-heptyl-2-(hydroxymethyl)piperidine-3,4,5-triol
Click to Show/Hide
|
||||
| Activity |
IC50 = 700000 nM
|
[5] | |||
| Compound Name |
N-Pentoxypentyl-1-deoxynojirimycin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651629; BDBM50335391
Click to Show/Hide
|
||||
| Activity |
IC50 = 705000 nM
|
[5] | |||
| Compound Name |
1-Cyano-1-deoxy-5-O-aza-alpha-D-glucopyranose
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3289678; SCHEMBL17189571; BDBM50018017; J3.506.548B
Click to Show/Hide
|
||||
| Activity |
Ki = 716000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4R,5S)-2-Methylpiperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,6-dideoxynojirimycin; CHEMBL324632; SCHEMBL2435560; CTK2G1654; DTXSID40438464; BDBM50280032; ZINC13687194; AKOS006350511; (2R,3R,4R,5S)-2-Methyl-piperidine-3,4,5-triol; 3,4,5-Piperidinetriol, 2-methyl-, (2R,3R,4R,5S)-
Click to Show/Hide
|
||||
| Activity |
Ki = 780000 nM
|
[30] | |||
| Compound Name |
(2R,3R,4R)-3,4-Dihydroxy-2-(hydroxymethyl)-N-octylpyrrolidine-1-carbothioamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953477; BDBM50197872
Click to Show/Hide
|
||||
| Activity |
IC50 = 788000 nM
|
[13] | |||
| Compound Name |
6-Hydroxymethyl-5-(3-hydroxy-pyridin-2-ylsulfanyl)-2-methoxy-tetrahydro-pyran-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL165565; BDBM50286729
Click to Show/Hide
|
||||
| Activity |
Ki = 800000 nM
|
[32] | |||
| Compound Name |
alpha-1-C-(1,10,13-Trihydroxytridecyl)-1,4-dideoxy-1,4-imino-D-arabinitol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469435; BDBM50242067; (1R)-1,4-Imino-1-C-[(1R)-1,5,7,12,13-pentahydroxytridecyl]-1,4-dideoxy-D-arabinitol
Click to Show/Hide
|
||||
| Activity |
IC50 = 970000 nM
|
[33] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(Cyclohexylmethylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735278
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(Benzylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735749
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
N-Butyl-L-ido-1-deoxynojirimycin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1076754; SCHEMBL20576705; ZINC3957104; BDBM50312526; (2S,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(Butylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735277
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| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(2-Methylpropylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736333
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(Cyclohexylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734817
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(Pentan-3-ylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736331
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
(1S,2S,3S,6R)-4-Methyl-6-(octylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735899
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(3-Methylbutylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736427
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
(1S,2S,3S,6R)-4-(Hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1922579
Click to Show/Hide
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| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
5-Methylene-piperidine-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL150938; BDBM50288854
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[20] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(Pentylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736146
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(3-Hydroxypropylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736474
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
N-Butoxypentyl-L-ido-1-deoxynojirimycin
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651634; BDBM50335386
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(Octylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735383
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
5-Methoxy-piperidine-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL414447; BDBM50288852
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[20] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(Decylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736274
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(2-Ethylbutylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736234
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(Hexylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736317
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
(2R,3R,4R)-3,4-Dihydroxy-2-(hydroxymethyl)-N-octylpiperidine-1-carbothioamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931823; BDBM50197868
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[13] | |||
| Compound Name |
(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-pentylpiperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-T5Y7NB5M2U; T5Y7NB5M2U; sinbaglustat (OGT2378); CHEMBL1651553; OGT-2378; Sinbaglustat; Sinbaglustat [INN]; SCHEMBL15698558; N-Pentyl-L-ido-1-deoxynojirimycin; BDBM50335397; (+)-OGT-2378; (2S,3R,4R,5S)-2-(Hydroxymethyl)-1-pentyl-3,4,5-piperidinetriol; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-pentyl-, (2S,3R,4R,5S)-
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
N-Hexyl-L-ido-1-deoxynojirimycin
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1651554; BDBM50335396
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
(1S,2S,3S,6R)-6-(2-Phenylethylamino)cyclohex-4-ene-1,2,3-triol;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735475
Click to Show/Hide
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||||
| Activity |
IC50 > 1000000 nM
|
[34] | |||
| Compound Name |
5-(3-Hydroxy-6-hydroxymethyl-pyridin-2-ylsulfanyl)-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL164780; BDBM50286728
Click to Show/Hide
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||||
| Activity |
Ki = 4000000 nM
|
[32] | |||
| Compound Name |
6-Hydroxymethyl-5-(3-hydroxy-6-methyl-pyridin-2-ylsulfanyl)-2-methoxy-tetrahydro-pyran-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL348752; BDBM50286727
Click to Show/Hide
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||||
| Activity |
Ki = 4500000 nM
|
[32] | |||
| Compound Name |
(2R,3S,4R,5S,6S)-5-[2-[(2S,3S,4R,5S,6R)-4,5-Dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-3-yl]sulfanylpyridin-3-yl]oxy-6-(hydroxymethyl)-2-methoxyoxane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2303777; BDBM50421365
Click to Show/Hide
|
||||
| Activity |
Ki = 5500000 nM
|
[32] | |||
| Compound Name |
6-Hydroxymethyl-2-methoxy-5-(pyridin-2-ylsulfanyl)-tetrahydro-pyran-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL165680; BDBM50286732
Click to Show/Hide
|
||||
| Activity |
Ki = 8000000 nM
|
[32] | |||
| Compound Name |
5-(6-Dimethylaminomethyl-3-hydroxy-pyridin-2-ylsulfanyl)-6-hydroxymethyl-2-methoxy-tetrahydro-pyran-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL164849; BDBM50286730
Click to Show/Hide
|
||||
| Activity |
Ki = 20000000 nM
|
[32] | |||
| Compound Name |
(2R,3R,4R,5S)-2-Methyl-tetrahydro-pyran-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL346964; BDBM50279838
Click to Show/Hide
|
||||
| Activity |
Ki = 42000000 nM
|
[35] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
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| REF 9 | US patent application no. 9119845B2, Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase | ||||
| REF 10 | US patent application no. 9402837B2, Method for the treatment of neurological disorders by enhancing the activity of beta-glucocerebrosidase | ||||
| REF 11 | Docking and SAR studies of D- and L-isofagomine isomers as human -glucocerebrosidase inhibitors. Bioorg Med Chem. 2011 Jun 1;19(11):3558-68. | ||||
| REF 12 | A new type of pharmacological chaperone for G M1-gangliosidosis related human lysosomal -galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3431-3435. | ||||
| REF 13 | Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts. Eur J Med Chem. 2016 Oct 4;121:880-891. | ||||
| REF 14 | Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease. J Med Chem. 2010 Jul 22;53(14):5248-55. | ||||
| REF 15 | Adamantane substituted aminocyclitols as pharmacological chaperones for Gaucher disease. Medchemcomm. 2013;4:1584-9. | ||||
| REF 16 | Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher's disease. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1519-22. | ||||
| REF 17 | Homoisofagomines: chemical-enzymatic synthesis and evaluation as alpha- and beta-glucosidase inhibitors. Bioorg Med Chem Lett. 1999 Feb 22;9(4):615-8. | ||||
| REF 18 | New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening. J Med Chem. 2011 Apr 14;54(7):2069-79. | ||||
| REF 19 | alpha-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral alpha-glucosidase inhibitor for improving postprandial hyperglycemia. J Med Chem. 2012 Dec 13;55(23):10347-62. | ||||
| REF 20 | Synthesis of a new inhibitor of alpha-fucosidase. Bioorg Med Chem Lett. 1996 Mar 5;6(5):553-8. | ||||
| REF 21 | Fluorinated Chaperone--Cyclodextrin Formulations for -Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease. J Med Chem. 2017 Mar 9;60(5):1829-1842. | ||||
| REF 22 | Potent glycosidase inhibitors, N-phenyl cyclic isourea derivatives of 5-amino- and 5-amino-1-C-(hydroxymethyl)-cyclopentane-1,2,3,4-tetraols. Bioorg Med Chem Lett. 1994 Nov;4(22):2643-8. | ||||
| REF 23 | Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention. J Med Chem. 2007 Jan 11;50(1):94-100. | ||||
| REF 24 | Docking and SAR studies of calystegines: binding orientation and influence on pharmacological chaperone effects for Gaucher's disease. Bioorg Med Chem. 2014 Apr 15;22(8):2435-41. | ||||
| REF 25 | Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease. J Med Chem. 2009 May 28;52(10):3146-9. | ||||
| REF 26 | Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors. Bioorg Med Chem. 2010 Apr 1;18(7):2645-50. | ||||
| REF 27 | Tuning of -glucosidase and alpha-galactosidase inhibition by generation and in situ screening of a library of pyrrolidine-triazole hybrid molecules. Eur J Med Chem. 2017 Sep 29;138:532-542. | ||||
| REF 28 | Novel alpha-glucosidase inhibitors with a tetrachlorophthalimide skeleton. Bioorg Med Chem Lett. 2000 May 15;10(10):1081-4. | ||||
| REF 29 | Conformationally-locked N-glycosides: exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease. Eur J Med Chem. 2015 Jan 27;90:258-66. | ||||
| REF 30 | Synthesis and biological activity of C-6 modified derivatives of the glucosidase inhibitor 1-deoxynojirimycin.. Bioorg Med Chem Lett. 1992;2(1):27-32. | ||||
| REF 31 | Synthesis and glycosidase inhibitory profiles of functionalised morpholines and oxazepanes. Bioorg Med Chem. 2011 Sep 15;19(18):5679-92. | ||||
| REF 32 | beta-Glucosidase inhibitors incorporating pyridinium as a glucosyl mimic. Bioorg Med Chem Lett. 1995 Apr 6;5(7):763-6. | ||||
| REF 33 | Glycosidase-inhibiting pyrrolidines and pyrrolizidines with a long side chain in Scilla peruviana. J Nat Prod. 2004 May;67(5):846-50. | ||||
| REF 34 | Potent chemical chaperone compounds for GM1-gangliosidosis: N-substituted (+)-conduramine F-4 derivatives. Medchemcomm. 2015;6:306-10. | ||||
| REF 35 | The Interaction of Anhydroalditols with Sweet-Almond beta-glucosidase and Escherichia coli beta-galactosidase: implications for the design of potent glycosidase inhibitors. Bioorg Med Chem Lett. 1991;1(12):667-72. | ||||
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