Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T59493 | Target Info | |||
| Target Name | Alanine/serine/cysteine transporter 2 (SLC1A5) | ||||
| Synonyms |
Solute carrier family 1 member 5; Sodium-dependent neutral amino acid transporter type 2; RDRC; RDR; RD114/simian type D retrovirus receptor; Neutral amino acid transporter B(0); M7V1; Baboon M7 virus receptor; ATB(0); ASCT2
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| Target Type | Literature-reported Target | ||||
| Gene Name | SLC1A5 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2S)-2-Amino-4-[bis[[2-[(3-chlorophenyl)methoxy]phenyl]methyl]amino]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3753808; BDBM50140125
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| Activity |
IC50 = 50800 nM
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[1] | |||
| Compound Name |
(2S)-2-Amino-4-[bis[[2-(3-methoxyphenoxy)phenyl]methyl]amino]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3753869; SCHEMBL20257685; BDBM50140134
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| Activity |
IC50 = 57200 nM
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[1] | |||
| Compound Name |
(2S)-2-Amino-4-[bis[(2-pyridin-2-yloxyphenyl)methyl]amino]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752494; SCHEMBL20257687; BDBM50140128
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| Activity |
IC50 = 59600 nM
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[1] | |||
| Compound Name |
(2S)-2-Amino-4-[bis[[2-(pyridin-3-ylmethoxy)phenyl]methyl]amino]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754415; BDBM50140080
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| Activity |
IC50 = 69100 nM
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[1] | |||
| Compound Name |
(2S)-2-Amino-4-[bis[[2-(4-fluorophenoxy)phenyl]methyl]amino]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752700; SCHEMBL20257684; BDBM50140129
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| Activity |
IC50 = 141700 nM
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[1] | |||
| Non Binders of This Target (in total, 19 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-glutamine
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Approved | Compound Info | ||
| Synonyms |
NutreStore; AES-14; Aesgen-14; Glutamine (INN); L-glutamine (oral, short bowel syndrome), Emmaus; L-glutamine (topical, chemotherapy-induced mucositis), Aesgen; L-glutamine (oral, sickle cell anemia/sickle beta-0 thalassemia), Emmaus; L-glutamine (oral, sickle cell anemia/sickle beta-0 thalassemia), Emmaus/University of California Los Angeles
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| Activity |
IC50 = 541000 nM
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[2] | |||
| Compound Name |
L-Proline
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Approved | Compound Info | ||
| Synonyms |
Carboxypyrrolidine; Pro; Prolina; Prolinum; Prolina [Spanish]; Prolinum [Latin]; CB 1707; L-Prolin; PRO (IUPACabbreviation); Proline (USP); Proline (VAN); Proline [USAN:INN]; H-Pro-OH; L-Proline (JAN); L-Proline-15N; L-alpha-Pyrrolidinecarboxylic acid; L-Proline, labeled with carbon-14; L-Pyrrolidine-2-carboxylic acid; L-(2,3-3H)Proline; (-)-(S)-Proline; (-)-2-Pyrrolidinecarboxylic acid; (-)-Proline (S)-2-Carboxypyrrolidine; (2S)-pyrrolidine-2-carboxylic acid; (S)-2-Carboxypyrrolidine; (S)-2-Pyrrolidinecarboxylic acid; (S)-Proline; (S)-Pyrrolidine-2-carboxylic acid; 2-pyrrolidinecarboxylic acid
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| Activity |
IC50 > 10000000 nM
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[2] | |||
| Compound Name |
D-Serine
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Phase 4 | Compound Info | ||
| Synonyms |
D-serine; 312-84-5; (R)-2-amino-3-hydroxypropanoic acid; (2R)-2-amino-3-hydroxypropanoic acid; Serine D-form; (R)-Serine; Serine, D-; d-(+)-serine; D-2-Amino-3-hydroxypropionic Acid; D-Serin; D-Ser; UNII-1K77H2Z9B1; EINECS 206-229-4; MFCD00004269; NSC 77689; (2R)-2-amino-3-hydroxy-propanoic acid; AI3-18476; CHEMBL285123; CHEBI:16523; MTCFGRXMJLQNBG-UWTATZPHSA-N; 1K77H2Z9B1; (R)-2-Amino-3-hydroxypropionic acid; DSN; NCGC00094363-03; D-Serine, 98%; D-2-Amino-3-hydroxypropanoic acid; NSC77689; serine d-; [3h]-d-serine; (2R)-serine
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| Activity |
IC50 = 4913000 nM
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[2] | |||
| Compound Name |
L-asparagine
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Investigative | Compound Info | ||
| Synonyms |
Agedoite; Altheine; Crystal VI
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| Activity |
IC50 = 674000 nM
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[2] | |||
| Compound Name |
L-serine
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Investigative | Compound Info | ||
| Synonyms |
L-serine; serine; 56-45-1; (S)-2-Amino-3-hydroxypropanoic acid; H-Ser-OH; (S)-Serine; beta-Hydroxyalanine; L-ser; L-(-)-Serine; Polyserine; Serine, L-; (2S)-2-amino-3-hydroxypropanoic acid; L-3-Hydroxy-alanine; Poly-L-serine; 2-Amino-3-hydroxypropionic acid; beta-Hydroxy-L-alanine; Serinum [Latin]; Serina [Spanish]; L-2-Amino-3-hydroxypropionic acid; Serine (VAN); L-3-Hydroxy-2-aminopropionic acid; Serine [USAN:INN]; SER (IUPAC abbrev); 3-Hydroxyalanine; L-Serin; (S)-(-)-Serine; (-)-Serine; alpha-Amino-beta-hydroxypropionic acid
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| Activity |
IC50 = 822000 nM
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[2] | |||
| Compound Name |
(S)-phenylglycine
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Investigative | Compound Info | ||
| Synonyms |
2935-35-5; H-Phg-Oh; L-Phenylglycine; (S)-2-Amino-2-phenylacetic acid; L-(+)-alpha-Phenylglycine; L-2-Phenylglycine; (2S)-amino(phenyl)acetic acid; L-(+)-2-Phenylglycine; Phenylglycine; (2S)-2-amino-2-phenylacetic acid; L-(+)-alpha-Aminophenylacetic acid; UNII-3I753R0XI6; L-alpha-Phenylglycine; L(+)-alpha-Phenylglycine; (S)-(+)-2-Phenylglycine; CHEMBL378605; (2S)-amino(phenyl)ethanoic acid; CHEBI:439819; 3I753R0XI6; MFCD00064403; (alphaS)-alpha-aminobenzeneacetic acid
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| Activity |
IC50 = 945000 nM
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[2] | |||
| Compound Name |
2-amino-2-(2-fluorophenyl)acetic acid
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Investigative | Compound Info | ||
| Synonyms |
84145-28-8; Amino(2-fluorophenyl)acetic acid; Amino-(2-fluoro-phenyl)-acetic acid; 2-(2-FLUOROPHENYL)GLYCINE; CHEMBL383715; DL-2-FLUOROPHENYLGLYCINE; CGNMJIBUVDGMIY-UHFFFAOYSA-N; Bionet2_000821; dl-O-Fluorophenylglycine; AC1LBC1Z; 2-fluoro-dl-phenylglycine; 2-(o-fluorophenyl)glycine; AC1Q4O3E; dl-(2-Fluorophenyl)-glycine; 2-fluoro-dl-; SCHEMBL2628067; AC1Q505A; 2-Fluoro-dl-alpha-phenylglycine; CTK8D0864; MolPort-000-000-424; HMS1366F07; 2-Fluoro-dl-.alpha.-phenylglycine
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| Activity |
IC50 > 3000000 nM
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[2] | |||
| Compound Name |
trans-4-hydroxy-proline
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Investigative | Compound Info | ||
| Synonyms |
4-hydroxyproline
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| Activity |
IC50 = 3475000 nM
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[2] | |||
| Compound Name |
(2S)-2-Amino-5-[2-(morpholin-4-ylmethyl)anilino]-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3576929; SCHEMBL19421300; BDBM50088534
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| Activity |
IC50 = 312000 nM
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[1] | |||
| Compound Name |
L-Cyclopropylglycine
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Investigative | Compound Info | ||
| Synonyms |
(s)-2-amino-2-cyclopropylacetic acid; 2-Cyclopropyl-L-glycine; H-Cyclopropyl-Gly-OH; l-cyclopropyl glycine; (2S)-2-amino-2-cyclopropylacetic acid; h-gly(cpropyl)-oh; L-alpha-Cyclopropylglycine; (2R)-Amino(cyclopropyl)acetic acid; MFCD06659116; L-Cyclopropylglycine 98%; alpha-cyclopropylglycine; (S)-Amino-cyclopropyl-acetic acid; PubChem17438; 2-Cyclopropyl-L-glycin; (S)-2-Cyclopropylglycine; KSC831A6R; SCHEMBL412802; CHEMBL4091914; CTK7D1068; DTXSID80363564; L-alpha-Cyclopropylglycine, 95%; ACT02816; BCP11588; KS-00000K3S; ZINC4202387; AKOS006282090; AC-3384; CS-W005759; AM803956; BR-44348; SC-20216; TS-01592; AB0010484; M-3572; 606C997
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| Activity |
IC50 = 428000 nM
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[2] | |||
| Compound Name |
(2S)-2-Amino-5-[2-(1,3-benzothiazol-2-yl)anilino]-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3576928; SCHEMBL19421302; BDBM50088535
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| Activity |
IC50 = 436000 nM
|
[3] | |||
| Compound Name |
(S)-4-Fluorophenylglycine
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Investigative | Compound Info | ||
| Synonyms |
(s)-2-amino-2-(4-fluorophenyl)acetic acid; L-4-Fluorophenylglycine; 4-fluoro-l-phenylglycine; (2S)-2-amino-2-(4-fluorophenyl)acetic acid; 4-Fluoro-L-alpha-phenylglycine; l(+)-4-fluorophenylglycine; (s)-(+)-4-(fluorophenyl)glycine; MFCD00213799; L-4FPG; 2-(4-fluorophenyl)-L-glycine; (s)-amino-(4-fluoro-phenyl)-acetic acid; BENZENEACETIC ACID, ALPHA-AMINO-4-FLUORO-, (ALPHAS)-; (S)-4-Fluorophenylglycine, 95%, (98% ee); l-(4-fluorophenyl) glycine; p-fluorophenyl glycine; PubChem5931; L4FPG; l-(4-fluorophenyl)glycine; H-Phg(4-F)-OH; 4-Fluoro-L-2-phenylglycine; SCHEMBL207638; CHEMBL4088806; CTK8B3703; DTXSID80357387; ZINC388691; ACN-S002923; ACT00058; ANW-42969; AKOS015854067; AB04848; AC-5309; CS-W002519; MCULE-4023441343; KS-000002D0; (2s)-amino(4-fluorophenyl)ethanoic acid; AM803458; AS-12524; BR-33958; SC-02180; (S)-alpha-amino-4-fluorobenzeneacetic acid; AB0005628; F0862; ST50405555; EN300-91504; 83F579; M-2836; 4-Fluoro-L-alpha-phenylglycine, >=99.0% (NT); Q-200473; Z1696844737
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| Activity |
IC50 = 437000 nM
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[2] | |||
| Compound Name |
(2S)-2-Amino-5-(2-morpholin-4-ylanilino)-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3576927; SCHEMBL19421298; BDBM50088536
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| Activity |
IC50 = 664000 nM
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[3] | |||
| Compound Name |
(2S)-2-Amino-5-[[2-(morpholin-4-ylsulfonylmethyl)phenyl]methylamino]-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3576943; SCHEMBL19421282; BDBM50088531
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| Activity |
IC50 = 677000 nM
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[3] | |||
| Compound Name |
(2S)-2-Amino-5-[[2-[(4-methylpiperazin-1-yl)methyl]phenyl]methylamino]-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3576944; SCHEMBL19410447; BDBM50088530
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| Activity |
IC50 = 697000 nM
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[3] | |||
| Compound Name |
(2S)-2-Amino-5-oxo-5-(2-piperidin-1-ylanilino)pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3576936; SCHEMBL19421306; BDBM50088533
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| Activity |
IC50 = 776000 nM
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[3] | |||
| Compound Name |
(2S)-2-Amino-5-oxo-5-[2-(2-pyridin-4-ylethyl)anilino]pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3576940; SCHEMBL19421310; BDBM50088532
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| Activity |
IC50 = 832000 nM
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[3] | |||
| Compound Name |
(S)-2-Amino-5-((4-nitrophenyl)amino)-5-oxopentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
N-(4-Nitrophenyl)-L-glutamine; L-Glutamine, N-(4-nitrophenyl)-; GAMMA-L-GLUTAMYL-4-NITROANILIDE; L-gamma-Glutamyl-p-nitroanilide; UNII-81SZ84NXWS; L-2-Amino-4'-nitroglutaranilic acid; N5-(4-Nitrophenyl)-L-glutamine; 81SZ84NXWS; CHEMBL6251; MFCD00036218; (S)-2-Amino-5-((4-nitrophenyl)-amino)-5-oxopentanoic acid; gamma-glutamyl-p-nitroanilide; gamma-glutamyl-p-nitroaniline; gamma-Glutamine-4-nitroanilide; L-gamma-GlutamyL-p-nitroanilidemonohydrate; EINECS 230-748-5; CCRIS 8420; H-Glu(pNA)-OH.nH2O; SCHEMBL465891; DTXSID9045057; L-.gamma.-Glutyl-p-nitroanilide; .gamma.-L-Glutamyl-p-nitroanilide; L-.gamma.-Glutamyl-p-nitroanilide; L-Glutamic acid-5(4-nitroanilide); ZINC4069928; .gamma.-L-Glutamyl-4-nitro anilide; Nomega-(4-Nitrophenyl)-L-glutamine; ANW-63105; BDBM50088537; L-Glutamic acid gamma-p-nitroanilide; AKOS016843231; 5-(4-Nitroanilino)-5-oxonorvaline #; KS-000015Q4; gamma-L-Glutamyl-4-nitroanilide, 98+%; AS-49082; SC-25339; L-Gamma-Glutamyl-p-nitroanilide Monohydrat; G0065; (2S)-2-azaniumyl-5-(4-nitroanilino)-5-oxopentanoate; Q27088423; (S)-2-amino-5-(4-nitrophenylamino)-5-oxopentanoic acid; L-Glutamic acid gamma-(4-nitroanilide), gamma-glutamyl transpeptidase substrate
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| Activity |
IC50 = 954000 nM
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[3] | |||
| Compound Name |
Oxfenicine
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Investigative | Compound Info | ||
| Synonyms |
4-Hydroxy-L-phenylglycine; H-Phg(4-OH)-OH; L-4-Hydroxyphenylglycine; (S)-2-AMINO-2-(4-HYDROXYPHENYL)ACETIC ACID; (S)-Amino-(4-hydroxyphenyl)acetic acid; (2s)-Amino(4-Hydroxyphenyl)Acetic Acid; (2S)-2-amino-2-(4-hydroxyphenyl)acetic acid; UNII-9YH0WH2Z02; L-2-(p-Hydroxyphenyl)glycine; L-2-(4-Hydroxyphenyl)glycine; (2S)-amino(4-hydroxyphenyl)ethanoic acid; Oxfenicine (USAN/INN); L-P-HYDROXYPHENYGLYCINE; 9YH0WH2Z02; UK-25842; UK-25,842; DSSTox_CID_26403; DSSTox_RID_81583; DSSTox_GSID_46403; Oxfenicina; Oxfenicinum; (S)-4-hydroxyphenylglycine; Oxfenicinum [INN-Latin]; p-Hydroxy-L-phenylglycine; Oxfenicina [INN-Spanish]; L-(+)-A-4-HYDROXYPHENYLGLYCINE; Oxfenicine [USAN:INN:BAN]; MFCD00065932; NCGC00164509-01; EINECS 251-061-7; PubChem13975; UK 25842; (S)-alpha-Amino-4-hydroxybenzeneacetic acid; (S)-2-Amino-2-(4-hydroxyphenyl)essigsaeure; bmse000629; SCHEMBL122315; (s)-(4-hydroxyphenyl)glycine; Benzeneacetic acid, alpha-amino-4-hydroxy-, (alphaS)-; CHEMBL1232077; DTXSID3046403; CTK4G8744; KS-00000MKP; 4-Hydroxy-L-(+)-2-phenylglycine; ACT05092; ZINC6667724; Tox21_112144; ANW-48447; BDBM50403035; L-(+)-2-(4-Hydroxyphenyl)glycine; AKOS016842371; Tox21_112144_1; CS-W018812; DB04291; HY-W018026; NCGC00344518-01; AC-24628; BR-28583; DS-11081; SC-20695; W5427; 4-Hydroxy-L-phenylglycine, >=99.0% (NT); C12323; D05292; S-1484; Benzeneacetic acid, a-amino-4-hydroxy-, (aS)-; (2S)-2-azanyl-2-(4-hydroxyphenyl)ethanoic acid; A821286; Benzeneacetic acid, alpha-amino-4-hydroxy-, (S)-; (S)-(+)-2-Amino-2-(4-hydroxyphenyl)acetic Acid; J-018746; Q27095113; UNII-7UYG7X0F53 component LJCWONGJFPCTTL-ZETCQYMHSA-N
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| Activity |
IC50 = 1728000 nM
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[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport. Bioorg Med Chem Lett. 2016 Feb 1;26(3):1044-1047. | ||||
| REF 2 | US patent application no. 8741955B2, D-serine transporter inhibitors as pharmaceutical compositions for the treatment of central nervous system disorders | ||||
| REF 3 | 2-Substituted N-glutamylanilides as novel probes of ASCT2 with improved potency. Bioorg Med Chem Lett. 2015 Jan 1;25(1):113-6. | ||||
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