Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T56496 | Target Info | |||
| Target Name | Phenylethanolamine N-methyltransferase (PNMT) | ||||
| Synonyms |
PNMTase; PENT; Noradrenaline N-methyltransferase
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| Target Type | Literature-reported Target | ||||
| Gene Name | PNMT | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 18 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
7,8-Dichloro-2-(6-phenyl-hexyl)-1,2,3,4-tetrahydro-isoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL165426; BDBM50028905
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| Activity |
IC50 = 50000 nM
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[1] | |||
| Compound Name |
Bicyclo(2.2.2)octan-1-amine, 4-phenyl-
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Investigative | Compound Info | ||
| Synonyms |
Exp 561; Exp-561 free base; Exp561; UNII-1P958G9T1V; 4-Phenylbicyclo[2.2.2]Octan-1-amine; CHEMBL288524; 1P958G9T1V; 4-Phenyl-bicyclo[2.2.2]oct-1-ylamine; Bicyclo[2.2.2]octan-1-amine, 4-phenyl-; 4-Phenylbicyclo(2.2.2)octan-1-amine; 1-Amino-4-phenylbicyclo(2.2.2)octane; SCHEMBL11046911; DTXSID20144571; BDBM50022781; 1-amino-4-phenylbicyclo[2,2,2]octane; 4-Phenylbicyclo[2.2.2]oct-1-ylamine #; (EXP-561)4-Phenyl-bicyclo[2.2.2]oct-1-ylamine; Q5324704; (4-phenyl-1-bicyclo[2.2.2]octanyl)azanium chloride
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| Activity |
Ki = 51000 nM
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[2] | |||
| Compound Name |
1-(3-Chlorophenyl)propan-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL149022; 2-(3-Chloro-phenyl)-1-methyl-ethylamine; 2-(3-chlorophenyl)-1-methylethylamine; 3-Chloroamphetamine; SCHEMBL266685; CTK6A7115; BDBM50029103; AKOS000152975; MB06208; MCULE-1219027466; AB01002132-01
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| Activity |
IC50 = 60000 nM
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[3] | |||
| Compound Name |
N-Ethyl-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL199008; BDBM50174117
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| Activity |
Ki = 60000 nM
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[4] | |||
| Compound Name |
1-(4,5,6,7-Tetrahydrothieno[3,2-c]pyridin-2-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL253010; 2-acetyl-4,5,6,7-tetrahydrothieno[3.2-c]pyridine; BDBM50227506
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| Activity |
Ki = 61000 nM
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[5] | |||
| Compound Name |
3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid benzylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL36909; BDBM50080518; 3-fluoromethyl-7-(N-benzylaminosulfonyl)-1,2,3,4-tetrahydro-isoquinoline
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| Activity |
Ki = 62000 nM
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[2] | |||
| Compound Name |
3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid isopropylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL426442; BDBM50151331
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| Activity |
Ki = 66000 nM
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[6] | |||
| Compound Name |
7-Sulfonyl-THIQ 25
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL214064; BDBM13035; ((+/-)-3-Fluoromethyl-7-(4,4,4-trifluorobutylsulfonyl)-1,2,3,4-tetrahydroisoquinoline; 3-(fluoromethyl)-7-[(4,4,4-trifluorobutane)sulfonyl]-1,2,3,4-tetrahydroisoquinoline
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| Activity |
Ki = 67000 nM
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[7] | |||
| Compound Name |
7-Sulfonyl-THIQ 29
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL212026; BDBM13039; 3-(fluoromethyl)-7-[(3-methoxypropane)sulfonyl]-1,2,3,4-tetrahydroisoquinoline
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| Activity |
Ki = 72000 nM
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[7] | |||
| Compound Name |
3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid adamantan-1-ylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL188117; BDBM50151342
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| Activity |
Ki = 88000 nM
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[6] | |||
| Compound Name |
3-(Fluoromethyl)-N-(4-phenylbutyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184296; BDBM50151339; 3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (4-phenyl-butyl)-amide
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| Activity |
Ki = 93000 nM
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[6] | |||
| Compound Name |
6-(7,8-Dichloro-3,4-dihydro-1H-isoquinolin-2-yl)-hexan-1-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL350571; BDBM50028907
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399178; SCHEMBL6421837; BDBM50227510; ZINC29039159; DA-48382; FT-0733504; 2-carbamoyl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine
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| Activity |
Ki = 100000 nM
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[5] | |||
| Compound Name |
2-(6-Bromo-hexyl)-7,8-dichloro-1,2,3,4-tetrahydro-isoquinoline
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL165252; BDBM50028904
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| Activity |
IC50 = 100000 nM
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[1] | |||
| Compound Name |
3-Thienylmethylamine
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Investigative | Compound Info | ||
| Synonyms |
thiophen-3-ylmethanamine; 3-(Aminomethyl)thiophene; 3-Thiophenemethanamine; 1-THIEN-3-YLMETHANAMINE; 3-Thiophenemethylamine; (3-thienylmethyl)amine; Thiophen-3-yl-methylamine; (thiophen-3-yl)methanamine; 1-(3-THIENYL)METHANAMINE; 1-(thiophen-3-yl)methanamine; CHEMBL252602; MFCD01529872; 3-aminomethylthiophene; PubChem12348; 3-Thiophene-methylamine; 3-thiopheneylmethanamine; Thiophene-3-methaneamine; ChemDiv2_001991; 1-thiophen-3-ylmethanamine; 3-Thienylmethylamine, 97%; C-Thiophen-3-yl-methylamine; C-thiophene-3-yl-methylamine; KSC201O5D; SCHEMBL120232; RARECHEM AL BW 0778; CTK1A1751; DTXSID50950445; HMS1374K11; ZINC158761; ALBB-015182; ANW-72829; BBL100341; BDBM50227509; SBB079179; STK089778; AKOS000149530; CS-W002779; MCULE-1358443205; PB12237; PS-4278; VZ27259; AK-48092; BP-12034; SC-24166; AB0001847; DB-002526; BB 0222327; EU-0017101; FT-0616399; Y8534; EN300-30647; KS-00001003; Q-1119; 222135A; 757T864; W-202163; Q27458556
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| Activity |
Ki = 110000 nM
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[5] | |||
| Compound Name |
N-(4-Nitrophenyl)-3-(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL381596; BDBM50186672; (+/-)-7-(N-4-nitrophenylaminosulfonyl)-3-trifluoromethyl-1,2,3,4-tetrahydroisoquinoline
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| Activity |
Ki = 110000 nM
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[8] | |||
| Compound Name |
(R)-6-Methyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL252606; BDBM50227508
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| Activity |
Ki = 150000 nM
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[5] | |||
| Compound Name |
4-Cyclohexylbicyclo[2.2.2]octane-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL288525; BDBM50100951; 1-cyclohexylbicyclo[2.2.2]octan-4-amine; 4-Cyclohexyl-bicyclo[2.2.2]oct-1-ylamine
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| Activity |
Ki = 180000 nM
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[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 10 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Para-chloroamphetamine
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Investigative | Compound Info | ||
| Synonyms |
p-CHLOROAMPHETAMINE; para-Chloroamphetamine; p-Chloramphetamine; 1-(4-chlorophenyl)propan-2-amine; 4-Chloramphetamine; 4-Chloroamphetamine; 64-12-0; Para Chloroamphetamine; DL-Chloramphetamine; (+-)-p-Chloramphetamine; C9H12ClN; (+-)-p-Chloroamphetamine; p-Chloroamphetamine (VAN); (+-)-4-Chloroamphetamine; NSC 287208; DL-p-Chloroamphetamine; LY-121860; alpha-Methyl-p-chlorophenethylamine; 4-Chloro-alpha-methylphenethylamine; Benzeneethanamine, 4-chloro-alpha-methyl-; (+-)-p-Chloro-alpha-methylphenethylamine; CHEMBL358967
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| Activity |
IC50 = 300000 nM
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[3] | |||
| Compound Name |
3-(Fluoromethyl)-N-(3-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184069; BDBM50151335; 3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (3-nitro-phenyl)-amide
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| Activity |
Ki = 250000 nM
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[6] | |||
| Compound Name |
Thiophene-2-ethylamine
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Investigative | Compound Info | ||
| Synonyms |
2-Thiopheneethylamine; 2-(thiophen-2-yl)ethanamine; 2-Thiopheneethanamine; Thiopheneethanamine; 2-thien-2-ylethanamine; 2-(2-Thienyl)ethylamine; 2-(2-Aminoethyl)thiophene; Thiopheneethylamine; 2-(thiophen-2-yl)ethan-1-amine; 2-thiophen-2-ylethanamine; MFCD00051495; Thiopheneethanamine(9CI); 2-(2'-thienyl)ethyl amine; CHEMBL252803; 2-(2-Thienyl)ethanamine; Thiophene-2-ethylamine, 98%; Thiophene-1-ethylamine; EINECS 264-646-7; thienylethylamine; 2-thienylethlamine; Thiopene ethylamine; 2-thienylethylamine; 2-thiophenethylamine; EINECS 250-196-9; 2-aminoethylthiophene; 2-thiophenyl ethylamine; ACMC-209hfw; 2-thiophen-2-ylethylamine; 2-(2-thienyl)ethyl amine; beta-(2-thienyl)ethylamine; EC 250-196-9; .beta.-2-Thienylethylamine; 2-(2-Thienyl)-ethylamine; 2-thiophen-2-yl ethylamine; 2-thiophen-2-yl-ethylamine; 2-(2-aminoethyl)-thiophene; 2-thiophene-2-yl-ethylamine; 2-(2-Thienyl)ethanamine #; 2-Thiopheneethylamine, 96%; KSC222G5D; BIDD:GT0488; SCHEMBL244450; 2-(2-thienyl)-1-ethanamine; 2-(thiophen-2-yl)ethaneamine; SCHEMBL7086137; SCHEMBL9221266; CTK1C2351; DTXSID60952773; HMS1789C01; ZINC154805; ALBB-006230; EBD32012; KS-000009GC; STR06269; 2-(THIOPHEN-2-YL)ETHYLAMINE; ANW-26874; BBL001466; BDBM50227513; SBB013250; STK501234; AKOS000125051; AC-6275; LS21113; MCULE-8334990165; PB12982; PS-3264; SB10582; NCGC00330609-01; AK-44822; AM803664; SC-03284; SC-03285; SY004316; AB0012147; DB-038131; ST4111306; BB 0221013; FT-0602566; Z5502; EN300-12163; AB01324885-02; 433T911; W-106941; F2190-0537
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| Activity |
Ki = 300000 nM
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[5] | |||
| Compound Name |
(1S)-1-Phenylethanamine
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Investigative | Compound Info | ||
| Synonyms |
(S)-(-)-1-Phenylethylamine; (S)-1-phenylethanamine; (S)-(-)-alpha-Methylbenzylamine; (S)-1-Phenylethylamine; L-alpha-Methylbenzylamine; L-1-Phenylethylamine; L(-)-alpha-Methylbenzylamine; (S)-alpha-Methylbenzenemethanamine; (s)-(-)-1-methylbenzylamine; (-)-alpha-Phenethylamine; L-(-)-1-Phenylethylamine; L-(-)-alpha-Phenylethylamine; S-Alfa-Methylbenzylamine; (S)-alpha-Methylbenzylamine; MFCD00064406; s-(-)-alpha-phenylethylamine; (alphaS)-alpha-methylbenzenemethanamine; (1S)-1-phenylethan-1-amine; L-(-)-alpha-methylbenzylamine; CHEMBL282700; (-)-1-phenethylamine; UNII-05780F90V3; (1S)-(-)-1-Phenylethylamine; 05780F90V3; L(-)-alpha-Methylbenzylamine, 99+%, (99% ee); (S)-(-)-a-methyl-benzylamine; 1-Phenethylamine, (-)-; (S)-(-)-a-methylbenzylamine; EINECS 220-098-0; PubChem6061; (S)-1phenylethylamine; 1(S)-phenylethylamine; L-alpha-Phenylethylamine; (S) -1phenylethylamine; (S)-1 phenylethylamine; 1-(S)-phenylethylamine; (S)1-Phenyl-Ethylamine; (s)-1-phenylethyl amine; 1(s)-phenyl ethyl amine; (1S)-1-phenylethylamine; (S)-1-phenyl-ethylamine; (S)-1-phenylethyl-amine; Benzenemethanamine, alpha-methyl-, (alphaS)-; EC 220-098-0; S(-)-; A-phenylethylamine; (1 S)-1-phenylethanamine; (1S)-1-phenyl-ethylamine; (S)-1-(phenyl)ethylamine; (5)-alpha-methylbenzylamine; SCHEMBL42904; (S)-(-)1-phenylethylamine; (S)-1-(phenyl)-ethylamine; (S)-1-phenylethan-1-amine; (S)-alpha-methyl benzylamine; (S)-alpha-methyl-benzylamine; (s)-alpha-methylbenzyl amine; (S)-PEA; [(1S)-1-phenylethyl]amine; KSC495O8T; (-)-(S)-1-penylethylamine; (S)-(-)-1-phenylethanamine; (S)-alpha methyl benzyl amine; SCHEMBL4166272; (S)(-)-alpha-methylbenzylamine; (S)-(-)-1-phenyl-ethylamine; l(-)-alpha-methyl-benzyl amine; (S)-(-)-; A-Methylbenzylamine; (S)-(-)-alpha-methylbenzylamin; (s)-(-)-alpha-phenylethylamine; (S)-(?)-; A-Methylbenzylamine; CTK3J5789; (-)-(S)-alpha-methylbenzylamine; (S)-(+)-alpha-methylbenzylamine; DTXSID701014613; (S)-(-)-alpha-methyl benzylamine; STR00933; ZINC6030374; (S)-(-)-alpha methyl benzyl amine; (S)-(-)-alpha-methyl benzyl amine; (S)-(-)-alpha-methyl-benzyl amine; ANW-75666; BDBM50028638; s6260; AKOS005259686; AKOS012313698; AC-8774; CS-W019840; LS30171; MCULE-6602875097; KS-000002Q5; (-)-(S)-alpha-methyl-benzenemethanamine; (S)-(-)-alpha-Methylbenzylamine, 98%; AS-14055; BR-47537; SC-02998; (S)(-) - 1 - PHENYLETHYLAMINE; AM20060475; P0793; EN300-67316; M-5951; 79514-EP2305695A2; 79514-EP2305696A2; 79514-EP2305697A2; 79514-EP2305698A2; J-505090; Q27116451; F0001-2350
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| Activity |
Ki = 430000 nM
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[2] | |||
| Compound Name |
2-Thiophenemethylamine
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Investigative | Compound Info | ||
| Synonyms |
thiophen-2-ylmethanamine; 2-Thienylmethylamine; 2-THIOPHENEMETHANAMINE; Thiophenemethanamine; Thiophene-2-methylamine; 2-(Aminomethyl)thiophene; 2-Aminomethylthiophene; 2-Thenylamine; (2-Thienylmethyl)amine; 1-(thiophen-2-yl)methanamine; (2-thienyl)methylamine; thiophene-2-methanamine; MFCD00005460; CHEMBL237711; 2-Thiophenemethylamine, 95%; thenylamine; thienylmethylamine; Thiophenemethylamine; EINECS 248-639-6; 2-thienylmethyl amine; 5-aminomethylthiophene; PubChem5606; thiophene methyl amine; 2-thiophenylmethylamine; thiophene methane amine; 2-aminomethyl thiophene; 2-aminomethyl-thiophene; 2-thiophene methylamine; 5-aminomethyl-thiophene; 2-Thienylmethanamine #; 2-Thiophene-methylamine; 2-thiopheneylmethanamine; thiophen-2-ylmethylamine; 2-thiophene methyl amine; thiophene-2-ylmethanamine; thiophen-2-yl-methanamine; thiophen-2-ylmethyl-amine; ACMC-1CFB0; 1-(2-thienyl)methanamine; 1-(2-thienyl)methylamine; 2-(aminomethyl)-thiophene; (thiophen-2-yl)methanamine; 1-thiophen-2-ylmethanamine; thiophen-2-yl-methyl-amine; 2-(2-Aminomethyl)thiophene; (thiophen-2-yl-methyl)amine; KSC202C7H; SCHEMBL121154; 1-THIEN-2-YLMETHANAMINE; DTXSID7075343; CTK1A2173; (2-Thienylmethyl)ammonium chloride; ZINC154648; C-THIOPHEN-2-YL-METHYLAMINE; KS-00000O2I; EINECS 231-011-0; ANW-26267; BDBM50227501; SBB004315; STL185547; AKOS000120646; CS-W007649; PB17027; PS-5819; VT20155; AC-15711; AK-46394; AM803624; BR-46394; SC-03078; SC-92710; 4-OH-7-3FmEt-3-quinolinecarboxylic acid; AB0014657; DB-015938; BB 0218285; FT-0608728; ST45244351; S-1365; 79517-EP2305695A2; 79517-EP2305696A2; 79517-EP2305697A2; 79517-EP2305698A2; J-640139; J-800143; W-107096; F2169-1040
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| Activity |
Ki = 450000 nM
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[5] | |||
| Compound Name |
9H-Fluorene-2-methanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL41079; (9H-fluoren-2-yl)methanamine; CTK1C0982; DTXSID70616970; 1-(9H-Fluoren-2-yl)methanamine; 9H-FLUOREN-2-YLMETHANAMINE; C-(9H-Fluoren-2-yl)-methylamine; BDBM50100956; ZINC29345813; SC-59177
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| Activity |
Ki = 530000 nM
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[2] | |||
| Compound Name |
2-Aminobenzonorbornene
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL39492; exo-2-aminobenzobicyclo[2.2.1]heptene; endo-2-Aminobenzonorbornene; 1,2,3,4-Tetrahydro-1,4-methano-naphthalen-2-ylamine; SCHEMBL5704636; CTK2I6231; DTXSID70874199; (exo)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-2-ylamine; BDBM50020491; BENZOBICYCLO(2,2,1)HEPTENE,2-EN-AMINO; 1,4-Methanonaphthalen-2-amine, 1,2,3,4-tetrahydro-; tricyclo[6.2.1.0?,?]undeca-2,4,6-trien-9-amine; tricyclo[6.2.1.02,7]undeca-2,4,6-trien-9-amine; endo-2-amino-1,2,3,4-tetrahydro-1,4-methanonaphthalene; 1,4-Methanonaphthalen-2-amine, 1,2,3,4-tetrahydro-, (1alpha,2beta,4alpha)-
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| Activity |
Ki = 730000 nM
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[2] | |||
| Compound Name |
1-Phenylethylamine
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Investigative | Compound Info | ||
| Synonyms |
1-Phenylethanamine; ALPHA-METHYLBENZYLAMINE; alpha-Phenylethylamine; DL-alpha-Methylbenzylamine; 1-Phenethylamine; alpha-Aminoethylbenzene; 1-Amino-1-phenylethane; a-methylbenzylamine; alpha-Methylbenzenemethanamine; alpha-Phenethylamine; 1-Phenyl-ethylamine; 1-phenylethan-1-amine; 1-Fenylethylamin; a-phenylethylamine; Benzenemethanamine, .alpha.-methyl-; DL-1-Phenylethylamine; Sumine 2079; Ethanamine, 1-phenyl-; Ethylamine, 1-phenyl-; DL-1-phenethylamine; (1-Aminoethyl)benzene; a-methylbenzenemethanamine; Benzylamine, .alpha.-methyl-; CHEMBL278059; (+/-)-alpha-Methylbenzylamine; (S)-.alpha.-Methylbenzenemethanamine; MFCD00008069; Benzenemethanamine, .alpha.-methyl-, (S)-; UNII-HZ9DM6B2MT; DL-alpha-Methylbenzylamine, 99%; r-(+)-alpha-phenylethylamine; 1-Fenylethylamin [Czech]; Benzylamine, alpha-methyl-; (S)-(-)-a-methyl-benzylamine; Benzene, (1-amino-ethyl)-; HZ9DM6B2MT; Benzenemethanamine, a-methyl-; a-phenethylamine; Timepidiumbromide; HSDB 2742; l-phenylethylamine; Benzenemethanamine, alpha-methyl-; a-aminoethylbenzene; Benzenemethaneamine, alpha-methyl-; NSC 8391; 1-phenylethyl amine; EINECS 202-706-6; EINECS 210-545-8; phenylethan-1-amine; 1-Phenyl ethylamine; alpha-methylbezylamine; APHEA; (1-phenylethyl)amine; 1-phenyl-ethyl-amine; 1-Phenylethanamine #; rac-1-phenylethanamine; .alpha.-Phenethylamine; dl-1-phenylethyl amine; PubChem21079; 1-Phenyl-1-ethanamine; alpha-methyl benzylamine; alpha-methyl-benzylamine; alpha-methylbenzyl amine; A-Phenylethylamine; .alpha.-Phenylethylamine; A-Methylbenzylamine; 1(r,s)-phenylethylamine; AI3-03116; (+)-1-phenylethylamine; (-)-1-phenylethylamine; alpha-methyl benzyl amine; (?)-1-Phenylethylamine; .alpha.-Methylbenzylamine; (-)alpha-phenylethylamine; racemic 1-phenylethanamine; racemic 1-phenylethylamine; SCHEMBL830; ACMC-209j2b; ACMC-20aj38; (-)-alpha-phenylethylamine; EC 210-545-8; (+) alpha-methylbenzylamine; (+)-alpha-methylbenzylamine; (+)1-phenylethan-1-amine; (+/-)-1-phenylethanamine; (-)-alpha-methylbenzylamine; (+/-)-1-Phenylethylamine; (RS)-alpha-methylbenzylamine; (-)-.alpha.-Phenethylamine; (+)-alpha-methyl-benzylamine; (-) alpha-methyl-benzylamine; (-)-alpha-methyl-benzylamine; WLN: 1M1R; (+/-)-1-phenyl-ethanamine; (+/-)-1-Phenyl-ethylamine; alpha-Methylbenzylamine, 99%; racemic alpha-methylbenzylamine; (+)-alpha-methyl benzyl amine; (+/-)-1-(phenyl)ethylamine; (-) alpha methyl benzyl amine; SCHEMBL4701869; L(-)-.alpha.-Methylbenzylamine; DTXSID40862301; L-(-)-.alpha.-Phenylethylamine; NSC8391; (-)-alpha-methylbenzenemethanamine; ALBB-032928; BCP32849; KS-00000G3I; NSC-8391; (^+)-1-Phenylethylamine, 98+%; (R)-.alpha.-Methylbenzenemethanamine; (S)-(-)-.alpha.-Methylbenzylamine; ANW-53664; BBL027673; BDBM50023171; Benzenemethaneamine, .alpha.-methyl-; SBB040514; STK397443; AKOS000119070; AKOS016039387; racemic alpha-methyl-benzenemethanamine; CS-W013564; MCULE-6637542099; PS-4601; SC-18396; Benzenemethanamine, .alpha.-methyl-, (R)-; DB-015888; DB-054000; A6546; AM20060838; Benzylamine, .alpha.-methyl-, (.+/-.)-; FT-0601072; FT-0604486; FT-0658781; M0165; ST45255353; C02455; A-Methylbenzylamine DL-; A-Phenylethylamine; (S)-1-phenylethanamine;(1S)-1-phenylethanamine; 83288-EP2270009A1; 83288-EP2272822A1; 83288-EP2284174A1; 83288-EP2298779A1; 83288-EP2305655A2; Benzenemethanamine, .alpha.-methyl-, (.+/-.)-; Benzenemethanamine, .alpha.-methyl-, (.alpha.R)-; Benzenemethanamine, .alpha.-methyl-, (.alpha.S)-; N-FMOC-AMINO-4-KETOCYCLOHEXYLCARBOXYLICACID; Q3560549; W-105090; F0798-0597
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| Activity |
Ki = 830000 nM
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[2] | |||
| Compound Name |
N-(3-Chlorophenyl)-3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL184471; BDBM50151345; 3-Fluoromethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (3-chloro-phenyl)-amide
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| Activity |
Ki = 890000 nM
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[6] | |||
| Compound Name |
(1R)-1-Phenylethanamine
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Investigative | Compound Info | ||
| Synonyms |
(R)-(+)-1-Phenylethylamine; (R)-1-phenylethanamine; (R)-1-Phenylethylamine; D-alpha-Methylbenzylamine; (R)-(+)-alpha-Methylbenzylamine; (1R)-1-phenylethan-1-amine; (R)-alpha-Methylbenzenemethanamine; UNII-V022ZK8GZ5; R-Alfa-Methylbenzylamine; (1R)-1-phenylethylamine; MFCD00064405; (R)-1-phenylethan-1-amine; R-(+)-ALPHA-METHYLBENZYLAMINE; CHEMBL19969; (alphaR)-alpha-methylbenzenemethanamine; V022ZK8GZ5; (+)-1-phenethylamine; R(+)-; A-phenylethylamine; (+)-alpha-phenylethylamine; (R)-alpha-methylbenzylamine; (1R)-(+)-1-Phenylethylamine; (+)-(R)-alpha-methylbenzylamine; [R]-1-phenylethylamine; [R]-(+)-1-phenylethylamine; R(+)-a- phenylethylamine; 1-Phenethylamine, (+)-; D(+)-alpha-Methylbenzylamine, 99+%, (99% ee); (R)-a-Methylbenzylamine; r-(+)-alpha-phenylethylamine; EINECS 223-423-4; (r)-phenylethylamine; PubChem6060; (R)-2-phenylethylamine; (R)1-Phenyl-Ethylamine; (R)-1-phenylethylarnine; (r)-1-phenyl ethylamine; 1(r)-phenyl ethyl amine; r(+)-1-phenylethylamine; (R)-1-phenyl-ethylamine; (R)alpha-methylbenzylamine; Benzenemethanamine, alpha-methyl-, (alphaR)-; (r)-1-phenyl-ethyl-amine; EC 223-423-4; (1 R)-1-phenylethanamine; (1R)-1-phenyl-ethylamine; (R)-(1-phenylethyl)amine; r(+)alpha-methylbenzylamine; (R)-alpha-methylbenzylarnine; SCHEMBL42393; (R)-1-(phenyl)-ethylamine; (R)-alpha-methyl benzylamine; [(1R)-1-phenylethyl]amine; alpha-Formylmandeloyl chloride; KSC495Q4T; (r)-(+)-a-methylbenzylamine; (1R)-1-phenyl-1-ethanamine; (R)-(-)-1-phenylethylamine; R-(+)-alpha methylbenzylamine; SCHEMBL4165369; (R)-(+)-; A-Methylbenzylamine; CTK3J5849; (R)-(+)-alfa-Methylbenzylamine; (R)-(+)-beta-Methylbenzylamine; DTXSID80930735; (R)-(-)-alpha-methylbenzylamine; (R)-(+)-alpha-methyl benzylamine; (R)-(+)-alpha-methyl-benzylamine; (R)-(+)-alpha-methylbenzyl amine; ACT09657; ZINC6037146; ANW-28977; BDBM50028628; AKOS005256786; AC-8773; CS-W008645; LS30099; MCULE-5411292127; (+)-(R)-alpha-methylbenzenemethanamine; (+)-(R)-alpha-methyl-benzenemethanamine; (R)-(+)-alpha-Methylbenzylamine, 98%; BR-41208; SC-04075; AB0006357; AM20060613; P0794; EN300-67366; M-6210; 79524-EP2305695A2; 79524-EP2305696A2; 79524-EP2305697A2; 79524-EP2305698A2; Q-200619; Q-200923; Q27116453; F8889-8738
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| Activity |
Ki = 4800000 nM
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[2] | |||
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| References | Top | ||||
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| REF 1 | Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 3. Bis[tetrahydroisoquinoline]s. J Med Chem. 1981 Jun;24(6):756-9. | ||||
| REF 2 | Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1579-82. | ||||
| REF 3 | Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis. 1. Chloro-substituted 1,2,3,4-tetrahydroisoquinolines. J Med Chem. 1980 May;23(5):506-11. | ||||
| REF 4 | Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5319-23. | ||||
| REF 5 | Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase. Bioorg Med Chem. 2008 Jan 1;16(1):542-59. | ||||
| REF 6 | Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the alpha2-adrenoceptor. J Med Chem. 2004 Aug 26;47(18):4483-93. | ||||
| REF 7 | Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phen... J Med Chem. 2006 Sep 7;49(18):5424-33. | ||||
| REF 8 | Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination. J Med Chem. 2006 May 18;49(10):2939-52. | ||||
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