Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T69685 | Target Info | |||
| Target Name | Glycine transporter GlyT-1 (SLC6A9) | ||||
| Synonyms |
Solute carrier family 6 member 9; Sodium- and chloride-dependent glycine transporter 1; Glycine type-1 transporter; Glycine transporter type 1; GlyT1; GlyT-1
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| Target Type | Clinical trial Target | ||||
| Gene Name | SLC6A9 | ||||
| Biochemical Class | Neurotransmitter:sodium symporter | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 16 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
sarcosine
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Investigative | Compound Info | ||
| Synonyms |
sarcosine; 107-97-1; N-methylglycine; Sarcosinic acid; Methylglycine; Glycine, N-methyl-; Methylaminoacetic acid; 2-(methylamino)acetic acid; N-Methylaminoacetic acid; Sarcosin; (Methylamino)acetic acid; (Methylamino)ethanoic acid; Sargosine hydrochloride; N-Methyl glycine; Acetic acid, (methylamino)-; Cocoylsarcosine; Polysarcosine; N-methyl-Glycine; H-Sar-OH; UNII-Z711V88R5F; BRN 1699442; Sarcosine, 98%; AI3-15410; Methylamino-Acetic Acid; EINECS 203-538-6; SAR; CHEMBL304383; CHEBI:15611; FSYKKLYZXJSNPZ-UHFFFAOYSA-N; Z711V88R5F
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| Activity |
IC50 = 91000 nM
|
[1] | |||
| Compound Name |
2-((2-(2-(3-Chlorophenylthio)phenoxy)ethyl)(ethyl)amino)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL209678; BDBM50187880
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| Activity |
IC50 = 50000 nM
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[2] | |||
| Compound Name |
{4-[5-Methoxy-2-(4-methoxy-phenylsulfanyl)-phenyl]-2,5-dimethyl-piperazin-1-yl}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL182618; BDBM50149867
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-((2-(2-(4-Acetamidophenylthio)phenoxy)ethyl)(methyl)amino)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL209474; BDBM50187887
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
{(2S,5R)-4-[2-(4-Methoxy-phenylsulfanyl)-phenyl]-2,5-dimethyl-piperazin-1-yl}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL182916; BDBM50149855; 2-[(2S,5R)-4-[2-(4-methoxyphenyl)sulfanylphenyl]-2,5-dimethylpiperazin-1-yl]acetic acid
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| Activity |
IC50 = 53000 nM
|
[3] | |||
| Compound Name |
2,4-Dichloro-N-[[1-(1-methylimidazol-4-yl)sulfonylazetidin-3-yl]-pyridin-2-ylmethyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115209; SCHEMBL2850636; BDBM50447996
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| Activity |
IC50 = 68000 nM
|
[4] | |||
| Compound Name |
Lithium;4-[methyl-[3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]amino]butanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL64102; ORG-24628
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| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
Ethyl N-[1-[(2,4-dichlorophenyl)methyl]-7-[2-(thiophen-2-ylsulfonylamino)ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3098869; CHEMBL3668272; BDBM164577; US9067871, 63
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Ethyl N-[1-[(3-chlorophenyl)methyl]-7-[2-[(2,5-dimethylthiophen-3-yl)sulfonylamino]ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3101493; CHEMBL3668269; BDBM164574; US9067871, 60
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Ethyl N-[1-[(3-chlorophenyl)methyl]-7-[2-[(4-methylthiophen-2-yl)sulfonylamino]ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3098776; CHEMBL3668263; BDBM164568; US9067871, 54
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
Lithium;2-[methyl-[3-(4-methylsulfonylphenoxy)-3-phenylpropyl]amino]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL60614; ORG-24872
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| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-ol
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3100512; CHEMBL3668244; BDBM164547; US9067871, 35; 7-amino-8-[(3,4-dichlorophenyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-ol
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| Activity |
Ki ~ 100000 nM
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[6] | |||
| Compound Name |
4-Benzyloxy-3,5-Dimethoxy-N-[(1-Dimethylaminocyclopentyl)Methyl]Benzamide
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Investigative | Compound Info | ||
| Synonyms |
ORG-25543; Org 25543; CHEMBL88588; 4-(benzyloxy)-N-{[1-(dimethylamino)cyclopentyl]methyl}-3,5-dimethoxybenzamide; N-[[1-(dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-phenylmethoxybenzamide; 4-(benzyloxy)-N-((1-(dimethylamino)cyclopentyl)methyl)-3,5-dimethoxybenzamide; GTPL4667; SCHEMBL5017542; CTK4H6354; DTXSID90415523; HMS3741O09; ZINC591392; BDBM50102692; AKOS006957820; MCULE-2419762952; NCGC00379203-01; Q27088214; 4-Benzyloxy-N-(1-dimethylamino-cyclopentylmethyl)-3,5-dimethoxy-benzamide; 4-benzyloxy-N-(1-dimethylaminocyclopentylmethyl)-3,5-dimethoxybenzamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[2-(1-Methylimidazol-4-yl)sulfonyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-4-yl]-2-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115221; SCHEMBL3078618; BDBM50448003
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| Activity |
IC50 = 112000 nM
|
[4] | |||
| Compound Name |
CID 46239400
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115222; SCHEMBL3075243; BDBM50448002
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| Activity |
IC50 = 115000 nM
|
[4] | |||
| Compound Name |
N-[[(1S,5R)-3-(1-Methylimidazol-4-yl)sulfonyl-6-pyridin-2-yl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]-2-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114968; BDBM50447891
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| Activity |
IC50 = 185000 nM
|
[7] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 19 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
HINOKININ
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Investigative | Compound Info | ||
| Synonyms |
Hinokinin; (-)-Hinokinin; 26543-89-5; CHEBI:5722; CHEMBL242011; (3R,4R)-3,4-Bis(benzo[d][1,3]dioxol-5-ylmethyl)dihydrofuran-2(3H)-one; (3R,4R)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydrofuran-2(3H)-one; (3R-trans)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydrofuran-2(3H)-one; hinoquinin; (-)-hinoquinin; AC1L9DKH; Epitope ID:116880; SCHEMBL1121862; MolPort-039-338-821; ZINC1872258; BDBM50218812; AKOS027324070; LS-190466; C10627; (2r,3r)-2,3-di-(3,4-methylenedioxybenzyl)-butyrolactone
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| Activity |
IC50 > 500000 nM
|
[8] | |||
| Compound Name |
2,4-Dichloro-N-[[1-(1-methylimidazol-4-yl)sulfonylpiperidin-4-yl]-phenylmethyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115208; SCHEMBL7795706; BDBM50447997
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| Activity |
IC50 = 201000 nM
|
[4] | |||
| Compound Name |
2,4-Dichloro-N-[[(1S,5R)-3-(1-methylimidazol-4-yl)sulfonyl-6-pyridin-2-yl-3-azabicyclo[3.1.0]hexan-6-yl]methyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3114967; BDBM50447892
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| Activity |
IC50 = 247000 nM
|
[7] | |||
| Compound Name |
2,4-Dichloro-N-[[1-(1-methylimidazol-4-yl)sulfonylpiperidin-4-yl]-thiophen-2-ylmethyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115212; SCHEMBL7803808; BDBM50447993
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|
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| Activity |
IC50 = 374000 nM
|
[4] | |||
| Compound Name |
N-[2-(1-Methylimidazol-4-yl)sulfonyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-4-yl]cyclohexanecarboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115230; SCHEMBL3081418; BDBM50448004
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| Activity |
IC50 = 617000 nM
|
[4] | |||
| Compound Name |
2,4-Dichloro-N-(phenyl(1-(propylsulfonyl)azetidin-3-yl)methyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115233; SCHEMBL2850232; BDBM50448021; 2,4-dichloro-N-[phenyl-(1-propylsulfonylazetidin-3-yl)methyl]benzamide
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| Activity |
IC50 = 627000 nM
|
[4] | |||
| Compound Name |
2,6-Difluoro-N-[2-(1-methylimidazol-4-yl)sulfonyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-4-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3112616; SCHEMBL3075838; BDBM50448011
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| Activity |
IC50 = 631000 nM
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[4] | |||
| Compound Name |
CID 46239504
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115229; SCHEMBL3085591; BDBM50448005
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| Activity |
IC50 = 891000 nM
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[4] | |||
| Compound Name |
2,4-Difluoro-N-[2-(1-methylimidazol-4-yl)sulfonyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115223; SCHEMBL3078344; BDBM50448012
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| Activity |
IC50 = 926000 nM
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[4] | |||
| Compound Name |
Ethyl N-[1-[(3-chlorophenyl)methyl]-7-[2-[[1-(difluoromethyl)pyrazol-4-yl]sulfonylamino]ethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3100979; CHEMBL3668290; BDBM164596; US9067871, 81
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| Activity |
IC50 > 1000000 nM
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[6] | |||
| Compound Name |
CID 46213935
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115228; SCHEMBL3080585; BDBM50448006
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| Activity |
IC50 = 1029000 nM
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[4] | |||
| Compound Name |
2,4-Dichloro-N-[phenyl-(1-propylsulfonylpiperidin-4-yl)methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115234; SCHEMBL7801602; BDBM50447999
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| Activity |
IC50 = 1500000 nM
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[4] | |||
| Compound Name |
CID 46239507
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115227; SCHEMBL3083456; BDBM50448007
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| Activity |
IC50 = 1569000 nM
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[4] | |||
| Compound Name |
CID 46239503
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115224; SCHEMBL3074928; BDBM50448010
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| Activity |
IC50 = 1815000 nM
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[4] | |||
| Compound Name |
CID 46239505
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115226; SCHEMBL3080432; BDBM50448008
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| Activity |
IC50 = 2215000 nM
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[4] | |||
| Compound Name |
2,4-Dichloro-N-[[1-(4-propylsulfonylpiperazin-1-yl)-2,3-dihydroinden-1-yl]methyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2324485; BDBM50427179
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| Activity |
IC50 = 6400000 nM
|
[9] | |||
| Compound Name |
4-({4-(4-Fluorophenyl)-3-[3-(trifluoromethyl)phenyl]-4,5-dihydro-1H-pyrazol-1-yl}sulfonyl)-1-methyl-1H-1,2,3-triazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3827278; SCHEMBL17581945
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| Activity |
Ki <= 10000000 nM
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[10] | |||
| Compound Name |
3-Fluoro-N-[2-(1-methylimidazol-4-yl)sulfonyl-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-4-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115225; BDBM50448009
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| Activity |
IC50 > 10000000 nM
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[4] | |||
| Compound Name |
CN1N=CC(=C1)S(=O)(=O)N1N=C(C(C1)C1=CC=CC=C1)C1=NC=CC=C1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3828560; SCHEMBL17581986
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| Activity |
Ki >= 10000000 nM
|
[10] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Modulation of Glycine-Mediated Spinal Neurotransmission for the Treatment of Chronic Pain. J Med Chem. 2018 Apr 12;61(7):2652-2679. | ||||
| REF 2 | The synthesis and SAR of 2-arylsulfanylphenyl-1-oxyalkylamino acids as GlyT-1 inhibitors. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3981-4. | ||||
| REF 3 | The synthesis and SAR of 2-arylsulfanyl-phenyl piperazinyl acetic acids as glyT-1 inhibitors. Bioorg Med Chem Lett. 2004 Aug 2;14(15):4027-30. | ||||
| REF 4 | Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 2: development of a [3.3.0]-based series and other piperidine bioisosteres. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1062-6. | ||||
| REF 5 | Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2007-9. | ||||
| REF 6 | US patent application no. 9067871B2, Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy | ||||
| REF 7 | Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1067-70. | ||||
| REF 8 | The lignan (-)-hinokinin displays modulatory effects on human monoamine and GABA transporter activities. J Nat Prod. 2013 Oct 25;76(10):1889-95. | ||||
| REF 9 | Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1257-61. | ||||
| REF 10 | Glycine Transporter 1 Inhibitors and the Promise of a New Schizophrenia Therapy. ACS Med Chem Lett. 2016 May 12;7(6):549-51. | ||||
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