Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59102 | Target Info | |||
| Target Name | Platelet-derived growth factor receptor beta (PDGFRB) | ||||
| Synonyms |
Platelet-derived growth factor receptor 1; PDGFR1; PDGFR-beta; PDGFR-1; PDGFR; PDGF-R-beta; CD140b antigen; CD140b; CD140 antigen-like family member B; Beta-type platelet-derived growth factor receptor; Beta-PDGFR; Beta platelet-derived growth factor receptor
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| Target Type | Successful Target | ||||
| Gene Name | PDGFRB | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 110 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Erlotinib
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Approved | Compound Info | ||
| Synonyms |
Erlotinin; Tarceva; Erlotinib Base; OSI 744; R 1415; CP 358,774; CP-358774; Erlotinib(Tarceva); Tarceva (TN); CP-358,774; Erlotinib, OS-774; N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-Quinazolinamine; [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline; 4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline
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| Activity |
IC50 = 83100 nM
|
[1] | |||
| Compound Name |
Niclosamide
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Approved | Compound Info | ||
| Synonyms |
niclosamide; 50-65-7; Niclocide; 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; Tredemine; Bayluscid; Phenasal; Yomesan; Fenasal; Dichlosale; Helmiantin; Sagimid; Iomezan; Devermine; Atenase; Vermitid; Radeverm; Mansonil; Iomesan; Devermin; Cestocid; Sulqui; Lintex; Nasemo; Mato; Fedal-Telmin; Bayer 73; Radewerm; Zestocarp; Bayer 2353; 2',5-Dichloro-4'-nitrosalicylanilide; Chemagro 2353; BAY 2353; Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-; 5-Chloro-2'-chloro-4'-nitrosalicylanilide; nicolsamide; HL 2447; Niclosamidum [I
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
SU5402
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Investigative | Compound Info | ||
| Synonyms |
su5402; 215543-92-3; SU 5402; SU-5402; 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone; (Z)-3-(4-methyl-2-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid; CHEMBL89363; 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE; J-502595; 3-{[3-(2-carboxyethyl)-4-methylpyrrol-2-yl]methylene}-2-indolinone; 3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid; (Z)-3-(4-Methyl-2-((2-oxoindolin-3-ylidene)-methyl)-1H-pyrrol-3-yl)propanoic acid
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| Activity |
IC50 = 60900 nM
|
[3] | |||
| Compound Name |
VEGF receptor 2 kinase inhibitor I
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Investigative | Compound Info | ||
| Synonyms |
VEGF Receptor 2 Kinase Inhibitor I; UNII-U07H877HUF; CHEMBL86943; U07H877HUF; 15966-93-5; (Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one; Vegfr-2 inhi; ethyl 2,4-dimethyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrole-3-carboxylate; Ethyl 2,4-dimethyl-5-(((3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene)methyl)-1H-pyrrole-3-carboxylate; AC1O4WEX; K00004; Vegfr 2 kinase inhibitor I; SCHEMBL378979; VEGFR2 KiN/Ase Inhibitor I; GTPL6053; MolPort-044-561-167; HMS3229O05; ZINC3875265
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-Substituted indolin-2-one 11c
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Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11c; BDBM4889; CHEMBL146697; SCHEMBL4407240; 3-[4-Methyl-5-(2-oxo-5-sulfamoyl-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl]propionic Acid
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL474538; BDBM50247802; 5H-1,2,4-Triazino[5,6-b]indole, 3-(1-imidazolidinyl)-5,8-dimethyl-; N4-(3-bromophenyl)-2-(naphthalen-1-ylmethyl)-1H-indole-4,6-diamine; N4-(3-bromophenyl)-6-(1-naphthylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-[2-(4-methoxyphenyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL485321; BDBM50271759
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-hexadecylbenzo[de]isoquinoline-1,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407635; BDBM50437557
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
Methyl 20-methoxy-3,10-dioxo-12-oxapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-1(13),2(11),4,6,8,14,16,18,20-nonaene-21-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL201840; BDBM50178493; 5-methoxy-7,12-dioxo-7,12-dihydro-dinaphtho[1,2-b;2'',3''-d]furan-6-carboxylic acid methyl ester
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
4-N-(3-Bromophenyl)-6-[(4-chlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956885; BDBM50366079
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N4-(3-Bromophenyl)-2-(naphthalen-2-ylmethyl)-1H-indole-4,6-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL502015; BDBM50271908
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-Benzyl-N4-(3-bromophenyl)-1H-indole-4,6-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL499344; BDBM50271906; 6-benzyl-N4-(3-bromophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095464; BDBM50318182
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-octylbenzo[de]isoquinoline-1,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598852; BDBM50437559
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-dodecylbenzo[de]isoquinoline-1,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL598022; BDBM50437558
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-[2-(2-chlorophenyl)ethyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL482489; BDBM50271760
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
3-Substituted indolin-2-one 16d
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Investigative | Compound Info | ||
| Synonyms |
BDBM4898; CHEMBL150177
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
4-N-(3-Bromophenyl)-6-[(4-phenylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956887; BDBM50366080
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-N-(4-Chloro-2-fluorophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929552; BDBM50360174
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3-Substituted indolin-2-one 16c
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Investigative | Compound Info | ||
| Synonyms |
BDBM4897; CHEMBL149073
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-Substituted indolin-2-one 11b
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Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11b; BDBM4888; CHEMBL435227; SCHEMBL4409949
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Methyl 3,10-dioxo-20-propoxy-12-oxapentacyclo[11.8.0.02,11.04,9.014,19]henicosa-1(13),2(11),4,6,8,14,16,18,20-nonaene-21-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL202216; BDBM50178496; 7,12-dioxo-5-propoxy-7,12-dihydro-dinaphtho[1,2-b;2'',3''-d]furan-6-carboxylic acid methyl ester
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
2-(2-Chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,6-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL499345; BDBM50271907; N4-(3-bromophenyl)-6-(2-chlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 ~ 50000 nM
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[5] | |||
| Compound Name |
4-N-(3-Bromophenyl)-6-[(3,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956886; BDBM50366078
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-Chloro-4-N-(3-methoxyphenyl)-9H-pyrimido[4,5-b]indole-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337366; BDBM50430567
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| Activity |
IC50 = 50500 nM
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[9] | |||
| Compound Name |
5-(6-Fluoro-1H-indol-3-yl)-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358980
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| Activity |
IC50 = 56000 nM
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[10] | |||
| Compound Name |
5-Naphthalen-1-ylsulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4088617; BDBM50235697
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| Activity |
IC50 = 58200 nM
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[11] | |||
| Compound Name |
3-Substituted indolin-2-one 11a
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Investigative | Compound Info | ||
| Synonyms |
SU5402 analog 11a; BDBM4887; CHEMBL344319; SCHEMBL4407207; 3-[4-Methyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl]propionic Acid; 3-(4-methyl-5-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid; 3-[2-[(2,3-Dihydro-2-oxo-1H-indole-3-ylidene)methyl]-3-methyl-1H-pyrrole-4-yl]propanoic acid
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| Activity |
IC50 = 58400 nM
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[4] | |||
| Compound Name |
5-Chloro-3-(4-hydroxy-3,5-diisopropyl-benzylidene)-1,3-dihydro-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL89723; BDBM50065307; 5-Chloro-3-[1-(4-hydroxy-3,5-diisopropyl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
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| Activity |
IC50 = 60400 nM
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[3] | |||
| Compound Name |
5-(4-Methoxyphenyl)sulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096329; BDBM50235700
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| Activity |
IC50 = 60500 nM
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[11] | |||
| Compound Name |
(3Z)-3-[(3-Ethyl-4,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL313433; SCHEMBL6000845; BDBM50065303; 3-[1-(3-Ethyl-4,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
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| Activity |
IC50 = 65500 nM
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[3] | |||
| Compound Name |
(3Z)-3-[[4-(Dimethylamino)phenyl]methylidene]-6-fluoro-1H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL329367; BDBM50065298; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-6-fluoro-1,3-dihydro-indol-2-one
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| Activity |
IC50 = 66000 nM
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[3] | |||
| Compound Name |
Methyl 3-[4-methyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL316009; SCHEMBL14519114; BDBM50065289
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| Activity |
IC50 = 66000 nM
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[3] | |||
| Compound Name |
(E)-3-[1-[4-(3-Ethynylanilino)quinazolin-6-yl]sulfonylpyrrol-3-yl]-N-hydroxyprop-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL4080295; CHEMBL3218002
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| Activity |
IC50 = 70000 nM
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[12] | |||
| Compound Name |
Indolin-2-one deriv. 4f
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Investigative | Compound Info | ||
| Synonyms |
BDBM4909; CHEMBL313746; 6-Phenyl-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one; (3Z)-6-phenyl-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
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| Activity |
IC50 = 70600 nM
|
[13] | |||
| Compound Name |
N-(4-Anilino-5-chloro-9H-pyrimido[4,5-b]indol-2-yl)-2,2-dimethylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337367; BDBM50430566
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| Activity |
IC50 = 70600 nM
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[9] | |||
| Compound Name |
4-N-(2-Aminophenyl)-1-N-[3-[(5-pyridin-3-yl-1,3-thiazol-2-yl)amino]phenyl]benzene-1,4-dicarboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL474015; BDBM50257076; N1-(2-aminophenyl)-N4-(3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)terephthalamidehydrate
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| Activity |
IC50 = 71000 nM
|
[14] | |||
| Compound Name |
2-Amino-4-(N-methyl-m-bromoanilino)-6-benzyl-7-methyl-pyrrolo[2,3-d]pyrimidine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254286; BDBM50326611
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| Activity |
IC50 = 71700 nM
|
[15] | |||
| Compound Name |
N4-1H-Indol-5-yl-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL499067; BDBM50271905; N4-(1H-indol-5-yl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 = 77400 nM
|
[16] | |||
| Compound Name |
5-Chloro-3-(1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL431025; SCHEMBL3912682; BDBM50065317; ZINC33034247; AKOS001473500; 5-Chloro-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
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| Activity |
IC50 = 85400 nM
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[3] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)pent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL595497
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| Activity |
IC50 = 88200 nM
|
[17] | |||
| Compound Name |
N-[4-(3-Bromo-4-fluoroanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335015; BDBM50429676
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| Activity |
IC50 = 89700 nM
|
[18] | |||
| Compound Name |
N4-(4-Fluoro-3-(trifluoromethyl)phenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL482715; BDBM50271852; N4-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
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| Activity |
IC50 = 90000 nM
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[16] | |||
| Compound Name |
5-Naphthalen-2-ylsulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060383; BDBM50235696
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| Activity |
IC50 = 90100 nM
|
[11] | |||
| Compound Name |
Indolin-2-one deriv. 4i
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Investigative | Compound Info | ||
| Synonyms |
BDBM4912; CHEMBL313500; 6-(4-Methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one; 6-(4-Methoxyphenyl)-3-[4,5,6,7-tetrahydro-1H-indole-2-ylmethylene]-2-indolinone; (3Z)-6-(4-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
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| Activity |
IC50 = 94010 nM
|
[13] | |||
| Compound Name |
3-[(Z)-(4-Bromo-2-thienyl)methylidene]-1H-indol-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL316268; (3Z)-3-[(4-bromothiophen-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one; SCHEMBL5728269; ZINC5903417; BDBM50065319; MFCD03012811; AKOS005094253; 5T-0045; 3-[1-(4-Bromo-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(Z)-1-Methyl-3-(4-dimethylaminobenzylidene)indoline-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL86921; SCHEMBL14589616; ZINC586193; BDBM50065315; MCULE-4166796331; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-1-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Pyrrolo[2,3-d]pyrimidin-6-one deriv. 26g
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5129; CHEMBL302552
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(2,3,4-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358971
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
5-(1H-Indol-3-yl)-6-methyl-3-(3,4,5-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3359001
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-(3-Tert-Butyl-4-methoxy-benzylidene)-5-chloro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86326; BDBM50065278; 3-[1-(3-tert-Butyl-4-methoxy-phenyl)-meth-(Z)-ylidene]-5-chloro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[1-(3-Tert-Butyl-4-methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86945; BDBM50065318; ZINC13780159
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-ethylbenzo[de]isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407517; BDBM50437562
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Pyrrolo[2,3-d]pyrimidin-6-one deriv. 26d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68920; BDBM5126; SCHEMBL6478237
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(3Z)-3-[(4-Bromophenyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SU 4942; CHEMBL86837; 3-(4-Bromobenzylidene)-1,3-dihydroindol-2-one; 3-(4-Bromobenzylidene)indolin-2-one; SU4942; SCHEMBL5465141; ZINC574906; BCP20736; BDBM50065305; MFCD00435354; 3-(4-Bromobenzylidene)indoline-2-one; AKOS001575405; (3Z)-3-(4-bromobenzylidene)-1,3-dihydro-2H-indol-2-one; 3-[1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[1-(4-Piperidin-1-yl-phenyl)-ethylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314798; SCHEMBL19451599; BDBM50065293; 3-[1-(4-Piperidin-1-yl-phenyl)-eth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(4-Dimethylamino-benzylidene)-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89809; BDBM50065294; 3-[1-(4-Dimethylamino-phenyl)-meth-(Z)-ylidene]-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[1-(4-Piperidin-1-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315701; SCHEMBL6001605; BDBM50065276
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(5-Methyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89697; BDBM50065309; 3-[1-(5-Methyl-furan-2-yl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3Z)-4-Methyl-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85403; Indolinone based inhibitor, 1a; SCHEMBL5728466; BDBM17016
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[(Z)-(3-Bromo-2-thienyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87783; (3Z)-3-[(3-bromothiophen-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one; ZINC4038356; BDBM50065272; MFCD05975006; AKOS005076668; 10X-0879; 3-[1-(3-Bromo-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
5-(1H-Indol-3-yl)-3-(2,4,6-trimethoxyphenyl)-1H-pyrazin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3358970
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(4S,6R,12E)-6-Bromo-18-hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),12,15,17-tetraene-2,8-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668414; BDBM50336462
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-methylbenzo[de]isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407516; BDBM50437563
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-5-[2-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]ethynyl]-6-methylpyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1934626; BDBM50360453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[21] | |||
| Compound Name |
(4S,6E,12Z)-18-Hydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1668420; BDBM50336460; (S,9E,15Z)-2-ethyl-4,7-dimethyl-5,11-dimethylene-5,6,7,8,11,12,13,14-octahydrobenzo[14]annulene
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
(3Z)-3-[(4-Methoxyphenyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87810; 3-(4-Methoxybenzylidene)-2-indolinone; SCHEMBL5475861; BDBM50065296; STL553883; ZINC12339635; AKOS016032064; 3-(4-Methoxybenzylidene)indoline-2-one; (Z)-3-(4-methoxybenzylidene)indolin-2-one; 3-[(Z)-4-Methoxybenzylidene]-1H-indol-2(3H)-one; (3Z)-3-(4-methoxybenzylidene)-1,3-dihydro-2H-indol-2-one; 3-[1-(4-Methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(3,5-Di-tert-butyl-4-hydroxybenzylidene)indolin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89505; SCHEMBL5472251; BDBM50065275; ZINC13780154; (3Z)-3-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1H-indol-2-one; 3-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-Methyl-3-(5-methylsulfanyl-thiophen-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86432; BDBM50065274; 4-Methyl-3-[1-(5-methylsulfanyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3Z)-3-[(4-Chloro-1-methylpyrazol-3-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89646; SCHEMBL5999800; BDBM50065279; 3-[1-(4-Chloro-1-methyl-1H-pyrazol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[1-(5-Ethyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314146; SCHEMBL6001148; BDBM50065295; ZINC12352634
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-Butyl-6-[2-[2-(dimethylamino)ethylamino]ethylamino]benzo[de]isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407518; BDBM50437561
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
(3E)-3-(Furan-2-ylmethylidene)-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL312826; SCHEMBL20838; HMS1433A06; ZINC4693315; BDBM50065301; IDI1_012097; 3-Furan-2-ylmethylene-1,3-dihydro-indol-2-one; 3-[1-Furan-2-yl-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(3,5-Dimethyl-1H-pyrrol-2-ylmethylene)-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330321; SCHEMBL13432277; BDBM50065288; 3-[1-(3,5-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-4-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Pyrrolo[2,3-d]pyrimidin-6-one deriv. 26h
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL69629; BDBM5130; ZINC26268853
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
3-[1-(4-Bromo-phenyl)-meth-(Z)-ylidene]-1-methyl-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314021; ZINC575064; BDBM50065316; AKOS001097016; AB00736582-01; SR-01000072622; SR-01000072622-1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Indolin-2-one deriv. 4g
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM4910; CHEMBL419682; SCHEMBL7838947; 6-(3-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1h-indol-2-ylmethylene)-1,3-dihydroindol-2-one; 6-(3-Methoxyphenyl)-3-[4,5,6,7-tetrahydro-1H-indole-2-ylmethylene]-2-indolinone; (3Z)-6-(3-methoxyphenyl)-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-2,3-dihydro-1H-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
3-[1-(4-Chloro-1H-pyrazol-3-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87402; SCHEMBL6001442; BDBM50065284
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
4-[2-Oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL313259; BDBM50065281
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-[1-(3,4-Dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316020; SCHEMBL6001449; BDBM50065311
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(5-Ethyl-furan-2-ylmethylene)-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328452; SCHEMBL5728117; BDBM50065291; 3-[1-(5-Ethyl-furan-2-yl)-meth-(E)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3Z)-3-[(5-Methylsulfanylthiophen-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL89721; BDBM50065273; 3-[1-(5-Methylsulfanyl-thiophen-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Pyrrolo[2,3-d]pyrimidin-6-one deriv. 28d
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM5146; CHEMBL264382
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
3-[1-(4-Pyrrolidin-1-yl-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL314217; SCHEMBL6001567; SCHEMBL14519135; ZINC574986; BDBM50065314
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3Z)-3-[(1-Methylpyrrol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86631; SCHEMBL21465; BDBM50065300; 3-[1-(1-Methyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3Z)-3-[(4-Ethyl-3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420411; SCHEMBL5728018; BDBM50065286; 3-[1-(4-Ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(3-Bromo-5-tert-butyl-4-methoxy-benzylidene)-5-chloro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86944; BDBM50065313; 3-[1-(3-Bromo-5-tert-butyl-4-methoxy-phenyl)-meth-(Z)-ylidene]-5-chloro-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
(3Z)-3-[(3-Bromo-5-tert-butyl-4-methoxyphenyl)methylidene]-1H-indol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL87746; BDBM50065285; 3-[1-(3-Bromo-5-tert-butyl-4-methoxy-phenyl)-meth-(Z)-ylidene]-1,3-dihydro-indol-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
6-[2-[2-(Dimethylamino)ethylamino]ethylamino]-2-hexylbenzo[de]isoquinoline-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2407519; BDBM50437560
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-Methyl-5-[2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrole-3-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316008; SCHEMBL5388917; BDBM50065283
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
N4-(3-Ethynylphenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520803; BDBM50271849; N4-(3-Ethynylphenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d ]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 100400 nM
|
[16] | |||
| Compound Name |
N-1H-Indol-5-yl-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1097368; BDBM50318168
Click to Show/Hide
|
||||
| Activity |
IC50 = 104200 nM
|
[16] | |||
| Compound Name |
6-(2,4-Dichlorobenzyl)-N-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094784; BDBM50318187
Click to Show/Hide
|
||||
| Activity |
IC50 = 110100 nM
|
[22] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 9
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL595757; BDBM33403; D2B
Click to Show/Hide
|
||||
| Activity |
IC50 = 118000 nM
|
[17] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(4-phenylphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956897; BDBM50366082
Click to Show/Hide
|
||||
| Activity |
IC50 = 129100 nM
|
[5] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-(naphthalen-1-ylmethyl)pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956895; BDBM50366084
Click to Show/Hide
|
||||
| Activity |
IC50 = 129300 nM
|
[5] | |||
| Compound Name |
6-(2,4-Dichlorobenzyl)-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1098440; BDBM50318188
Click to Show/Hide
|
||||
| Activity |
IC50 = 142200 nM
|
[22] | |||
| Compound Name |
4-N-(4-Chloro-2-fluorophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929556; BDBM50360178
Click to Show/Hide
|
||||
| Activity |
IC50 = 145900 nM
|
[1] | |||
| Compound Name |
5-[(1z)-2-(2-Methoxyphenyl)prop-1-En-1-Yl]furo[2,3-D]pyrimidine-2,4-Diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606039; BDBM33395; 2,4-diaminofuro[2,3-d]pyrimidine, 1b; Q27455399
Click to Show/Hide
|
||||
| Activity |
IC50 = 151900 nM
|
[17] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(2-methylphenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956889; BDBM50366089
Click to Show/Hide
|
||||
| Activity |
IC50 = 159600 nM
|
[5] | |||
| Compound Name |
N-[5-Chloro-4-(4-chloro-2-fluoroanilino)-9H-pyrimido[4,5-b]indol-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337370; BDBM50430563
Click to Show/Hide
|
||||
| Activity |
IC50 = 170800 nM
|
[9] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094782; BDBM50318185
Click to Show/Hide
|
||||
| Activity |
IC50 = 171300 nM
|
[22] | |||
| Compound Name |
5-Chloro-4-N-(3-fluorophenyl)-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337365; BDBM50430568
Click to Show/Hide
|
||||
| Activity |
IC50 = 172200 nM
|
[9] | |||
| Compound Name |
N4-(4-Isopropylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095463; BDBM50318180
Click to Show/Hide
|
||||
| Activity |
IC50 = 174900 nM
|
[22] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2-methylbenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095466; BDBM50318184
Click to Show/Hide
|
||||
| Activity |
IC50 = 182000 nM
|
[22] | |||
| Compound Name |
6-[(2,4-Dichlorophenyl)methyl]-4-N-(3-fluorophenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095131; BDBM50318176; N4-(3-Fluorophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo-[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 183100 nM
|
[22] | |||
| Compound Name |
N-(3-Bromo-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096737; BDBM50318165; N-(3-bromo-4-flurophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 192400 nM
|
[16] | |||
| Compound Name |
4-N-(4-Chlorophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929553; BDBM50360175
Click to Show/Hide
|
||||
| Activity |
IC50 = 193200 nM
|
[1] | |||
| Compound Name |
N-[5-Chloro-4-(3-methoxyanilino)-9H-pyrimido[4,5-b]indol-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337372; BDBM50430561
Click to Show/Hide
|
||||
| Activity |
IC50 = 196200 nM
|
[9] | |||
| Compound Name |
N'-(4-Chlorophenyl)-5-chloro-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337363; BDBM50430570
Click to Show/Hide
|
||||
| Activity |
IC50 = 196200 nM
|
[9] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 67 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Lapatinib
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
FMM; Tycerb; Lapatinib Ditosylate; Lapatinib [INN]; Lapatinib tosilate hydrate; GSK 572016; GSK572016; GW 572016; GW 572016X; GW572016; Lapatinib (INN); Tykerb (TN); Lapatinib, Tykerb, GW572016; N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine; N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine; N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine; 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline; Lapatinib (ERBB2 inhibitor)
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[2-methylsulfonyl-1-(propan-2-ylamino)ethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344213; BDBM50030384
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344217; BDBM50030378
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 8
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL605413; BDBM33402
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(ethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344211; SCHEMBL1352826; BDBM50030382
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
N-[5-Chloro-4-(4-chloroanilino)-9H-pyrimido[4,5-b]indol-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337369; BDBM50430564
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] pentanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344218; BDBM50030377
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[2-methylsulfonyl-1-(2-methylsulfonylethylamino)ethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344214; BDBM50030375
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
6-[5-(1-Amino-2-methylsulfonylethyl)furan-2-yl]-N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344209; SCHEMBL1351084; BDBM50030387
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
5-[2-Cyclopropyl-2-(2-methoxyphenyl)ethenyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594320
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
5-Chloro-4-N-phenyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337374; BDBM50430572
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(cyclohexylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344212; BDBM50030388
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
CID 46866615
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344220; SCHEMBL1352619; BDBM50030389
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
[[(1S)-1-[5-[4-[3-Chloro-4-[(3-fluorophenyl)methoxy]anilino]quinazolin-6-yl]furan-2-yl]-2-methylsulfonylethyl]amino] heptanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344219; BDBM50030381
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)-3-methylpent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603849
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 10
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL603198; BDBM33404; D2E
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(1R)-1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344221; SCHEMBL1353012; BDBM50030380
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(1S)-1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344216; SCHEMBL1351262; BDBM50030383
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
5-(2,5-Dimethoxyphenyl)sulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069070; BDBM50235698
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[11] | |||
| Compound Name |
CID 46866616
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344215; SCHEMBL1351081; BDBM50030385
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 12
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606362; BDBM33406
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(methylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344210; SCHEMBL1353264; BDBM50030379
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
N-[5-Chloro-4-(3-fluoroanilino)-9H-pyrimido[4,5-b]indol-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337371; BDBM50430562
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
5-Chloro-4-N-(4-propan-2-ylphenyl)-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337362; BDBM50430571
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
5-Chloro-4-N-(4-chloro-2-fluorophenyl)-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337364; BDBM50430569
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
2,4-Diaminofuro[2,3-d]pyrimidine, 11
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594790; BDBM33405; D2F
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
N-[5-Chloro-4-(4-propan-2-ylanilino)-9H-pyrimido[4,5-b]indol-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337368; BDBM50430565
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)-4-methylpent-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL593154
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[1-(dimethylamino)-2-methylsulfonylethyl]furan-2-yl]quinazolin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344208; SCHEMBL1351264; BDBM50030376
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[23] | |||
| Compound Name |
5-(4-Chlorophenyl)sulfanyl-9H-pyrimido[4,5-b]indole-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079829; BDBM50235699
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[11] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)-3-methylbut-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL594810
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
5-[2-(2-Methoxyphenyl)hex-1-enyl]furo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL604879
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[17] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-(naphthalen-2-ylmethyl)pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956896; BDBM50366083
Click to Show/Hide
|
||||
| Activity |
IC50 = 212400 nM
|
[5] | |||
| Compound Name |
N-(3-Bromophenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094783; BDBM50318186
Click to Show/Hide
|
||||
| Activity |
IC50 = 220400 nM
|
[22] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(3,4-dichlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956894; BDBM50366085
Click to Show/Hide
|
||||
| Activity |
IC50 = 229600 nM
|
[5] | |||
| Compound Name |
N4-(3-Fluoro-4-trifluoromethylphenyl)-6-(2,4-dichlorobenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094808; BDBM50318179
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[22] | |||
| Compound Name |
4-N-(4-Chloro-2-fluorophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1929554; BDBM50360176
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[1] | |||
| Compound Name |
N4-(3-Bromophenyl)-6-(2,5-dimethoxybenzyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095465; BDBM50318183
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[1] | |||
| Compound Name |
6-[(2,4-Dichlorophenyl)methyl]-4-N-(3-ethynylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094475; BDBM50318178; N4-(3-Ethynylphenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[22] | |||
| Compound Name |
N4-(4-Bromo-2-chlorophenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095762; BDBM50318173; 7H-Pyrrolo[2,3-d]pyrimidine-2,4-diamine, N4-(4-bromo-2-chlorophenyl)-6-[(2,4-dichlorophenyl)methyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[22] | |||
| Compound Name |
6-[(2,4-Dichlorophenyl)methyl]-4-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095445; BDBM50318177; N4-(3-Trifluoromethylphenyl)-6-(2,4-dichlorobenzyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[22] | |||
| Compound Name |
4-N-(3-Ethynylphenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335379; BDBM50429678
Click to Show/Hide
|
||||
| Activity |
IC50 = 331500 nM
|
[18] | |||
| Compound Name |
2-Amino-4-(m-bromoanilino)-6-(2,5-dimethoxybenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254522; BDBM50326616
Click to Show/Hide
|
||||
| Activity |
IC50 = 348000 nM
|
[15] | |||
| Compound Name |
N-[4-(3-Ethynylanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335017; BDBM50429677
Click to Show/Hide
|
||||
| Activity |
IC50 = 430100 nM
|
[18] | |||
| Compound Name |
2-Amino-4-(N-methyl-m-bromoanilino)-6-(2,5-dimethoxybenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254523; BDBM50326617
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
N-(4-Chloro-2-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096416; BDBM50318167
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
N4-(3-Chloro-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL504416; BDBM50271804
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
N-(3-Ethynylphenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096972; BDBM50318163
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
4-N-(3-Bromophenyl)-7-[(4-chlorophenyl)methyl]pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956891; BDBM50366090
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
2-Amino-4-(N-methyl-m-bromoanilino)-6-benzyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254199; BDBM50326609
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
6-(2-Phenylethyl)-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1097743; BDBM50318164
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
2-Amino-4-(N-methyl-m-bromoanilino)-6-(2-methylbenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254443; BDBM50326614
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
7-Benzyl-4-N-(3-bromophenyl)pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1956888; BDBM50366088
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
N-[4-(3-Chloro-4-fluoroanilino)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335016; BDBM50429670
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[18] | |||
| Compound Name |
N-[4-[4-Fluoro-3-(trifluoromethyl)anilino]-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335019; BDBM50429668
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[18] | |||
| Compound Name |
6-(2-Pyridin-2-ylethyl)-4-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335013; BDBM50429672
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[18] | |||
| Compound Name |
2-Amino-4-(m-bromoanilino)-6-(2-methylbenzyl)-7-methyl-pyrrolo[2,3-d]pyrimidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1254364; BDBM50326613
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[15] | |||
| Compound Name |
4-N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335014; BDBM50429671
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[18] | |||
| Compound Name |
6-Phenethyl-N4-(3-(trifluoromethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483312; BDBM50271848; N4-(3-Trifluromethylphenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
2,2-Dimethyl-N-[6-(2-pyridin-2-ylethyl)-4-[3-(trifluoromethyl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335018; BDBM50429669
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[18] | |||
| Compound Name |
4-N-(3-Bromo-4-fluorophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335377; BDBM50429674
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[18] | |||
| Compound Name |
N4-(4-Chloro-2-fluorophenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483313; BDBM50271850; N4-(4-chloro-2-fluorophenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1096415; BDBM50318166
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
4-N-(3-Chloro-4-fluorophenyl)-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335378; BDBM50429673
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[18] | |||
| Compound Name |
4-N-(4-Chlorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519147; BDBM50271851; N4-(4-Chlorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d ]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[6] | |||
| Compound Name |
N4-(3-Bromo-4-fluorophenyl)-6-phenethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL483108; BDBM50271803; N4-(3-bromo-4-fluorophenyl)-6-(2-phenylethyl)-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[16] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[24] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | N4-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors. Bioorg Med Chem. 2012 Jan 15;20(2):910-4. | ||||
| REF 2 | Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Med Chem Lett. 2010 Sep 7;1(9):454-9. | ||||
| REF 3 | Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998 Jul 2;41(14):2588-603. | ||||
| REF 4 | Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and P... J Med Chem. 1999 Dec 16;42(25):5120-30. | ||||
| REF 5 | N4-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation. Bioorg Med Chem. 2012 Apr 1;20(7):2444-54. | ||||
| REF 6 | Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents. Bioorg Med Chem. 2008 May 15;16(10):5514-28. | ||||
| REF 7 | Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs). Eur J Med Chem. 2013 Jul;65:477-86. | ||||
| REF 8 | Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Feb;16(3):737-42. | ||||
| REF 9 | Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents. Bioorg Med Chem. 2013 Apr 1;21(7):1857-64. | ||||
| REF 10 | Optimization of potent DFG-in inhibitors of platelet derived growth factor receptor (PDGF-R) guided by water thermodynamics. J Med Chem. 2015 Jan 8;58(1):170-82. | ||||
| REF 11 | Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Bioorg Med Chem Lett. 2017 Apr 1;27(7):1602-1607. | ||||
| REF 12 | Chimerically designed HDAC- and tyrosine kinase inhibitors. A series of erlotinib hybrids as dual-selective inhibitors of EGFR, HER2 and histone deacetylases. Medchemcomm. 2012;3:829-35. | ||||
| REF 13 | Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases. J Med Chem. 2000 Jul 13;43(14):2655-63. | ||||
| REF 14 | Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases. J Med Chem. 2009 Apr 23;52(8):2265-79. | ||||
| REF 15 | Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents. Bioorg Med Chem. 2010 Jul 15;18(14):5261-73. | ||||
| REF 16 | The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines. Bioorg Med Chem Lett. 2010 May 15;20(10):3177-81. | ||||
| REF 17 | Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase i... Bioorg Med Chem. 2009 Oct 15;17(20):7324-36. | ||||
| REF 18 | N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents. Bioorg Med Chem. 2013 Mar 1;21(5):1312-23. | ||||
| REF 19 | Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185(erbB)) tyrosine kinases. Bioorg Med Chem Lett. 2002 Aug 19;12(16):2153-7. | ||||
| REF 20 | Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1167-70. | ||||
| REF 21 | Discovery of novel 5-alkynyl-4-anilinopyrimidines as potent, orally active dual inhibitors of EGFR and Her-2 tyrosine kinases. Bioorg Med Chem Lett. 2012 Jan 1;22(1):456-60. | ||||
| REF 22 | Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endo... Bioorg Med Chem. 2010 May 15;18(10):3575-87. | ||||
| REF 23 | Design and synthesis of Lapatinib derivatives containing a branched side chain as HER1/HER2 targeting antitumor drug candidates. Eur J Med Chem. 2014 Nov 24;87:631-42. | ||||
| REF 24 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
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