Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66252 | Target Info | |||
| Target Name | Dipeptidyl peptidase 9 (DPP-9) | ||||
| Synonyms |
Dipeptidyl peptidase-like protein 9; Dipeptidyl peptidase IX; Dipeptidyl peptidase IV-related protein 2; DPRP2; DPRP-2; DPP IX; DPLP9; DP9
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| Target Type | Clinical trial Target | ||||
| Gene Name | DPP9 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 588 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sitagliptin
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|
Approved | Compound Info | ||
| Synonyms |
486460-32-6; Januvia; Xelevia; Sitagliptan; MK-0431; UNII-QFP0P1DV7Z; Tesavel; QFP0P1DV7Z; (3R)-3-AMINO-1-[3-(TRIFLUOROMETHYL)-5H,6H,7H,8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7-YL]-4-(2,4,5-TRIFLUOROPHENYL)BUTAN-1-ONE; (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE; CHEBI:40237; (R)-3-AMINO-1-(3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL)-4-(2,4,5-TRIFLUOROPHENYL)BUTAN-1-ONE; Janumet; Sitagliptin phosphate; Januvia (TN); Sitagliptin (PropINN); Januvia (merck & Co); (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; (3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; Sitagliptin/atovastatin
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| Activity |
IC50 = 61900 nM
|
[1] | |||
| Compound Name |
Linagliptin
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Approved | Compound Info | ||
| Synonyms |
Ondero; BI 1356; BI-1356; Ondero (TN); BI-1356-BS; (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
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| Activity |
IC50 = 100000 nM
|
[2] | |||
| Compound Name |
Alogliptin
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Approved | Compound Info | ||
| Synonyms |
850649-61-5; UNII-JHC049LO86; alogliptina; 2-({6-[(3r)-3-Aminopiperidin-1-Yl]-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl}methyl)benzonitrile; SYR-322; JHC049LO86; (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; CHEBI:72323; AK322010; 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile; vipidia; Alogliptin [INN]; Alogliptin (SYR-322); alogliptinum; alogliptine; HSDB 8203; UNII-JHC049LO86
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
MK-3102
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Phase 3 | Compound Info | ||
| Synonyms |
Omarigliptin
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| Activity |
IC50 ~ 67000 nM
|
[3] | |||
| Compound Name |
Pyrimidine derivative 33
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Patented | Compound Info | ||
| Synonyms |
PMID25482888-Compound-67
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
BDBM50382283
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Patented | Compound Info | ||
| Synonyms |
CHEMBL2022530; SCHEMBL15138748; BDBM50382283
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
BDBM50434165
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Patented | Compound Info | ||
| Synonyms |
CHEMBL2385271; SCHEMBL15129912; BDBM50434165
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|
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
BDBM50434164
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|
Patented | Compound Info | ||
| Synonyms |
CHEMBL2385272; SCHEMBL15129855; BDBM50434164
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
CRWCYVOHVXAEMF-LBPRGKRZSA-N
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Patented | Compound Info | ||
| Synonyms |
CHEMBL2385270; SCHEMBL15138926; CRWCYVOHVXAEMF-LBPRGKRZSA-N; BDBM50434166; (S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)-6-fluoroquinoline-4-carboxamide
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| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
US8470836, 6
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Patented | Compound Info | ||
| Synonyms |
SCHEMBL13099347; CHEMBL3644787; BDBM97579; US8470836, 6
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
US8470836, 8
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Patented | Compound Info | ||
| Synonyms |
SCHEMBL13099353; CHEMBL3644788; BDBM97581; US8470836, 8
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| Activity |
IC50 ~ 130000 nM
|
[6] | |||
| Compound Name |
TAK-100
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Discontinued in Phase 1 | Compound Info | ||
| Synonyms |
CHEMBL1672127
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| Activity |
IC50 = 60000 nM
|
[7] | |||
| Compound Name |
N4-(4-chlorobenzyl)-2,4-diaminobutanoylpiperidine
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Investigative | Compound Info | ||
| Synonyms |
DNVZYSMOLXCOLY-HNNXBMFYSA-N; UAMC00039; CHEMBL98869; SCHEMBL6824340; GTPL6538; ZINC13561228; BDBM50146972; NCGC00379239-01; 1-[(S)-2-Amino-4-[(4-chlorobenzyl)amino]butyryl]piperidine; (S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1-yl)butan-1-one; (2S)-2-amino-4-[(4-chlorophenyl)methylamino]-1-piperidin-1-ylbutan-1-one; 2-(S)-Amino-4-(4-chloro-benzylamino)-1-piperidin-1-yl-butan-1-one
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| Activity |
IC50 = 76600 nM
|
[8] | |||
| Compound Name |
(2S,4S)-1-(2-((1,1-Dimethyl-3-oxo-3-(1-pyrrolidinyl)propyl)amino)acetyl)-4-fluoro-2-pyrrolidinecarbonitrile
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Investigative | Compound Info | ||
| Synonyms |
DBPR-108; DBPR108; UNII-E329HG23ZT; E329HG23ZT; CHEMBL1082462; SCHEMBL2401277; BDBM50320120; ZINC43207516; CS-3825; NCGC00485889-01; HY-12528; Q27276810
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(1H-imidazol-5-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233567; SCHEMBL15129888; BDBM50009333
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(2S)-1-[(2S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243248
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
CID 44123747
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819090; SCHEMBL162310; BDBM50351402
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-5-methylquinoline-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233835; SCHEMBL15129783; BDBM50009360
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-(5-Trifluoromethyl-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242966; SCHEMBL3395102; BDBM50326379
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-methyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251404; BDBM50222487
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|
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| Activity |
IC50 = 50000 nM
|
[12] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-7-phenylquinoline-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233836; SCHEMBL15130008; BDBM50009332
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-((1r,4S)-4-(5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)cyclohexyl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL235198; CHEMBL235199; BDBM50221969; BDBM50221976
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| Activity |
IC50 = 50000 nM
|
[13] | |||
| Compound Name |
1-[6-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyridin-3-yl]-4-phenylmethoxypyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011535; BDBM50379790
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
1-Isoleucyl-1,2,5,6-tetrahydropyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL452470; BDBM50243552; (2S,3S)-2-amino-1-(5,6-dihydropyridin-1(2H)-yl)-3-methylpentan-1-one
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243402; SCHEMBL3393551; BDBM50326375
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 56; CHEMBL373268; BDBM11954
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| Activity |
IC50 = 50000 nM
|
[15] | |||
| Compound Name |
(3R,4R)-1-Pyrido[2,3-b]pyrazin-6-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL231092
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| Activity |
IC50 = 50000 nM
|
[16] | |||
| Compound Name |
(2s,4s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4-fluoropyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243126; SCHEMBL3393518; BDBM50326390
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(3-chloropyrrolidin-1-yl)-3-methylpentan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL460887; BDBM50243556
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(5-iodoisoindolin-2-yl)-3-methylpentan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL508193; BDBM50243080
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| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-(5-Chloro-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242939; SCHEMBL3395629; BDBM50326377
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| Activity |
IC50 ~ 50000 nM
|
[10] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)-5-phenylquinoline-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233838; SCHEMBL15129619; BDBM50009362; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-5-phenylquinoline-4-carboxamide
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-benzyl-3,5-dimethyl-1,2-oxazole-4-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683093; BDBM50338459
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| Activity |
IC50 = 51000 nM
|
[18] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683104; BDBM50338470; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylnicotinamide
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| Activity |
IC50 = 51000 nM
|
[18] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL402496; BDBM50222480
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| Activity |
IC50 = 51000 nM
|
[12] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(2H-tetrazol-5-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL195378
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| Activity |
IC50 = 52000 nM
|
[19] | |||
| Compound Name |
(3R)-3-Amino-1-[(5R,8R)-5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536311
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| Activity |
IC50 = 52000 nM
|
[20] | |||
| Compound Name |
(3R)-3-Amino-1-[(6S)-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL557990
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| Activity |
IC50 = 53000 nM
|
[20] | |||
| Compound Name |
(3R)-3-Amino-1-[(4R)-4-methyl-6-(trifluoromethyl)-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021529
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| Activity |
IC50 = 53000 nM
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[20] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,2-dimethylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683100; BDBM50338466; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylisobutyramide
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| Activity |
IC50 = 53000 nM
|
[18] | |||
| Compound Name |
(R)-3-Amino-1-((R)-8-(cyclopropylmethyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL400752; BDBM50221451
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| Activity |
IC50 = 54000 nM
|
[21] | |||
| Compound Name |
(3R)-3-Amino-1-[5,5-dimethyl-3-(trifluoromethyl)-6,8-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL536765
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| Activity |
IC50 = 54000 nM
|
[20] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-benzylmethanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683096; BDBM50338462
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| Activity |
IC50 = 55000 nM
|
[18] | |||
| Compound Name |
3-[3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]-1,4-dihydro-1,2,4-triazol-5-one;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL195905
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| Activity |
IC50 = 56000 nM
|
[19] | |||
| Compound Name |
N-[[(2S,3As,7aS)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-2,3,3a,4,5,6,7,7a-octahydroindol-2-yl]methyl]-1,1,1-trifluoromethanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357782; BDBM50037682
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| Activity |
IC50 = 56720 nM
|
[22] | |||
| Compound Name |
(3R,4R)-1-(2-Cyclopropyl-3-methylimidazo[4,5-b]pyridin-5-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389804
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| Activity |
IC50 = 57000 nM
|
[16] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(3-cyanophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL190269
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| Activity |
IC50 = 57000 nM
|
[23] | |||
| Compound Name |
4-[3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]-1,3-dihydroimidazol-2-one;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL364057
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| Activity |
IC50 = 57000 nM
|
[19] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpyridine-3-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683090; BDBM50338456; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylpyridine-3-sulfonamide
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| Activity |
IC50 = 57000 nM
|
[18] | |||
| Compound Name |
(2S,4S)-1-[(2S)-2-Amino-3-(4-nitrophenyl)propanoyl]-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093906; BDBM50443734
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 58000 nM
|
[24] | |||
| Compound Name |
(3R,4R)-1-Pyrimidin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL427259
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[16] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-(2,4-difluorophenyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389599; BDBM50210668
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 58000 nM
|
[25] | |||
| Compound Name |
CID 16035094
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259198; BDBM50375032; (2S,4S,5S)-2-N-(cyanomethyl)-2-N,4-N,4-N,5-tetramethylpyrrolidine-2,4-dicarboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[26] | |||
| Compound Name |
N-[3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]-1,1,1-trifluoromethanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192117
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[19] | |||
| Compound Name |
(R)-2-(2,5-Difluorophenyl)-1-(1-(methylsulfonyl)piperidin-4-yl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683130; BDBM50338424
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[18] | |||
| Compound Name |
Ethyl N-[5-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-fluoro-1-methyl-2-oxopyridin-4-yl]carbamate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438265
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[27] | |||
| Compound Name |
(2R,3R)-6,8-Difluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558253
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[28] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(2R,3R)-6,7,8-trifluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562530
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[28] | |||
| Compound Name |
1-[3-(Aminomethyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]piperazine-2,5-dione;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3897109; CHEMBL3142227
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[29] | |||
| Compound Name |
4-Amino-N-[4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682979; BDBM50338445; trans-4-amino-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[18] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-4-pyrrolidin-1-ylbutane-1,4-dione;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191258
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[23] | |||
| Compound Name |
(3R)-3-Amino-1-[5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536089
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[20] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682975; BDBM50338441
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[18] | |||
| Compound Name |
(R)-2-Amino-3-mercapto-1-(pyrrolidin-1-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459159; BDBM50243454
Click to Show/Hide
|
||||
| Activity |
IC50 = 62400 nM
|
[8] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-ethyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398492; BDBM50222488
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[12] | |||
| Compound Name |
(R)-3-Amino-1-((R)-8-(cyclopropylfluoromethyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249945; BDBM50221445
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[21] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]cyclohexyl]-4-methoxybenzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245380
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[30] | |||
| Compound Name |
N-[(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-7-yl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561793
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[28] | |||
| Compound Name |
cis-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683098; CHEMBL1683099; BDBM50338464; BDBM50338465; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[18] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-{3-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 45; CHEMBL426469; BDBM11943
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[15] | |||
| Compound Name |
(2S,4S)-4-Fluoro-1-(2-((1S,5R,6s)-3-(5-(trifluoromethyl)pyridin-2-yl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL480324; BDBM50251465
Click to Show/Hide
|
||||
| Activity |
IC50 = 63200 nM
|
[31] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-ethyl-3,5-dimethyl-1,2-oxazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683092; BDBM50338458
Click to Show/Hide
|
||||
| Activity |
IC50 = 64000 nM
|
[18] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 46; CHEMBL197413; BDBM11944
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[15] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxo-4-pyrrolidin-1-ylbutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190466
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methylsulfanylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192365
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[19] | |||
| Compound Name |
(3R,4R)-1-Pyrimidin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230984
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[16] | |||
| Compound Name |
((2S,4R)-4-Aminopyrrolidin-2-yl)(isoindolin-2-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452520; BDBM50243316
Click to Show/Hide
|
||||
| Activity |
IC50 = 67800 nM
|
[17] | |||
| Compound Name |
(S)-2-Amino-4-methyl-1-(pyrrolidin-1-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453574; SCHEMBL7817249; BDBM50243408; ZINC11960880; (2S)-1-Pyrrolizino-2-amino-4-methyl-1-pentanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 68100 nM
|
[8] | |||
| Compound Name |
(2S,3S)-3-Amino-2-(4''-fluorobiphenyl-4-yl)-4-((S)-3-fluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237119; SCHEMBL5251559; BDBM50221967
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[13] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191067
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[30] | |||
| Compound Name |
(2S,3As,6aS)-1-[(3R)-3-amino-4-(2-methylphenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330064; BDBM50098991
Click to Show/Hide
|
||||
| Activity |
IC50 = 70460 nM
|
[32] | |||
| Compound Name |
(2R,3R)-7-Fluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552071
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[28] | |||
| Compound Name |
2-[4-[[[(4R)-3-[3-Amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183060
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[33] | |||
| Compound Name |
(R)-3-Amino-4-(4-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243231; BDBM50210660
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[25] | |||
| Compound Name |
(1S,2R,5S)-5-(2-Cyclopropyl-5H-pyrrolo[3,4-d]pyrimidin-6(7H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233563; SCHEMBL1528614; BDBM50212928
Click to Show/Hide
|
||||
| Activity |
IC50 = 72300 nM
|
[34] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-thiophen-3-ylpropanoyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127980; BDBM50449227
Click to Show/Hide
|
||||
| Activity |
IC50 = 72400 nM
|
[35] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(2-(4-fluorophenyl)-1-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398661; BDBM50222482
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[12] | |||
| Compound Name |
(2R,3R)-7-Methoxy-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550598
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[28] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[2-(trifluoromethyl)imidazo[1,2-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389803
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[16] | |||
| Compound Name |
1-Pentanone, 2-amino-3-methyl-1-(1-piperidinyl)-, (2S,3S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL83418; 1-(L-Ile-)Piperidine; SCHEMBL16578291; BDBM50243497; ZINC11959236; (2S,3S)-2-amino-3-methyl-1-(piperidin-1-yl)pentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[8] | |||
| Compound Name |
3-Amino-N-[4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683102; BDBM50338468; trans-3-amino-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylpropanamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[18] | |||
| Compound Name |
(S)-2-Amino-3-(4-hydroxyphenyl)-1-(pyrrolidin-1-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL511346; SCHEMBL14390395; BDBM50243456; (2S)-1-Pyrrolizino-2-amino-3-(4-hydroxyphenyl)-1-propanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 76900 nM
|
[8] | |||
| Compound Name |
trans-(R)-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683121; BDBM50338415
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[18] | |||
| Compound Name |
(R)-Ethyl 7-(3-amino-4-(2,5-difluorophenyl)butanoyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389600; BDBM50210651
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 78000 nM
|
[25] | |||
| Compound Name |
(R)-Ethyl 7-(3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233686; SCHEMBL5497876; BDBM50210666
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[25] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL366173
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(3,5-difluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191812
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[19] | |||
| Compound Name |
(2R,3R)-8-Fluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560669
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[28] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(3,4-difluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190217
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[23] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-1,2-oxazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683106; BDBM50338472; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylisoxazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[18] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(2R,3R)-8-(trifluoromethyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550801
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[28] | |||
| Compound Name |
(2S,3S)-2-Amino-3-methyl-1-(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453199; BDBM50243083
Click to Show/Hide
|
||||
| Activity |
IC50 = 82800 nM
|
[17] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(4-chloroquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425895; BDBM50440472
Click to Show/Hide
|
||||
| Activity |
IC50 = 84500 nM
|
[4] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-ethylmethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683095; BDBM50338461
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[18] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237336; SCHEMBL5251423; BDBM50221977; (2S,3S)-2-amino-3-(4''-fluorobiphenyl-4-yl)-1-((S)-3-fluoropyrrolidin-1-yl)butan-1-one; (2S,3S)-2-amino-3-(4''-fluoro-biphenyl-4-yl)-1-((S)-3-fluoro-pyrrolidin-1-yl)-butan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[13] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-benzylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683111; BDBM50338404
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[18] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189881
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[30] | |||
| Compound Name |
(2S)-2-[4-[[[(2S)-1-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445949
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 86000 nM
|
[36] | |||
| Compound Name |
(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364102
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[33] | |||
| Compound Name |
(3R)-3-Amino-1-(4-ethyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250204; BDBM50222468
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[12] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[(4-fluorophenyl)-hydroxymethyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536536
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[20] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228311
Click to Show/Hide
|
||||
| Activity |
IC50 = 90000 nM
|
[16] | |||
| Compound Name |
(3R,4R)-1-(3-Ethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390080
Click to Show/Hide
|
||||
| Activity |
IC50 = 91000 nM
|
[16] | |||
| Compound Name |
cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)cyclohexyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681802; CHEMBL1683115; BDBM50338408; BDBM50338409
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[18] | |||
| Compound Name |
(3S)-1-[(2S,3S)-2-Amino-3-(4-fluorophenyl)-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365575; SCHEMBL5364475
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(5-azidoisoindolin-2-yl)-3-methylpentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL487432; BDBM50243082
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[17] | |||
| Compound Name |
DPP-4 ligand 3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL427261; BDBM15561
Click to Show/Hide
|
||||
| Activity |
IC50 = 98000 nM
|
[25] | |||
| Compound Name |
(R)-3-Amino-1-((S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251376; BDBM50221455
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(R)-3-Amino-4-(2-chloro-4,5-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233058; BDBM50210643
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(2,5-difluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191486
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
CID 53312239
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329699; SCHEMBL12518740; BDBM50101332
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]acetamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245971
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
N-[4-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL193887
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(3R)-3-Amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[3,4-d][1,3]oxazol-5-yl}-4-(2,5-difluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
oxazolopiperidine 77; CHEMBL197082; BDBM11975
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(3R,4R)-1-(3-Methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231497
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-2-(4-imidazo[1,2-a]pyridin-6-ylphenyl)-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378673
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
2-[[3-Methyl-2-oxo-7-(piperidin-4-ylamino)imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329690; BDBM50102859
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385280; SCHEMBL15129566; BDBM50434189
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxo-4-piperidin-1-ylbutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190923
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-(4,4,4-trifluorobutyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683112; BDBM50338405; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-(4,4,4-trifluorobutyl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329627; SCHEMBL12518747; BDBM50102865
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoroazetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364355
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(2-methylphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372472
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209710
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1,4-dimethylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425039
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(R)-3-Amino-4-(2-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388475; BDBM50210663
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-(cyclopropylmethyl)pyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL383323
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(S)-2,6-Diamino-1-(3,4-dihydroquinolin-1(2H)-yl)hexan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL449318; BDBM50243606
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,3,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243872; SCHEMBL1409245; BDBM50210655
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(S)-2-Amino-1-(pyrrolidine-1-yl)-3-(1H-indole-3-yl)propane-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452029; CTK1B8962; DTXSID20444841; BDBM50243409; ZINC11754554; MCULE-6977406476; (2S)-2-amino-3-(1H-indol-3-yl)-1-pyrrolidin-1-ylpropan-1-one; (S)-2-amino-3-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one; Pyrrolidine, 1-[(2S)-2-amino-3-(1H-indol-3-yl)-1-oxopropyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-morpholin-4-yl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371347
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,3,6-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394833; BDBM50210653
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(S)-1-((2S,4R)-4-(2-(Isoindolin-2-yl)-2-oxoethyl)-5-oxopyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243403; SCHEMBL3395715; BDBM50326376
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385277; SCHEMBL15129564; BDBM50434159
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(3R)-3-Amino-1-[(8R)-8-[cyclopropyl(hydroxy)methyl]-2-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404210; BDBM50221440
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
4-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191906
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210621
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
(3R,4R)-1-Pyrido[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231194
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S,3S)-3-Amino-N-ethyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189067
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2-(trifluoromethyl)phenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397744; BDBM50210644
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-3-[(6-bromoquinolin-2-yl)methyl]-1-but-2-ynylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425888; BDBM50440465
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-chloroquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425889; BDBM50440464
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4213950
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454658
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
6-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385301; SCHEMBL15138744; BDBM50434168
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(3R,4R)-1-[3-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228312
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-(2-hydroxyethyl)-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190593
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220301; alpha-amino acid pyrrolidide 17; BDBM11655
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(R)-1-((R)-8-((1H-1,2,4-Triazol-1-yl)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400068; BDBM50221444
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(R)-3-Amino-4-(2-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388431; BDBM50210661
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-(hydroxymethyl)-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203169
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-ethylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683110; BDBM50338476
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-pyridin-4-ylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233561; SCHEMBL15129716; BDBM50009342
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(S)-Benzyl 5-amino-6-(3,4-dihydroquinolin-1(2H)-yl)-6-oxohexylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512705; BDBM50243647
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2S,4S)-1-{(2S,4S)-4-[2-(5-Chloro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243127; SCHEMBL16509426; BDBM50326391
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438992
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-chloro-4-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203267
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(R)-3-Amino-4-(3,4-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388433; BDBM50210656
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-(3-pyridin-1-ium-1-ylphenyl)phenyl]butanamide;2,2,2-trifluoroacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL541919
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
alpha-Amino acid pyrrolidide 29
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219278; BDBM11667
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
Chembl4207996
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(R)-3-Amino-4-(4-chloro-2,5-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232845; BDBM50210669
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-[4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2h)-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243061; SCHEMBL3399417; BDBM50326386
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(R)-3-Amino-1-(3-(difluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390240; SCHEMBL18104703; BDBM50210649
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
7-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-chlorophenyl)methyl]-3-methylimidazo[4,5-b]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329636; SCHEMBL12518750; BDBM50102839
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1,6-dimethylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206252
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-(4-fluorophenyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233472; BDBM50210672
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
US9346814, Cmpd No 29 Example 34
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3929674; SCHEMBL15138774; BDBM233323
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
8-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385275; SCHEMBL16267174; BDBM50434161; N-[2-[[(2S)-2alpha-Cyanopyrrolidine]-1-yl]-2-oxoethyl]-8-bromoquinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
1-Benzyl-7-but-2-ynyl-3-methyl-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616904
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluoro-phenyl)-1-[3-(4-fluoro-benzyl)-2-trifluoromethyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl]-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400761; BDBM50222479
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378597
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
3-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329634; SCHEMBL12518770; BDBM50102842
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
US9051329, Example 5
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687980; SCHEMBL14554341; BDBM162380
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
Chembl4215849
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454649
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyrazolo[1,5-a]pyrimidin-5-ylphenyl)butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210459
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191327
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-methyl-1,3-oxazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233569; SCHEMBL15129604; BDBM50009349
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-phenylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362973
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-(hydroxymethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233684; BDBM50210670
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-[(2,4-difluorophenyl)sulfonylamino]cyclohexyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(3R,4R)-1-Pyrazino[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231196
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(R)-3-Amino-1-(2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399499; SCHEMBL5228197; BDBM50221447
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375414; alpha-amino acid pyrrolidide 13; BDBM11651
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-2-Amino-3-phenyl-1-(1,3-thiazolidin-3-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
thiazolidide 4; CHEMBL192983; BDBM11466
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL377724
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(3-methylbut-2-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616918
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MK-0626; CHEMBL537869
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
CID 53311141
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329638; SCHEMBL12518869; BDBM50102847
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
CID 53311071
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329639; SCHEMBL12518871; BDBM50102846
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S)-1-({(2S,4S)-4-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243028; SCHEMBL3393509; BDBM50326384
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 47; CHEMBL195721; BDBM11945
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(3-(trifluoromethyl)phenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243227; BDBM50210659
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
Ethyl 2-[5-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-2-oxopyridin-1-yl]acetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL382674
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
Methyl (2S,3S)-3-amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372004
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-2-(4-Acetamidophenyl)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245970
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(2R,3R)-7-(trifluoromethyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552479
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-6-(trifluoromethoxy)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385302; SCHEMBL15138749; BDBM50434167
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-1-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 57; CHEMBL193802; BDBM11955
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)-3-hydroxyquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385298; SCHEMBL15129988; BDBM50434171; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-3-hydroxyquinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2R,3R)-6-Fluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537962
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,5-dimethyl-1H-pyrazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683086; BDBM50338452
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[3-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230449
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-5-methylhexan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219371
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220021; alpha-amino acid pyrrolidide 15; BDBM11653
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
N-[4-[5-[(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-4-oxobutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375146
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3R)-3-Amino-1-[(6R)-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553787
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-[3-(tetrazol-1-yl)phenyl]phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191473
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2R,3R)-7-Ethylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560192
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
(2S,3S)-3-{3-[4-(Methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-oxo-1-pyrrolidin-1-ylbutan-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374936; alpha-amino acid pyrrolidide 20; BDBM11658; DB07067; (2S,3S)-2-amino-3-[3-(4-methanesulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one; Q27095982
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362976
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]butanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086264; BDBM50242264
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[42] | |||
| Compound Name |
2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2S)-cyanopyrrolidine 4; CHEMBL201644; SCHEMBL1069325; BDBM11719; (2S)-Cyanopyrrolidine analogue 21d
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210974
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(benzenesulfonamido)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245772
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,5-dimethyl-1,2-oxazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683088; BDBM50338454; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N,5-dimethylisoxazole-4-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[(2R)-1-[(2S)-2-Cyanopyrrolidin-1-yl]-3-hydroxy-1-oxopropan-2-yl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233538; SCHEMBL15129756; BDBM50009313
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
US9346814, Cmpd No 27 Example 32
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3900683; BDBM233322
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
trans-(R)-2-(2,5-Difluorophenyl)-1-(4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683113; CHEMBL1683114; BDBM50338406; BDBM50338407; cis-(R)-2-(2,5-difluorophenyl)-1-(4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl)ethanamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3-chlorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192781
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-2-Amino-3-methyl-1-(4-methylisoindolin-2-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469892; BDBM50242853
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-methoxy-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL380496
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(3R)-3-Amino-1-[8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536999
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-fluoroquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425890; BDBM50440463
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxobenzimidazol-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329633; BDBM50102852
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190752
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243153; SCHEMBL3395679; BDBM50326392
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,3,5-trimethyl-1,2-oxazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683091; BDBM50338457
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(2-methoxyphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365953
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2R,3R)-8-Methylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549645
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424687
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[(5S)-3-oxo-5-(hydroxymethyl)piperazino]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616896
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(trifluoromethyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL194489
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385281; SCHEMBL15138980; BDBM50434188; (S)-N-(2-(2-cyanopyrrolidine-1-yl)-2-oxoethyl)quinoline-4-carboxamide; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[5-(2,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220404
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
US9051329, Example 2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687978; SCHEMBL14554395; BDBM162377
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-piperazin-1-yl-1-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616909
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(1,3-thiazol-2-yl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192396
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
7-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-cyanophenyl)methyl]-3-methyl-2-oxoimidazo[4,5-b]pyridine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329700; BDBM50102843
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(3R)-3-Amino-1-[8-ethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556606
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-[[7-[(3S)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329694; BDBM50102849
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
alpha-Amino acid pyrrolidide 21
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218911; BDBM11659
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3R)-1-(4-(4-Fluorobenzyl)-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250285; SCHEMBL8311489; BDBM50222484
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
7-But-2-ynyl-8-ethoxy-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616893
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-methoxyquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425892; BDBM50440461
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-[3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370072
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-b]pyridin-4-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 65; CHEMBL364461; BDBM11963
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-3,5-dimethyl-N-(4,4,4-trifluorobutyl)-1,2-oxazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683094; BDBM50338460
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL426335; alpha-amino acid pyrrolidide 10; BDBM11648
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
CID 89705098
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233575; SCHEMBL15129785; BDBM50009357; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-[1,2,4]triazolo[1,5-a]pyrimidine-7-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1H-pyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381145
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(1,1,2,2,2-pentafluoroethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 55; CHEMBL366166; BDBM11953
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(1,1-dioxo-1,3-thiazolidin-3-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365967
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(3R)-3-Amino-1-[3-(trifluoromethyl)-8-[[2-(trifluoromethyl)phenyl]methyl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536090
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(2S,3S)-2-Amino-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3-(4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375442
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3R)-3-Amino-1-[8-prop-2-enyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537000
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(2R,3R)-8-(trifluoromethoxy)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563155
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-3-(1H-benzimidazol-2-ylmethyl)-1-but-2-ynylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425885; BDBM50440468
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-3-benzyl-1-but-2-ynylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425883; BDBM50440470
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-[3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370033
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-pyrazolo[1,5-a]pyrimidin-5-ylphenyl)butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL208957
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-6-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL205872
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
2-[[6-[(3R)-3-Aminopiperidin-1-yl]-9-methyl-8-oxopurin-7-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329632; BDBM50102853
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3R)-2-Amino-4-(dimethylamino)-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189046
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374032; alpha-amino acid pyrrolidide 23; BDBM11661
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3R)-3-Amino-1-(1-methyl-4-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400954; BDBM50222477
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537400
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(2,5-difluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278729
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-3-Amino-N-cyclopropyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190788
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210999
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616915
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]propan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189645
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206501
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195755
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-[4-[5-[(2S,3S)-3-Amino-4-[(3R)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218776
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2R,3R)-2-Amino-N,N-dimethyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole-7-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560729
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-(4-fluoropiperidin-1-yl)-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202634
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
trans-4-((4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)(methyl)amino)-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683103; BDBM50338469
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090635; BDBM50242274
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[42] | |||
| Compound Name |
CID 53312243
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329697; SCHEMBL13719893; BDBM50101396
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(3-methylsulfonylphenyl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370677
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-methylsulfonylphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL194437
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2r)-4-[(8r)-8-Methyl-2-(Trifluoromethyl)-5,6-Dihydro[1,2,4]triazolo[1,5-A]pyrazin-7(8h)-Yl]-4-Oxo-1-(2,4,5-Trifluorophenyl)butan-2-Amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250787; SCHEMBL21068050; BDBM50221443; DB07081; Q27095996
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
2-[(3S,5S)-5-[(2S)-2-Cyanopyrrolidine-1-carbonyl]-2-oxopyrrolidin-3-yl]-N-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243093; SCHEMBL3395680; BDBM50326389; 2-[(3s,5s)-5-{[(2s)-2-cyanopyrrolidin-1-yl]carbonyl}-2-oxopyrrolidin-3-yl]-n-phenylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-5-methoxy-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329695; BDBM50102848
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
US9346814, Ref. Cmpd No 4
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3896942; BDBM233325
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,3S)-2-Amino-N-cyclopentyl-3-methylpentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N-Cyclopentyl L-isoleucinamide; CHEMBL457550; N-Cyclopentylisoleucinamide; BDBM50243557; ZINC11959231; K-5714
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
3,7-Dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616914
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
8-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385274; SCHEMBL15138756; BDBM50434162
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-2-oxo-3H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329626; SCHEMBL12518746; BDBM50102856
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
Sitagliptin Analog 13
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL725863; Triazolopiperazine Analogue 25; CHEMBL216186; BDBM11160; 4-Desfluoro Sitagliptin; Sitagliptin EP Impurity B
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-4-methyl-1,3-thiazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233568; SCHEMBL15129841; BDBM50009348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(tetrazol-1-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195739
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(3R,4R)-1-Isoquinolin-1-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231091
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(R)-3-Amino-1-(2-phenyl-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL401057; BDBM50221448
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-4H,5H,6H,7H-pyrido[4,3-c][1,2]oxazol-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
isoxazolopiperidine 59; CHEMBL363606; BDBM11957
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
alpha-Amino acid pyrrolidide 28
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216835; BDBM11666
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
1-(Quinoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616902; BDBM50277300
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
CID 53312238
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329701; SCHEMBL12518737; BDBM50102841
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3R)-2-Amino-3-methyl-1-(5-(trifluoromethyl)isoindolin-2-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL488225; BDBM50243131
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
2-[(3R)-3-Aminopiperidin-1-yl]-3-[(2-chloro-5-fluorophenyl)methyl]-5-methyl-4-oxoimidazo[4,5-c]quinoline-7-carboxylic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147070
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[44] | |||
| Compound Name |
(R)-3-Amino-4-(3-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232262; BDBM50210662
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-isobutyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429829; BDBM50222478
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
US9346814, Ref Cmpd No 10
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934376; BDBM233329
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-ethylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206792
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(3R,4R)-1-Pteridin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231195
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191823
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,6-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394834; BDBM50210658
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(R)-3-Amino-4-(3-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243230; BDBM50210650
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(3s,5s)-3-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243154; SCHEMBL3395728; BDBM50326393; (3S,5S)-3-[2-(1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-(1,3-thiazolidine-3-carbonyl)pyrrolidin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
7-But-2-ynyl-1-[[2-(hydroxymethyl)-1,3-thiazol-4-yl]methyl]-3-methyl-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-4-hydroxybutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365567
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(1S,2R,5S)-5-(3-(Trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234635; BDBM50210527
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(acetylamino)ethylamino]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616898
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxo-5-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329698; SCHEMBL12518805; BDBM50101385
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
CID 53311222
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329692; SCHEMBL12518751; BDBM50102851
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-5-hydroxypentan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220357
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536312
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(2S,3S)-3-Amino-2-(4-(1,8a-dihydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)-4-((S)-3-fluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459357; BDBM50276598
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-methylimidazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233564; SCHEMBL15129945; BDBM50009345
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2s)-1-({(2s,4s)-5-Oxo-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243091; SCHEMBL3393495; BDBM50326387
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[4-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]phenyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616906
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-2-((1s,4R)-4-(2,6-dimethoxypyrimidin-4-yl)cyclohexyl)-N,N-dimethyl-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235004; CHEMBL235223; BDBM50221973; BDBM50221983
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(R)-3-Amino-1-(2-cyclopropyl-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248936; SCHEMBL5230936; BDBM50221441
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-1-(naphthalen-2-ylmethyl)-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616903
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(R)-3-Amino-1-(5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248743; BDBM50221450
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,2-pentafluoroethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559011
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
1-(4-Methoxyquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616901; BDBM50277301
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(R)-3-Amino-1-(3-ethyl-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233685; BDBM50210652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2H-triazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233565; SCHEMBL15139038; BDBM50009346; (S)-N-(2-(2-cyanopyrrolidine-1-yl)-2-oxoethyl)-1H-1,2,3-triazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(2-chlorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191769
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL377221
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(2-chloro-4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195862
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
alpha-Amino acid pyrrolidide 18
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218882; BDBM11656
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-5-morpholin-4-yl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329703; BDBM50102866
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
Chembl4208513
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454657
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(1,3,4-oxadiazol-2-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195667
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(R)-1-(4-(1-Amino-2-(2,5-difluorophenyl)ethyl)piperidin-1-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683129; BDBM50338423
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(2S,3S)-2-Amino-3-methyl-1-(5-(trifluoromethyl)isoindolin-2-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469679; BDBM50243078
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
5-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385300; SCHEMBL15130006; BDBM50434169
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-((1S,4r)-4-((2S,3S)-3-Amino-4-((S)-3-fluoropyrrolidin-1-yl)-4-oxobutan-2-yl)cyclohexyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237547; BDBM50221982
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]cyclohexyl]-N-methylacetamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245545
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
Imigliptin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-68UX3YT8DK; 68UX3YT8DK; CHEMBL3329696; SCHEMBL12517256; BDBM50102854; Q27264277
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxo-5-pyrrolidin-1-ylimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329702; BDBM50102868
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-3-(benzo[f]quinolin-3-ylmethyl)-1-but-2-ynylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425887; BDBM50440466
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-(3,4-dimethoxyphenyl)pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233559; SCHEMBL15129796; BDBM50009340
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[2-(4-pyridylcarbonylamino)ethylamino]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616899
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[7-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-yl]-N,N-dimethylacetamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556979
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(R)-1-(1-(4-Fluorobenzyl)-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-3-amino-4-(2,5-difluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248788; BDBM50222483
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopyrrolidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329641; SCHEMBL13719188; BDBM50102844
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[(4-methoxyphenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539352
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(2S)-N-Tert-butyl-1-[(2S,4S)-4-[2-(1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243215; BDBM50326396
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(3R)-3-Amino-1-[(8R)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558779
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
US9051329, Example 1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687977; SCHEMBL14554328; US9051329, Example 4; BDBM162376
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3-phenyl-1,2,4-oxadiazol-5-yl)-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
alpha-amino acid pyrrolidide 8; CHEMBL216854; BDBM11646
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3R)-3-Amino-4-(3,4-difluorophenyl)-1-(3-ethyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537844
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
1-Isoleucylazetidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461496; CTK0A1560; DTXSID80442363; BDBM50243496; (2S,3S)-2-amino-1-(azetidin-1-yl)-3-methylpentan-1-one; Azetidine, 1-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
US9346814, Ref. Cmpd No 3 (Example 5)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3937692; SCHEMBL16267642; BDBM233321; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-propan-2-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616913
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-isobutyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400278; BDBM50222472
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(3R)-3-Amino-1-[8-(pyridin-2-ylmethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(3R)-3-Amino-4-(3,4-difluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558196
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(5-tert-butylisoindolin-2-yl)-3-methylpentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469678; BDBM50243077
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
IP5Pms7gwy
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-IP5PMS7GWY; CHEMBL389151; SCHEMBL12323237; BDBM50210665; Sitagliptin phosphate impurity C [EP]; 5-Desfluoro Sitagliptin; Sitagliptin EP Impurity C
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)-1-naphthamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243374; SCHEMBL715747; BDBM50326374; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-[(6S)-1,4-diazabicyclo[4.3.0]nonane-4-yl]xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616891
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(4-bromo-2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374703; alpha-amino acid pyrrolidide 25; BDBM11663
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
2-(4-Cyanophenyl)-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233560; SCHEMBL15129643; BDBM50009341
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(2,4-difluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363584
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-4-(trifluoromethoxy)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682980; BDBM50338446
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]cyclohexyl]-3-fluoro-N-methylbenzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246374
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(4-chloro-2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370734
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209064
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3,5-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195270
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-(4-pyridin-1-ium-1-ylphenyl)phenyl]butanamide;2,2,2-trifluoroacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552503
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[23] | |||
| Compound Name |
(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[[4-(trifluoromethyl)phenyl]methyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL435882
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
2-[[7-(3-Aminoazetidin-1-yl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329640; SCHEMBL12518748; BDBM50102845
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
4-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329635; SCHEMBL12517523; BDBM50102840
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(3R)-3-Amino-1-(2-benzoyldiazinan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL535180
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[46] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,2-pentafluoroethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 53; CHEMBL370269; BDBM11951
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
7-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methylpyrimido[1,2-b]pyridazin-4-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231397
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidine-1-yl)-2-oxoethyl)piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233562; SCHEMBL15129577; BDBM50009343; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]piperidine-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(3-hydroxypyrrolidin-1-yl)-3-methylpentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL503809; BDBM50243553; AKOS012240510
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 50; CHEMBL194979; BDBM11948
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(7-fluoroquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425894; BDBM50440459
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-3-ylmethyl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616911
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
7-Benzyl-1-[(4-methoxyquinazolin-2-yl)methyl]-3-methyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616920
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2R,3R)-7-Methyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562953
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
(2S,3R)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-4-(tetrazol-1-yl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL359581
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-(1,4-dimethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250006; BDBM50222481
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
US9051329, Example 7
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687982; SCHEMBL14554312; BDBM162382
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616895
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251205; BDBM50222475
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(3R)-3-Amino-1-[8-benzyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539350
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(2S,3S)-3-Amino-1-(azetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]butane-1,4-dione;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188043
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-3-hydroxy-2-methylquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385294; SCHEMBL15138746; BDBM50434175
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(11R,12R)-11-(2,4,5-Trifluorophenyl)-1,5,8-triazatricyclo[7.4.0.02,7]trideca-2(7),3,5,8-tetraen-12-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552068
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233554; SCHEMBL15139029; BDBM50009334
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
4-{5-[(2S,3S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butan-2-yl]-1,2,4-oxadiazol-3-yl}benzene-1-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219602; alpha-amino acid pyrrolidide 19; BDBM11657
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(R)-3-Amino-1-((R)-8-(cyclopropyl(hydroxy)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400722; BDBM50221446
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243216; BDBM50326397
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Sitagliptin Hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-IEL0A0OS7E; IEL0A0OS7E; Sitagliptin HCl; CHEMBL539077; SCHEMBL1533793; Q27280690
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
1-(4-Methylquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616890; SCHEMBL1772451; BDBM50277311; 1-[(4-Methylquinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(piperazin-1-yl)-xanthine; 7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-piperazin-1-ylpurine-2,6-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-[[4-(trifluoromethoxy)phenyl]sulfonylamino]cyclohexyl]butanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397854
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(S)-4-Amino-5-oxo-5-(pyrrolidin-1-yl)pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL455542; SCHEMBL6475399; BDBM50243411; (4S)-4-Amino-5-oxo-5-pyrrolizinovaleric acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[4-(2H-tetrazol-5-yl)butyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184346
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
1-[6-[(3R)-3-Aminopyrrolidin-1-yl]pyridin-3-yl]-4-phenylmethoxypyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011537; SCHEMBL14222785; BDBM50379784
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(2R,3R)-7-Methylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559940
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[2-(trifluoromethyl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425375
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(1S,2R,5R)-5-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232191; SCHEMBL13938022; BDBM50210526
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
N-[4-[5-[(2S,3S)-3-Amino-4-oxo-4-pyrrolidin-1-ylbutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386812
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216855; alpha-amino acid pyrrolidide 26; BDBM11664
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220249; alpha-amino acid pyrrolidide 16; BDBM11654
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-(pyrrolidine-1-carbonyl)pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243183; SCHEMBL16502392; BDBM50326394
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-bromo-1,6-dimethylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203323
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-piperidin-1-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362930
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
6-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390241
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-2-methyl-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 58; CHEMBL197301; BDBM11956
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
1-[(4-Methoxyquinazolin-2-yl)methyl]-3,7-dimethyl-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616916
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2,4-dichlorophenyl)-1H-1,2,4-triazol-5-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218306
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(R)-3-Amino-4-(perfluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397743; BDBM50210654
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(2S,3S)-3-Amino-N-ethyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425558
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1,3-bis(but-2-ynyl)pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425882; BDBM50440471
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
7-Bromo-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385273; SCHEMBL15129949; BDBM50434163
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-2-methylquinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385293; SCHEMBL15138987; BDBM50434176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078112; BDBM50242265
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[42] | |||
| Compound Name |
Ethyl 4-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363175
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Unii-Z82X63Q1Z5
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Z82X63Q1Z5; CHEMBL3616894; Linagliptin metabolite m515(1)
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-(4,4,4-trifluorobutyl)methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683097; BDBM50338463
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
1-Isoleucylhexahydro-1H-azepine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL446007; BDBM50243498; ZINC13529436; (2S,3S)-2-amino-1-(azepan-1-yl)-3-methylpentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(R)-3-Amino-4-(4-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242811; BDBM50210645
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
Ethyl 2-[5-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-2-oxopyridin-1-yl]-2,2-difluoroacetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438258
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
6-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methyl-3H-pyrido[3,2-d]pyrimidin-4-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231395
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-methylphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191514
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
3-[(7-But-2-ynyl-3-methyl-2,6-dioxo-8-piperazin-1-ylpurin-1-yl)methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616905
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363115
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(azetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370509
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxo-N-(tetrazol-1-yl)butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188444
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-2-[4-[Acetyl(methyl)amino]cyclohexyl]-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428747
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzenesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL366031
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-ethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251405; BDBM50222486
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
2-[[7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,6-dioxopurin-8-yl]amino]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616897
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N-methoxy-N-methyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370755
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
[(2R)-1-[(2S)-3-Methyl-2-(pyridine-3-carbonylamino)butanoyl]pyrrolidin-2-yl]boronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333024; BDBM50431227
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL207348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 48; CHEMBL191805; BDBM11946
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxo-N-propan-2-ylbutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188643
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232648; BDBM50210664
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219369; alpha-amino acid pyrrolidide 11; BDBM11649
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
US9051329, Example 8
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687983; SCHEMBL14554317; BDBM162383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL435320
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3R)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372486
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 62; CHEMBL371521; BDBM11961
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methylsulfonylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370079
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 49; CHEMBL196010; BDBM11947
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(3R,4R)-1-([1,2,4]Triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231496
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
US9346814, Cmpd No 37 Example 42
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233566; SCHEMBL15129600; BDBM233324; BDBM50009347; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]-1H-1,2,4-triazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
1-(Quinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616900; BDBM50277317
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376498
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
2-[4-[Amino-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]amino]piperidin-1-yl]-N-(5-chloropyridin-2-yl)acetamide;trihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216684
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
Chembl4205581
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454656
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3-fluoro-4-phenylphenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365996
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(R)-3-Amino-1-(3-cyclopropyl-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390239; BDBM50210647
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(3R)-3-Amino-1-(4-benzyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250284; SCHEMBL8311484; BDBM50222470
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(2S,3S)-2-Amino-3-{3-[2-(difluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
alpha-amino acid pyrrolidide 9; CHEMBL216774; BDBM11647
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-2-(4-imidazo[1,2-b]pyridazin-6-ylphenyl)-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL379702
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[2-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219370; alpha-amino acid pyrrolidide 12; BDBM11650
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-N-methylacetamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246169
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
CID 53311226
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329628; SCHEMBL12517238; BDBM50102864
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(4-chlorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190454
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242967; SCHEMBL3399176; BDBM50326380
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
N-[3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263326
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S)-1-[{(2S,4S)-5-Oxo-4-(2-oxo-2-(piperidin-1-yl)ethyl)pyrrolidine-2-yl}carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243092; BDBM50326388
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
CID 53311144
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329625; SCHEMBL12517499; BDBM50102858; 2-[[7-[(3R)-3-aminopiperidin-1-yl]-3,3-dimethyl-2-oxopyrrolo[3,2-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-[2-(5-Fluoro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242940; SCHEMBL3399137; BDBM50326378
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
US9346814, Ref. Cmpd No 2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3913191; BDBM233320
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
5-Chloro-N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385299; SCHEMBL15129952; BDBM50434170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,3R)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-4-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190031
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(4-(trifluoromethyl)phenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245181; BDBM50210667
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
6-(4-{(1S,2S)-2-Amino-1-[(dimethylamino)carbonyl]-3-[(3S)-3-fluoropyrrolidin-1-YL]-3-oxopropyl}phenyl)-1H-[1,2,4]triazolo[1,5-A]pyridin-4-ium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237337; SCHEMBL14591260; BDBM50221972; DB08504; Q27097704
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(3R)-3-Amino-1-(6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557187
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-bromo-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL383651
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N',N'-dimethyl-4-oxobutanehydrazide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371588
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
1-(2-Pyridylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616910
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-(pyridin-4-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233474; BDBM50210648
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375875; alpha-amino acid pyrrolidide 14; BDBM11652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
N-[2-[(2S)-2-Cyanopyrrolidin-1-yl]-2-oxoethyl]-1,7-naphthyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233833; SCHEMBL15129791; BDBM50009358
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
Chembl4204176
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454650
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
N-[(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-7-yl]acetamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556494
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
(3R)-3-Amino-1-[(5S,8S)-5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557219
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
1-[4-(1H-Pyrazole-1-yl)benzyl]-3-methyl-7-(2-butynyl)-8-piperazinoxanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616908
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2-[(3-Methyl-2-oxo-7-piperazin-1-ylimidazo[4,5-b]pyridin-1-yl)methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329689; SCHEMBL12518806; BDBM50102861
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-[4-(Pyridine-4-yl)-piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243060; SCHEMBL3398698; BDBM50326385
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
N-(4-Quinolinoyl)glycyl-(2-cyanopyrrolidine)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3920977; SCHEMBL16267187; BDBM233328; US9346814, Ref Cmpd No 9; N-[2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl]quinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1-yl-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98762; SCHEMBL7062524; BDBM50146971
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyridin-4-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371846
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(3R)-3-Amino-1-[(8S)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557542
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[4-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389602
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-(4-fluorophenyl)pyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206172
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
2-[5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-methyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3215607
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyridin-2-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191858
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-N,4-dimethylbenzamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396168
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(3R)-3-Amino-1-(1,4-dimethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250202; SCHEMBL8312244; BDBM50222485
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209162
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(pyrazol-2-ium-1-carbonyl)phenyl]butan-1-one;2,2,2-trifluoroacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552788
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
CID 89704940
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233574; SCHEMBL15129575; BDBM50009356
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-(quinolin-2-ylmethyl)pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425886; BDBM50440467
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S,3S)-2-[4-[Acetyl(methyl)amino]phenyl]-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246168
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-fluoro-N-methylbenzamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437379
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(3R)-3-Amino-1-[(8S)-8-[(4-fluorophenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559371
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-sulfanylideneimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329629; SCHEMBL12518780; BDBM50102863
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyridin-3-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195205
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(1H-1,2,4-triazol-5-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190979
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(R)-7-(3-Amino-4-(2,4,5-trifluorophenyl)butanoyl)-N-tert-butyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233891; SCHEMBL5494170; BDBM50210671
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
1-(4-Methoxyquinazoline-2-ylmethyl)-3-methyl-7-(2-butynyl)-8-(3-oxopiperazino)xanthine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616917
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-4-cyclopropyl-3-[3-(2-fluoro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375745; SCHEMBL2896776
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
US9346814, Ref Cmpd No 8
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3914236; BDBM233327
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
(2S,4S)-4-Fluoro-1-(2-((1S,5R,6s)-3-(pyrimidin-2-yl)-3-aza-bicyclo[3.1.0]hexan-6-ylamino)acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482261; BDBM50251852
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
4-[[[(2S)-1-[3-Amino-4-(3,4-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]benzoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL182223
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210829
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
2-[[9-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]quinolin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329631; SCHEMBL13719091; BDBM50102855
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,3,4,5,6-pentafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183289
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(2-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370240
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209111
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-4-fluoro-N-methylbenzamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245969
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(2S,3S)-3-Amino-N,N-diethyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364939
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyrimidin-5-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192449
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(1R)-1-(3,4-Difluorobenzyl)-3-oxo-3-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]propylamine hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242813; 2-Desfluoro Sitagliptin; Triazolopiperazine Analogue 24; SCHEMBL2667453; BDBM11159
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-oxo-4-pyrrolidin-1-ylbutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203379
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,3S)-2-Amino-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3-(2-methyl-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219434
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
2-[[7-(1,4-Diazepan-1-yl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329691; SCHEMBL12518739; BDBM50102857
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-[methyl-(4-methylphenyl)sulfonylamino]phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429653
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(2,4-dichlorophenyl)-1,3-oxazol-2-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218254
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-8-(3-oxopiperazin-1-yl)-1-(pyridin-4-ylmethyl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616912
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(3R)-1-(8-((1H-Pyrazol-1-yl)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250351; BDBM50221442
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(3R)-3-Amino-4-(3,4-difluorophenyl)-1-(6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537625
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
1-[(4-Methoxyquinazolin-2-yl)methyl]-3-methyl-7-(4-methylpent-3-enyl)-8-(3-oxopiperazin-1-yl)purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616919
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(1S,2R,5S)-5-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-A]pyrazin-7(8H)-YL]-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233360; SCHEMBL3904882; BDBM50212927; CHEMBL233360 (15); DB07072; Q27095987
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[34] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[(2-fluorophenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(2R,3R)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549913
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191208
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
(2R)-1-[2-[2-[3-(3,4-Dimethoxyphenyl)-2-oxoimidazolidin-1-yl]ethylamino]acetyl]pyrrolidine-2-carbonitrile;oxalic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1202080
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-4H,5H,6H,7H-pyrido[3,4-d][1,3]thiazol-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
thiazolopiperidine 73; CHEMBL363375; BDBM11971
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-phenylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191933
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-methoxyphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195443
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Ethyl 3-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192425
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-({2-[(3r)-3-Aminopiperidin-1-Yl]-5-Methyl-6,9-Dioxo-5,6,7,9-Tetrahydro-1h-Imidazo[1,2-A]purin-1-Yl}methyl)-4-Fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687984; SCHEMBL14554320; Q27456296; 6AJ
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-(pyrimidin-2-ylmethyl)pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425884; BDBM50440469
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(3,5-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219382; alpha-amino acid pyrrolidide 22; BDBM11660
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3R)-3-Amino-1-[3-(1,1,2,2,2-pentafluoroethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558585
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole-7-carboxylic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[28] | |||
| Compound Name |
(S)-2-Amino-3-(1H-imidazol-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501521; SCHEMBL21794988; BDBM50243494; (2S)-1-Pyrrolizino-2-amino-3-(1H-imidazole-4-yl)-1-propanone; (2S)-2-amino-3-(1H-imidazol-5-yl)-1-pyrrolidin-1-ylpropan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[2-(trifluoromethyl)-[1,2,4]triazolo[1,5-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231293
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methoxyphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL369888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Methyl 2-[4-[[[(4R)-3-[3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186482
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[33] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191354
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Chembl4212894
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454653
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
US9051329, Example 3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687979; SCHEMBL14554368; BDBM162378
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-[[7-(3-Aminoazepan-1-yl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329688; SCHEMBL12517557; BDBM50102867
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
7-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-fluorophenyl)methyl]-3-methylimidazo[4,5-b]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329637; SCHEMBL12518867; BDBM50102838
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(2,4-difluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188096
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[23] | |||
| Compound Name |
N-[4-[5-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387333
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
CID 53311140
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329624; SCHEMBL12518870; BDBM50102860; 2-[[7-[(3R)-3-aminopiperidin-1-yl]-2-oxo-[1,3]oxazolo[5,4-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203736
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(1,1,2,2,2-pentafluoroethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 54; CHEMBL369894; BDBM11952
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(3R)-1-(8-((1H-1,2,4-Triazol-1-yl)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250353; SCHEMBL8340200; BDBM50221453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220402
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
N-((R)-1-((S)-2-Cyanopyrrolidine-1-yl)-1-oxopropan-2-yl)quinoline-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3233539; SCHEMBL15129971; BDBM50009314; N-[(2R)-1-[(2S)-2-cyanopyrrolidin-1-yl]-1-oxopropan-2-yl]quinoline-4-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[5] | |||
| Compound Name |
N-[(3R)-1-[1-[(2-Cyanophenyl)methyl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-7-yl]piperidin-3-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329693; BDBM50102850
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,1-dimethylimidazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683087; BDBM50338453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(3R)-3-Amino-1-(4-cyclopropyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248810; BDBM50222469
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
7-But-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-8-piperidin-1-ylpurine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3616892; SCHEMBL15083818
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[4-(trifluoromethyl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192980
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-methylquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425891; BDBM50440462
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S,3As,6aS)-1-[(3R)-3-amino-4-phenylbutanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330062; BDBM50098993
Click to Show/Hide
|
||||
| Activity |
IC50 = 107660 nM
|
[32] | |||
| Compound Name |
(6S)-1-[(2S)-2-Amino-4-oxo-4-[2-thiophen-2-yl-4-(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]butyl]-5,5-difluoro-6-hydroxypiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3644792; SCHEMBL13099364; BDBM97585; US8470836, 12
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 110000 nM
|
[6] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-pyridin-2-ylpropanoyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127983; BDBM50449226
Click to Show/Hide
|
||||
| Activity |
IC50 = 143600 nM
|
[35] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
US8470836, 5
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
SCHEMBL3111337; CHEMBL3644786; BDBM97578; US8470836, 5
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[6] | |||
| Compound Name |
US8470836, 2
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
SCHEMBL3101345; CHEMBL3644783; BDBM97575; US8470836, 2
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[6] | |||
| Compound Name |
(6S)-1-[(2S)-2-Amino-4-[2-(2-methoxyethyl)-4-(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoro-6-hydroxypiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3644790; SCHEMBL13099358; BDBM97583; US8470836, 10
Click to Show/Hide
|
||||
| Activity |
IC50 > 210000 nM
|
[6] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-(furan-3-yl)propanoyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127979; BDBM50449223
Click to Show/Hide
|
||||
| Activity |
IC50 > 288200 nM
|
[35] | |||
| Compound Name |
Chembl4162340
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50283545
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[50] | |||
| Compound Name |
Ala-boroPro
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63860; [(2R)-1-[(2S)-2-aminopropanoyl]pyrrolidin-2-yl]boronic acid; Alaninyl-L-Boroproline; SCHEMBL8286523; US8933056, Ala-boroPro; BDBM50050525; (R)-1-((S)-2-aminopropanoyl)pyrrolidin-2-ylboronic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 360000 nM
|
[51] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2014 Feb 1;24(3):731-6. | ||||
| REF 2 | Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold. Medchemcomm. 2014;5:1700-7. | ||||
| REF 3 | Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem. 2014 Apr 24;57(8):3205-12. | ||||
| REF 4 | Highly potent dipeptidyl peptidase IV inhibitors derived from Alogliptin through pharmacophore hybridization and lead optimization. Eur J Med Chem. 2013 Oct;68:312-20. | ||||
| REF 5 | US patent application no. 9346814B2, FAP inhibitors | ||||
| REF 6 | US patent application no. 8470836B2, Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent | ||||
| REF 7 | Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor. J Med Chem. 2011 Feb 10;54(3):831-50. | ||||
| REF 8 | Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4154-8. | ||||
| REF 9 | (2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3596-600. | ||||
| REF 10 | Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein. J Med Chem. 2010 Sep 23;53(18):6572-83. | ||||
| REF 11 | 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A. Bioorg Med Chem. 2011 Sep 15;19(18):5490-9. | ||||
| REF 12 | Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5853-7. | ||||
| REF 13 | 4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5806-11. | ||||
| REF 14 | An example of designed multiple ligands spanning protein classes: dual MCH-1R antagonists/DPPIV inhibitors. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2464-9. | ||||
| REF 15 | Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole. Bioorg Med Chem Lett. 2005 May 2;15(9):2253-8. | ||||
| REF 16 | Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4579-83. | ||||
| REF 17 | Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4159-62. | ||||
| REF 18 | Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1880-6. | ||||
| REF 19 | Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2533-6. | ||||
| REF 20 | Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines. J Med Chem. 2008 Feb 14;51(3):589-602. | ||||
| REF 21 | Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5934-9. | ||||
| REF 22 | (R)-3-amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: design, synthesis, biological evaluation, and molecular modeling. Bioorg Med Chem. 2014 Dec 1;22(23):6684-6693. | ||||
| REF 23 | Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3048-52. | ||||
| REF 24 | Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem. 2013 Dec 1;21(23):7418-29. | ||||
| REF 25 | Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate). Bioorg Med Chem Lett. 2007 Jun 15;17(12):3373-7. | ||||
| REF 26 | Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV. Bioorg Med Chem. 2008 Jan 1;16(1):190-208. | ||||
| REF 27 | Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1346-9. | ||||
| REF 28 | Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4097-101. | ||||
| REF 29 | Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554. Bioorg Med Chem. 2011 Aug 1;19(15):4482-98. | ||||
| REF 30 | 4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2007 May 15;17(10):2879-85. | ||||
| REF 31 | Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4087-91. | ||||
| REF 32 | Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors. Eur J Med Chem. 2014 Oct 30;86:242-56. | ||||
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| REF 34 | Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3877-9. | ||||
| REF 35 | Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors. Eur J Med Chem. 2014 Mar 21;75:111-22. | ||||
| REF 36 | Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes. Bioorg Med Chem. 2009 Mar 1;17(5):1783-802. | ||||
| REF 37 | Discovery of Imigliptin, a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6. | ||||
| REF 38 | (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2006 Jun 15;49(12):3614-27. | ||||
| REF 39 | Surrogating and redirection of pyrazolo[1,5-a]pyrimidin-7(4H)-one core, a novel class of potent and selective DPP-4 inhibitors. Bioorg Med Chem. 2018 Feb 15;26(4):903-912. | ||||
| REF 40 | Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5373-7. | ||||
| REF 41 | Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2016 Mar 12;7(5):498-501. | ||||
| REF 42 | Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2313-2318. | ||||
| REF 43 | (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005 Jan 13;48(1):141-51. | ||||
| REF 44 | Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorg Med Chem. 2012 Oct 1;20(19):5864-83. | ||||
| REF 45 | Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3384-7. | ||||
| REF 46 | Docking-based 3D-QSAR study for selectivity of DPP4, DPP8, and DPP9 inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3716-21. | ||||
| REF 47 | Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem. 2013 May 9;56(9):3467-77. | ||||
| REF 48 | Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5021-5. | ||||
| REF 49 | Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors. Eur J Med Chem. 2009 Aug;44(8):3318-22. | ||||
| REF 50 | Rapid generation of a novel DPP-4 inhibitor with long-acting properties: SAR study and PK/PD evaluation. Eur J Med Chem. 2017 Dec 1;141:519-529. | ||||
| REF 51 | Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. J Med Chem. 2008 Oct 9;51(19):6005-13. | ||||
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