Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0HR8Z
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| Former ID |
DAP000609
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| Drug Name |
Miglustat
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| Synonyms |
BuDNJ; Butyldeoxynojirimycin; Miglustatum; NBV; Vevesca; Zavesca; Miglustat [USAN]; OGT 918; SC 48334; SC48334; Miglustat, Hydrochloride; N-Butyl deoxynojirimycin; N-Butyl dnj; N-Butyldeoxynojirimycin; N-Butylmoranoline; NB-DNJ; OGT-918; SC-48334; Zavesca (TN); Miglustat (USAN/INN); N-Bu-DNJ; N-Butyl-DNJ; N-Butyl-deoxynojirimycin; N-(n-Butyl)deoxynojirimycin; N-butyl-1-deoxynojirimycin; N-(n-butyl)-1,5-dideoxy-1,5-imino-D-glucitol; (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Dideoxy-1,5-N-butylimino-D-glucitol
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| Drug Type |
Small molecular drug
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| Indication | Type 1 gaucher disease [ICD-11: 5C56.0Y; ICD-9: 272.7] | Approved | [1], [2] | |
| Therapeutic Class |
Anti-HIV Agents
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| Structure |
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Download2D MOL |
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| Formula |
C10H21NO4
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| Canonical SMILES |
CCCCN1CC(C(C(C1CO)O)O)O
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| InChI |
1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
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| InChIKey |
UQRORFVVSGFNRO-UTINFBMNSA-N
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| CAS Number |
CAS 72599-27-0
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| PubChem Compound ID | ||||
| PubChem Substance ID |
596124, 8182164, 12014416, 14797912, 14822645, 17406560, 26718242, 34716028, 46482895, 46506350, 46518432, 47206759, 49655212, 50017245, 50139361, 57313411, 79091966, 92309276, 103277564, 104297748, 124886898, 126649082, 129406984, 134223536, 134337900, 135011418, 137003330, 139435618, 144204381, 160963765, 170464950, 175267081, 176484549, 178101543, 179117091, 184590288, 198994023, 210275570, 210281218, 221678822, 223679942, 226596648, 241131903, 249582554, 252225017, 252480144
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| ChEBI ID |
CHEBI:50381
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| ADReCS Drug ID | BADD_D01465 | |||
| SuperDrug ATC ID |
A16AX06
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| SuperDrug CAS ID |
cas=072599270
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Ceramide glucosyltransferase (UGCG) | Target Info | Inhibitor | [3] |
| KEGG Pathway | Sphingolipid metabolism | |||
| Metabolic pathways | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| Pathwhiz Pathway | Sphingolipid Metabolism | |||
| Pathway Interaction Database | IL2 signaling events mediated by PI3K | |||
| Reactome | Glycosphingolipid metabolism | |||
| WikiPathways | Sphingolipid metabolism | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4841). | |||
| REF 2 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. | |||
| REF 3 | Effect of miglustat on bone disease in adults with type 1 Gaucher disease: a pooled analysis of three multinational, open-label studies. Clin Ther. 2007 Aug;29(8):1645-54. | |||
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