Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T76285 | Target Info | |||
| Target Name | Phosphodiesterase I beta (ENPP3) | ||||
| Synonyms |
Phosphodiesterase I/nucleotide pyrophosphatase 3; PDNP3; PD-Ibeta; NPP3; Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; E-NPP 3; CD203c
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| Target Type | Clinical trial Target | ||||
| Gene Name | ENPP3 | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-(3,4-Dimethoxyphenyl)-2-(5-methoxy-3H-imidazo[4,5-b]pyridine-2-ylthio)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3360884; SCHEMBL20305107; BDBM50031827
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| Activity |
Ki = 68100 nM
|
[1] | |||
| Compound Name |
Chembl4164185
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276785
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4165654
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276782
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Chembl4172790
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276786
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4174849
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276790
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4161473
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276794
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4173693
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276787
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4159729
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276781
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4164891
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276791
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4169839
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Investigative | Compound Info | ||
| Synonyms |
BDBM50276783
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1). J Med Chem. 2014 Dec 11;57(23):10080-100. | ||||
| REF 2 | Chemoselective synthesis and biological evaluation of arylated 2-(Trifluoromethyl) quinolines as nucleotide pyrophosphatase (NPPs) inhibitors. Eur J Med Chem. 2017 Sep 29;138:816-829. | ||||
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