Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T67363 | Target Info | |||
| Target Name | Integrin alpha-V/beta-3 (ITGAV/B3) | ||||
| Synonyms |
Integrin alphaVbeta3; Integrin alpha-v beta-3; Integrin alpha V beta 3; Alpha(v)beta(3) Integrin; Alpha v beta 3 integrin
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| Target Type | Clinical trial Target | ||||
| Gene Name | ITGAV-ITGB3 | ||||
| Biochemical Class | Integrin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 126 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Tirofiban
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|
Approved | Compound Info | ||
| Synonyms |
AGG; Aggrastat; Agrastat; Tirofibanum; Aggrastat (TN); Agrastat (TN); L-700462; MK-383; Tirofiban (INN); Tirofiban[BAN:INN]; Tirofiban [INN:BAN]; L-700,462; N-(BUTYLSULFONYL)-O-[4-(4-PIPERIDINYL)BUTYL]-L-TYROSINE; N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine; N-(butylsulfonyl)-O-(4-piperidin-4-ylbutyl)-L-tyrosine; N-(butylsulfonyl)-o-[4-(piperidin-4-yl)butyl]-l-tyrosine; (2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid
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| Activity |
IC50 = 62000 nM
|
[1] | |||
| Compound Name |
ELAROFIBAN
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Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
Elarofiban; RWJ-53308; UNII-T9YH5NSL8U; T9YH5NSL8U; 198958-88-2; CHEMBL87728; (3s)-3-[({(3r)-1-[3-(piperidin-4-yl)propanoyl]piperidin-3-yl}carbonyl)amino]-3-(pyridin-3-yl)propanoic acid; Elarofiban [INN]; AC1L50BO; AC1Q5T2G; SCHEMBL1650115; CTK4E2665; BDBM50104600; AKOS027326865; (S)-beta-((R)-1-(3-(4-Piperidyl)propionyl)nipecotamido)-3-pyridinepropionic acid; (S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperidine-3-carbonyl]-amino}-3-pyridin-3-yl-propionic acid
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
meta-chlorphenylbiguanide
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Investigative | Compound Info | ||
| Synonyms |
m-Chlorophenylbiguanide; mCPBG; 1-(3-Chlorophenyl)biguanide; 1-(m-Chlorophenyl)biguanide; N-(3-Chlorophenyl)imidodicarbonimidic diamide; 48144-44-1; Imidodicarbonimidic diamide, N-(3-chlorophenyl)-; UNII-910A4X901V; M-Chlorophenylbiguanidine; 3-Chloro-Phenyl biguanide; 2-(3-chlorophenyl)-1-(diaminomethylidene)guanidine; CHEMBL13790; CHEBI:32347; N-(3-chlorophenyl)-N'-(diaminomethylene)guanidine; 910A4X901V; C8H10ClN5; Imidodicarbonimidicdiamide, N-(3-chlorophenyl)-; 1-carbamimidamido-N-(3-chlorophenyl)methanimidamide; 1-(3-chlorophenyl)biguanide; m-chlorophenylbiguanide; 3-chlorophenyl-biguanide; [3H]meta-chlorophenylbiguanide
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| Activity |
IC50 = 190600 nM
|
[3] | |||
| Compound Name |
(R)-3-Benzyloxycarbonylamino-4-[4-(4-benzyloxycarbonylamino-benzylamino)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL47176; BDBM50122235
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
3-[2-(5-Guanidinopentanoyl)hydrazinocarbonylamino]-3-phenylpropionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL266151; SCHEMBL12259092; BDBM50100144; 3-{N-[N''-(5-guanidinopentanoyl)hydrazino]carbonyl}-amino-3-phenylpropionic acid; 3-({[2-(5-{[(Z)-amino(imino)methyl]amino}pentanoyl)hydrazino]carbonyl}amino)-3-phenylpropanoic acid
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Sibrafiban
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL435176; Ro-48-3657; Ro 48-3657/001; ro483657; BDBM50092123; Q7507267
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(S)-2-Benzyloxycarbonylamino-3-[4-(4-benzyloxycarbonylamino-benzylamino)-5-methyl-2-oxo-2H-pyrimidin-1-yl]-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL47603; BDBM50122208
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
5-[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-5-oxo-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL64592; BDBM50143849
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-{[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]decane-8-carbonyl]-amino}-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL65477; CT 50728; SCHEMBL8285974; BDBM50143842; ML 728
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(R)-4-{4-[4-(Benzothiazol-2-ylaminomethyl)-piperidin-1-yl]-5-methyl-2-oxo-2H-pyrimidin-1-yl}-3-benzyloxycarbonylamino-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL295223; BDBM50122233
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
3-[7-[(4-Methyl-2-pyridyl)amino]heptanoylamino]-3-(3-nitrophenyl)propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL417426; SCHEMBL12259089; BDBM50110225; 3-[7-(4-Methyl-pyridin-2-ylamino)-heptanoylamino]-3-(3-nitro-phenyl)-propionic acid
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-[[(2S)-6-Amino-2-[(3R)-3-[3-(diaminomethylideneamino)propyl]-2-oxopyrrolidin-1-yl]hexanoyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3407515; BDBM50498190
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| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
{2-[2-(4-Carbamimidoyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-2-oxo-ethoxy}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL65525; BDBM50143852
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(Z)-N-(2,6-Dimethoxypyrimidin-4-yl)-4-((1-(4-iodophenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)methylamino)benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL221248; ZINC8440974; BDBM50195100; AKOS025141456; ZINC100374201; MCULE-6925065933; AG-690/13155003
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| Activity |
IC50 = 53500 nM
|
[3] | |||
| Compound Name |
[7-(4-Carbamimidoyl-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL18911; SCHEMBL7592841; BDBM50036086
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| Activity |
Ki = 56000 nM
|
[8] | |||
| Compound Name |
2-Benzyloxycarbonylamino-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL85152; BDBM50004060; N-(Benzyloxycarbonyl)-O-[4-(piperidin-4-yl)butyl]-L-tyrosine; (S)-2-Benzyloxycarbonylamino-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionic acid
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| Activity |
IC50 = 56000 nM
|
[1] | |||
| Compound Name |
beta-[[3-[(5-Amidinobenzofuran-2-yl)carbonylamino]propanoyl]amino]benzenepropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL136694; BDBM50061837; 3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amino]-propionylamino}-3-phenyl-propionic acid
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| Activity |
IC50 = 60000 nM
|
[9] | |||
| Compound Name |
N-(2,4-Dichlorophenyl)imidodicarbonimidic diamide
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Investigative | Compound Info | ||
| Synonyms |
1-(diaminomethylidene)-2-(2,4-dichlorophenyl)guanidine; 1-carbamimidamido-N-(2,4-dichlorophenyl)methanimidamide; CHEMBL220979; Imidodicarbonimidicdiamide, N-(2,4-dichlorophenyl)-; 1-(2,4-Dichlorophenyl)biguanide; ACMC-20m4au; SCHEMBL4098884; CTK0H2390; DTXSID20328758; HMS1594H22; ZINC528557; ALBB-022021; BDBM50195099; MFCD00448709; STK107178; AKOS002224859; JS-3044; MCULE-4837327258; NCGC00335725-01; R3057; ST50106273; KS-00002779; AB00365130-03; Imidodicarbonimidic diamide, N-(2,4-dichlorophenyl)-; amino{[(2,4-dichlorophenyl)amino]iminomethyl}carboxamidine
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| Activity |
IC50 = 66900 nM
|
[3] | |||
| Compound Name |
N-(2,3-Dichlorophenyl)imidodicarbonimidic diamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL185802; Maybridge1_007194; SCHEMBL1307253; 1-(diaminomethylidene)-2-(2,3-dichlorophenyl)guanidine; HMS561O22; ZINC89377; 1-(2,3-dichlorophenyl)biguanide; ALBB-022023; BDBM50154223; MFCD00276882; AKOS005203078; CCG-244742; CCG-248157; MCULE-3732339111; R2800; Imidodicarbonimidic diamide, N-(2,3-dichlorophenyl)-; 1-CARBAMIMIDAMIDO-N-(2,3-DICHLOROPHENYL)METHANIMIDAMIDE
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| Activity |
IC50 = 87300 nM
|
[3] | |||
| Compound Name |
1-(3-Chloro-4-fluorophenyl)biguanide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222122; N-(3-chloro-4-fluorophenyl)imidodicarbonimidic diamide; Maybridge1_006973; C8H9ClFN5; SCHEMBL4103672; CTK7D2082; ZINC88731; 2-(3-chloro-4-fluorophenyl)-1-(diaminomethylidene)guanidine; BDBM50195101; STK106998; AKOS002224883; CCG-245902; MCULE-5750063196; ST50106275; AS-813/41839236; N-(3-chloro-4-fluorophenyl)dicarbonimido/ic diamide/imido; amino{[(3-chloro-4-fluorophenyl)amino]iminomethyl}carboxamidine
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| Activity |
IC50 = 97300 nM
|
[3] | |||
| Compound Name |
[(1R,18S,19R,20S)-14-(3-Guanidino-propyl)-19,20-dihydroxy-5-isopropyl-4,7,10,13,16-pentaoxo-21-oxa-3,6,9,12,15-pentaaza-bicyclo[16.2.1]henicos-8-yl]-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370452; BDBM50122993
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| Activity |
IC50 = 98100 nM
|
[10] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3-fluorophenyl)methyl]amino]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808955; BDBM50349615
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,4-difluorophenyl)methyl]amino]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952408; BDBM50365124
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,5-difluorophenyl)methyl]amino]-2-oxoacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808954; BDBM50349614
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| Activity |
IC50 ~ 100000 nM
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[11] | |||
| Compound Name |
2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl}amino)-2-oxoacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL459941; BDBM50253859
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,4-difluorophenyl)methyl]amino]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808957; BDBM50349617
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[(2R,5S,9R)-5-Benzyl-9-[3-(diaminomethylideneamino)propyl]-3,8,11,13-tetraoxo-1,4,7,10-tetrazacyclotridec-2-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL571628; BDBM50378574
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3-fluorophenyl)methyl]amino]-2-oxoacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952406; BDBM50365122
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| Activity |
IC50 ~ 100000 nM
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[11] | |||
| Compound Name |
7-[[(6-Amidino-1H-indol-3-yl)carbonyl]amino]heptanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL318493; BDBM50059688; 7-[(6-Carbamimidoyl-1H-indole-3-carbonyl)-amino]-heptanoic acid
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| Activity |
IC50 ~ 100000 nM
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[13] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(4-fluorophenyl)methyl]amino]-2-oxoacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952400; BDBM50365115
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(4-fluorophenyl)methyl]amino]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808948; BDBM50349608
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,5-difluorophenyl)methyl]amino]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949835; BDBM50365128
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3-fluorophenyl)methyl]amino]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952403; BDBM50365118
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
6-Oxo-6-[9-(4-amidinobenzoyl)-3,9-diazaspiro[5.5]undecane-3-yl]hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL283692; BDBM50100354; 6-[9-(4-Carbamimidoyl-benzoyl)-3,9-diaza-spiro[5.5]undec-3-yl]-6-oxo-hexanoic acid
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(S)-2-(Butane-1-sulfonylamino)-3-{3-[(5-carbamimidoyl-benzofuran-2-carbonyl)-amino]-propionylamino}-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL137639; BDBM50061847; N-(Butylsulfonyl)-3-[[3-[(5-amidinobenzofuran-2-yl)carbonylamino]propanoyl]amino]-L-alanine
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(4-fluorophenyl)methyl]amino]-2-oxoacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952402; BDBM50365117
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3-fluorophenyl)methyl]amino]-2-oxoacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952405; BDBM50365121
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
3-[[2-[(5R)-3-(4-Carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]acetyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL129766; CHEMBL152360; BDBM50055900; (R)-XR-299; 3-{2-[(R)-3-(4-Carbamimidoyl-phenyl)-4,5-dihydro-isoxazol-5-yl]-acetylamino}-propionic acid; TFA
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
5-Oxo-5-[9-(4-amidinobenzoyl)-3,9-diazaspiro[5.5]undecane-3-yl]valeric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL26047; SCHEMBL6619801; BDBM50100345; 5-[9-(4-Carbamimidoyl-benzoyl)-3,9-diaza-spiro[5.5]undec-3-yl]-5-oxo-pentanoic acid
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
8-Oxo-8-[9-(4-pyridinyl)-3,9-diazaspiro[5.5]undecane-3-yl]octanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL287641; SCHEMBL7012192; BDBM50100357; 8-Oxo-8-(9-pyridin-4-yl-3,9-diaza-spiro[5.5]undec-3-yl)-octanoic acid; 8-oxo-8-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecan-3-yl)octanoic acid
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,5-difluorophenyl)methyl]amino]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808950; BDBM50349610
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(4-fluorophenyl)methyl]amino]-2-oxoacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952401; BDBM50365116
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-(Butane-1-sulfonylamino)-3-{3-[(6-carbamimidoyl-1H-indazole-3-carbonyl)-amino]-propionylamino}-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL433684; BDBM50061859
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
1-[9-(4-Pyridinyl)-3,9-diazaspiro[5.5]undecane-3-ylcarbonyl]-4-piperidinyloxyacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL24562; SCHEMBL7014909; BDBM50100343; 2-[1-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)piperidin-4-yl]oxyacetic acid; 2-{1-[9-(4-pyridyl)-3,9-diazaspiro[5.5]undec-3-ylcarbonyl]hexahydro-4-pyridinyloxy}acetic acid
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-[[(2S)-2-[(3R)-3-[3-(Diaminomethylideneamino)propyl]-2-oxopyrrolidin-1-yl]-6-(phenylmethoxycarbonylamino)hexanoyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3408938; BDBM50498192
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| Activity |
IC50 = 100000 nM
|
[7] | |||
| Compound Name |
4-Oxo-4-[9-(4-amidinobenzoyl)-3,9-diazaspiro[5.5]undecane-3-yl]butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL282087; SCHEMBL6621953; BDBM50100348; 4-[9-(4-Carbamimidoyl-benzoyl)-3,9-diaza-spiro[5.5]undec-3-yl]-4-oxo-butyric acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-Oxo-3-[9-(4-amidinobenzoyl)-3,9-diazaspiro[5.5]undecane-3-yl]propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL276974; BDBM50100349; 3-[9-(4-Carbamimidoyl-benzoyl)-3,9-diaza-spiro[5.5]undec-3-yl]-3-oxo-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-[9-(4-Carbamimidoyl-phenyl)-3,9-diaza-spiro[5.5]undec-3-yl]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL283563; BDBM50100356
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-[(2R,5R,9R)-5-Benzyl-9-[3-(diaminomethylideneamino)propyl]-3,8,11,13-tetraoxo-1,4,7,10-tetrazacyclotridec-2-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572266; BDBM50378573
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(2S)-4-[(3S)-3-[[4-[(2-Methylphenyl)carbamoylamino]phenyl]methylcarbamoyl]pyrrolidin-1-yl]-4-oxo-2-[(2-phenylacetyl)amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115406; BDBM50447508
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,4-difluorophenyl)methyl]amino]-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952411; BDBM50365127
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(4-fluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808952; BDBM50349612
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460144; BDBM50253817
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3-fluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808947; BDBM50349607
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
7-Oxo-7-[9-(4-pyridinyl)-3,9-diazaspiro[5.5]undecane-3-yl]heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277885; SCHEMBL7015828; BDBM50100342; 7-Oxo-7-(9-pyridin-4-yl-3,9-diaza-spiro[5.5]undec-3-yl)-heptanoic acid; 7-oxo-7-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecan-3-yl)heptanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-[(5Z)-3-[[4-[(2-Aminoacetyl)amino]phenyl]methyl]-5-ethylidene-2,6-dioxo-4-propan-2-yl-1,3-diazinan-1-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2418219; BDBM50439685
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(S)-3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amino]-propionylamino}-2-(4-iodo-benzenesulfonylamino)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL134912; BDBM50061862; N-[(4-Iodophenyl)sulfonyl]-3-[[3-[(5-amidinobenzofuran-2-yl)carbonylamino]propanoyl]amino]-L-alanine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,5-difluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949838; BDBM50365131
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)-2-oxoacetic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460355; BDBM50253818
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(4-fluorophenyl)methyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952398; BDBM50365133
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(S)-N-Benzyl-3-{[(R)-1-(3-guanidino-propionyl)-pyrrolidine-2-carbonyl]-amino}-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398783; BDBM50204821
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(2S)-2-(Butylsulfonylamino)-5-oxo-5-[9-(4-pyridinyl)-3,9-diazaspiro[5.5]undecane-3-yl]valeric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24590; SCHEMBL7141689; BDBM50100347; (2S)-2-(butylsulfonylamino)-5-oxo-5-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecan-3-yl)pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-[[3-[(5-Amidinobenzofuran-2-yl)carbonylamino]propanoyl]amino]-L-alanine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263320; BDBM50061869; (S)-2-Amino-3-{3-[(5-carbamimidoyl-benzofuran-2-carbonyl)-amino]-propionylamino}-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,5-difluorophenyl)methyl]amino]-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949839; BDBM50365132
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl}amino)acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460143; BDBM50253816
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(Z)-2-[1-[(4-Aminophenyl)methylamino]ethyl]but-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2418214; BDBM50439689
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3-fluorophenyl)methyl]amino]-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952404; BDBM50365120
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,4-difluorophenyl)methyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952407; BDBM50365123
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[(2R,5S,9S)-5-Benzyl-9-[3-(diaminomethylideneamino)propyl]-3,8,11,13-tetraoxo-1,4,7,10-tetrazacyclotridec-2-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL570963; BDBM50378572
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,5-difluorophenyl)methyl]amino]-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949837; BDBM50365130
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3-fluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808951; BDBM50349611
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-Benzenesulfonylamino-3-{3-[(5-carbamimidoyl-benzofuran-2-carbonyl)-amino]-propionylamino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116457; BDBM50061849; N-(Phenylsulfonyl)-3-[[3-[(5-amidinobenzofuran-2-yl)carbonylamino]propanoyl]amino]-L-alanine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
beta-[[3-[(5-Amidinobenzofuran-2-yl)carbonylamino]propanoyl]amino]-3,5-difluorobenzenepropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137532; BDBM50061865
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S)-2-(Benzyloxycarbonylamino)-5-oxo-5-[9-(4-pyridinyl)-3,9-diazaspiro[5.5]undecane-3-yl]valeric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL417836; SCHEMBL7141576; BDBM50100351; (S)-2-Benzyloxycarbonylamino-5-oxo-5-(9-pyridin-4-yl-3,9-diaza-spiro[5.5]undec-3-yl)-pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-[[3-[(5-Amidinobenzofuran-2-yl)carbonylamino]propanoyl]amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137244; BDBM50061864; 3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amino]-propionylamino}-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
3-[(3S)-1-[(2S)-1-[2-(Diaminomethylideneamino)ethylamino]-1-oxo-6-(phenylmethoxycarbonylamino)hexan-2-yl]-2-oxopyrrolidin-3-yl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3408939; BDBM50498191
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2-(3,5-Dimethyl-isoxazole-4-sulfonylamino)-5-oxo-5-(9-pyridin-4-yl-3,9-diaza-spiro[5.5]undec-3-yl)-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL25770; SCHEMBL7143576; BDBM50092105; CT-51688
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(S)-N-Benzyl-3-({(S)-1-[(S)-5-guanidino-2-(toluene-4-sulfonylamino)-pentanoyl]-pyrrolidine-2-carbonyl}-amino)-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241107; BDBM50204823
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[18] | |||
| Compound Name |
7-[[(6-Amidino-1H-indazol-3-yl)carbonyl]amino]heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98461; BDBM50059694; 7-[(6-Carbamimidoyl-1H-indazole-3-carbonyl)-amino]-heptanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-(Butane-1-sulfonylamino)-3-{3-[(6-carbamimidoyl-1H-indole-3-carbonyl)-amino]-propionylamino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL423175; BDBM50061839
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(S)-3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amino]-propionylamino}-2-(5-dimethylamino-naphthalene-1-sulfonylamino)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137802; BDBM50061840
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amino]-propionylamino}-3-(2,5-difluoro-phenyl)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137148; BDBM50061855
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S)-2-(Butoxycarbonylamino)-5-oxo-5-[9-(4-pyridinyl)-3,9-diazaspiro[5.5]undecane-3-yl]valeric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL26550; SCHEMBL7152283; BDBM50100344; (S)-2-Butoxycarbonylamino-5-oxo-5-(9-pyridin-4-yl-3,9-diaza-spiro[5.5]undec-3-yl)-pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(4-fluorophenyl)methyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952399; BDBM50365114
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl}amino)-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461210; BDBM50253858
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-methyl-amino]-propionylamino}-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137590; BDBM50061846
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[(2S,5R,9R)-5-Benzyl-9-[3-(diaminomethylideneamino)propyl]-3,8,11,13-tetraoxo-1,4,7,10-tetrazacyclotridec-2-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL570087; BDBM50378576
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
3-Oxo-3-[4-[9-(4-pyridinyl)-3,9-diazaspiro[5.5]undecane-3-ylcarbonyl]piperidino]propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL282772; SCHEMBL7117231; BDBM50100352; 3-Oxo-3-[4-(9-pyridin-4-yl-3,9-diaza-spiro[5.5]undecane-3-carbonyl)-piperidin-1-yl]-propionic acid; 3-oxo-3-[4-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecane-3-carbonyl)piperidin-1-yl]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,4-difluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808949; BDBM50349609
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
5-Oxo-5-[9-(4-pyridinyl)-3,9-diazaspiro[5.5]undecane-3-yl]valeric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24373; SCHEMBL7018518; BDBM50100353; 5-Oxo-5-(9-pyridin-4-yl-3,9-diaza-spiro[5.5]undec-3-yl)-pentanoic acid; 5-oxo-5-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecan-3-yl)pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL517875; BDBM50253780
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amino]-butyrylamino}-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440346; BDBM50061841
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,4-difluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808953; BDBM50349613
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
6-Oxo-6-[9-(4-pyridinyl)-3,9-diazaspiro[5.5]undecane-3-yl]hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL26354; SCHEMBL7015367; BDBM50100355; 6-Oxo-6-(9-pyridin-4-yl-3,9-diaza-spiro[5.5]undec-3-yl)-hexanoic acid; 6-oxo-6-(9-pyridin-4-yl-3,9-diazaspiro[5.5]undecan-3-yl)hexanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,4-difluorophenyl)methyl]amino]-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952409; BDBM50365125
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,5-difluorophenyl)methyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949836; BDBM50365129
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
7-[[(5-Amidinobenzofuran-2-yl)carbonyl]amino]heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95974; BDBM50059679; 7-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amino]-heptanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(2S)-2-(Tosylamino)-5-oxo-5-[9-(4-pyridinyl)-3,9-diazaspiro[5.5]undecane-3-yl]valeric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24209; SCHEMBL7146965; BDBM50100350
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-[[3-[(5-Amidinobenzofuran-2-yl)carbonylamino]propanoyl]amino]-4,4,4-trifluorobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137469; BDBM50061853; 3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amino]-propionylamino}-4,4,4-trifluoro-butyric acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
beta-[[3-[(5-Amidinobenzofuran-2-yl)carbonylamino]propanoyl]amino]-3,4-difluorobenzenepropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL337672; BDBM50061851
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
3-{2-[(Z)-4-Carbamimidoyl-benzoylimino]-3,4-dimethyl-2,3-dihydro-thiazol-5-yl}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8572; BDBM50098965
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(4-fluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808956; BDBM50349616
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3-fluorophenyl)methyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949701; BDBM50365119
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(3S)-4-[(3S)-3-[[4-[(2-Methylphenyl)carbamoylamino]phenyl]methylcarbamoyl]pyrrolidin-1-yl]-4-oxo-3-[(2-phenylacetyl)amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3115407; BDBM50447509
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amino]-propionylamino}-3-pyridin-3-yl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL335641; BDBM50061843
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[9] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,5-difluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808958; BDBM50349618
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
3-{3-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-methyl-amino]-propionylamino}-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL344917; BDBM50061848
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Cyclo(-Arg-Ala-Asp-D-Phe-Val)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL571979; cyclo(Arg-Ala-Asp-D-Phe-Val); BDBM50378577; MFCD01318823; ZINC49694914
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(S)-2-(3,5-Dimethyl-isoxazole-4-sulfonylamino)-3-[(9-pyridin-4-yl-3,9-diaza-spiro[5.5]undecane-3-carbonyl)-amino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL23814; SCHEMBL7012246; BDBM50100346
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
3-{3-[(5-Carbamimidoyl-benzofuran-2-carbonyl)-amino]-propionylamino}-pent-4-ynoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL132975; BDBM50061838
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,4-difluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952410; BDBM50365126
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
1-(2,5-Dichlorophenyl)biguanide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL221952; N-(2,5-dichlorophenyl)imidodicarbonimidic diamide; Maybridge1_007092; AJ-264/37420012; N-(2,5-dichlorophenyl)dicarbonimido/ic diamide/imido; SCHEMBL4107486; 1-(diaminomethylidene)-2-(2,5-dichlorophenyl)guanidine; CTK1E5005; ZINC89404; DTXSID70369636; BDBM50195089; AKOS003745785; MCULE-9983569098; Imidodicarbonimidic diamide, N-(2,5-dichlorophenyl)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 100200 nM
|
[3] | |||
| Compound Name |
1-[4-(Trifluoromethylthio)phenyl]biguanide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219378; SCHEMBL16679372; ZINC351508; BDBM50195088; N-{4-[(trifluoromethyl)thio]phenyl}imidodicarbonimidic diamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 101400 nM
|
[3] | |||
| Compound Name |
3-((1-(4-Carbamimidoylbenzyl)-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydropyridin-3-yl)(propyl)amino)-3-oxopropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239334; BDBM50222351
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[20] | |||
| Compound Name |
3-{3-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-butyrylamino}-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343550; BDBM50061856
Click to Show/Hide
|
||||
| Activity |
IC50 = 125000 nM
|
[9] | |||
| Compound Name |
N-[2-Chloro-5-(trifluoromethyl)phenyl]imidodicarbonimidic diamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219484; SCHEMBL16679018; ZINC73041; HMS3604D03; BDBM50195102; CCG-51800; AKOS003747685; DB08478; MCULE-1846003734; 1-[2-Chloro-5-(trifluoromethyl)phenyl]biguanide; SR-01000641078-1; Q27097682; 2-[2-Chloro-5-(trifluoromethyl)phenyl]-1-(diaminomethylene)guanidine
Click to Show/Hide
|
||||
| Activity |
IC50 = 127200 nM
|
[3] | |||
| Compound Name |
{2-Bromo-6-ethoxy-4-[(Z)-(8-methyl-3-oxo[1,3]thiazolo[3,2-a]benzimidazol-2(3H)-ylidene)methyl]phenoxy}acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385111; ZINC8854961; BDBM50195090; STK676430; AKOS005594237; MCULE-3156031580
Click to Show/Hide
|
||||
| Activity |
IC50 = 132000 nM
|
[3] | |||
| Compound Name |
2-(2,4-Dichlorophenoxy)-N-(4-{[(2,6-dimethoxy-4-pyrimidinyl)amino]sulfonyl}phenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220869; Oprea1_043276; Oprea1_735079; ARONIS020235; HMS1799O06; ZINC670681; BDBM50195096; STK015070; AKOS000487119; MCULE-4756506425; KS-00004C03; NCGC00099589-01; AN-329/13568001; SR-01000493610; SR-01000493610-1
Click to Show/Hide
|
||||
| Activity |
IC50 = 137000 nM
|
[3] | |||
| Compound Name |
3-[4-(7-Amino-heptyloxy)-phenyl]-2-benzyloxycarbonylamino-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85544; BDBM50004062; N-(Benzyloxycarbonyl)-O-(7-aminoheptyl)-L-tyrosine; (S)-3-[4-(7-Amino-heptyloxy)-phenyl]-2-benzyloxycarbonylamino-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 147000 nM
|
[1] | |||
| Compound Name |
4-Chlorophenylbiguanide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-(4-Chlorophenyl)biguanide; N-(4-chlorophenyl)imidodicarbonimidic diamide; 2-(4-chlorophenyl)-1-(diaminomethylidene)guanidine; UNII-61UQ98597T; (4-chlorophenyl)biguanide; CHEMBL840; 61UQ98597T; N-(4-chlorophenyl)imidodicarbonimidic diamide hydrochloride; 1-carbamimidoyl-3-(4-chlorophenyl)guanidine; EINECS 226-155-6; NSC 220325; p-Chlorophenyldiguanide; AI3-52174; Maybridge1_007004; Maybridge1_007100; Maybridge4_003042; 4-Chloro-Phenyl biguanide; 1-carbamimidamido-N-(4-chlorophenyl)methanimidamide; SCHEMBL305068; Biguanide, 1-(p-chorophenyl)-; SCHEMBL19038548; CTK1H0553; HMS561K16; DTXSID10201086; HMS1529K06; ALBB-012973; BBL003340; BDBM50053595; MFCD00045590; NSC220325; STK105980; ZINC13467525; AKOS002224800; CCG-248174; MCULE-9401524875; NSC-220325; 1-(4-CHLOROPHENYL)BIGUANIDE HCL; NCGC00176274-01; NCGC00341330-01; VS-01306; AB0218174; ST50106265; T8360; AB00443650-03; Imidodicarbonimidic diamide, N-(4-chlorophenyl)-; Imidodicarbonimidicdiamide, N-(4-chlorophenyl)-; ([(4-chloroanilino)(imino)methyl]amino)methanimidamide; amino{[(4-chlorophenyl)amino]iminomethyl}carboxamidine; BRD-K18824214-001-01-8; Q27263381; ({amino[(4-chlorophenyl)amino]methylidene}amino)methanimidamide; Imidodicarbonimidic diamide, N-(4-chlorophenyl)-, hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 = 148600 nM
|
[3] | |||
| Compound Name |
3-[4-(6-Amino-hexyloxy)-phenyl]-2-(butane-1-sulfonylamino)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86115; L-Tyrosine, O-(6-aminohexyl)-N-(butylsulfonyl)-; CTK0B3051; ZINC3806114; BDBM50004065; N-(Butylsulfonyl)-O-(6-aminohexyl)-L-tyrosine; (2S)-3-[4-(6-aminohexoxy)phenyl]-2-(butylsulfonylamino)propanoic acid; (S)-3-[4-(6-Amino-hexyloxy)-phenyl]-2-(butane-1-sulfonylamino)-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[1] | |||
| Compound Name |
(4S)-4-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[(2-Aminoacetyl)amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-[[(2S,3R)-1-[[2-[[2-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067904
Click to Show/Hide
|
||||
| Activity |
IC50 = 152000 nM
|
[21] | |||
| Compound Name |
N-[3-Hydroxy-4-[6-[[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]amino]-1,3-benzoxazol-2-yl]phenyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386940; Oprea1_292595; BDBM50195098; ZINC44069651
Click to Show/Hide
|
||||
| Activity |
IC50 = 162100 nM
|
[3] | |||
| Compound Name |
(4S)-4-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[2-[[2-[[2-[[2-[[2-[[2-[(2-Aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-[[(2S,3R)-1-[[2-[[2-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090048
Click to Show/Hide
|
||||
| Activity |
IC50 = 171000 nM
|
[21] | |||
| Compound Name |
1-[4-(Difluoromethylthio)phenyl]biguanide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL221306; AF-399/37402002; ZINC351509; BDBM50195093; N-{4-[(difluoromethyl)thio]phenyl}imidodicarbonimidic diamide; N-{4-[(difluoromethyl)sulfanyl]phenyl}dicarbonimido/ic diamide/imido
Click to Show/Hide
|
||||
| Activity |
IC50 = 178100 nM
|
[3] | |||
| Compound Name |
2-(4-(5-(4-Nitrophenoxy)-1,3-dioxoisoindolin-2-yl)benzamido)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376494; Oprea1_278801; ZINC3668375; BDBM50195104; STK296067; AKOS001741532; MCULE-9258819481; ST072589
Click to Show/Hide
|
||||
| Activity |
IC50 = 180400 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 29 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-phenylbiguanide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
phenylbiguanide; 1-Phenylbiguanide; Phenyl biguanide; 102-02-3; Phenyldiguanide; Phenylguanide; phenyl diguanide; N-Phenyl-N'-guanylguanidine; N-phenylimidodicarbonimidic diamide; Biguanide, phenyl-; Imidodicarbonimidic diamide, N-phenyl-; UNII-W8PKA3T2I3; BIGUANIDE, 1-PHENYL-; C8H11N5; N-Phenyl-imidocarbonimidic diamide; EINECS 202-998-5; W8PKA3T2I3; CHEMBL13791; CHEBI:75377; P 1426; Imidodicarbonimidicdiamide, N-phenyl-; 1-(diaminomethylidene)-2-phenylguanidine; SR-01000075565; N-phenylbiguanide; N'-phenylbiguanide
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
Ethyl 2-[benzyl-[(2S)-2-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337676
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
1-(2-Chlorophenyl)biguanide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-(2-chlorophenyl)-N'-(diaminomethylene)guanidine; 2-(2-chlorophenyl)-1-(diaminomethylidene)guanidine; 2-Chloro-Phenyl biguanide; CHEMBL42752; N-(2-chlorophenyl)imidodicarbonimidic diamide; Maybridge1_006916; SCHEMBL725722; CTK1D0319; DTXSID00274880; ALBB-025591; BDBM50053629; MFCD04225715; SBB072601; STK107576; ZINC16450314; AKOS002224830; AKOS003334648; MCULE-6853765838; NCGC00340582-01; FT-0605521; R8430; AB01331795-02; Imidodicarbonimidic diamide, N-(2-chlorophenyl)-; N-(2-chlorophenyl)dicarbonimido/ic diamide/imido; AG-205/04772048; 1-carbamimidamido-N-(2-chlorophenyl)methanimidamide; guanidine, N-(2-chlorophenyl)-N'-(diaminomethylene)-; (3,3-diamino-1-imino-2-azaprop-2-enyl)(2-chlorophenyl)amine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
Ethyl 2-[benzyl-[(2R)-2-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337675
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
Ethyl 2-[benzyl-[(3R)-3-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337669
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
2-[Benzyl-[(2S)-2-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337672; BDBM50429809
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
2-[Benzyl-[(3R)-3-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337673; BDBM50429808
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
N-(5-Chloro-2-methylphenyl)imidodicarbonimidic diamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375434; 2-(5-chloro-2-methylphenyl)-1-(diaminomethylidene)guanidine; MLS000672349; SCHEMBL11839653; HMS2716B13; ZINC477754; ALBB-022020; BDBM50195091; MFCD03615418; STK108570; AKOS002224947; MCULE-9367730074; SMR000295768; R7776; ST50106282; SR-01000290372; SR-01000290372-1; N-(5-Chloro-2-methylphenyl)imidodicarbonimidicdiamide; imidodicarbonimidic diamide, N-(5-chloro-2-methylphenyl)-; amino{[(5-chloro-2-methylphenyl)amino]iminomethyl}carboxamidine; 1-CARBAMIMIDAMIDO-N-(5-CHLORO-2-METHYLPHENYL)METHANIMIDAMIDE
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
N-[2-(Methylthio)phenyl]imidodicarbonimidic diamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL221310; Maybridge1_007046; BDBM50195105; ZINC20459009; MCULE-1680239121
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
Ethyl 3-{[{[amino(imino)methyl]amino}(imino)methyl]amino}benzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL221309; ZINC1017822; BDBM50195095
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
Ethyl 2-[benzyl-[(3S)-3-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337670
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
2-[Benzyl-[(3S)-3-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337674; BDBM50429807
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
N-[3-(Methylthio)phenyl]imidodicarbonimidic diamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL221253; ZINC1017821; BDBM50195103
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
2-[Benzyl-[(2R)-2-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337671; BDBM50429810
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[22] | |||
| Compound Name |
N-(2-Ethoxyphenyl)imidodicarbonimidic diamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375650; 1-(diaminomethylidene)-2-(2-ethoxyphenyl)guanidine; AJ-292/41839335; ZINC470380; ALBB-022014; BDBM50195097; MFCD03615408; STK131548; AKOS002224799; MCULE-2196226658; R7774; ST50106264; Imidodicarbonimidic diamide, N-(2-ethoxyphenyl)-; N-(2-ethoxyphenyl)dicarbonimido/ic diamide/imido; SR-01000266102; SR-01000266102-1; amino{[(2-ethoxyphenyl)amino]iminomethyl}carboxamidine; 1-CARBAMIMIDAMIDO-N-(2-ETHOXYPHENYL)METHANIMIDAMIDE
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
[1-((S)-4-Methyl-2-{2-[4-(3-o-tolyl-ureido)-phenyl]-acetylamino}-pentanoyl)-piperidin-2-yl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL102299; SCHEMBL20756248; BDBM50106751; 1-[N-[4-[3-(2-Methylphenyl)ureido]phenylacetyl]-L-leucyl]piperidine-2-acetic acid
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| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
(S)-N-Benzyl-3-{[(R)-1-(5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-amino}-succinamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241285; BDBM50204819
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| Activity |
IC50 = 230000 nM
|
[18] | |||
| Compound Name |
3-[(3S,6S,12S,15S,21S,24S,30S,36S,39S,42S)-6,15,24-Tris(carboxymethyl)-12,21,30-tris[3-(diaminomethylideneamino)propyl]-36-[(1R)-1-hydroxyethyl]-3-(2-methylpropyl)-2,5,8,11,14,17,20,23,26,29,32,35,38,41-tetradecaoxo-1,4,7,10,13,16,19,22,25,28,31,34,37,40-tetradecazabicyclo[40.3.0]pentatetracontan-39-yl]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068971
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| Activity |
IC50 = 257000 nM
|
[21] | |||
| Compound Name |
2-Benzyloxycarbonylamino-3-[4-(3-tert-butylamino-2-hydroxy-propoxy)-phenyl]-propionic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL83247; BDBM50004072; N-(Benzyloxycarbonyl)-O-[3-(tert-butylamino)-2-hydroxypropyl]-L-tyrosine; (S)-2-Benzyloxycarbonylamino-3-[4-(3-tert-butylamino-2-hydroxy-propoxy)-phenyl]-propionic acid
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| Activity |
IC50 > 300000 nM
|
[1] | |||
| Compound Name |
2-[(1R,6S,7R,8S,9R,23S,24R,25S)-19-[3-(Diaminomethylideneamino)propyl]-7,8,24,25-tetrahydroxy-4,12,15,18,21-pentaoxo-26,27-dioxa-3,11,14,17,20-pentazatricyclo[21.2.1.16,9]heptacosan-13-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL113277; BDBM50122991
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||||
| Activity |
IC50 = 597000 nM
|
[10] | |||
| Compound Name |
Arg-Gly-Asp-Arg-Gly-Asp
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL141005; BDBM50054481
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|
||||
| Activity |
IC50 = 619000 nM
|
[21] | |||
| Compound Name |
(S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amino]-3-[4-(2,6-dichloro-benzyloxy)-phenyl]-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL351547; SCHEMBL6453971; BDBM50089005; CT-5219
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||||
| Activity |
IC50 > 800000 nM
|
[24] | |||
| Compound Name |
4-((1-(4-Carbamimidoylbenzyl)-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydropyridin-3-yl)(propyl)amino)-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL392102; BDBM50222354
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||||
| Activity |
IC50 > 1000000 nM
|
[20] | |||
| Compound Name |
2-((1-(4-Carbamimidoylbenzyl)-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydropyridin-3-yl)(propyl)carbamoyl)-4-methoxy-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL392355; BDBM50222350
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||||
| Activity |
IC50 > 1000000 nM
|
[20] | |||
| Compound Name |
2-({1-[(4-Aminophenyl)methyl]-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydropyridin-3-yl}(propyl)carbamoyl)butanedioic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL238658; BDBM50222358
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||||
| Activity |
IC50 > 1000000 nM
|
[20] | |||
| Compound Name |
3-(3-(3-Amino-N-propylpropanamido)-4-methyl-2-oxo-6-phenyl-5,6-dihydropyridin-1(2H)-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238697; BDBM50222348
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||||
| Activity |
IC50 > 1000000 nM
|
[20] | |||
| Compound Name |
3-(3-(6-Amino-N-propylhexanamido)-4-methyl-2-oxo-6-phenyl-5,6-dihydropyridin-1(2H)-yl)propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239330; BDBM50222355
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|
||||
| Activity |
IC50 > 1000000 nM
|
[20] | |||
| Compound Name |
N-{6-(4-Carbamimidoyl-phenyl)-1-[(S)-1-(4-methoxy-phenyl)-ethyl]-4-methyl-2-oxo-1,2,5,6-tetrahydro-pyridin-3-yl}-N-propyl-malonamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL239333; BDBM50222352
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[20] | |||
| Compound Name |
2-((1-(4-Carbamimidoylbenzyl)-4-methyl-2-oxo-6-phenyl-1,2,5,6-tetrahydropyridin-3-yl)(propyl)carbamoyl)succinic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238440; BDBM50222346
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|
||||
| Activity |
IC50 > 1000000 nM
|
[20] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp. J Med Chem. 1994 Aug 5;37(16):2537-51. | ||||
| REF 2 | Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5227-32. | ||||
| REF 3 | Discovery of small molecule inhibitors of integrin alphavbeta3 through structure-based virtual screening. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5878-82. | ||||
| REF 4 | Highly potent and selective alphaVbeta3-receptor antagonists: solid-phase synthesis and SAR of 1-substituted 4-amino-1H-pyrimidin-2-ones. Bioorg Med Chem Lett. 2003 Jan 20;13(2):165-9. | ||||
| REF 5 | Nanomolar small molecule inhibitors for alphav(beta)6, alphav(beta)5, and alphav(beta)3 integrins. J Med Chem. 2002 Feb 28;45(5):1045-51. | ||||
| REF 6 | Discovery of novel 2,8-diazaspiro[4.5]decanes as orally active glycoprotein IIb-IIIa antagonists. J Med Chem. 2004 Apr 8;47(8):2037-61. | ||||
| REF 7 | In silico studies, synthesis and binding evaluation of substituted 2-pyrrolidinones as peptidomimetics of RGD tripeptide sequence. Eur J Med Chem. 2015 Mar 26;93:360-72. | ||||
| REF 8 | Discovery of potent nonpeptide vitronectin receptor (alpha v beta 3) antagonists. J Med Chem. 1997 Jul 18;40(15):2289-92. | ||||
| REF 9 | Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors. J Med Chem. 1997 Dec 19;40(26):4308-18. | ||||
| REF 10 | Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors. Bioorg Med Chem Lett. 2003 Feb 10;13(3):331-4. | ||||
| REF 11 | Fluorinated dual antithrombotic compounds based on 1,4-benzoxazine scaffold. Eur J Med Chem. 2012 Apr;50:255-63. | ||||
| REF 12 | Antiangiogenic effect of dual/selective alpha(5)beta(1)/alpha(v)beta(3) integrin antagonists designed on partially modified retro-inverso cyclotetr... J Med Chem. 2010 Jan 14;53(1):106-18. | ||||
| REF 13 | Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists. J Med Chem. 1997 Aug 29;40(18):2843-57. | ||||
| REF 14 | Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: design of potent and specific 3,9-diazaspiro[5.5]undecanes. Bioorg Med Chem Lett. 2001 May 21;11(10):1289-92. | ||||
| REF 15 | Isoxazolines as potent antagonists of the integrin alpha(v)beta(3). J Med Chem. 2000 Jan 13;43(1):27-40. | ||||
| REF 16 | Synthesis and assay of retro-alpha41 integrin-targeting motifs. Eur J Med Chem. 2014 Feb 12;73:225-32. | ||||
| REF 17 | Modulation of alphavbeta1- and alpha5beta1-integrin-mediated adhesion by dehydro-beta-amino acids containing peptidomimetics. Eur J Med Chem. 2013 Aug;66:258-68. | ||||
| REF 18 | Inhibition of cancer cell adhesion by heterochiral Pro-containing RGD mimetics. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2329-33. | ||||
| REF 19 | 2-Acylimino-3H-thiazoline derivatives: a novel template for platelet GPIIb/IIIa receptor antagonists. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1031-5. | ||||
| REF 20 | Synthesis and biological evaluation of non-peptide alpha(v)beta(3)/alpha(5)beta(1) integrin dual antagonists containing 5,6-dihydropyridin-2-one sc... Bioorg Med Chem. 2007 Dec 1;15(23):7380-90. | ||||
| REF 21 | New potent and selective alphav 3 integrin ligands: Macrocyclic peptides containing RGD motif synthesized by sortase A-mediated ligation. Bioorg Med Chem Lett. 2017 May 1;27(9):1911-1913. | ||||
| REF 22 | Towards dual antithrombotic compounds - balancing thrombin inhibitory and fibrinogen GPIIb/IIIa binding inhibitory activities of 2,3-dihydro-1,4-benzodioxine derivatives through regio- and stereoisomerism. Eur J Med Chem. 2013 Apr;62:329-40. | ||||
| REF 23 | Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists. Bioorg Med Chem Lett. 2001 Dec 3;11(23):3019-21. | ||||
| REF 24 | Discovery and evaluation of potent, tyrosine-based alpha4beta1 integrin antagonists. Bioorg Med Chem Lett. 2000 May 1;10(9):997-9. | ||||
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