Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T50688 | Target Info | |||
| Target Name | Glycoprotein IIb/IIIa receptor (GPIIb/IIIa) | ||||
| Synonyms |
Platelet membrane glycoprotein IIb; Platelet membrane glycoprotein IIIa; GP
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| Target Type | Successful Target | ||||
| Gene Name | ITGA2B; ITGB3 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 175 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Aspirin
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|
Approved | Compound Info | ||
| Synonyms |
ACETYLSALICYLIC ACID; 50-78-2; 2-Acetoxybenzoic acid; o-Acetoxybenzoic acid; O-Acetylsalicylic acid; Polopiryna; Acylpyrin; Ecotrin; Easprin; Acetylsalicylate; Acetophen; Acenterine; Acetosal; Colfarit; Salicylic acid acetate; o-Carboxyphenyl acetate; Enterosarein; Aspergum; Salcetogen; Pharmacin; Acetosalin; Premaspin; Micristin; Benaspir; Aspirdrops; Acetonyl; Aceticyl; Temperal; Acetylin; Empirin; Ecolen; Rhodine; Endydol; Saletin; Rheumintabletten; Solprin acid; Acidum acetylsalicylicum; Globentyl; Pravigard
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
BIO-1211
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Phase 2 | Compound Info | ||
| Synonyms |
BIO-1211; BIO 1211; 187735-94-0; UNII-61G4E2353I; CHEMBL88478; 61G4E2353I; BIO1211; GTPL6589; SCHEMBL1223367; MolPort-023-276-985; ZINC3930111; BDBM50074661; AKOS024457866; L-Proline, N-(2-(4-((((2-methylphenyl)amino)carbonyl)amino)phenyl)acetyl)-L-leucyl-L-alpha-aspartyl-L-valyl-; L-Proline, N-((4-((((2-methylphenyl)amino)carbonyl)amino)phenyl)acetyl)-L-leucyl-L-alpha-aspartyl-L-valyl-
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
VL-0395
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL137814; GTPL886; BDBM50061836; 3-{3-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic acid; beta-[[3-[(5-Amidino-1H-indol-2-yl)carbonylamino]benzoyl]amino]benzenepropanoic acid; 3-[[3-[(5-carbamimidoyl1H-indole-2-carbonyl)amino]benzoyl]amino]-3-phenylpropanoic acid
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
CYCLORGDFV
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Investigative | Compound Info | ||
| Synonyms |
CYCLORGDFV; cyclo(Arg-Gly-Asp-D-Phe-Val); CHEMBL411941; cyclo[Arg-Gly-Asp-D-Phe-Val]; Cyclo(-Arg-Gly-Asp-D-Phe-Val); 137813-35-5; c-[-Arg-Gly-Asp-fV-]; c[Arg-Gly-Asp-(R)-Phe-Val]; cyclo-(Arg-Gly-Asp-D-Phe-Val); Cyclo(Arg-Gly-Asp-D-Phe-Val-); cyclo(-Arg-Gly-Asp-D-Phe-Val-); BDBM50237601; ZINC17655303; NCGC00167283-01; [(2S,5R,8S,11S)-5-Benzyl-11-(3-guanidino-propyl)-8-isopropyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl]-acetic acid
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Gly-Arg-Gly-Asp-Ser
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Investigative | Compound Info | ||
| Synonyms |
Gly-arg-gly-asp-ser; 96426-21-0; GRGDS; glycyl-arginyl-glycyl-aspartyl-serine; H-Gly-Arg-Gly-Asp-Ser-OH; CHEMBL417553; L-Serine, N-(N-(N-(N2-glycyl-L-arginyl)glycyl)-L-alpha-aspartyl)-; GRGDS Peptide; C17H30N8O9; AC1L3XCA; NH2-Gly-Arg-Gly-Asp-Ser; SCHEMBL17440322; RGNVSYKVCGAEHK-GUBZILKMSA-N; HY-P0295; ZINC13455558; MFCD00076459; BDBM50414896; BDBM50006330; AKOS030622941; NCGC00167212-01; Gly-Arg-Gly-Asp-Ser, > LS-178299; FT-0772116; L-Serine,glycyl-L-arginylglycyl-L-a-aspartyl-
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| Activity |
IC50 = 160000 nM
|
[5] | |||
| Compound Name |
(2S)-3-Oxo-4-methyl-7-[2-(phenylamino)ethylcarbamoyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL50075; BDBM50078699
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
CID 10458809
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL362114; SCHEMBL3689225; BDBM50155807
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
(3R)-4-[1-[3-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)propanoyl]piperidin-4-yl]-3-(5,6,7,8-tetrahydroquinolin-3-yl)butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL187014; BDBM50155809
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
(2S)-3-[[2-[(3R,5S)-1-(3,3-Dimethylbutanoyl)-5-[(pyridin-2-ylamino)methyl]pyrrolidin-3-yl]oxyacetyl]amino]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL412400; SCHEMBL14453385; BDBM50217432
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
{(R)-7-[(1H-Benzoimidazol-2-ylmethyl)-methyl-carbamoyl]-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL72941; BDBM50059126
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| Activity |
Ki ~ 50000 nM
|
[9] | |||
| Compound Name |
N-[3-(Diethylamino)propyl]-1-[4-(3-methylphenyl)-1,3-thiazol-2-yl]-5-(trifluoromethyl)pyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL133562; BDBM50035969
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
{(S)-7-[(1H-Indol-2-ylmethyl)-carbamoyl]-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl}-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL409241; SCHEMBL7398023; BDBM50072484
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| Activity |
Ki ~ 50000 nM
|
[10] | |||
| Compound Name |
(2S)-3-[[2-[(3R,5S)-5-[[(4-Methoxypyridin-2-yl)amino]methyl]-1-phenylmethoxycarbonylpyrrolidin-3-yl]oxyacetyl]amino]-2-[(1-methylcyclohexanecarbonyl)amino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241834; SCHEMBL14453479; BDBM50217425
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
{(S)-4-Methyl-3-oxo-7-[2-(pyrimidin-2-ylamino)-ethylcarbamoyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL53725; BDBM50078708
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
6-[2-(4-Pyridinyl)-2,8-diazaspiro[4.5]decane-8-ylcarbonylamino]hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL12524; BDBM50111426; 6-[(2-Pyridin-4-yl-2,8-diaza-spiro[4.5]decane-8-carbonyl)-amino]-hexanoic acid
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
(2S)-3-[[2-[(3R,5S)-1-(3,3-Dimethylbutanoyl)-5-[[(4-methoxypyridin-2-yl)amino]methyl]pyrrolidin-3-yl]oxyacetyl]amino]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390398; SCHEMBL14453477; BDBM50217419
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
3-Oxo-8-[methyl(4-amidinophenyl)carbamoyl]-2,3,4,5-tetrahydro-1H-2-benzazepine-2-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL358645; BDBM50074032
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| Activity |
Ki ~ 50000 nM
|
[12] | |||
| Compound Name |
(2S)-2-[(1-Methylcyclohexanecarbonyl)amino]-3-[[2-[(3R,5S)-1-phenylmethoxycarbonyl-5-[(pyridin-2-ylamino)methyl]pyrrolidin-3-yl]oxyacetyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL243949; SCHEMBL14453427; BDBM50217423
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|
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
(3R)-3-(6-Methoxypyridin-3-yl)-4-[1-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propanoyl]piperidin-4-yl]butanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186206; SCHEMBL4251938; BDBM50155810
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
{7-[2-(1H-Benzoimidazol-2-yl)-ethylcarbamoyl]-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl}-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL73703; SCHEMBL7333550; BDBM50059132
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| Activity |
Ki ~ 50000 nM
|
[9] | |||
| Compound Name |
3-[Methyl(1H-benzimidazole-2-ylmethyl)carbamoyl]-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-10-acetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL299402; SCHEMBL7091035; BDBM50078715
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| Activity |
Ki ~ 50000 nM
|
[13] | |||
| Compound Name |
6-Oxo-6-[8-(4-pyridinyl)-2,8-diazaspiro[4.5]decane-2-yl]hexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL13033; SCHEMBL7014133; BDBM50111402; 6-Oxo-6-(8-pyridin-4-yl-2,8-diaza-spiro[4.5]dec-2-yl)-hexanoic acid; 6-oxo-6-(8-pyridin-4-yl-2,8-diazaspiro[4.5]decan-2-yl)hexanoic acid
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
(2S)-3-[[2-[(3R,5S)-1-(3,3-Dimethylbutanoyl)-5-[[(4-methoxypyridin-2-yl)amino]methyl]pyrrolidin-3-yl]oxyacetyl]amino]-2-[(1-methylcyclohexanecarbonyl)amino]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL241835; SCHEMBL14453480; BDBM50217426
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|
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
beta-[[[(5-Amidino-1H-indol-2-yl)carbonylamino]acetyl]amino]benzenepropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL137069; BDBM50061872; 3-{2-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-acetylamino}-3-phenyl-propionic acid
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
(2S)-3-[[2-[(3R,5S)-5-[[(4-Methoxypyridin-2-yl)amino]methyl]-1-phenylmethoxycarbonylpyrrolidin-3-yl]oxyacetyl]amino]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396014; BDBM50217428
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
3-{[1-(3-Piperidin-4-yl-propionyl)-piperidine-3-carbonyl]-amino}-cyclohexanecarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL309536; BDBM50287975
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| Activity |
IC50 ~ 50000 nM
|
[14] | |||
| Compound Name |
beta-[[(2S)-1-[(5-Amidinobenzofuran-2-yl)carbonyl]-2-pyrrolidinyl]carbonylamino]benzenepropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL344183; BDBM50061873
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
N-[3-(Diethylamino)propyl]-1-(4-phenyl-1,3-thiazol-2-yl)-5-(trifluoromethyl)pyrazole-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL334815; BDBM50035958
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
4-[2-(4-Pyridinyl)-2,8-diazaspiro[4.5]decane-8-ylcarbonylamino]butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL12789; BDBM50111416; 4-[(2-Pyridin-4-yl-2,8-diaza-spiro[4.5]decane-8-carbonyl)-amino]-butyric acid
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
3-{3-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-4,4,4-trifluoro-butyrylamino}-3-phenyl-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL135710; BDBM50061842
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| Activity |
IC50 = 50000 nM
|
[3] | |||
| Compound Name |
(3S)-3-[1-[4-(5,6,7,8-Tetrahydro-1,8-naphthyridin-2-yl)butanoyl]piperidin-4-yl]-3-(1,2,3,4-tetrahydroquinolin-3-yl)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL186699; BDBM50155808
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
[7-(1H-Benzoimidazol-2-ylcarbamoyl)-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73811; SCHEMBL7329758; BDBM50059134
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| Activity |
Ki ~ 50000 nM
|
[9] | |||
| Compound Name |
(2S)-3-[[2-[(3S,5R)-1-(3,3-Dimethylbutanoyl)-5-[(pyridin-2-ylamino)methyl]pyrrolidin-3-yl]oxyacetyl]amino]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594166; BDBM50423717
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
(2S)-3-[[2-[(3R,5S)-1-Phenylmethoxycarbonyl-5-[(pyridin-2-ylamino)methyl]pyrrolidin-3-yl]oxyacetyl]amino]-2-[(2,4,6-trimethylbenzoyl)amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL396743; SCHEMBL14453397; BDBM50217434
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
{[1-((S)-6-Amino-2-tert-butoxycarbonylamino-hexanoyl)-piperidine-3-carbonyl]-amino}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL40888; BDBM50034699
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| Activity |
IC50 = 50000 nM
|
[16] | |||
| Compound Name |
3-(3-Pyridin-4-yl-3-aza-spiro[5.5]undec-9-ylamino)-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL285691; BDBM50100366; N-[3-(4-Pyridinyl)-3-azaspiro[5.5]undecane-9-yl]-beta-alanine
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| Activity |
IC50 = 50000 nM
|
[17] | |||
| Compound Name |
4-[[(5-Amidino-1H-indol-2-yl)carbonylaminoacetyl]amino]butanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL319715; BDBM50059706; 4-{2-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-acetylamino}-butyric acid
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| Activity |
IC50 = 50000 nM
|
[18] | |||
| Compound Name |
(2S)-3-[[2-[(3R,5S)-1-(3,3-Dimethylbutanoyl)-5-[(pyridin-2-ylamino)methyl]pyrrolidin-3-yl]oxyacetyl]amino]-2-[(1-methylcyclohexanecarbonyl)amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389136; SCHEMBL16229364; BDBM50217427
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| Activity |
IC50 ~ 50000 nM
|
[8] | |||
| Compound Name |
{(S)-7-[(1H-Benzoimidazol-2-ylmethyl)-carbamoyl]-4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL73078; SCHEMBL6941347; BDBM50059136
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| Activity |
Ki = 52000 nM
|
[9] | |||
| Compound Name |
Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)-2-oxoacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL460144; BDBM50253817
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| Activity |
IC50 = 52000 nM
|
[19] | |||
| Compound Name |
[19-Acetylamino-4-carbamoyl-13-(3-guanidino-propyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicos-7-yl]-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL107169; BDBM50010175
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| Activity |
IC50 = 52000 nM
|
[20] | |||
| Compound Name |
1-[Methyl[4-(guanidinomethyl)benzoyl]aminoacetyl]piperidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL67606; BDBM50421451
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| Activity |
IC50 = 52480.75 nM
|
[21] | |||
| Compound Name |
(S)-2-Benzyloxycarbonylamino-3-{[5-(3-guanidino-propyl)-4,5-dihydro-isoxazole-3-carbonyl]-amino}-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL174012; BDBM50076585
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| Activity |
IC50 = 53000 nM
|
[22] | |||
| Compound Name |
Ethyl 2-(benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl}amino)acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL460143; BDBM50253816
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| Activity |
IC50 = 54000 nM
|
[19] | |||
| Compound Name |
(S)-2-Benzyloxycarbonylamino-3-{[3-(4-guanidino-butyl)-4,5-dihydro-isoxazole-5-carbonyl]-amino}-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL176820; BDBM50076567
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| Activity |
IC50 = 55000 nM
|
[22] | |||
| Compound Name |
6-[(4-Piperidinyl)methoxy]-1,2,3,4-tetrahydro-1-oxoisoquinoline-2-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL302177; BDBM50058919; [1-Oxo-6-(piperidin-4-ylmethoxy)-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid
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| Activity |
IC50 = 55000 nM
|
[23] | |||
| Compound Name |
Arg-gly-asp-ser
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Investigative | Compound Info | ||
| Synonyms |
Rgds peptide; Fibronectin tetrapeptide; UNII-AC6UDA2MFC; AC6UDA2MFC; CHEMBL265628; MFCD00076452; Arginyl-glycyl-aspartyl-serine; C15H27N7O8; L-Arginylglycyl-L-alpha-aspartyl-L-serine; L-Serine, L-arginylglycyl-L-alpha-aspartyl-; SCHEMBL7394659; L-Serine, N-(N-(N-L-arginylglycyl)-L-alpha-aspartyl)-; KS-00000XPX; DTXSID50920002; ZINC3927570; 3450AH; BDBM50241180; AKOS024457642; Arg-Gly-Asp-Ser, >=95% (HPLC); CS-3266; NCGC00167153-01; AS-56630; HY-12290; Q27273860
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| Activity |
IC50 = 55000 nM
|
[24] | |||
| Compound Name |
Acetic acid;ethyl 1-[4-[(5S)-5-[[(4-carbamimidoylphenyl)methylamino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391194
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[25] | |||
| Compound Name |
[16-Acetylamino-13-(4-amino-butyl)-4-carbamoyl-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraaza-cycloheptadec-7-yl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370399; BDBM50010166
Click to Show/Hide
|
||||
| Activity |
IC50 = 55300 nM
|
[20] | |||
| Compound Name |
(3S)-3-[[2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL321152; BDBM50010184
Click to Show/Hide
|
||||
| Activity |
IC50 = 55500 nM
|
[20] | |||
| Compound Name |
4-{[1-((R)-6-Amino-2-tert-butoxycarbonylamino-hexanoyl)-piperidine-3-carbonyl]-amino}-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL40197; BDBM50034693; 4-[[[1-(Boc-D-Lys-)-3-Piperidinyl]carbonyl]amino]butyric acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[16] | |||
| Compound Name |
3-Hexyl-7-[[(5-amidino-1H-indol-2-yl)carbonyl]amino]heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97648; BDBM50059682; 3-{4-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-butyl}-nonanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[18] | |||
| Compound Name |
Acetic acid;ethyl (2S)-2-[[(2S)-2-benzyl-3-[[4-[(4-carbamimidoylphenyl)methyl]-3-oxo-1,4-benzoxazin-7-yl]amino]-3-oxopropanoyl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192978
Click to Show/Hide
|
||||
| Activity |
Ki = 59050 nM
|
[26] | |||
| Compound Name |
(3S)-3-[8-(Diaminomethylideneamino)octanoylamino]-4-oxo-4-(2-phenylethylamino)butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL145963
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[27] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3-fluorophenyl)methyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949701; BDBM50365119
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[19] | |||
| Compound Name |
(S)-2-(2,4,6-Trimethylphenylsulfonylamino)-3-[[5-[3-(1H-imidazol-2-ylcarbamoyl)propyl]-2-isoxazolin-3-yl]carbonylamino]propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL130805; BDBM50083785
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[28] | |||
| Compound Name |
Acetyl-arginyl-glycyl-aspartyl-serinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Ac-Arg-gly-asp-ser-NH2; CHEMBL420106; Ac-Rgds-NH2; SCHEMBL5606014; N2-Acetyl-L-arginylglycyl-L-alpha-aspartyl-L-serinamide; DTXSID40153544; ZINC3934572; BDBM50003326; L-Serinamide, N2-acetyl-L-arginylglycyl-L-alpha-aspartyl-
Click to Show/Hide
|
||||
| Activity |
Ki = 62000 nM
|
[20] | |||
| Compound Name |
7-[2-(3-Carbamimidoyl-phenylamino)-acetylamino]-heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95446; BDBM50059697
Click to Show/Hide
|
||||
| Activity |
IC50 = 64000 nM
|
[29] | |||
| Compound Name |
6-Carboxymethyl-12-(3-guanidino-propyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaaza-cyclononadecane-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL432725; BDBM50006341; N-[3-Mercapto(1)propanoyl]-Gly-L-Arg-Gly-L-Asp-L-Ala(1)-OH
Click to Show/Hide
|
||||
| Activity |
IC50 = 64300 nM
|
[5] | |||
| Compound Name |
(S)-2-Benzyloxycarbonylamino-2-methyl-3-[4-(4-piperidin-4-yl-butoxy)-phenyl]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419117; BDBM50039578
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[30] | |||
| Compound Name |
6,15-Bis-carboxymethyl-12-(3-guanidino-propyl)-1,5,8,11,14,17-hexaoxo-1lambda*4*-thia-4,7,10,13,16-pentaaza-cyclooctadecane-3-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62970; BDBM50006267
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[5] | |||
| Compound Name |
7-[2-(4-Carbamimidoyl-phenylamino)-acetylamino]-heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94337; BDBM50059693
Click to Show/Hide
|
||||
| Activity |
IC50 = 67000 nM
|
[18] | |||
| Compound Name |
(2R)-3-[[5-[4-(1H-Imidazol-2-ylamino)butyl]-4,5-dihydro-1,2-oxazole-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2111850; BDBM50408869
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[31] | |||
| Compound Name |
(3S)-3-[[2-[[(2R)-2-Acetamido-6-(diaminomethylideneamino)hexanoyl]amino]acetyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL430862; BDBM50010168
Click to Show/Hide
|
||||
| Activity |
IC50 = 68200 nM
|
[20] | |||
| Compound Name |
2-(Biphenyl-4-sulfonylamino)-3-({5-[4-(pyridin-2-ylamino)-butyl]-4,5-dihydro-isoxazole-3-carbonyl}-amino)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128966; BDBM50083773
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[31] | |||
| Compound Name |
N-[3-(Diethylamino)propyl]-1-[4-(4-methylphenyl)-1,3-thiazol-2-yl]-5-(trifluoromethyl)pyrazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL335070; BDBM50035965
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[1] | |||
| Compound Name |
(S)-2-((S)-3-Carboxy-2-{4-[(E)-3-(4-guanidino-phenyl)-acryloylamino]-butyrylamino}-propionylamino)-3-methyl-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL48509; BDBM50289684
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[32] | |||
| Compound Name |
2-[(2-Ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[4-[(pyridin-2-ylamino)methyl]piperidin-1-yl]phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590354; SCHEMBL4516020; BDBM141981; US8927534, 120
Click to Show/Hide
|
||||
| Activity |
IC50 = 71700 nM
|
[33] | |||
| Compound Name |
[16-Acetylamino-4-carbamoyl-13-(3-guanidino-propyl)-3,3,11-trimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraaza-cycloheptadec-7-yl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL353203; BDBM50010183; BDBM50040766
Click to Show/Hide
|
||||
| Activity |
IC50 = 73400 nM
|
[20] | |||
| Compound Name |
2-(2-{2-[2-(2-Amino-acetylamino)-5-guanidino-pentanoylamino]-acetylamino}-3-carboxy-propionylamino)-3-methyl-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64629; BDBM50006320
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[5] | |||
| Compound Name |
2-[(8S,11S,14S,20S)-2,20-Diamino-8-benzyl-11-(hydroxymethyl)-4,7,10,13,16,19-hexaoxo-1,3,6,9,12,15,18-heptazacyclotricosen-14-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2369776; BDBM50059135
Click to Show/Hide
|
||||
| Activity |
Ki = 75000 nM
|
[9] | |||
| Compound Name |
3-[4-Amino(imino)methylamino-1-methylcarboxamido-(1S)-butylcarboxamidomethylcarboxamido]-3-phenethylcarbamoylpropanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107910; BDBM50010182
Click to Show/Hide
|
||||
| Activity |
IC50 = 75900 nM
|
[20] | |||
| Compound Name |
2-[(6S,12R,18R,21S)-18-[3-(Diaminomethylideneamino)propyl]-2,5,11,14,17,20-hexaoxo-1,4,10,13,16,19-hexazatricyclo[19.3.0.06,10]tetracosan-12-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129782; BDBM50003314
Click to Show/Hide
|
||||
| Activity |
IC50 = 76600 nM
|
[34] | |||
| Compound Name |
(2S)-2-(3-Oxo-1H-isoindol-2-yl)-3-[4-[4-[(pyridin-2-ylamino)methyl]piperidin-1-yl]phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591779; BDBM50423734
Click to Show/Hide
|
||||
| Activity |
IC50 = 76700 nM
|
[33] | |||
| Compound Name |
2-(2-{2-[2-(2-Acetylamino-acetylamino)-5-guanidino-pentanoylamino]-acetylamino}-3-carboxy-propionylamino)-3-methyl-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62519; BDBM50006347; N-Acetyl-Gly-L-Arg-Gly-L-Asp-L-Val-OH
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[5] | |||
| Compound Name |
6-[3-(Aminomethyl)benzyloxy]-1,2,3,4-tetrahydro-1-oxoisoquinoline-2-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68001; BDBM50058922; [6-(3-Aminomethyl-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[23] | |||
| Compound Name |
2-[(2,6-Dimethylbenzoyl)amino]-3-[4-[4-[(pyridin-2-ylamino)methyl]piperidin-1-yl]phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591544; SCHEMBL4510353; BDBM50423737
Click to Show/Hide
|
||||
| Activity |
IC50 = 77700 nM
|
[33] | |||
| Compound Name |
(S)-2-(2,4,6-Trimethylphenylsulfonylamino)-3-[[5-[4-(isoquinolin-1-ylamino)butyl]-2-isoxazolin-3-yl]carbonylamino]propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129259; BDBM50083779
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[31] | |||
| Compound Name |
(S)-3-[(S)-2-((S)-2-Benzyloxycarbonylamino-5-guanidino-pentanoylamino)-propionylamino]-N-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45903; BDBM50282118
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[35] | |||
| Compound Name |
3-({5-[3-(6-Amino-pyridin-2-yl)-propyl]-4,5-dihydro-isoxazole-3-carbonyl}-amino)-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128131; BDBM50083791
Click to Show/Hide
|
||||
| Activity |
IC50 = 78000 nM
|
[31] | |||
| Compound Name |
1-[4-[(5S)-5-[[(2-Amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391039
Click to Show/Hide
|
||||
| Activity |
IC50 = 78400 nM
|
[25] | |||
| Compound Name |
2-[[2-[(4-Carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,4-difluorophenyl)methyl]amino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952408; BDBM50365124
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[19] | |||
| Compound Name |
3-[4-(2-Guanidino-acetylamino)-phenylsulfanyl]-3-pyridin-3-yl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158777; BDBM50139211; beta-[4-(Guanidinoacetylamino)phenylthio]pyridine-3-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 81000 nM
|
[36] | |||
| Compound Name |
[4-Acetyl-16-acetylamino-13-(2-carbamimidoyl-ethyl)-13-(2-guanidino-ethyl)-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraaza-cycloheptadec-7-yl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370398; BDBM50010178
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[20] | |||
| Compound Name |
(S)-2-Amino-3-[[5-[4-(1H-imidazole-2-ylamino)butyl]-2-isoxazoline-3-yl]carbonylamino]propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL127503; BDBM50083787
Click to Show/Hide
|
||||
| Activity |
IC50 = 84000 nM
|
[31] | |||
| Compound Name |
2-Benzyloxycarbonylamino-3-({5-[4-(pyridin-2-ylamino)-butyl]-4,5-dihydro-isoxazole-3-carbonyl}-amino)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129445; BDBM50083776
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[31] | |||
| Compound Name |
3-[4-(3-Guanidino-propionylamino)-phenylsulfanyl]-3-pyridin-3-yl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL161314; BDBM50139238; beta-[4-(3-Guanidinopropionylamino)phenylthio]pyridine-3-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[36] | |||
| Compound Name |
2-[(2-Ethyl-6-methylbenzoyl)amino]-3-[4-[4-[(pyridin-2-ylamino)methyl]piperidin-1-yl]phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591545; SCHEMBL4524669; BDBM50423738
Click to Show/Hide
|
||||
| Activity |
IC50 = 87200 nM
|
[33] | |||
| Compound Name |
1-[(S)-2-[4-(Guanidinomethyl)benzoylamino]propionyl]piperidine-4-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65025; BDBM50421478
Click to Show/Hide
|
||||
| Activity |
IC50 = 91201.08 nM
|
[21] | |||
| Compound Name |
3-[2-(2-Amino-5-guanidino-pentanoylamino)-acetylamino]-N-[1-carboxy-2-(4-hydroxy-phenyl)-ethyl]-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64550; BDBM50006342
Click to Show/Hide
|
||||
| Activity |
IC50 = 94000 nM
|
[5] | |||
| Compound Name |
(S)-2-Tert-Butoxycarbonylamino-3-[4-(3-tert-butylamino-propoxy)-phenyl]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL86038; BDBM50039589
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[30] | |||
| Compound Name |
Acetic acid;ethyl 1-[4-[(5R)-5-[[(4-carbamimidoylbenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391193
Click to Show/Hide
|
||||
| Activity |
IC50 = 96000 nM
|
[25] | |||
| Compound Name |
(4R)-4-[[2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-5-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104274; BDBM50010173
Click to Show/Hide
|
||||
| Activity |
IC50 = 97000 nM
|
[20] | |||
| Compound Name |
(5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-[(S)-2-carboxy-2-(2,4,6-trimethyl-benzenesulfonylamino)-ethylcarbamoyl]-1-oxa-2,7-diaza-spiro[4.4]non-2-ene-7-carboxylic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL435806; BDBM50138321
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
2-[(4-Bromophenyl)sulfonylamino]-3-[6-(2-piperidin-4-ylethoxy)naphthalen-2-yl]propanoic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3894590; BDBM50210684
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
Arg-Gly-Asp-Arg-Gly-Asp
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL141005; BDBM50054481
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
3-{2-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-2-methyl-propionylamino}-3-phenyl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL336304; BDBM50061860
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3-fluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808955; BDBM50349615
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
3-[2-(2-Guanidino-acetylamino)-phenylsulfanyl]-3-pyridin-3-yl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158665; BDBM50139222; beta-[2-(Guanidinoacetylamino)phenylthio]pyridine-3-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,5-difluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808954; BDBM50349614
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl}amino)-2-oxoacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459941; BDBM50253859
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(2S)-2-[[(2R)-2-[(3S)-3-[[2-(4-Carbamimidoylphenyl)acetyl]amino]-2-oxopyrrolidin-1-yl]-3-carboxypropanoyl]amino]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL44666
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,4-difluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808957; BDBM50349617
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(4-fluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808948; BDBM50349608
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
6-Oxo-6-[9-(4-amidinobenzoyl)-3,9-diazaspiro[5.5]undecane-3-yl]hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL283692; BDBM50100354; 6-[9-(4-Carbamimidoyl-benzoyl)-3,9-diaza-spiro[5.5]undec-3-yl]-6-oxo-hexanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3-fluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952405; BDBM50365121
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
3-[2-(3-Guanidino-propionylamino)-phenylsulfanyl]-3-pyridin-3-yl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL158170; BDBM50139232; beta-[2-(3-Guanidinopropionylamino)phenylthio]pyridine-3-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[36] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,5-difluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808950; BDBM50349610
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(4-fluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952401; BDBM50365116
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
4-Oxo-4-[9-[4-(4-piperidinyl)piperidinocarbonyl]-3-azaspiro[5.5]undecane-3-yl]butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24638; BDBM50100378; 4-[9-([4,4'']Bipiperidinyl-1-carbonyl)-3-aza-spiro[5.5]undec-3-yl]-4-oxo-butyric acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[17] | |||
| Compound Name |
7-[[(5-Amidino-1H-indol-3-yl)carbonyl]amino]heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97226; BDBM50059692; 7-[(5-Carbamimidoyl-1H-indole-3-carbonyl)-amino]-heptanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
2-[(4-Bromophenyl)sulfonylamino]-3-[6-(3-piperidin-4-ylpropoxy)naphthalen-2-yl]propanoic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3922603; BDBM50210685
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
3-[4-(3-Guanidino-benzoylamino)-phenylsulfanyl]-3-pyridin-3-yl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL350668; SCHEMBL2835962; SCHEMBL13024514; BDBM50139204; beta-[4-(3-Guanidinobenzoylamino)phenylthio]pyridine-3-propionic acid; 3-[4-[[3-(diaminomethylideneamino)benzoyl]amino]phenyl]sulfanyl-3-pyridin-3-ylpropanoic acid
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3-fluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808947; BDBM50349607
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
7-[[4-(2-Thiazolylamino)butyrylamino]methyl]-6,9-dihydro-5H-benzocycloheptene-5-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL110039; BDBM50120522; (7-{[4-(Thiazol-2-ylamino)-butyrylamino]-methyl}-6,9-dihydro-5H-benzocyclohepten-5-yl)-acetic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,5-difluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1949838; BDBM50365131
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-(Benzyl{2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)-2-oxoacetic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460355; BDBM50253818
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(3S)-4-[[(1S)-1-Carboxy-2-phenylethyl]amino]-3-[(3R)-3-[[(2S)-5-(diaminomethylideneamino)-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-2-oxopyrrolidin-1-yl]-4-oxobutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL432096
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
3-{[5-(3-Guanidino-3-oxo-propyl)-thiophene-2-carbonyl]-amino}-3-naphthalen-1-yl-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60836; SCHEMBL6016279; BDBM50101778
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[42] | |||
| Compound Name |
2-(3,5-Dimethyl-biphenyl-4-sulfonylamino)-3-({5-[4-(pyridin-2-ylamino)-butyl]-4,5-dihydro-isoxazole-3-carbonyl}-amino)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129747; BDBM50083780
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
2-[1-[2-[3-(4-Carbamimidoylphenyl)-4,5-dihydro-1,2-oxazol-5-yl]acetyl]piperidin-2-yl]acetic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL141289
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
5-Oxo-5-[9-[4-(4-piperidinyl)piperidinocarbonyl]-3-azaspiro[5.5]undecane-3-yl]valeric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL26294; BDBM50100361; 5-[9-([4,4'']Bipiperidinyl-1-carbonyl)-3-aza-spiro[5.5]undec-3-yl]-5-oxo-pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[17] | |||
| Compound Name |
2-[2-(4-Carbamimidoylbenzyloxy)-4-methyl-3-oxo-N-phenyl-3,4-dihydro-2H-1,4-benzoxazine-7-carbonylamino]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461417; BDBM50253777
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(S)-2-(1-Naphthylsulfonylamino)-3-[[5-[4-(2-pyridylamino)butyl]-2-isoxazolin-3-yl]carbonylamino]propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL340321; BDBM50083784
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(S)-2-(4-Isopropylphenylsulfonylamino)-3-[[5-[4-(2-pyridylamino)butyl]-2-isoxazolin-3-yl]carbonylamino]propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421444; BDBM50083792
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
[(4S,7R,13R,16S)-16-Acetylamino-14-benzyl-4-carbamoyl-13-(3-guanidino-propyl)-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraaza-cycloheptadec-7-yl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL165153; BDBM50040738
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[44] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3-fluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808951; BDBM50349611
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
4-[Benzyl-[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL517269; BDBM50253898
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
2-Butyl-7-[[(5-amidino-1H-indol-2-yl)carbonyl]amino]heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94578; BDBM50059711; 2-Butyl-7-[(5-carbamimidoyl-1H-indole-2-carbonyl)-amino]-heptanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
2-[2-(Carboxymethoxy)-4-[2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carbonylamino)acetyl]phenoxy]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL315036; ME3277; SCHEMBL7680039; BDBM50288220; ME-3277
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[45] | |||
| Compound Name |
8-[[(5-Amidino-1H-indol-3-yl)carbonyl]amino]octanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97565; BDBM50059695; 8-[(5-Carbamimidoyl-1H-indole-3-carbonyl)-amino]-octanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
3-[2-(3-Piperidin-4-ylmethyl-4,5-dihydro-isoxazol-5-yl)-acetylamino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL152642; BDBM50055897; 3-[[[[3-[(4-Piperidinyl)methyl]-4,5-dihydroisoxazol]-5-yl]acetyl]amino]propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
Ethyl 4-[benzyl-[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]amino]-4-oxobutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512630; BDBM50253899
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
2-[(2R,5S,11S,14R)-11-(Carboxymethyl)-5,14-bis[3-(diaminomethylideneamino)propyl]-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexazacyclooctadec-2-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343122; BDBM50054479
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-Ethyl-7-[[(5-amidino-1H-indol-2-yl)carbonyl]amino]heptanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL328141; BDBM50059687; 7-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-2-ethyl-heptanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(S)-3-[(R)-2-((S)-2-Benzyloxycarbonylamino-5-guanidino-pentanoylamino)-propionylamino]-N-((S)-1-methoxycarbonyl-2-phenyl-ethyl)-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL295792; BDBM50282123
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[35] | |||
| Compound Name |
(S)-2-[(S)-3-Carboxy-2-((S)-4-methyl-2-{2-[4-(3-o-tolyl-ureido)-phenyl]-acetylamino}-pentanoylamino)-propionylamino]-3-methyl-butyric acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL369635; BDBM50074659; N-[4-[3-(2-Methylphenyl)ureido]phenylacetyl]-L-Leu-L-Asp-Val-OH
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,4-difluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808949; BDBM50349609
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
5-[[(5-Amidino-1H-indol-2-yl)carbonyl]amino]pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320670; BDBM50059702; 5-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-pentanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-6-yl]-[(3,4-difluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808953; BDBM50349613
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
2-[(4-Bromophenyl)sulfonylamino]-3-[6-(piperidin-4-ylmethoxy)naphthalen-2-yl]propanoic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931514; BDBM50210690
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[38] | |||
| Compound Name |
2-[(2S,5R,11S,14S)-11-(Carboxymethyl)-5,14-bis[3-(diaminomethylideneamino)propyl]-3,6,9,12,15,18-hexaoxo-1,4,7,10,13,16-hexazacyclooctadec-2-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL343123; BDBM50054478
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(S)-2-Benzyloxycarbonylamino-3-[3-(5-guanidinomethyl-4,5-dihydro-isoxazol-3-yl)-propionylamino]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL173462; BDBM50076566
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
1-[Methyl(4-guanidinobenzoyl)aminoacetyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68291; BDBM50421469
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[21] | |||
| Compound Name |
[4-Methyl-3-oxo-7-(4-phenyl-piperazine-1-carbonyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL74880; SCHEMBL7541762; BDBM50059128
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[9] | |||
| Compound Name |
3-[4-(6-Aminohexyloxy)phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL420043; BDBM50004057; ZINC13731015; 3-[4-(6-Amino-hexyloxy)-phenyl]-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[47] | |||
| Compound Name |
3-{2-[(Z)-4-Carbamimidoyl-benzoylimino]-3,4-dimethyl-2,3-dihydro-thiazol-5-yl}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL8572; BDBM50098965
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(S)-2-((S)-4-Methyl-2-{2-[4-(3-o-tolyl-ureido)-phenyl]-acetylamino}-pentanoylamino)-succinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL173552; BDBM50074668; N-[4-[3-(2-Methylphenyl)ureido]phenylacetyl]-L-Leu-L-Asp-OH
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(4-fluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808956; BDBM50349616
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(S)-2-Benzyloxycarbonylamino-3-{4-[3-(1,1,3,3-tetramethyl-butylamino)-propoxy]-phenyl}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85698; BDBM50039575; O-[3-[(1,1,3,3-Tetramethylbutyl)amino]propyl]-N-Cbz-L-Tyr-OH
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(S)-2-Benzyloxycarbonylamino-3-{[3-(3-guanidino-propyl)-4,5-dihydro-isoxazole-5-carbonyl]-amino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL408665; BDBM50076586
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(5S,8S)-8-[(1H-Benzoimidazol-2-ylamino)-methyl]-3-[(S)-2-carboxy-2-(2,4,6-trimethyl-benzenesulfonylamino)-ethylcarbamoyl]-1-oxa-2,7-diaza-spiro[4.4]non-2-ene-7-carboxylic acid butyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL126071; BDBM50138313
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(S)-2-Benzyloxycarbonylamino-3-{[3-(2-guanidino-ethyl)-4,5-dihydro-isoxazole-5-carbonyl]-amino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL172014; BDBM50076578
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,5-difluorophenyl)methyl]amino]acetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1808958; BDBM50349618
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
6-[[(5-Amidino-1H-indol-2-yl)carbonyl]amino]hexanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95389; BDBM50059708; 6-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-hexanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
Ethyl 2-[[2-[(4-carbamimidoylphenoxy)methyl]-2,4-dimethyl-3H-1,4-benzoxazin-7-yl]-[(3,4-difluorophenyl)methyl]amino]-2-oxoacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952410; BDBM50365126
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
8-[[(5-Amidino-1H-indol-2-yl)carbonyl]amino]octanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94814; BDBM50059709; 8-[(5-Carbamimidoyl-1H-indole-2-carbonyl)-amino]-octanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(S)-2-(2,4,6-Trimethylphenylsulfonylamino)-3-[[5-[4-(sulfamoylamino)butyl]-2-isoxazolin-3-yl]carbonylamino]propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL129156; BDBM50083782
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
3-[4-Amino(imino)methylamino-1-methylcarboxamido-(1S)-butylcarboxamidomethylcarboxamido]-3-[1-carbamoyl-2-(4-hydroxyphenyl)-(1S)-ethylcarbamoyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107629; SCHEMBL9326037; BDBM50010192
Click to Show/Hide
|
||||
| Activity |
IC50 = 102000 nM
|
[20] | |||
| Compound Name |
2-[(4-Fluoro-2,6-dimethylbenzoyl)amino]-3-[4-[4-[(pyridin-2-ylamino)methyl]piperidin-1-yl]phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL591778; SCHEMBL4528865; BDBM50423739
Click to Show/Hide
|
||||
| Activity |
IC50 = 105000 nM
|
[33] | |||
| Compound Name |
1-[(S)-2-(4-Amidinobenzoylamino)propionyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL67468; BDBM50421432
Click to Show/Hide
|
||||
| Activity |
IC50 = 109647.82 nM
|
[21] | |||
| Compound Name |
(3S)-3-[[2-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL105092; BDBM50010188
Click to Show/Hide
|
||||
| Activity |
IC50 = 113000 nM
|
[20] | |||
| Compound Name |
(S)-2-(2,4,6-Trimethylphenylsulfonylamino)-3-[[5-[2-[3-(1H-imidazol-2-yl)ureido]ethyl]-2-isoxazolin-3-yl]carbonylamino]propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL128784; BDBM50083775
Click to Show/Hide
|
||||
| Activity |
IC50 = 120000 nM
|
[31] | |||
| Compound Name |
(2S)-2-[(2-Ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[4-[(pyridin-2-ylamino)methyl]piperidin-1-yl]phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590389; BDBM50423732
Click to Show/Hide
|
||||
| Activity |
IC50 = 121000 nM
|
[33] | |||
| Compound Name |
Arginyl-glycyl-aspartic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Arg-gly-asp; Rgd peptide; Arginylglycylaspartic acid; RGD (Arg-Gly-Asp) Peptides; L-Aspartic acid, L-arginylglycyl-; UNII-78VO7F77PN; 78VO7F77PN; CHEMBL313763; (S)-2-(2-((S)-2-amino-5-guanidinopentanamido)acetamido)succinic acid; Rgd tripeptide sequence; Bitiscetin; Bitistatin; Arginyl-glycyl-asparagilin; l-arginylglycylaspartic acid; Poly(rgd); Poly(arg-gly-asp); C12H22N6O6; F-336; N-(N-L-Arginylglycyl)-L-aspartic acid; arginine-glycine-aspartic acid; Tripeptide RGD; L-Arginyl-Glycyl-L-Aspartic acid; Poly (arginyl-glycyl-aspartic acid); Arg-gly-Asp peptide; L-Aspartic acid, N-(N-L-arginylglycyl)-; SCHEMBL19139; CTK8D8707; AOB5939; DTXSID30912420; Arg-Gly-Asp, >=97% (TLC); HY-P0278; KS-00000XS3; ZINC3922521; 2226AH; BDBM50107402; MFCD00057952; s8008; AKOS015854089; AKOS015902678; CCG-267987; NCGC00167210-01; AC-32859; AS-61345; Q4068819; L-Aspartic acid, N-(N-L-arginylglycyl)-, homopolymer; 2-[2-(2-Amino-5-guanidino-pentanoylamino)-acetylamino]-succinic acid(RGD); (2S)-2-{2-[(2S)-2-amino-5-carbamimidamidopentanamido]acetamido}butanedioic acid; (S)-2-[2-((S)-2-Amino-5-guanidino-pentanoylamino)-acetylamino]-succinic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[49] | |||
| Compound Name |
(3S)-3-[[2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(2R)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106629; BDBM50010160
Click to Show/Hide
|
||||
| Activity |
IC50 = 138000 nM
|
[20] | |||
| Compound Name |
Ac-RGD-NH2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104534; BDBM50010174; ZINC13735061
Click to Show/Hide
|
||||
| Activity |
IC50 = 138000 nM
|
[20] | |||
| Compound Name |
[3-Carbamoyl-12-(3-guanidino-propyl)-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaaza-cyclooctadec-6-yl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64388; BDBM50006268
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[5] | |||
| Compound Name |
(2R)-2-[(2-Ethyl-4-fluoro-6-methylbenzoyl)amino]-3-[4-[4-[(pyridin-2-ylamino)methyl]piperidin-1-yl]phenyl]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590622; BDBM50423731
Click to Show/Hide
|
||||
| Activity |
IC50 = 159000 nM
|
[33] | |||
| Compound Name |
(2S)-3-Oxo-4-methyl-7-(6-amino-2-pyridinylcarbamoyl)-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-2-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL50510; BDBM50078701
Click to Show/Hide
|
||||
| Activity |
Ki = 160000 nM
|
[6] | |||
| Compound Name |
Gly-Arg-Gly-Asp-Tyr
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64748; SCHEMBL2790810; BDBM50006322; glycyl-arginyl-glycyl-aspartyl-tyrosine
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[5] | |||
| Compound Name |
2-(2-{2-[2-(2-Amino-acetylamino)-5-guanidino-pentanoylamino]-acetylamino}-3-carboxy-propionylamino)-4-methyl-pentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL304864; BDBM50006299
Click to Show/Hide
|
||||
| Activity |
IC50 = 170000 nM
|
[5] | |||
| Compound Name |
2-[(1R,6S,7R,8S,9R,23S,24R,25S)-19-[3-(Diaminomethylideneamino)propyl]-7,8,24,25-tetrahydroxy-4,12,15,18,21-pentaoxo-26,27-dioxa-3,11,14,17,20-pentazatricyclo[21.2.1.16,9]heptacosan-13-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL113277; BDBM50122991
Click to Show/Hide
|
||||
| Activity |
IC50 = 198000 nM
|
[50] | |||
| Compound Name |
1-[3-(4-Guanidinobenzoylamino)propionyl]piperidine-4-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66379; BDBM50421441
Click to Show/Hide
|
||||
| Activity |
IC50 = 199526.23 nM
|
[21] | |||
| Compound Name |
[16-Acetylamino-4-carbamoyl-13-(3-guanidino-propyl)-3,3,10-trimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraaza-cycloheptadec-7-yl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370401; BDBM50010162
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[20] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 62 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Cilengitide
Click to Show/Hide
|
Phase 3 | Compound Info | ||
| Synonyms |
Cilengitide; 188968-51-6; EMD-121974; Cilengitide [USAN:INN]; UNII-4EDF46E4GI; EMD121974; EMD-12192; EMD 121974; 4EDF46E4GI; CHEMBL429876; 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid; Cyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl); Cyclo(L-arginylglycyl-L-alpha-aspartyl-D-phenylalanyl-N-methyl-L-valyl); Cilengitide (TFA salt)
Click to Show/Hide
|
||||
| Activity |
IC50 = 206000 nM
|
[49] | |||
| Compound Name |
(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]acetyl]amino]propanoyl]amino]-6-aminohexanoyl]amino]-5-amino-5-oxopentanoyl]amino]propanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL408419; BDBM50010167
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
16-Acetylamino-7-carbamoylmethyl-13-(3-guanidino-propyl)-3,3,14-trimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraaza-cycloheptadecane-4-carboxylic acid amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370400; BDBM50010185
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
(3S)-3-[[2-[[(2S)-2-Acetamido-5-(carbamoylamino)pentanoyl]amino]acetyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370391; BDBM50010156
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
(3S)-3-[[(2S)-1-[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107339; BDBM50010165
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
Ethyl 2-[benzyl-[(2S)-2-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337676
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[51] | |||
| Compound Name |
(3S)-3-[[2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(2S)-1-(ethylamino)-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL325332; BDBM50010158
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
(3S)-3-[[(2S)-2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107340; BDBM50010180
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
Ethyl 2-[benzyl-[(2R)-2-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337675
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[51] | |||
| Compound Name |
(2R)-2-[[2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL320678; BDBM50010164
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
[(4S,7S,13R,16S)-16-Acetylamino-4-carbamoyl-13-(3-guanidino-propyl)-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraaza-cycloheptadec-7-yl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL351938; BDBM50040751
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
Ethyl 2-[benzyl-[(3R)-3-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337669
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[51] | |||
| Compound Name |
(4S)-4-[[2-[[(2S)-2-Acetamido-6-aminohexanoyl]amino]acetyl]amino]-5-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL107803; BDBM50010191
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
(2S)-2-[[2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-N-[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]butanediamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104428; BDBM50010190
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
(3S)-3-[[2-[[(2S)-2-Acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]acetyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419909; BDBM50010172
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
Cyclo(Arg-Gly-Asp-D-Pro-Pro-Gly)
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450009; BDBM50003320; Cyclo(L-Pro-Gly-L-Arg-Gly-L-Asp-D-Pro-)
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[34] | |||
| Compound Name |
(3S)-3-[[2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]-methylamino]acetyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106724; BDBM50010186
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
(3S)-3-[[2-[[(2R)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL106251; BDBM50010163
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
(3R)-3-[[2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2111672; BDBM50421885
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
Ethyl 2-[benzyl-[(3S)-3-[(4-carbamimidoylphenoxy)methyl]-2,3-dihydro-1,4-benzodioxin-6-yl]amino]-2-oxoacetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2337670
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[51] | |||
| Compound Name |
16-(2-Acetylamino-6-amino-hexanoylamino)-7-carboxymethyl-3,3,13-trimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraaza-cycloheptadecane-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370405; BDBM50010194
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
(4S)-4-[[2-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-5-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104012; BDBM50010170
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
2-[(3S,6R,12R,15S,21S,24R,30R,33S)-3,21-Dibenzyl-24-(carboxymethyl)-12,30-bis[3-(diaminomethylideneamino)propyl]-2,5,8,11,14,20,23,26,29,32-decaoxo-1,4,7,10,13,19,22,25,28,31-decazatricyclo[31.3.0.015,19]hexatriacontan-6-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384237; BDBM50003324
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[34] | |||
| Compound Name |
(3S)-3-[[2-[[(2S)-2-Acetamido-6-aminohexanoyl]amino]acetyl]amino]-4-[[(2S)-1-amino-3-hydroxy-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL104018; BDBM50010169
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[20] | |||
| Compound Name |
3-(4-Piperazin-1-yl-benzoylamino)-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL168391; BDBM50076057; N-(4-Piperazinobenzoyl)-beta-alanine
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[52] | |||
| Compound Name |
Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]-2-oxopiperidine-4-carboxylate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391185
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
Ethyl 1-[4-[(5S)-5-[[(3-amino-4-chlorobenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391199; BDBM50435611
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
3-{[6-(2-Piperidin-4-yl-ethylcarbamoyl)-pyridine-2-carbonyl]-amino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL441613; SCHEMBL7396150; BDBM50282910; 3-[[6-(2-piperidin-4-ylethylcarbamoyl)pyridine-2-carbonyl]amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 300000 nM
|
[53] | |||
| Compound Name |
Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]-3-methyl-2-oxopiperidine-3-carboxylate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391186
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
1-[4-[(5S)-5-[[(5-Chlorothiophene-2-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391037; BDBM50435634
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391038
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
Ethyl 1-[4-[(5R)-5-[[(3-amino-4-chlorobenzoyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391200; BDBM50435610
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-3-carboxylate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391042
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
3-{[1-Oxo-9-phenyl-2-(2-piperidin-4-yl-ethyl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepine-8-carbonyl]-amino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL142982; BDBM50286529
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[54] | |||
| Compound Name |
Ethyl 1-[4-[(5R)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391040
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
1-[4-[(5S)-5-[[(2-Amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391183
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
1-[4-[(5S)-5-[[(2-Amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]-3-methyl-2-oxopiperidine-3-carboxylic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391187
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
Ethyl 1-[4-[(5S)-5-[[(2-amino-1,3-thiazole-5-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-2-carboxylate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391184
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
1-[4-[(5R)-5-[[(5-Chlorothiophene-2-carbonyl)amino]methyl]-2-oxo-1,3-oxazolidin-3-yl]phenyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391036; BDBM50435612
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[25] | |||
| Compound Name |
3-{3-[(Piperidin-4-ylmethyl)-carbamoyl]-benzoylamino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL53275; SCHEMBL7402093; BDBM50282913; 3-[[3-(piperidin-4-ylmethylcarbamoyl)benzoyl]amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 330000 nM
|
[55] | |||
| Compound Name |
Methyl 1-[2-[(4-carbamimidoylbenzoyl)-methylamino]acetyl]piperidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL169760; BDBM50421483
Click to Show/Hide
|
||||
| Activity |
IC50 = 331131.12 nM
|
[21] | |||
| Compound Name |
[16-Acetylamino-4-carbamoyl-13-(4-guanidino-butyl)-3,3-dimethyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraaza-cycloheptadec-7-yl]-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2370402; BDBM50010181
Click to Show/Hide
|
||||
| Activity |
IC50 = 385000 nM
|
[20] | |||
| Compound Name |
(S)-2-[((S)-3-Acetyl-thiazolidine-4-carbonyl)-amino]-3-[4-(2,6-dichloro-benzyloxy)-phenyl]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL351547; SCHEMBL6453971; BDBM50089005; CT-5219
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[56] | |||
| Compound Name |
2-(2-{2-[2-(2-Amino-acetylamino)-5-guanidino-pentanoylamino]-acetylamino}-3-carboxy-propionylamino)-succinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL416855; BDBM50006333
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
3-{2-[2-(2-Acetylamino-acetylamino)-5-guanidino-pentanoylamino]-acetylamino}-N-(1-carbamoyl-2-methyl-propyl)-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62394; BDBM50006295
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[5] | |||
| Compound Name |
1-[(S)-2-[4-(Guanidinomethyl)benzoylamino]propionyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL66470; BDBM50421430
Click to Show/Hide
|
||||
| Activity |
IC50 = 707945.78 nM
|
[21] | |||
| Compound Name |
Arginyl-glycyl-aspartyl-phenylalanine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303561; Rgdf peptide; Arg-gly-asp-phe; DTXSID40149361; N-(N-(N-L-Arginylglycyl)-L-alpha-aspartyl)-L-phenylalanine; BDBM50003851; L-Phenylalanine, N-(N-(N-L-arginylglycyl)-L-alpha-aspartyl)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 725000 nM
|
[49] | |||
| Compound Name |
2-[1-[(2S)-2-[[4-(Diaminomethylideneamino)benzoyl]amino]propanoyl]piperidin-4-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63841; BDBM50421453
Click to Show/Hide
|
||||
| Activity |
IC50 = 741310.24 nM
|
[21] | |||
| Compound Name |
1-[Methyl(4-guanidinobenzoyl)aminoacetyl]piperidine-4-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL68343; BDBM50421463
Click to Show/Hide
|
||||
| Activity |
IC50 = 758577.58 nM
|
[21] | |||
| Compound Name |
1-[3-(4-Guanidinobenzoylamino)propionyl]piperidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL306913; BDBM50421468
Click to Show/Hide
|
||||
| Activity |
IC50 = 758577.58 nM
|
[21] | |||
| Compound Name |
(2S)-2-[[2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]butanedioic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3298392; BDBM50023182
Click to Show/Hide
|
||||
| Activity |
IC50 = 947000 nM
|
[49] | |||
| Compound Name |
((S)-1-{2-[(4-Guanidinomethyl-cyclohexanecarbonyl)-amino]-acetyl}-3-oxo-4-phenethyl-piperazin-2-yl)-acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL147553; BDBM50062786
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[57] | |||
| Compound Name |
4-(2-Bromoacetamido)-TEMPO
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606966; BDBM50366326; AKOS015916484; 4-(2-BROMOACETAMIDO)-TEMPO FREE RADICAL; 4-(2-Bromoacetamido)-TEMPO, for ESR-spectroscopy; J-015572; 4-(2-Bromoacetamido)-2,2,6,6-Tetramethylpiperidine-1-oxyl, 98% (CP)
Click to Show/Hide
|
||||
| Activity |
Ki > 1000000 nM
|
[58] | |||
| Compound Name |
2-Benzyloxycarbonylamino-3-[4-(3-phenyl-propoxy)-phenyl]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL85951; BDBM50004068; N-(Benzyloxycarbonyl)-O-(3-phenylpropyl)-L-tyrosine; (S)-2-Benzyloxycarbonylamino-3-[4-(3-phenyl-propoxy)-phenyl]-propionic acid
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[30] | |||
| Compound Name |
2-[5-[2-[[4-(1H-Benzimidazol-2-ylamino)cyclohexyl]methylamino]-2-oxoethyl]-6-oxo-11H-benzo[c][1]benzazepin-11-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL344162; BDBM50109298
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[59] | |||
| Compound Name |
2-[5-[2-[[4-(1H-Benzimidazol-2-ylamino)phenyl]methylamino]-2-oxoethyl]-6-oxo-11H-benzo[c][1]benzazepin-11-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL342019; BDBM50109296
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[59] | |||
| Compound Name |
(5S,8S)-3-[(S)-2-Carboxy-2-(2,4,6-trimethyl-benzenesulfonylamino)-ethylcarbamoyl]-8-(pyridin-2-ylaminomethyl)-1-oxa-2,7-diaza-spiro[4.4]non-2-ene-7-carboxylic acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL338439; BDBM50138318
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[37] | |||
| Compound Name |
(S)-N-((S)-1-Carboxy-2-cyclohexyl-ethyl)-3-{2-[ethyl-(4-piperidin-4-yl-butyryl)-amino]-acetylamino}-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL82264; SCHEMBL3673630; RGD-039; BDBM50065171; N-[N-[N-(4-(piperidin-4-yl)butanoyl)-N-ethylglycyl]aspartyl]-beta-cyclohexylalanine
Click to Show/Hide
|
||||
| Activity |
IC50 = 1012000 nM
|
[60] | |||
| Compound Name |
(S)-N-((R)-1-Carboxy-3-cyclohexyl-propyl)-3-{2-[ethyl-(4-piperidin-4-yl-butyryl)-amino]-acetylamino}-succinamic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL309250; BDBM50065174
Click to Show/Hide
|
||||
| Activity |
IC50 = 1930000 nM
|
[60] | |||
| Compound Name |
3-{[3-Oxo-2-(2-piperidin-4-yl-ethyl)-indane-5-carbonyl]-amino}-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL54842; SCHEMBL7435293; BDBM50282912; 3-[[3-oxo-2-(2-piperidin-4-ylethyl)-1,2-dihydroindene-5-carbonyl]amino]propanoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 2300000 nM
|
[55] | |||
| Compound Name |
Klerval
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL82231; BDBM50065166
Click to Show/Hide
|
||||
| Activity |
IC50 > 2350000 nM
|
[60] | |||
| Compound Name |
3-[1-Oxo-6-(2-piperidin-4-yl-ethylcarbamoyl)-1,3-dihydro-isoindol-2-yl]-propionic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL299947; BDBM50282906
Click to Show/Hide
|
||||
| Activity |
IC50 = 10000000 nM
|
[55] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel thiazole-based heterocycles as selective inhibitors of fibrinogen-mediated platelet aggregation. J Med Chem. 1995 Jan 6;38(1):34-41. | ||||
| REF 2 | Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. J Med Chem. 1999 Mar 11;42(5):920-34. | ||||
| REF 3 | Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors. J Med Chem. 1997 Dec 19;40(26):4308-18. | ||||
| REF 4 | Synthesis and solution conformation of cyclo[RGDRGD]: a cyclic peptide with selectivity for the alpha V beta 3 receptor. J Med Chem. 1996 Oct 25;39(22):4520-6. | ||||
| REF 5 | Cyclic RGD peptide analogues as antiplatelet antithrombotics. J Med Chem. 1992 May 29;35(11):2040-8. | ||||
| REF 6 | Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1801-6. | ||||
| REF 7 | 1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5937-41. | ||||
| REF 8 | Design and synthesis of a new class of selective integrin alpha5beta1 antagonists. J Med Chem. 2007 Aug 9;50(16):3786-94. | ||||
| REF 9 | Discovery of potent nonpeptide vitronectin receptor (alpha v beta 3) antagonists. J Med Chem. 1997 Jul 18;40(15):2289-92. | ||||
| REF 10 | Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3165-70. | ||||
| REF 11 | Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1103-7. | ||||
| REF 12 | Conformational preferences in a benzodiazepine series of potent nonpeptide fibrinogen receptor antagonists. J Med Chem. 1999 Feb 25;42(4):545-59. | ||||
| REF 13 | Orally bioavailable nonpeptide vitronectin receptor antagonists with efficacy in an osteoporosis model. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1807-12. | ||||
| REF 14 | Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ-50042. Bioorg Med Chem Lett. 1996 Oct 22;6(20):2371-6. | ||||
| REF 15 | Discovery of orally available integrin alpha5beta1 antagonists. Bioorg Med Chem Lett. 2010 Jan 1;20(1):380-2. | ||||
| REF 16 | Design and evaluation of nonpeptide fibrinogen gamma-chain based GPIIb/IIIa antagonists. J Med Chem. 1995 May 12;38(10):1582-92. | ||||
| REF 17 | Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: design of potent antagonists containing the 3-azaspiro[5.5]undecanes. Bioorg Med Chem Lett. 2001 May 21;11(10):1293-6. | ||||
| REF 18 | Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists. J Med Chem. 1997 Aug 29;40(18):2843-57. | ||||
| REF 19 | Fluorinated dual antithrombotic compounds based on 1,4-benzoxazine scaffold. Eur J Med Chem. 2012 Apr;50:255-63. | ||||
| REF 20 | Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro. J Med Chem. 1991 Oct;34(10):3114-25. | ||||
| REF 21 | Three-Dimensional quantitative structure-Activity relationship analyses of RGD mimetics as fibrinogen receptor antagonists. Bioorg Med Chem Lett. 2000 May 1;10(9):859-63. | ||||
| REF 22 | Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: identification of alphavbeta3 antagonists lead compounds. Bioorg Med Chem Lett. 1999 Apr 5;9(7):937-42. | ||||
| REF 23 | Non-peptide RGD surrogates which mimic a Gly-Asp beta-turn: potent antagonists of platelet glycoprotein IIb-IIIa. J Med Chem. 1997 Jun 20;40(13):2085-101. | ||||
| REF 24 | Determination of the binding specificity of an integral membrane protein by saturation transfer difference NMR: RGD peptide ligands binding to integrin alphaIIbbeta3. J Med Chem. 2001 Sep 13;44(19):3059-65. | ||||
| REF 25 | Low molecular weight dual inhibitors of factor Xa and fibrinogen binding to GPIIb/IIIa with highly overlapped pharmacophores. Eur J Med Chem. 2013 Jun;64:302-13. | ||||
| REF 26 | Toward a novel class of antithrombotic compounds with dual function. Discovery of 1,4-benzoxazin-3(4H)-one derivatives possessing thrombin inhibitory and fibrinogen receptor antagonistic activities. J Med Chem. 2005 May 5;48(9):3110-3. | ||||
| REF 27 | Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor. J Med Chem. 1992 Dec 25;35(26):4914-7. | ||||
| REF 28 | Disubstituted indazoles as potent antagonists of the integrin alpha(v)beta(3). J Med Chem. 2000 Jan 13;43(1):41-58. | ||||
| REF 29 | Platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa) antagonists derived from amidinoindoles. Bioorg Med Chem Lett. 1996 Jan 9;6(1):81-6. | ||||
| REF 30 | Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp. J Med Chem. 1994 Aug 5;37(16):2537-51. | ||||
| REF 31 | Isoxazolines as potent antagonists of the integrin alpha(v)beta(3). J Med Chem. 2000 Jan 13;43(1):27-40. | ||||
| REF 32 | Constrained beta-alanine based GpIIb/IIIa antagonists. Bioorg Med Chem Lett. 1997 Jul 8;7(13):1773-8. | ||||
| REF 33 | SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists. Bioorg Med Chem Lett. 2010 Jan 1;20(1):65-8. | ||||
| REF 34 | Investigation of conformational specificity at GPIIb/IIIa: evaluation of conformationally constrained RGD peptides. J Med Chem. 1992 Oct 16;35(21):3962-9. | ||||
| REF 35 | Fibrinogen receptor antagonists containing a gamma-lactam Gly-Asp isostere. Bioorg Med Chem Lett. 1993 Aug;3(8):1675-80. | ||||
| REF 36 | Solid-phase synthesis of a small library of 3-phenylthio-3-nicotinyl propionic acid derivatives acting as antagonists of the integrin alphaVbeta3. Bioorg Med Chem Lett. 2004 Feb 9;14(3):657-61. | ||||
| REF 37 | Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists. J Med Chem. 2005 Jun 30;48(13):4204-7. | ||||
| REF 38 | Design, synthesis and evaluation of novel 2-amino-3-(naphth-2-yl)propanoic acid derivatives as potent inhibitors of platelet aggregation. Eur J Med Chem. 2017 Jan 5;125:197-209. | ||||
| REF 39 | 3,4-Dihydro-2H-1,4-benzoxazine derivatives combining thrombin inhibitory and glycoprotein IIb/IIIa receptor antagonistic activity as a novel class of antithrombotic compounds with dual function. J Med Chem. 2008 Sep 25;51(18):5617-29. | ||||
| REF 40 | Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: design of potent and specific 3,9-diazaspiro[5.5]undecanes. Bioorg Med Chem Lett. 2001 May 21;11(10):1289-92. | ||||
| REF 41 | Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3291-6. | ||||
| REF 42 | alpha(v)beta(3) Antagonists based on a central thiophene scaffold. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2011-5. | ||||
| REF 43 | Ring constrained analogues of beta-alanine-containing GPIIb/IIIa receptor antagonists. Bioorg Med Chem Lett. 2000 Mar 6;10(5):449-52. | ||||
| REF 44 | Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation. J Med Chem. 1994 Mar 18;37(6):769-80. | ||||
| REF 45 | Tetrahydrothienopyridine derivatives as novel GPIIb/IIIa antagonists. Bioorg Med Chem Lett. 1996 Nov 5;6(21):2601-6. | ||||
| REF 46 | Discovery of potent isoxazoline glycoprotein IIb/IIIa receptor antagonists. J Med Chem. 1997 Jan 3;40(1):50-60. | ||||
| REF 47 | Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors. J Med Chem. 1992 Nov 27;35(24):4640-2. | ||||
| REF 48 | 2-Acylimino-3H-thiazoline derivatives: a novel template for platelet GPIIb/IIIa receptor antagonists. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1031-5. | ||||
| REF 49 | Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides. J Med Chem. 2014 Jul 10;57(13):5829-34. | ||||
| REF 50 | Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors. Bioorg Med Chem Lett. 2003 Feb 10;13(3):331-4. | ||||
| REF 51 | Towards dual antithrombotic compounds - balancing thrombin inhibitory and fibrinogen GPIIb/IIIa binding inhibitory activities of 2,3-dihydro-1,4-benzodioxine derivatives through regio- and stereoisomerism. Eur J Med Chem. 2013 Apr;62:329-40. | ||||
| REF 52 | Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors. Bioorg Med Chem Lett. 1999 Mar 22;9(6):863-8. | ||||
| REF 53 | Non-peptide fibrinogen receptor antagonists. 3. design and discovery of a centrally constrained inhibitor. Bioorg Med Chem Lett. 1994 Aug 11;4(15):1835-40. | ||||
| REF 54 | Non-peptide glycoprotein IIb/IIIa inhibitors. 6. Design and synthesis of rigid, centrally constrained non-peptide fibrinogen receptor antagonists. Bioorg Med Chem Lett. 1995 Mar 2;5(5):475-80. | ||||
| REF 55 | Non-peptide fibrinogen receptor antagonists. 4. Proposed three-dimensional requirements in centrally constrained inhibitors.. Bioorg Med Chem Lett. 1994 Aug 11;4(15):1841-6. | ||||
| REF 56 | Discovery and evaluation of potent, tyrosine-based alpha4beta1 integrin antagonists. Bioorg Med Chem Lett. 2000 May 1;10(9):997-9. | ||||
| REF 57 | Novel non-peptide fibrinogen receptor antagonists. 1. Synthesis and glycoprotein IIb-IIIa antagonistic activities of 1,3,4-trisubstituted 2-oxopiperazine derivatives incorporating side-chain functions of the RGDF peptide. J Med Chem. 1998 Feb 12;41(4):489-502. | ||||
| REF 58 | Preparation and Properties of a fibrinogen receptor antagonist containing the Arg-Gly-Asp sequence and nitroxide radicals. Bioorg Med Chem Lett. 1993 Jun;3(6):1179-84. | ||||
| REF 59 | Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective alpha(V)beta(3) antagonists. Bioorg Med Chem Lett. 2002 Feb 11;12(3):441-6. | ||||
| REF 60 | Design of a new class of orally active fibrinogen receptor antagonists. J Med Chem. 1998 Jul 2;41(14):2492-502. | ||||
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