Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T39996 | Target Info | |||
| Target Name | Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) | ||||
| Synonyms |
EHMT1
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| Target Type | Literature-reported Target | ||||
| Gene Name | EHMT1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 16 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Glutathione
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Approved | Compound Info | ||
| Synonyms |
glutathione; 70-18-8; Glutathion; Isethion; Tathion; Glutathione-SH; Glutinal; reduced glutathione; Neuthion; Deltathione; Copren; L-Glutathione reduced; Glutide; Tathione; Triptide; Ledac; Glutatione; GSH; Glutatiol; Panaron; gamma-L-Glutamyl-L-cysteinylglycine; Glutathione SH; L-Glutatione; Glutathione (reduced); Agifutol S; L-gamma-glutamyl-L-cysteinylglycine; gamma-L-glutamyl-L-cysteinyl-glycine; 5-L-Glutamyl-L-cysteinylglycine; Glutathione [JAN]; glutathione red; gamma-L-Glutamylcysteinylglycine; red. glutathione
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
ANTHRAQUINONE
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Investigative | Compound Info | ||
| Synonyms |
84-65-1; 9,10-Anthraquinone; anthracene-9,10-dione; 9,10-Anthracenedione; Anthradione; Hoelite; 9,10-Dioxoanthracene; Corbit; Morkit; 9,10-Anthrachinon; Anthra-9,10-quinone; Anthrapel; 9,10-quinone; Anthrachinon; Caswell No. 052A; Anthraquinone [BSI:ISO]; UNII-030MS0JBDO; NSC 7957; Bis-alkylamino anthraquinone; 9,10-Anthrachinon [Czech]; CCRIS 649; 9,10-Anthracendion; Anthracene, 9,10-dihydro-9,10-dioxo-; CHEBI:40448; HSDB 2074; EINECS 201-549-0; Anthracene-9,10-quinone; EPA Pesticide Chemical Code 122701
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Cystamine
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Investigative | Compound Info | ||
| Synonyms |
Cystamine dihydrochloride; 56-17-7; 2,2'-Disulfanediyldiethanamine dihydrochloride; Ethanamine, 2,2'-dithiobis-, dihydrochloride; Cystamin dihydrochloride; Bis(2-aminoethyl) disulfide dihydrochloride; USAF CB-34; 2-Aminoethyl disulfide dihydrochloride; Cystamine 2HCL; UNII-I90T518457; EINECS 200-260-7; NSC 39322; 2,2'-Dithiodi(ethylammonium) dichloride; Decarboxycystine dihydrochloride; 2,2'-Dithio-bis-(ethylamine) dihydrochloride; Usafcb-34; MFCD00012905; 2-Aminoethyl Dislufide Dihydrochloride
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
N-(4-((2-Amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamide
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Investigative | Compound Info | ||
| Synonyms |
SGI-1027; DNA Methyltransferase Inhibitor II; SGI 1027; CHEMBL2336409; GTPL8891; SCHEMBL3655385; C27H23N7O; AOB6458; SGI1027; HMS3653O06; HMS3748A21; BCP09928; EX-A2160; BDBM50430056; FD5030; MFCD27937047; s7276; ZINC95591603; AKOS024458519; CCG-269354; SB19043; KS-00000T67; NCGC00381561-65; AC-33115; AK175455; AS-74078; DA-48337; HY-13962; FT-0755513; SGI-1027, >=98% (HPLC); SW220204-1; Y1873; A14120; J-000537; Q27088794
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| Activity |
IC50 = 65000 nM
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[2] | |||
| Compound Name |
Sodium diethyldithiocarbamate
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Investigative | Compound Info | ||
| Synonyms |
Ditiocarb sodium; Sodium N,N-diethyldithiocarbamate; Sodium diethylcarbamodithioate; Carbamodithioic acid, diethyl-, sodium salt; Dithiocarb; Imuthiol; UNII-A5304YEB5E; Thiocarb; Cupral; Diethyldithiocarbamic acid, sodium salt; Sodium DEDT; Carbamodithioic acid, N,N-diethyl-, sodium salt (1:1); A5304YEB5E; Sodium N,N-Diethyldithiocarbamate (25% solution in water); Usaf ek-2596; Diethyl sodium dithiocarbamate; NCI CO2835; Sodium diethylaminocarbodithioate; Diethyldithiocarbamic acid, sodium; GS 694A; Diethyl dithiocarbamate sodium salt; DSSTox_CID_2956; DSSTox_RID_76806; Diethylcarbamodithioic acid, sodium salt; DSSTox_GSID_22956; Sodium salt of N,N-diethyldithiocarbamic acid; Kupral; Ditiocarbo sodico; Na-ddtc; Nocceler SDC; CHEMBL107217; Soxinol ESL; Ditiocarbe sodique; NSC4857; Ditiocarbum natricum; Ditiocarb sodium [INN]; NCGC00166328-01; Diethyldithiocarbamate sodium; Ditiocarbe sodique [French]; Ditiocarbo sodico [Spanish]; Ditiocarbum natricum [Latin]; CCRIS 235; HSDB 4091; EINECS 205-710-6; NSC 38583; sodium (diethylcarbamothioyl)sulfanide; PubChem16843; AI3-14688; Carbamic acid, diethyldithio-, sodium salt; N,N-Diethyldithiocarbamic acid, sodium salt; C5H10NNaS2; EC 205-710-6; KSC175K6T; SCHEMBL168133; DTXSID3022956; CTK0H5569; KS-00000ZCE; sodium;N,N-diethylcarbamodithioate; HY-B1637; Tox21_112412; Tox21_200403; MFCD00066667; AKOS015897389; AKOS016358586; AKOS025310122; N,N-diethyl(sodiosulfanyl)carbothioamide; NCGC00257957-01; AS-12092; SC-65385; CS-0013580; FT-0631848; C19599; K-4713; Q413008; J-008449; F8880-1809; Z1522566622
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| Activity |
IC50 = 81000 nM
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[1] | |||
| Compound Name |
(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-pentyloxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263624; SCHEMBL16486895; BDBM50010378
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| Activity |
IC50 = 87000 nM
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[3] | |||
| Compound Name |
(2R,3S,4R,5R)-2-[(2S)-2-Amino-3-cyclopentylpropyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089220; BDBM50260383
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| Activity |
IC50 = 95100 nM
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[4] | |||
| Compound Name |
6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
UNC0379; UNC-0379; CHEMBL3318285; UNC 0379; 6,7-Dimethoxy-2-pyrrolidin-1-yl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine; C23H35N5O2; CS-3345; HY-12335; SCHEMBL22568439; AOB6365; EX-A461; SYN5081; BCP10429; KS-00000T5A; 3362AH; BDBM50051117; MFCD28167817; s7570; ZINC98214604; AKOS025404942; UNC 0379;UNC-0379; CCG-268809; SB19349; NCGC00384189-06; NCGC00384189-10; AK174945; AS-16447; DA-43617; B8009; FT-0699830; A14320; UNC0379 trifluoroacetate salt, >=98% (HPLC)
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| Activity |
IC50 ~ 100000 nM
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[5] | |||
| Compound Name |
Ninhydrin
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Investigative | Compound Info | ||
| Synonyms |
Ninhydrine; Ninhydrin hydrate; 1H-Indene-1,3(2H)-dione, 2,2-dihydroxy-; 2,2-Dihydroxy-1H-indene-1,3(2H)-dione; 2,2-Dihydroxy-1,3-indandione; Triketohydrindene hydrate; 2,2-Dihydroxy-1,3-indanedione; 1,2,3-Indantrione, 2-hydrate; 2,2-Dihydroxyindane-1,3-dione; 2,2-dihydroxyindene-1,3-dione; Ninhydrin Spray; Trioxohydrindene monohydrate; UNII-HCL6S9K23A; MFCD00003791; Ninhydrin, ACS reagent; 1,3-Indandione, 2,2-dihydroxy-; 2,2-dihydroxy-2,3-dihydro-1H-indene-1,3-dione; HCL6S9K23A; CHEMBL1221925; Ninhydrin, spectrophotometric grade; CCRIS 4849; EINECS 207-618-1; BRN 1910963; 2,2-dihydroxy-2-hydrocyclopenta[1,2-a]benzene-1,3-dione; Ningidrin; nin-hydrin; AI3-04464; ninhydrin monohydrate; Ninhydrin ACS grade; zlchem 153; DSSTox_CID_5716; DSSTox_RID_77890; DSSTox_GSID_25716; Ninhydrin, AR, >=99%; SCHEMBL17986; 4-07-00-02786 (Beilstein Handbook Reference); MLS002454421; DTXSID7025716; CTK7H1849; ZLB0142; Ninhydrin, >=95.0% (UV); ZINC388306; ACT05788; ALBB-033740; HY-D0908; Tox21_200705; 1,2,3-Triketohydrindene Monohydrate; BBL012206; BDBM50324901; Ninhydrin, puriss. p.a., >=99%; SBB009147; STL163548; AKOS004906785; 1H-Indene-1,2,3, trione Monohydrate; 1H-Indene-1,2,3-trione, 2-hydrate; CS-W018489; MCULE-8190517984; NE10279; NCGC00091114-01; NCGC00091114-02; NCGC00091114-03; NCGC00258259-01; AC-11764; AS-14832; BP-11883; Ninhydrin, p.a., ACS reagent, 99.0%; SMR001372015; ST094931; Ninhydrin spray reagent, 0.2% in ethanol; Ninhydrin, SAJ special grade, >=98.0%; DB-051560; Ninhydrin, ACS reagent, >=98.0% (UV); FT-0632202; I0015; N0094; N0719; Ninhydrin, suitable for amino acid detection; 27828-EP2292592A1; 27828-EP2292628A2; 27828-EP2298767A1; 27828-EP2305671A1; 27828-EP2305808A1; 27828-EP2311842A2; 27828-EP2314587A1; AQ-911/40896973; Q421098; J-610068; Q-201472; Ninhydrin, ozone friendly ready to use spray for TLC; F0001-2517; Ninhydrin, >=98.0%, suitable for amino acid analysis
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
N-[4-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-3-(quinolin-4-ylamino)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3126645; BDBM50448485
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| Activity |
IC50 = 100000 nM
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[2] | |||
| Compound Name |
N-[3-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-3-(quinolin-4-ylamino)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3126646; MC3343; BDBM50448484; N-(3-(2-amino-6-methylpyrimidin-4-ylamino)phenyl)-3-(quinolin-4-ylamino)benzamide
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| Activity |
IC50 = 100000 nM
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[2] | |||
| Compound Name |
Cysteamine
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Investigative | Compound Info | ||
| Synonyms |
2-Aminoethanethiol; Mercaptamine; Thioethanolamine; Becaptan; Mercamine; Cysteinamine; beta-Mercaptoethylamine; 2-Mercaptoethylamine; Cysteamin; Lambraten; Lambratene; beta-Aminoethanethiol; Cystagon; Riacon; Decarboxycysteine; Mercaptoethylamine; 2-Amino-1-ethanethiol; Ethanethiol, 2-amino-; Cisteamina; 2-Aminoethyl mercaptan; beta-Aminoethylthiol; 2-Mercaptoethanamine; Mercaptamin; (2-Mercaptoethyl)amine; MEA (mercaptan); Ethanethiolamine; 2-AMINO-ETHANETHIOL; beta-MEA; Aminoethyl mercaptan; Mercaptamina; Mercaptaminum; Cysteamide; Mecramine; Mercamin; Merkamin; Cisteamina [Italian]; Cystaran; Mercaptaminum [INN-Latin]; Mercaptamina [INN-Spanish]; 1-Amino-2-mercaptoethylamine; L-1573; Cysteamine (USAN); WR 347; 2-aminoethane-1-thiol; UNII-5UX2SD1KE2; NSC 647528; Cysteamine [USAN]; Mercaptamine (INN); .beta.-Mercaptoethylamine; 5UX2SD1KE2; 2-aminoethane-1-thiol; Cysteamine; Mercaptamine [INN]; NSC647528; NSC-647528; NCGC00015691-03; 2-Aminoethanethiol, 95%; Cysteamine [USAN:BAN]; C2H7NS; Cysteamine bitartate; CCRIS 3083; HSDB 7353; EINECS 200-463-0; L 1573; Cystagone; b-Aminoethylthiol; 2-aminoethanethio; b-Aminoethanethiol; mercapto ethylamine; b-Mercaptoethylamine; MFCD00008196; 2-amino-ethyl thiol; .beta.-MEA; Cysteamine, ~95%; Cysteamine, free base; .beta.-Aminoethylthiol; Spectrum_001755; .beta.-Aminoethanethiol; ACMC-1AVBC; SpecPlus_000654; (Mercaptoethyl)ammonium toluene-p-sulphonate; Lopac-M-6500; DSSTox_CID_2875; bmse000388; CHEMBL602; C-9500; DSSTox_RID_76770; DSSTox_GSID_22875; KBioSS_002235; KSC490G2L; DivK1c_006750; 2-$l^{1}-sulfanylethanamine; BDBM7968; GTPL7440; 2,3-DESHYDROLANTHIONINE; DTXSID3022875; CTK3J0325; KBio1_001694; KBio2_002235; KBio2_004803; KBio2_007371; KS-00000WES; Cysteamine, >=98.0% (RT); BCP15015; ZINC8034121; EINECS 221-235-7; Tox21_113092; ANW-33452; HY-77591A; s6402; STK315355; AKOS003793343; CCG-204834; DB00847; MCULE-1838427828; NE18622; SDCCGSBI-0050727.P004; NCGC00015691-01; NCGC00015691-02; NCGC00015691-04; NCGC00015691-14; NCGC00162236-01; NCGC00162236-02; AS-56218; BP-13401; NCI60_002000; SC-18413; SBI-0050727.P003; AB0020070; DB-053562; A0648; FT-0611243; V0810; C01678; D03634; AB00053754_09; AB00053754_10; 106791-EP2292597A1; 106791-EP2295407A1; 106791-EP2298736A1; 213515-EP2371809A1; Q617563; F0001-1576; 2DFDA1F8-7010-4225-8280-AB1C4C43F546
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
(2R,3S,4R,5R)-2-[(2R)-2-Amino-3-cyclobutylpropyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085649; BDBM50260385
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| Activity |
IC50 = 115000 nM
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[4] | |||
| Compound Name |
(2R,3S,4R,5R)-2-[(2R)-2-Amino-3-cyclohexylpropyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077793; BDBM50260384
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| Activity |
IC50 = 145800 nM
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[4] | |||
| Compound Name |
(2R,3S,4R,5R)-2-[2-Amino-3-(3,4-dimethoxyphenyl)propyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263627; SCHEMBL16487123; BDBM50010381
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| Activity |
IC50 = 147000 nM
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[3] | |||
| Compound Name |
Click to Show/Hide
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Compound Info | |||
| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 7 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sinefungin
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Investigative | Compound Info | ||
| Synonyms |
sinefungin; ADENOSYL-ORNITHINE; Sinefunginum; Sinefungina; Sinefungine; Antibiotic A 9145; Compound 57926; Adenosylornithine; 58944-73-3; A 9145; Antibiotic 32232 RP; Sinefungin [USAN:INN]; Sinefungine [INN-French]; Sinefunginum [INN-Latin]; UNII-W2U467CIIL; Sinefungina [INN-Spanish]; 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxydecofuranuronic acid; 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-beta-D-ribo-decofuranuronic acid; BRN 3574678; W2U467CIIL; RP 32232; LY 57926; CHEBI:45453; Decofuranuronic
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| Activity |
IC50 = 513000 nM
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[3] | |||
| Compound Name |
(2R,3S,4R,5R)-2-[(2S)-2-Amino-3-cyclohexylpropyl]-5-(6-aminopurin-9-yl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4065774; BDBM50260386
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| Activity |
IC50 = 203700 nM
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[4] | |||
| Compound Name |
(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(3-phenylpropyl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3263625; SCHEMBL16487371; BDBM50010379
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| Activity |
IC50 = 235000 nM
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[3] | |||
| Compound Name |
N-[2-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3126644; BDBM50448486
Click to Show/Hide
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| Activity |
IC50 = 400000 nM
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[2] | |||
| Compound Name |
N-[2-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-3-(quinolin-4-ylamino)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3126647; BDBM50448483
Click to Show/Hide
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| Activity |
IC50 = 500000 nM
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[2] | |||
| Compound Name |
N-[3-[(2-Amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2385821; SCHEMBL3657042; BDBM50448487
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| Activity |
IC50 = 600000 nM
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[2] | |||
| Compound Name |
5'-[(R)-1-Amino-2-cyclopropylethyl]-5'-deoxyadenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103578; BDBM50260388; J3.657.506I
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| Activity |
IC50 = 794300 nM
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[4] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibition of histone lysine methyltransferases G9a and GLP by ejection of structural Zn(II). Bioorg Med Chem Lett. 2018 Apr 15;28(7):1234-1238. | ||||
| REF 2 | Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells. J Med Chem. 2014 Feb 13;57(3):701-13. | ||||
| REF 3 | Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2. ACS Med Chem Lett. 2014 Jan 31;5(4):293-7. | ||||
| REF 4 | Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors. Bioorg Med Chem. 2017 Sep 1;25(17):4579-4594. | ||||
| REF 5 | Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. J Med Chem. 2014 Aug 14;57(15):6822-33. | ||||
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