TTD_Target_ID Target_Name TTD_Drug_ID Drug_Name Drug_Highest_Status Drug_PubchemID Molecular_Formula Molecular_Weight Canonical_SMILES Activity Binder_Type T59493 Alanine/serine/cysteine transporter 2 B1TIW4 (2S)-2-Amino-4-[bis[[2-(3-methoxyphenoxy)phenyl]methyl]amino]butanoic acid Investigative 127037439 C32H34N2O6 542.6 COC1=CC(=CC=C1)OC2=CC=CC=C2CN(CC[C@@H](C(=O)O)N)CC3=CC=CC=C3OC4=CC=CC(=C4)OC IC50 = 57200 nM Poor binder T59493 Alanine/serine/cysteine transporter 2 B6B8MI (2S)-2-Amino-4-[bis[[2-[(3-chlorophenyl)methoxy]phenyl]methyl]amino]butanoic acid Investigative 127035849 C32H32Cl2N2O4 579.5 C1=CC=C(C(=C1)CN(CC[C@@H](C(=O)O)N)CC2=CC=CC=C2OCC3=CC(=CC=C3)Cl)OCC4=CC(=CC=C4)Cl IC50 = 50800 nM Poor binder T59493 Alanine/serine/cysteine transporter 2 BC15WT (2S)-2-Amino-4-[bis[[2-(4-fluorophenoxy)phenyl]methyl]amino]butanoic acid Investigative 127036648 C30H28F2N2O4 518.5 C1=CC=C(C(=C1)CN(CC[C@@H](C(=O)O)N)CC2=CC=CC=C2OC3=CC=C(C=C3)F)OC4=CC=C(C=C4)F IC50 = 141700 nM Poor binder T59493 Alanine/serine/cysteine transporter 2 BDY6V1 (2S)-2-Amino-4-[bis[(2-pyridin-2-yloxyphenyl)methyl]amino]butanoic acid Investigative 127035846 C28H28N4O4 484.5 C1=CC=C(C(=C1)CN(CC[C@@H](C(=O)O)N)CC2=CC=CC=C2OC3=CC=CC=N3)OC4=CC=CC=N4 IC50 = 59600 nM Poor binder T59493 Alanine/serine/cysteine transporter 2 BT92WN (2S)-2-Amino-4-[bis[[2-(pyridin-3-ylmethoxy)phenyl]methyl]amino]butanoic acid Investigative 127026009 C30H32N4O4 512.6 C1=CC=C(C(=C1)CN(CC[C@@H](C(=O)O)N)CC2=CC=CC=C2OCC3=CN=CC=C3)OCC4=CN=CC=C4 IC50 = 69100 nM Poor binder