TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T59493 Alanine/serine/cysteine transporter 2 D01JIA L-glutamine Approved 5961 C5H10N2O3 146.14 C(CC(=O)N)[C@@H](C(=O)O)N IC50 = 541000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 D0DZ3X L-Proline Approved 145742 C5H9NO2 115.13 C1C[C@H](NC1)C(=O)O IC50 > 10000000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 D02UDJ D-Serine Phase 4 71077 C3H7NO3 105.09 C([C@H](C(=O)O)N)O IC50 = 4913000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 B3CYR9 (2S)-2-Amino-5-[2-(1,3-benzothiazol-2-yl)anilino]-5-oxopentanoic acid Investigative 122177330 C18H17N3O3S 355.4 C1=CC=C(C(=C1)C2=NC3=CC=CC=C3S2)NC(=O)CC[C@@H](C(=O)O)N IC50 = 436000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 B3NL8K (S)-4-Fluorophenylglycine Investigative 853015 C8H8FNO2 169.15 C1=CC(=CC=C1[C@@H](C(=O)O)N)F IC50 = 437000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 B6A4VB (2S)-2-Amino-5-[2-(morpholin-4-ylmethyl)anilino]-5-oxopentanoic acid Investigative 122177331 C16H23N3O4 321.37 C1COCCN1CC2=CC=CC=C2NC(=O)CC[C@@H](C(=O)O)N IC50 = 312000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 B6MHY5 (2S)-2-Amino-5-[[2-[(4-methylpiperazin-1-yl)methyl]phenyl]methylamino]-5-oxopentanoic acid Investigative 122177346 C18H28N4O3 348.4 CN1CCN(CC1)CC2=CC=CC=C2CNC(=O)CC[C@@H](C(=O)O)N IC50 = 697000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 B8HDK5 (S)-2-Amino-5-((4-nitrophenyl)amino)-5-oxopentanoic acid Investigative 81732 C11H13N3O5 267.24 C1=CC(=CC=C1NC(=O)CC[C@@H](C(=O)O)N)[N+](=O)[O-] IC50 = 954000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 BEZ2K1 Oxfenicine Investigative 36143 C8H9NO3 167.16 C1=CC(=CC=C1[C@@H](C(=O)O)N)O IC50 = 1728000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 BLW39R (2S)-2-Amino-5-oxo-5-[2-(2-pyridin-4-ylethyl)anilino]pentanoic acid Investigative 122177342 C18H21N3O3 327.4 C1=CC=C(C(=C1)CCC2=CC=NC=C2)NC(=O)CC[C@@H](C(=O)O)N IC50 = 832000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 BQP48M L-Cyclopropylglycine Investigative 1501944 C5H9NO2 115.13 C1CC1[C@@H](C(=O)O)N IC50 = 428000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 BQU3F1 (2S)-2-Amino-5-[[2-(morpholin-4-ylsulfonylmethyl)phenyl]methylamino]-5-oxopentanoic acid Investigative 122177345 C17H25N3O6S 399.5 C1COCCN1S(=O)(=O)CC2=CC=CC=C2CNC(=O)CC[C@@H](C(=O)O)N IC50 = 677000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 BU4BN0 (2S)-2-Amino-5-oxo-5-(2-piperidin-1-ylanilino)pentanoic acid Investigative 122177338 C16H23N3O3 305.37 C1CCN(CC1)C2=CC=CC=C2NC(=O)CC[C@@H](C(=O)O)N IC50 = 776000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 BV15PN (2S)-2-Amino-5-(2-morpholin-4-ylanilino)-5-oxopentanoic acid Investigative 122177329 C15H21N3O4 307.34 C1COCCN1C2=CC=CC=C2NC(=O)CC[C@@H](C(=O)O)N IC50 = 664000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 D02YMI trans-4-hydroxy-proline Investigative 5810 C5H9NO3 131.13 C1[C@H](CN[C@@H]1C(=O)O)O IC50 = 3475000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 D03KKH (S)-phenylglycine Investigative 99291 C8H9NO2 151.16 C1=CC=C(C=C1)[C@@H](C(=O)O)N IC50 = 945000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 D03MYY L-asparagine Investigative 6267 C4H8N2O3 132.12 C([C@@H](C(=O)O)N)C(=O)N IC50 = 674000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 D0T6GM L-serine Investigative 5951 C3H7NO3 105.09 C([C@@H](C(=O)O)N)O IC50 = 822000 nM Non binder T59493 Alanine/serine/cysteine transporter 2 D0V6SS 2-amino-2-(2-fluorophenyl)acetic acid Investigative 580073 C8H8FNO2 169.15 C1=CC=C(C(=C1)C(C(=O)O)N)F IC50 > 3000000 nM Non binder