Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T82795 | Target Info | |||
| Target Name | Beta-catenin (CTNNB1) | ||||
| Synonyms |
Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; Catenin beta-1; CTNNB
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| Target Type | Successful Target | ||||
| Gene Name | CTNNB1 | ||||
| Biochemical Class | Beta-catenin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 29 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Calphostin C
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|
Terminated | Compound Info | ||
| Synonyms |
calphostin C; CHEMBL460433; UNII-I271P23G24; I271P23G24; CHEMBL1256495; Ucn 1028 C; UCN 1028C; BSPBio_001520; GTPL5156; SCHEMBL15185703; HSDB 7592; SRJYZPCBWDVSGO-NHCUHLMSSA-N; HMS1989L22; HMS3402L22; HMS1791L22; BDBM213748; Carbonic acid, 2-(12-(2-(benzoyloxy)propyl)-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl)-1-methylethyl 4-hydroxyphenyl ester; Carbonic acid, (1R)-2-(12-((2R)-2-(benzoyloxy)propyl)-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl)-1-methylethyl 4-hydroxy
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| Activity |
IC50 = 77000 nM
|
[1] | |||
| Compound Name |
1-Hydroxy-5-(2H-tetrazol-5-ylmethoxy)benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967639; SCHEMBL15185519; BDBM213757; US9284299, 8
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| Activity |
Ki = 50400 nM
|
[2] | |||
| Compound Name |
C(Cc1nn[nH]n1)Cn1c2ccccc2c2nc3nonc3nc12
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589161; SCHEMBL18249670; SCHEMBL18257904; BDBM50094485
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| Activity |
Ki = 51000 nM
|
[1] | |||
| Compound Name |
CCOC(=O)CCCn1c2ccccc2c2nc3nonc3nc12
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589025; SCHEMBL18257903; BDBM50094491
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|
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| Activity |
Ki = 52000 nM
|
[1] | |||
| Compound Name |
Nc1nonc1C(=O)N\\N=C1\\c2ccccc2-c2nc3nonc3nc12
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589012; SCHEMBL18249583; SCHEMBL18249585; SCHEMBL18255109; BDBM50094590; MCULE-9942044972; J3.583.511C
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
C(Cn1c2ccccc2c2nc3nonc3nc12)c1nn[nH]n1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589160; SCHEMBL18249666; SCHEMBL18257910; BDBM50094486; J3.583.512A; 9-[2-(1H-Tetrazole-5-yl)ethyl]-9H-1,3,4,9,10-pentaaza-2-oxacyclopenta[b]fluorene
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| Activity |
Ki = 53000 nM
|
[1] | |||
| Compound Name |
(5Z)-5-{[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene}-3-phenyl-1,3-thiazolidine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
iCRT 14; iCRT14; iCRT-14; CHEMBL3589010; CRT Inhibitor iCRT14; SCHEMBL12006920; DTXSID40421533; EX-A1707; ZINC4688072; 3732AH; BDBM50094602; s8704; STK155594; AKOS005266725; iCRT14, >=98% (HPLC); CS-3178; AS-55963; HY-16665; B4687; J3.655.084H; Q33641012
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| Activity |
Ki = 53510 nM
|
[2] | |||
| Compound Name |
1-Hydroxy-5-[2-(2H-tetrazol-1-ium-1-yl)ethyl]benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4109443; BDBM213754; US9284299, 5
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| Activity |
Ki = 54200 nM
|
[2] | |||
| Compound Name |
4-(13-Oxa-8,10,12,14,16-pentazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-yl)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589156; SCHEMBL18249657; BDBM50094490
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|
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| Activity |
Ki = 59000 nM
|
[1] | |||
| Compound Name |
CCOC(=O)Cn1c2ccccc2c2nc3nonc3nc12
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589021; SCHEMBL18257902; BDBM50094508
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|
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| Activity |
Ki = 63000 nM
|
[1] | |||
| Compound Name |
3-[2-(1-Hydroxyindazol-5-yl)ethyl]-2H-1,2,4-oxadiazole-5-thione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943439; SCHEMBL15174724
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| Activity |
Ki = 70370 nM
|
[2] | |||
| Compound Name |
5-[4-(4-Chlorophenoxy)phenyl]-3-isoxazolecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323028; SCHEMBL20149361; BDBM50094597; ZINC43573885; 5-(4-(4-Chlorophenoxy)phenyl)isoxazole-3-carboxylic acid
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| Activity |
Ki = 77000 nM
|
[1] | |||
| Compound Name |
4-[(5E)-5-[(3,4-Dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956161; 4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]butyric acid; ZINC1297903; BDBM50094605; STK711027; AKOS002540790; 4-[(5E)-5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]butanoic acid
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| Activity |
Ki = 80000 nM
|
[1] | |||
| Compound Name |
4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid
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|
Investigative | Compound Info | ||
| Synonyms |
iCRT5; 4-(5-(3,4-Dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid; CRT Inhibitor iCRT5; CHEMBL3914848; SCHEMBL12006900; 4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]butyric acid; BDBM213749; HMS1474F12; US9284299, iCRT5; ZINC12504556; AKOS000121722; NCGC00174467-01; EN300-00774; BRD-K80184082-001-01-9
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| Activity |
Ki = 80340 nM
|
[2] | |||
| Compound Name |
Nc1nonc1NC(=O)Cn1c2ccccc2c2nc3nonc3nc12
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589019; SCHEMBL18249633; BDBM50094510
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|
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| Activity |
Ki = 88000 nM
|
[1] | |||
| Compound Name |
1-Hydroxy-5-(2H-tetrazol-5-ylmethyl)benzotriazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3964919; SCHEMBL15185524; BDBM213750; US9284299, 1; US9284299, 9
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|
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| Activity |
Ki = 94400 nM
|
[2] | |||
| Compound Name |
3-[2-(1-Hydroxyindazol-5-yl)ethyl]-2H-1,2,4-oxadiazol-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3940134; SCHEMBL15173630; SCHEMBL16408496
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|
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| Activity |
Ki = 97700 nM
|
[2] | |||
| Compound Name |
COC(=O)CCn1c2ccccc2c2nc3nonc3nc12
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589023; SCHEMBL18257906; BDBM50094493
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|
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| Activity |
Ki = 100000 nM
|
[1] | |||
| Compound Name |
3-[(1-Hydroxybenzotriazol-5-yl)methyl]-2H-1,2,4-oxadiazole-5-thione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3914359; SCHEMBL15173246
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|
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| Activity |
Ki = 105900 nM
|
[2] | |||
| Compound Name |
5H-[1,2,5]Oxadiazolo[3',4':5,6]pyrazino[2,3-b]indole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589020; ST4031310; Oprea1_459368; SCHEMBL18241110; ZINC51507; BDBM50094509; STK756029; AKOS001716164; MCULE-1711984849; EU-0018092; indolo[2,3-e]1,2,5-oxadiazolo[3,4-b]pyrazine; SR-01000516494; SR-01000516494-1
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|
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| Activity |
Ki = 120000 nM
|
[1] | |||
| Compound Name |
4-(13-Oxa-8,10,12,14,16-pentazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-yl)butanenitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589159; SCHEMBL18249609; BDBM50094487
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|
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| Activity |
Ki = 120000 nM
|
[1] | |||
| Compound Name |
3-[(1-Hydroxybenzotriazol-5-yl)methyl]-2H-1,2,4-oxadiazol-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3976142; SCHEMBL15173803
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|
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| Activity |
Ki = 125100 nM
|
[2] | |||
| Compound Name |
2-(13-Oxa-8,10,12,14,16-pentazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-yl)acetonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589157; SCHEMBL18249665; BDBM50094489
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|
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| Activity |
Ki ~ 130000 nM
|
[1] | |||
| Compound Name |
Cercosporin, pure
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Investigative | Compound Info | ||
| Synonyms |
CERCOSPORIN; CHEMBL2323033; AC1L7HLI; AC1Q6BG4; (+)-Isocercosporin; SCHEMBL15185706; CTK4H3517; BDBM50094484; NSC153111; NSC623610; ZINC100264644; ZINC100397674; CGP-049090; NSC-153111; NSC-623610; C10309; Q27106130
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|
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| Activity |
IC50 = 130000 nM
|
[1] | |||
| Compound Name |
1-Hydroxy-5-(2H-tetrazol-5-ylmethoxymethyl)benzotriazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3889918; SCHEMBL15185510; BDBM213753; US9284299, 4
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|
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| Activity |
Ki = 155100 nM
|
[2] | |||
| Compound Name |
N-(1-Hydroxyindazol-5-yl)-N-(2H-tetrazol-5-ylmethyl)pyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3966910; SCHEMBL15185520
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|
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| Activity |
Ki = 179930 nM
|
[2] | |||
| Compound Name |
5-[2-(2H-Tetrazol-5-yl)ethyl]-1H-indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948771; SCHEMBL15185515; BDBM213765; ZINC205561999; US9284299, 16
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| Activity |
Ki = 179930 nM
|
[2] | |||
| Compound Name |
2-Phenoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2152586; phenoxybenzamide; SCHEMBL5724; Oprea1_299741; CTK9A2463; DTXSID50391112; ZINC2774449; BDBM50392084; STK127625; AKOS003282685; MCULE-1503641736; DA-03295; FT-0766665; ST50721718
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| Activity |
Ki = 180990 nM
|
[2] | |||
| Compound Name |
Icrt3
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Investigative | Compound Info | ||
| Synonyms |
iCRT-3; CHEMBL3589009; ChemDiv3_009799; SCHEMBL12007212; AOB5647; HMS1500N09; BCP32691; EX-A2625; ZINC5057585; BDBM50094606; CCG-268593; MCULE-4106397177; IDI1_027709; NCGC00408921-01; AK210257; BS-17818; HY-103705; CS-0033387; FT-0775219; S8647; A16847; BRD-K35271190-001-01-9; 2-(((2-(4-Ethylphenyl)-5-methyloxazol-4-yl)methyl)thio)-N-phenethylacetamide
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| Activity |
Ki = 195470 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 13 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
GNF-PF-67
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Investigative | Compound Info | ||
| Synonyms |
Toxoflavin; Toxoflavine; Xanthothricin; Xanthotricin; 84-82-2; Xanthothricin (VAN); UNII-5N5YI4IP1P; GNF-Pf-67; NSC 67078; 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione; 1,6-Dimethylpyrimido(5,4-e)-as-triazine-5,7(1H,6H)-dione; 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione; BRN 0021014; 5N5YI4IP1P; MLS000087831; CHEBI:80729; NSC67078; 1,6-Dimethyl-5,7-dioxo-1,5,6,7-tetrahydropyrimido(5,4-E)-as-triazine-5,7(1H,6H)-dione; SMR000024051; Pyrimido(5,4-e)-as-triazine-5,7-(1H,6H)-dione, 1,6-dimethyl-
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| Activity |
IC50 = 340000 nM
|
[1] | |||
| Compound Name |
(S)-4-((S)-3-Carboxy-2-((S)-2-(2-(5-chloro-1H-indol-2-yl)acetamido)-3-(naphthalen-2-yl)propanamido)propanamido)-5-methoxy-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
UU-T02; CHEMBL3260853; SCHEMBL20149548; BDBM50014148
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| Activity |
IC50 = 210000 nM
|
[1] | |||
| Compound Name |
N\\N=C1\\c2Ccccc2-c2nc3nonc3nc12
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589014; SCHEMBL18257912; BDBM50094588
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| Activity |
Ki = 230000 nM
|
[1] | |||
| Compound Name |
(9Z)-9H-Indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one thiosemicarbazone
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Investigative | Compound Info | ||
| Synonyms |
GNF-Pf-1848; CHEMBL3589015; CHEMBL586548; SCHEMBL18257914; BDBM50094583; STK747176; ZINC14920640; AKOS001710441; MCULE-5917507826; MCULE-7161184478; SR-01000088860; SR-01000088860-1
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| Activity |
Ki = 240000 nM
|
[1] | |||
| Compound Name |
2-(13-Oxa-8,10,12,14,16-pentazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-yl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589022; SCHEMBL18249656; BDBM50094494
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| Activity |
IC50 = 280000 nM
|
[1] | |||
| Compound Name |
1-Hydroxy-5-[2-(2H-tetrazol-5-yl)ethyl]indazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2323032; SCHEMBL15174982; BDBM50014132; DB-103259
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| Activity |
IC50 = 300000 nM
|
[1] | |||
| Compound Name |
9H-Indeno[1,2-b][1,2,5]oxadiazolo[3,4-E]pyrazin-9-one
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Investigative | Compound Info | ||
| Synonyms |
SMER 3; SMER3; 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one; SMER-3; C11H4N4O2; LSM-42773; 9H-Indeno-[1,2-e]-[1,2,5]-oxadiazolo-[3,4-b]-pyrazin-9-one; indeno[2,3-b]1,2,5-oxadiazolo[3,4-e]pyrazin-5-one; 2-Oxa-1,3,4,10-tetraaza-cyclopenta[b]fluoren-9-one; SMER3(SMER 3); Oprea1_175199; Oprea1_783821; SCHEMBL7984580; CHEMBL3589013; ZINC27763; AOB5567; DTXSID40340952; BDBM188214; HMS1607O01; BCP14360; 2188AH; MFCD00451458; SBB000632; STK120842; SMER3, >=98% (HPLC); AKOS000479457; MCULE-1070513713; AS-55891; ST000573; DB-073845; FT-0701471; Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one; Indeno[1,2-b]furazano[3,4-E]pyrazin-9-one,; US9073941, 28; US9073941, 30; SR-01000388225; SR-01000388225-1; Q27224946; 9H-Indeno[1,2-b][1,2,5]oxadiazolo[3,4-E]pyrazin-9-one #
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| Activity |
Ki = 310000 nM
|
[1] | |||
| Compound Name |
3-[2-(1-Hydroxybenzotriazol-5-yl)ethyl]-2H-1,2,4-oxadiazol-5-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960052; SCHEMBL15185512
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| Activity |
Ki = 551250 nM
|
[2] | |||
| Compound Name |
3-(13-Oxa-8,10,12,14,16-pentazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589024; SCHEMBL18249664; BDBM50094492
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| Activity |
IC50 = 580000 nM
|
[1] | |||
| Compound Name |
4-Amino-N-benzyl-1,2,5-oxadiazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589018; (4-amino(1,2,5-oxadiazol-3-yl))-N-benzylcarboxamide; Oprea1_210566; SCHEMBL18257911; CTK7G0638; ZINC128069; BDBM50094511; MFCD02647192; SBB001915; STK763302; AKOS001737736; MCULE-4285025630; NCGC00330604-01; ST037383; EU-0085865; 4-Amino-furazan-3-carboxylic acid benzylamide; AB01324874-02; AG-205/15156088; SR-01000530625; SR-01000530625-1; 4-amino-N-benzyl-1,2,5-oxadiazole-3-carboxamide, AldrichCPR
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| Activity |
Ki = 1700000 nM
|
[1] | |||
| Compound Name |
(4-Amino-1,2,5-oxadiazol-3-yl)(pyrrolidin-1-yl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1503018; 4-(pyrrolidine-1-carbonyl)-1,2,5-oxadiazol-3-amine; 4-amino(1,2,5-oxadiazol-3-yl) pyrrolidinyl ketone; (4-amino-1,2,5-oxadiazol-3-yl)-pyrrolidin-1-ylmethanone; BAS 00253663; Oprea1_074084; Oprea1_719756; MLS000688505; 4-(pyrrolidin-1-ylcarbonyl)-1,2,5-oxadiazol-3-amine; SCHEMBL18257913; CTK7G0635; ZINC36165; HMS1680A06; HMS2622K21; BBL012550; BDBM50094573; MFCD00456445; SBB000233; SP2064; STK150412; AKOS000112223; MCULE-4034726214; SC-31818; SMR000284391; ST006443; T7665; EN300-56185; 4-[(pyrrolidin-1-yl)carbonyl]-1,2,5-oxadiazol-3-; 4-(PYRROLIDIN-1-YLCARBONYL)-1,2,5-OXADIAZOL-3-AMIN; 4-(pyrrolidin-1-ylcarbonyl)-1,2,5-oxadiazol-3-amine, AldrichCPR
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| Activity |
Ki = 1700000 nM
|
[1] | |||
| Compound Name |
4-Amino-N-isobutyl-1,2,5-oxadiazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589017; 4-amino-N-(2-methylpropyl)-1,2,5-oxadiazole-3-carboxamide; Oprea1_847624; SCHEMBL20149587; CTK4I3288; DTXSID70403049; ZINC4418886; BDBM50094512; AKOS010970574; MCULE-1743741010; W-9855; AG-205/40650686; SR-01000532387; SR-01000532387-1; 4-Amino-N-isobutyl-1,2,5-oxadiazole-3-carboxamide, AldrichCPR; 4-AMINO-N-ISOBUTYL-1,2,5-OXADIAZOLE-3-CARBOXAMIDE 95%
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| Activity |
Ki > 2000000 nM
|
[1] | |||
| Compound Name |
4-Amino-1,2,5-oxadiazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
4-Amino-3-furazanecarboxamide; 1,2,5-Oxadiazole-3-carboxamide,4-amino-; CHEMBL3589016; Oprea1_090449; Oprea1_581910; Oprea1_811464; 4-aminofurazan-3-carboxamide; SCHEMBL5672197; CTK4B8294; DTXSID90337332; ALBB-006702; ZINC5670118; 3786AD; BBL005262; BDBM50094582; MFCD00460523; SBB001563; STK501685; AKOS000265098; MCULE-7036883680; ST058109; VS-01564; 4-Aminofurazanyl-3-carboxylic acid, amide; AB0118223; DB-006615; BB 0260047; FT-0617426; W-7032; 4-Amino-1,2,5-oxadiazole-3-carboximidic acid #; AG-205/25011040; Methanol, (4-amino-1,2,5-oxadiazol-3-yl)(imino)-
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| Activity |
Ki > 2000000 nM
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[1] | |||
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of Selective Small-Molecule Inhibitors for the -Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015 Jun 11;58(11):4678-92. | ||||
| REF 2 | US patent application no. 9284299B2, Substituted 1H-indazol-1-ol analogs as inhibitors of beta catenin/Tcf protein-protein interactions | ||||
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