Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T39321 | Target Info | |||
| Target Name | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) | ||||
| Synonyms |
Peptidyl-cysteine S-nitrosylase GAPDH; OK/SW-cl.12; GAPD; D-glyceraldehyde-3-phosphate dehydrogenase; CDABP0047
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| Target Type | Clinical trial Target | ||||
| Gene Name | GAPDH | ||||
| Biochemical Class | Aldehyde/oxo donor oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 40 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Benznidazole
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|
Approved | Compound Info | ||
| Synonyms |
BENZNIDAZOLE; Radanil; Benzonidazole; 22994-85-0; Benznidazol; benzonidazol; Benznidazolum;Ro 07-1051; Rochagan; UNII-YC42NRJ1ZD; Benznidazolum [INN-Latin]; Benznidazol [INN-Spanish]; Ro 71051; NSC 299972; Benznidazole [INN]; CCRIS 2200
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Pentamidine
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|
Approved | Compound Info | ||
| Synonyms |
Lomidine; Nebupent; PENTAM; PNT; Pentacarinat; Pentamide; Pentamidin; Pentamidina; Pentamidinum; Pneumopent; PENTAMIDINE ISETHIONATE; Pentamidina [DCIT]; Pentamidine isetionate; Pentamidine mesylate; MB 800; Pentam 300; Lomidine (TN); MB-800; Nebupent (as isethionate); Pentacarinat (as isethionate); Pentam 300 (as isethionate); Pentamidine (INN); Pentamidinum [INN-Latin]; RP-2512; Nebupent (*Isethionate); Pentacarinat (*Isethionate); Pentam 300 (*Isethionate); Pentamidine Isethionate 2-Hydroxy-Ethanesulfonic Acid;Pentamidine [INN:BAN:DCF]; RP 2512 (*Isethionate); P,p'-(Pentamethylenedioxy)bis[benzamidine]; P,p'-(Pentamethylenedioxy)dibenzamidine; P,p'-(Pentamethylene-dioxy)bis-benzamidine; Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-(9CI); 1,3-BIS(4-AMIDINOPHENOXY)PENTANE; 4, 4'-Diamidinodiphenoxypentane; 4,4'-(1,5-Pentanediylbis(oxy))bis-benzenecarboximidamide; 4,4'-(Pentamethylenedioxy)dibenzamide; 4,4'-(Pentamethylenedioxy)dibenzamidine; 4,4'-Diamidino-.alpha.,.omega.-diphenoxypentane; 4,4'-Diamidinodiphenoxypentane; 4,4'-[pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide; 4-[5-(4-Carbamimidoylphenoxy)pentoxy]benzenecarboximidamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Adenosine
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Approved | Compound Info | ||
| Synonyms |
Adenosine, homopolymer; Adenine 9-beta-D-arabinofuranoside; Adenine-9-beta-D-ribofuranoside; Beta-D-Ribofuranoside, adenine-9; EA6C60C2-6AFB-4264-A2F0-541373DB950E; (2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 4-Aminopyrazolo[3,4-d]pyrimidine ribonucleoside; 6-Amino-9-.beta.-ribofuranosyl-9H-purine; 6-Amino-9-beta-D-ribofuranosyl-9H-purine; 6-Amino-9beta-D-ribofuranosyl-9H-purine; 9-(beta-D-Arabinofuranosyl)adenine; 9-beta-D-Ribofuranosidoadenine; 9-beta-D-Ribofuranosyl-9H-purin-6-amine; 9-beta-D-Ribofuranosyladenine; 9beta-D-Ribofuranosyladenine
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
N-(3-Hydroxy-1-naphthylmethyl)-2'-(3,5-dimethoxybenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303751; BDBM50100479
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-Naphthalen-1-ylmethyl-2'-[3,5-dimethoxybenzamido]-2'-deoxy-adenosine
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Investigative | Compound Info | ||
| Synonyms |
NMDBA; CHEMBL303934; SCHEMBL4324146; BDBM50100471; DB03331; 2'-Deoxy-2'-[(3,5-dimethoxybenzoyl)amino]-N-(1-naphthylmethyl)adenosine; N-NAPHTHALEN-1-YLMETHYL-2''-[3,5-DIMETHOXYBENZAMIDO]-2''-DEOXY-ADENOSINE
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(1-Naphthylmethyl)-2'-(3,4-dimethoxybenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303595; BDBM50100470
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Hydroxy-5-hydroxymethyl-2-{6-[(naphthalen-2-ylmethyl)-amino]-purin-9-ylmethyl}-tetrahydro-furan-3-yl)-3-methoxy-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL291418; BDBM50100468
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(1-Naphthylmethyl)-2'-(3,5-dichlorobenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL294813; BDBM50100476
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(1-Naphthylmethyl)-2'-(3,5-dihydroxybenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303730; BDBM50100465
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
3,5-Dichloro-N-(4-hydroxy-5-hydroxymethyl-2-{6-[(naphthalen-2-ylmethyl)-amino]-purin-9-ylmethyl}-tetrahydro-furan-3-yl)-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL65460; BDBM50100493
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-((2R,3R,4S,5R)-4-Hydroxy-5-hydroxymethyl-2-{6-[(naphthalen-1-ylmethyl)-amino]-purin-9-yl}-tetrahydro-furan-3-yl)-3-methoxy-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL464924; BDBM50096600; N-(1-Naphthylmethyl)-2'-(3-methoxybenzoylamino)-2'-deoxyadenosine
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(3-Methoxy-1-naphthylmethyl)-2'-(3-methoxybenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63569; BDBM50100472
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Hydroxy-5-hydroxymethyl-2-{6-[(naphthalen-2-ylmethyl)-amino]-purin-9-ylmethyl}-tetrahydro-furan-3-yl)-3,5-dimethoxy-benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63338; BDBM50100483
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(3-Methoxy-1-naphthylmethyl)-2'-(3,5-dimethoxybenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303342; BDBM50100469
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(4-Methoxy-1-naphthylmethyl)-2'-(3-methoxybenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62124; BDBM50100482
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|
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
N-(3-Hydroxy-1-naphthylmethyl)-2'-(3-chlorobenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303752; BDBM50100475
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(3-Hydroxy-1-naphthylmethyl)-2'-(3-methoxybenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL431169; BDBM50100488
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(1-Naphthylmethyl)-2'-(3,5-diacetoxybenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL63403; BDBM50100474
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(3-Hydroxy-1-naphthylmethyl)-2'-(3,5-dichlorobenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL291088; BDBM50100481
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-(3-Methoxy-1-naphthylmethyl)-2'-(3,5-dichlorobenzoylamino)-2'-deoxyadenosine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL64311; BDBM50100467
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
6,4'-Diacetoxy-3-phenylcoumarin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL303027; BDBM50404369
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|
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| Activity |
IC50 = 52480.75 nM
|
[3] | |||
| Compound Name |
6-(1,1-Dimethylallyl)-2-(1-hydroxy-1-methylethyl)-2,3-dihydro-7H-furo[3,2-G]chromen-7-one
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Investigative | Compound Info | ||
| Synonyms |
(+)-rutamarin alcohol; UNII-V0632559OD; V0632559OD; Rutamarin alcohol; (+)-Chalepin; Chalepin, (+)-; Rutamarin alcohol, (+)-; MEGxp0_001084; CHEMBL1231470; ACon1_000926; ZINC898293; BDBM50220736; DB02205; MCULE-7971404433; NCGC00169223-01; BRD-K34596419-001-01-5; Q27093253
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| Activity |
IC50 = 54954.09 nM
|
[3] | |||
| Compound Name |
3-(1,3-Benzodioxole-5-yl)-6-[(1H-pyrrole-2-ylmethylene)amino]-2H-1-benzopyran-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL67979; BDBM50404372
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|
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| Activity |
IC50 = 56234.13 nM
|
[3] | |||
| Compound Name |
3-(1,3-Benzodioxole-5-yl)-6-[(2-furylmethylene)amino]-2H-1-benzopyran-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL419813; BDBM50404358
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|
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| Activity |
IC50 = 56234.13 nM
|
[3] | |||
| Compound Name |
3-(1,3-Benzodioxole-5-yl)-6-acetoxy-2H-1-benzopyran-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL70378; BDBM50404365
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| Activity |
IC50 = 64565.42 nM
|
[3] | |||
| Compound Name |
3-(m-Hydroxyphenyl)coumarin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL71407; SCHEMBL22132745; BDBM50404362
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| Activity |
IC50 = 67608.3 nM
|
[3] | |||
| Compound Name |
16-Methyl-3,11,14-trioxatetracyclo[8.7.0.02,7.013,17]heptadeca-1(10),2(7),5,8,16-pentaene-4,15-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL302011; BDBM50404368
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| Activity |
IC50 = 74131.02 nM
|
[3] | |||
| Compound Name |
[3-(3-Methoxyphenyl)-2-oxochromen-6-yl] acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL305426; BDBM50404371
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|
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| Activity |
IC50 = 85113.8 nM
|
[3] | |||
| Compound Name |
((2R,3S,4R,5R)-3-Hydroxy-4-(3-methoxybenzamido)-5-(6-(naphthalen-1-ylmethylamino)-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl dihydrogen phosphate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL366942; BDBM50096598; N-(1-Naphthylmethyl)-2'-(3-methoxybenzoylamino)-2'-deoxyadenosine 5'-phosphoric acid
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2h-1-Benzopyran-2-one,6-(acetyloxy)-3-phenyl-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL70732; 6-acetoxy-3-phenylcoumarin; BDBM50404366; ZINC26294992; Acetic acid (3-phenylcoumarin-6-yl) ester; J3.505.699H
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| Activity |
IC50 = 123026.88 nM
|
[3] | |||
| Compound Name |
Seselin
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Investigative | Compound Info | ||
| Synonyms |
Amyrolin; Pyranocoumarin deriv.; 8,8-dimethylpyrano[2,3-f]chromen-2-one; UNII-5634E8957P; 8,8-Dimethyl-2H,8H-pyrano[2,3-f]chromen-2-one; CHEMBL71358; 8,8-Dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-2-one; 2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 8,8-dimethyl-; 5634E8957P; 3',4'-Di-O-(-)-Camphanoyl-(+)-cis-khellactone; 2H,8H-Benzo(1,2-b:3,4-b')dipyran-2-one, 8,8-dimethyl-; 8,8-Dimethyl-2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one; Sesalin; Seseline; Oprea1_187929; SCHEMBL8993385; CTK4J5797; DTXSID60200322; HMS1648A10; ZINC265504; BDBM50361397; AKOS000276897; MCULE-7289743021; 2',2'-dimethyl-3-pyreno[6'5:7,8]coumarin; C09312; 8,8-DIMETHYLPYRANO[2,3-H]CHROMEN-2-ONE; 8,8-Dimethyl-2H,8H-pyrano[2,3-f]chromen-2-one #; Q27104968; 8,8-Dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-2-one, 9CI; 2H-1-Benzopyran-6-acrylic acid, 5-hydroxy-2,2-dimethyl-, .delta.-lactone
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| Activity |
IC50 = 123026.88 nM
|
[3] | |||
| Compound Name |
7-Hydroxy-8-[(2R,3R)-3-prop-1-en-2-yloxiran-2-yl]chromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL306160; BDBM50404367
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| Activity |
IC50 = 128824.96 nM
|
[3] | |||
| Compound Name |
Ammirin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL306543; Oprea1_478213; ZINC225559; BDBM50404363; AKOS030503395
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| Activity |
IC50 = 144543.98 nM
|
[3] | |||
| Compound Name |
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(naphthalen-1-ylmethylamino)purin-9-yl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL132960; SCHEMBL10870357; CTK0I9038; DTXSID80440581; BDBM50085667; RDT-2-185; Adenosine, N-(1-naphthalenylmethyl)-
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| Activity |
IC50 = 150000 nM
|
[5] | |||
| Compound Name |
N-Benzyl-2'-[(3-methoxybenzoyl)amino]-2'-deoxyadenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143238
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| Activity |
IC50 = 159000 nM
|
[5] | |||
| Compound Name |
7-Hydroxy-3-(1,1-dimethylprop-2-enyl)coumarin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL71850; Angustifolin[coumarin]; 7-hydroxy-3-(2-methylbut-3-en-2-yl)chromen-2-one; CTK5A5853; DTXSID20418603; BDBM50404370; 7-hydroxy-3-(2-methylbut-3-en-2-yl)-2H-chromen-2-one; 3-(1,1-Dimethyl-2-propenyl)-7-hydroxy-2H-chromen-2-one #; 2H-1-Benzopyran-2-one,3-(1,1-dimethyl-2- propenyl)-7-hydroxy-
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| Activity |
IC50 = 162181.01 nM
|
[3] | |||
| Compound Name |
(8S)-5-Hydroxy-8-prop-1-en-2-yl-8,9-dihydrofuro[2,3-h]chromen-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL305510; BDBM50404364
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| Activity |
IC50 = 190546.07 nM
|
[3] | |||
| Compound Name |
Xanthyletin
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Investigative | Compound Info | ||
| Synonyms |
Xanthyletine; 2,2-dimethylpyrano[3,2-g]chromen-8-one; UNII-3N789LD38N; Spectrum_000673; SpecPlus_000132; CHEMBL303846; 3N789LD38N; 8,8-Dimethyl-8H-pyrano[3,2-g]chromen-2-one; 8,8-Dimethyl-2H,8H-benzo(1,2-b:5,4-b')dipyran-2-one; 8,8-dimethyl-2H,8H-benzo[1,2-b:5,4-b']dipyran-2-one; Spectrum2_000365; Spectrum3_000124; Spectrum4_001401; Spectrum5_000162; BSPBio_001768; KBioGR_001782; KBioSS_001153; SPECTRUM100609; cid_65188; MLS000863611; DivK1c_006228; SPBio_000489; MEGxp0_000991; SCHEMBL2120500; ACon1_000507; KBio1_001172; KBio2_001153; KBio2_003721; KBio2_006289; KBio3_000928; DTXSID60203818; HMS2269H15; ZINC338304; HY-N4116; BDBM50292575; CCG-38639; AKOS000278141; MCULE-4193827138; SDCCGMLS-0066430.P001; NCGC00095444-01; NCGC00095444-02; NCGC00095444-03; SMR000440697; CS-0032126; C09317; 2,2-dimethyl-8-pyrano[3,2-g][1]benzopyranone; A830590; SR-01000780630; 8,8-Dimethyl-2H,8H-pyrano[3,2-g]chromen-2-one; SR-01000780630-2; 8,8-Dimethyl-2H,8H-pyrano[3,2-g]chromen-2-one #; BRD-K28108221-001-02-3; Q27108571; 2H,8H-Benzo[1,2-b:5,4-b']dipyran-2-one, 8,8-dimethyl-; NCGC00095444-05!2,2-dimethylpyrano[3,2-g]chromen-8-one
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| Activity |
IC50 = 194984.46 nM
|
[3] | |||
| Compound Name |
2'-[(3-Chlorobenzoyl)amino]-2'-deoxyadenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143018
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| Activity |
IC50 = 200000 nM
|
[6] | |||
| Compound Name |
2'-[(Biphenyl-4-ylcarbonyl)amino]-2'-deoxyadenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143020
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| Activity |
IC50 = 200000 nM
|
[6] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 56 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
METRIFUDIL
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Terminated | Compound Info | ||
| Synonyms |
Metrifudil; UNII-7K4GKQ4XSE; 7K4GKQ4XSE; 23707-33-7; CHEMBL331382; Y-341; N-[(2-Methylphenyl)methyl]adenosine; TH-322; Metrifudilum; Metrifudil [INN]; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[(2-methylphenyl)methylamino]purin-9-yl]oxolane-3,4-diol; Metrifudilum [INN-Latin]; Th 322; NCGC00015640-02; Adenosine analog, 16; Y 341; AC1L23SZ; DSSTox_RID_80718; DSSTox_CID_25168; DSSTox_GSID_45168; GTPL426; SCHEMBL472516; n6 -(2-methylbenzyl)adenosine; DTXSID1045168; OOEMZCZWZXHBKW-SCFUHWHPSA-N; ZINC4216929; Tox21_110187; BDBM50080390
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| Activity |
IC50 = 700000 nM
|
[5] | |||
| Compound Name |
SCOPOLETIN
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Investigative | Compound Info | ||
| Synonyms |
scopoletin; 92-61-5; Gelseminic acid; 6-Methylesculetin; 7-Hydroxy-6-methoxy-2H-chromen-2-one; Chrysatropic acid; Scopoletine; 7-Hydroxy-6-methoxycoumarin; Scopoletol; Murrayetin; 6-O-Methylesculetin; Escopoletin; 6-Methoxy-7-hydroxycoumarin; 7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one; 6-Methoxyumbelliferone; 2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy-; Esculetin 6-methyl ether; beta-Methylesculetin; Esculetin-6-methyl ether; .beta.-Methylesculetin; Buxuletin; UNII-KLF1HS0SXJ; COUMARIN, 7-HYDROXY-6-METHOXY-
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| Activity |
IC50 = 257039.58 nM
|
[3] | |||
| Compound Name |
7-hydroxycoumarin
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Investigative | Compound Info | ||
| Synonyms |
Umbelliferone; 93-35-6; 7-Hydroxy-2H-chromen-2-one; Skimmetin; Hydrangin; 7-hydroxycoumarine; 7-Oxycoumarin; Umbelliferon; Skimmetine; Hydrangine; 2H-1-Benzopyran-2-one, 7-hydroxy-; 7-Hydroxy-2H-1-benzopyran-2-one; Coumarin, 7-hydroxy-; beta-Umbelliferone; 7-hydroxychromen-2-one; 7 HC; UNII-60Z60NTL4G; 7-hydroxy-coumarin; NSC 19790; CCRIS 3591; NSC19790; EINECS 202-240-3; 7H-1-Benzopyran-7-one, 2-hydroxy-; BRN 0127683; CHEMBL51628; AI3-38054; 7-hydroxy-1-benzopyran-2-one; 7-HC; 60Z60NTL4G; CHEBI:27510; UMBELLIFERONE
Click to Show/Hide
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||||
| Activity |
IC50 = 616595 nM
|
[3] | |||
| Compound Name |
COUMARIN
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|
Investigative | Compound Info | ||
| Synonyms |
coumarin; 2H-Chromen-2-one; 91-64-5; 2H-1-Benzopyran-2-one; cumarin; 1,2-Benzopyrone; Rattex; Tonka bean camphor; Coumarinic anhydride; chromen-2-one; Coumarine; Benzo-alpha-pyrone; cis-o-Coumarinic acid lactone; o-Hydroxycinnamic acid lactone; o-Hydroxycinnamic lactone; 2-Oxo-1,2-benzopyran; Coumarinic lactone; Kumarin; Benzo-a-pyrone; Kumarin [Czech]; 5,6-Benzo-2-pyrone; 2H-1-Benzopyran, 2-oxo-; 5,6-Benzo-alpha-pyrone; 2H-Benzo(b)pyran-2-one; 2H-Benzo[b]pyran-2-one; Caswell No. 259C; o-Coumaric acid lactone
Click to Show/Hide
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||||
| Activity |
IC50 = 691830.97 nM
|
[3] | |||
| Compound Name |
N6-CYCLOPENTYLADENOSINE
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|
Investigative | Compound Info | ||
| Synonyms |
N6-Cyclopentyladenosine; 41552-82-3; n-cyclopentyladenosine; (2R,3R,4S,5R)-2-(6-(Cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; Cyclopentyladenosine; CHEMBL68738; MLS000028368; N(6)-Cyclopentyladenosine; SMR000058639; (2R,3R,4S,5R)-2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol; Adenosine, N-cyclopentyl-; UNII-7LG47VG1ID; 7LG47VG1ID; N6-CyclopentylAdo; n-cyclopentyl-adenosine; n6-cyclopentyl-adenosine; AC1LCWG1; Opera_ID_1056; GTPL380; MLS002153196; MLS001077332; SCHEMBL120481
Click to Show/Hide
|
||||
| Activity |
IC50 > 5000000 nM
|
[5] | |||
| Compound Name |
Osthole
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
Osthol; Ostol; Ostole; 7-Methoxy-8-isopentenylcoumarin; 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one; NSC 31868; 8-(3-Methyl-2-butenyl)herniarin; 7-METHOXY-8-(3-METHYL-2-BUTENYL)-COUMARIN; 7-methoxy-8-(3-methyl-2-butenyl)coumarin; UNII-XH1TI1759C; Coumarin, 7-methoxy-8-(3-methyl-2-butenyl)-; CHEMBL52229; XH1TI1759C; NSC31868; 7-Methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one; MFCD00076049; 7-methoxy-8-(3-methylbut-2-enyl)-2H-chromen-2-one; SMR000156202; Osthole (Osthol); Osthole,(S); Cnidium Fruit Extract; Spectrum_001542; SpecPlus_000946; Spectrum2_000723; Spectrum3_001645; Spectrum4_001687; Spectrum5_000334; Osthole, analytical standard; Oprea1_642606; Oprea1_873803; SCHEMBL50436; BSPBio_003369; KBioGR_001954; KBioSS_002022; ZINC566; MLS000574904; MLS001048988; MLS006011425; DivK1c_007042; SPECTRUM1504165; SPBio_000646; MEGxp0_000155; ACon1_002155; CTK7A8592; GTPL10302; HSDB 8479; KBio1_001986; KBio2_002022; KBio2_004590; KBio2_007158; KBio3_002589; DTXSID20197507; HMS2267O21; HMS3656A07; BCP10832; EBD33224; HY-N0054; KS-00000N3A; ANW-50075; BBL013019; BDBM50240512; CCG-40172; CO0040; NSC-31868; s2337; STK396321; AKOS000277663; AC-8041; DS-0881; MCULE-5691054147; SDCCGMLS-0066780.P001; NCGC00095694-01; NCGC00095694-02; NCGC00095694-03; NCGC00095694-05; WLN: T66 BOVJ IO1 J2UY1&1; AK-35300; BR-35300; AB0021820; FT-0601535; N1825; O0426; ST50909221; SW219438-1; W1256; C09280; J10077; S-3211; 484O128; A827530; SR-01000721624; Q-100535; Q4338679; SR-01000721624-4; BRD-K78294846-001-03-3
Click to Show/Hide
|
||||
| Activity |
IC50 = 208929.61 nM
|
[3] | |||
| Compound Name |
(3R,4S,5R)-2-[6-(Benzhydrylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL606064; BDBM50367410
Click to Show/Hide
|
||||
| Activity |
IC50 = 240000 nM
|
[5] | |||
| Compound Name |
N-[[(2R,3S,4R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-2,2-diphenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL609489; BDBM50369051
Click to Show/Hide
|
||||
| Activity |
IC50 = 250000 nM
|
[6] | |||
| Compound Name |
2'-[(3,4,5-Trihydroxybenzoyl)amino]-2'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143233
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|
||||
| Activity |
IC50 = 250000 nM
|
[5] | |||
| Compound Name |
N-(2-Methylbenzyl)-2'-[(3-methoxybenzoyl)amino]-2'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143237
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|
||||
| Activity |
IC50 > 270000 nM
|
[5] | |||
| Compound Name |
N-[(2R,3R,4S,5R)-2-(6-Aminopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NSC677934; SCHEMBL7684261; CHEMBL3142964; CTK7J7576; 2'-[(3-Methoxybenzoyl)amino]-2'-deoxyadenosine; 2'-deoxy-2'-{[(3-methoxyphenyl)carbonyl]amino}adenosine
Click to Show/Hide
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||||
| Activity |
IC50 = 300000 nM
|
[6] | |||
| Compound Name |
Adenosine, 8-(2-thienyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL124807; 8-(2-thienyl)adenosine; SCHEMBL1096941; CTK0E7095; DTXSID80435114; BDBM50030949; (2R,3R,4S,5R)-2-(6-amino-8-thiophen-2-ylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3R,4S,5R)-2-(6-Amino-8-(thiophen-2-yl)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol; (2R,3R,4S,5R)-2-(6-Amino-8-thiophen-2-yl-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol
Click to Show/Hide
|
||||
| Activity |
Ki = 300000 nM
|
[7] | |||
| Compound Name |
(2R,3S,4R)-2-(Hydroxymethyl)-5-[6-[[2-[2-(hydroxymethyl)phenyl]sulfanylphenyl]methylamino]purin-9-yl]oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611898; BDBM50369416
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|
||||
| Activity |
IC50 = 340000 nM
|
[5] | |||
| Compound Name |
4-Methoxy-2,3-dihydrofuro[3,2-g]chromen-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421484; SCHEMBL9133590; BDBM50404361
Click to Show/Hide
|
||||
| Activity |
IC50 = 346736.85 nM
|
[3] | |||
| Compound Name |
Chembl604351
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350060; SCHEMBL10869781; BDBM50368219; PD-117973
Click to Show/Hide
|
||||
| Activity |
IC50 = 360000 nM
|
[5] | |||
| Compound Name |
2'-[(3-Ethoxybenzoyl)amino]-2'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143019; adenosine, 2'-deoxy-2'-[(3-ethoxybenzoyl)amino]-
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|
||||
| Activity |
IC50 = 400000 nM
|
[6] | |||
| Compound Name |
9-(2-Benzylamino-ethyl)-8-thiophen-2-yl-9H-purin-6-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL330972; BDBM50030957; 8-(Thiophen-2-yl)-9-[2-(benzylamino)ethyl]-9H-purin-6-amine
Click to Show/Hide
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||||
| Activity |
IC50 = 400000 nM
|
[6] | |||
| Compound Name |
8-(2-Thienyl)-2'-[benzoylamino]-2'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143014; adenosine, 2'-(benzoylamino)-2'-deoxy-8-(2-thienyl)-
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|
||||
| Activity |
IC50 = 500000 nM
|
[6] | |||
| Compound Name |
2'-[(Quinolin-7-ylcarbonyl)amino]-2'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143021
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|
||||
| Activity |
IC50 = 500000 nM
|
[6] | |||
| Compound Name |
2'-[(3-Methoxy-4-hydroxybenzoyl)amino]-2'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143236
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|
||||
| Activity |
IC50 = 500000 nM
|
[5] | |||
| Compound Name |
NAD+ analogue
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3350919; CHEMBL174337; BDBM50096597
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|
||||
| Activity |
IC50 > 500000 nM
|
[4] | |||
| Compound Name |
Nicotinamide mononucleotide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
beta-Nicotinamide mononucleotide; Nicotinamide ribotide; beta-NMN; NMN zwitterion; nicotinamide ribonucleotide; nicotinamide D-ribonucleotide; nicotinamide nucleotide; beta-nicotinamide D-ribonucleotide; UNII-2KG6QX4W0V; beta-Nicotinamide ribonucleotide; 3-(Aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium; 2KG6QX4W0V; 3-(Aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium inner salt; MFCD00038748; beta-delta-NMN; EINECS 214-136-5; BETANMN; b-NMN; Nicotinamidmononucleotid; b-D-NMN; bmse000260; SCHEMBL105618; CHEMBL610238; EX-A3534; HY-F0004; BDBM50366763; AKOS015896881; CCG-267847; CS-4996; Nicotinamide ribonucleoside 5'-phosphate; AS-59655; C00455; J-002287; Q21547155; 3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium; 3-Carbamoyl-1-b-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt; 3-(aminocarbonyl)-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt; 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridinium, inner salt; AfAE'A centa' notA inverted exclamation markAfasA'A
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[4] | |||
| Compound Name |
2'-[(2-Hydroxy-3-methoxybenzoyl)amino]-2'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143235
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|
||||
| Activity |
IC50 = 600000 nM
|
[5] | |||
| Compound Name |
2'-[(3,5-Dihydroxybenzoyl)amino]-2'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143241
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|
||||
| Activity |
IC50 = 650000 nM
|
[5] | |||
| Compound Name |
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-[6-(m-tolylmethylamino)purin-9-yl]tetrahydrofuran-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389706; N-(3-Methylbenzyl)adenosine; SCHEMBL640363; BDBM50487839; (2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-[(3-methylphenyl)methylamino]purin-9-yl]oxolane-3,4-diol; 9H-Purin-6-amine, N-[(3-methylphenyl)methyl]-9-b-D-ribofuranosyl-
Click to Show/Hide
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||||
| Activity |
IC50 = 700000 nM
|
[5] | |||
| Compound Name |
N-[(1R,2R)-2-(6-Amino-purin-9-yl)-cyclopentyl]-3-bromo-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL124074; BDBM50030964; 3-Bromo-N-[2alpha-(6-amino-9H-purin-9-yl)cyclopentan-1beta-yl]benzamide
Click to Show/Hide
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||||
| Activity |
IC50 = 700000 nM
|
[6] | |||
| Compound Name |
N-[[(2R,3S,4R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-4-(4-ethylphenyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611252; BDBM50369053
Click to Show/Hide
|
||||
| Activity |
IC50 = 750000 nM
|
[6] | |||
| Compound Name |
2-N-[[(2R,3S,4R)-5-[6-(Benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl]benzene-1,2-dicarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL610692; BDBM50366561
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|
||||
| Activity |
Ki = 800000 nM
|
[7] | |||
| Compound Name |
2'-[(3-Hydroxybenzoyl)amino]-2'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143234
Click to Show/Hide
|
||||
| Activity |
IC50 = 850000 nM
|
[5] | |||
| Compound Name |
(3R,4S,5R)-2-(6-Amino-8-cyclohexylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL610952; BDBM50369054
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[6] | |||
| Compound Name |
N-[(2R,3R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-[6-(2-methylpropanoylamino)purin-9-yl]oxolan-3-yl]-3-methoxybenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143243
Click to Show/Hide
|
||||
| Activity |
IC50 = 1200000 nM
|
[5] | |||
| Compound Name |
(3R,4S,5R)-2-[6-Amino-8-(propan-2-ylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608637; BDBM50366559
Click to Show/Hide
|
||||
| Activity |
Ki = 1500000 nM
|
[7] | |||
| Compound Name |
8-(Thiophen-2-yl)-9-(2-aminoethyl)-9H-purin-6-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL124034; BDBM50030955; 9-(2-Amino-ethyl)-8-thiophen-2-yl-9H-purin-6-ylamine
Click to Show/Hide
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||||
| Activity |
IC50 = 1600000 nM
|
[6] | |||
| Compound Name |
(2R,3R,4S,5R)-2-[6-(Cycloheptylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2113430; N-Cycloheptyladenosine; n6-cycloheptyladenosine; Adenosine, N-cycloheptyl-; CTK1D3772; DTXSID00332752; BDBM50408666
Click to Show/Hide
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||||
| Activity |
IC50 = 1800000 nM
|
[5] | |||
| Compound Name |
N-[(1R,2R)-2-(6-Amino-purin-9-yl)-cyclopentyl]-3-chloro-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL341494; BDBM50030965; 3-Chloro-N-[2alpha-(6-amino-9H-purin-9-yl)cyclopentan-1beta-yl]benzamide
Click to Show/Hide
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||||
| Activity |
IC50 > 2000000 nM
|
[6] | |||
| Compound Name |
(3R,4S,5R)-2-(6-Amino-8-pyrimidin-2-ylsulfanylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL608641; BDBM50369052
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||||
| Activity |
IC50 = 2000000 nM
|
[6] | |||
| Compound Name |
N-[2-(6-Amino-purin-9-yl)-ethyl]-4-methyl-benzamide
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL124198; BDBM50030950
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||||
| Activity |
IC50 > 2000000 nM
|
[6] | |||
| Compound Name |
N6-Benzyladenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-Benzylaminopurine riboside; UNII-0M6S0FAH3T; N-Benzyladenosine; 0M6S0FAH3T; Benzyladenosine; (2R,3R,4S,5R)-2-[6-(benzylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol; CHEMBL388757; 6-Benzyladenosine; MFCD00005740; ST057089; NSC 70423; (4S,2R,3R,5R)-5-(hydroxymethyl)-2-{6-[benzylamino]purin-9-yl}oxolane-3,4-diol; N(6)-Benzyladenosine; N6-benzylado; EINECS 224-298-9; N6 -Benzyladenosine; N6-Benzyl Adenosine; 6-Benzylamino-9beta-D-ribofuranosylpurine; N6-(benzyl)-adenosine; 6-Benzylaminopurine riboside (N-6-Benzyladenosine); SCHEMBL219438; Adenosine, N-benzyl- (8CI); N6-Benzyladenosine, >=99.0%; DTXSID901017782; ZINC1318428; 5941AH; BDBM50241166; EBD166903; PDSP1_001032; PDSP2_001016; Adenosine, N-(phenylmethyl)- (9CI); AKOS024282558; KS-000018R6; NCGC00142490-01; AS-55043; 6-Benzylamino-9-(beta-D-ribofuranosyl)purine; A-7712; 294B160; Q27236958; 2-(6-Benzylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol; 2-[6-(benzylamino)purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Click to Show/Hide
|
||||
| Activity |
Ki = 2800000 nM
|
[7] | |||
| Compound Name |
8-Bromo-2'-[benzoylamino]-2'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143024; adenosine, 8-bromo-2'-benzamido-2'-deoxy-
Click to Show/Hide
|
||||
| Activity |
IC50 = 3000000 nM
|
[6] | |||
| Compound Name |
2'-[(1H-Benzimidazol-5-ylcarbonyl)amino]-2'-deoxyadenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143017
Click to Show/Hide
|
||||
| Activity |
IC50 = 3000000 nM
|
[6] | |||
| Compound Name |
N-[(4-Aminophenyl)methyl]adenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
4-Abza; N6-(p-Aminobenzyl)adenosine; CHEMBL259188; N-(4-Aminobenzyl)adenosine; n6-(4-aminobenzyl)adenosine; N6-(p-aminobenzyl)-adenosine; SCHEMBL639974; N(6)-(4-Aminobenzyl)adenosine; DTXSID30914949; ZINC5161863; BDBM50411989; CS-5606; Adenosine, N-((4-aminophenyl)methyl)-; HY-100130; N-[(4-Aminophenyl)methyl]-9-pentofuranosyl-9H-purin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 3100000 nM
|
[5] | |||
| Compound Name |
N-[[(2R,3S,4R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL610982; BDBM50366563
Click to Show/Hide
|
||||
| Activity |
Ki = 3300000 nM
|
[7] | |||
| Compound Name |
N-Isopentyladenosine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
N6-Isopentyladenosine; Adenosine, N-(3-methylbutyl)-; n-(3-methylbutyl)adenosine; EINECS 241-638-1; SCHEMBL547462; Adenosine,N-(3-methylbutyl)-; CHEMBL1290747; CTK4D6253; DTXSID40938818; ZINC5441082; 659M788; N-(3-Methylbutyl)-9-pentofuranosyl-9H-purin-6-amine
Click to Show/Hide
|
||||
| Activity |
IC50 = 3700000 nM
|
[5] | |||
| Compound Name |
N-[2-(6-Amino-purin-9-yl)-ethyl]-3-chloro-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL123804; BDBM50030956
Click to Show/Hide
|
||||
| Activity |
IC50 > 4000000 nM
|
[6] | |||
| Compound Name |
2-[[(2R,3S,4R)-5-[6-(Benzylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl]isoindole-1,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL611570; BDBM50366562
Click to Show/Hide
|
||||
| Activity |
Ki = 4000000 nM
|
[7] | |||
| Compound Name |
N-[(1R,2R)-2-(6-Amino-purin-9-yl)-cyclopentyl]-3-methoxy-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL340033; BDBM50030968; 3-Methoxy-N-[2alpha-(6-amino-9H-purin-9-yl)cyclopentan-1beta-yl]benzamide
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| Activity |
IC50 > 4000000 nM
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[6] | |||
| Compound Name |
N-[2-(6-Amino-purin-9-yl)-ethyl]-3-fluoro-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL123808; BDBM50030954
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| Activity |
IC50 > 4000000 nM
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[6] | |||
| Compound Name |
N-[(1R,2R)-2-(6-Amino-purin-9-yl)-cyclopentyl]-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL338038; BDBM50030969; N-[2alpha-(6-Amino-9H-purin-9-yl)cyclopentan-1beta-yl]benzamide
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| Activity |
IC50 > 4000000 nM
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[6] | |||
| Compound Name |
Riboprine
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Investigative | Compound Info | ||
| Synonyms |
N6-(3-Methyl-2-butenyl)adenosine; Isopentenyladenosine; N6-(2-Isopentenyl)adenosine; Isopentenyladenosine riboside; Riboprina; Riboprinum; 6-(gamma,gamma-Dimethylallylamino)purine riboside; 2-IPA; ADENOSINE, N-(3-METHYL-2-BUTENYL)-; 6-(3-Methyl-2-butenylamino)purine riboside; UNII-8EU82FAZ5J; Dimethylallyladenosine; N-(3-methylbut-2-en-1-yl)adenosine; N-Isopentenyladenosine; Isopentenyl adenosine; Isopentenyl adenine riboside; N(6)-(Delta(2)-isopentenyl)adenosine; 8EU82FAZ5J; N-(3-Methyl-2-butenyl)adenosine; N(6)-(2-isopentenyl)adenosine; N-(3-methylbut-2-enyl)adenosine; N(6)-(3-methyl-2-butenyl)adenosine; SQ 22558; ZK 20 242; Riboprine [USAN:INN]; Riboprinum [INN-Latin]; Riboprina [INN-Spanish]; N(sup 6)-Isopentenyladenosine; N(sup 6)-Dimethylallyladenosine; EINECS 231-771-3; N(sup 6)-(2-Isopentenyl)adenosine; NSC 105546; Riboprin; MFCD00005741; 2iP Riboside; N(sup 6)-(delta(sup 2)-Isopentenyl)adenosine; NSC-105546; 6-N-((3-Methyl-2-butenyl)amino)-9beta-D-ribofuranosylpurine; 9beta-D-Ribofuranosyl-9H-purine, N-(3-methyl-2-butenylamino)-; Riboprine (USAN/INN); N6-Dimethylallyladenosine; 6-N-((3-Methyl-2-butenyl)amino)-9-beta-D-ribofuranosyl-9H-purine; 6-(3,3-Dimethylallylamino)-9-(b-D-ribofuranosyl)purine; SCHEMBL4599; DSSTox_CID_31617; DSSTox_RID_97501; DSSTox_GSID_57828; 6-N-((3-Methyl-2-butenyl)amino)-9.beta.-D-ribofuranosylpurine; CHEMBL452867; 6-N-((3-Methyl-2-butenyl)amino)-9-.beta.-D-ribofuranosyl-9H-purine; DTXSID1057828; ZINC57125; EBD80372; N-6-(delta-2-Isopentenyl)adenosine; Tox21_113776; 2058AC; AKOS016009606; CS-W011925; DB11933; DS-5147; SB19217; NCGC00253650-01; N6-(.DELTA.2-Isopentenyl)adenine riboside; N6-(.gamma.,.gamma.-Dimethylallyl)adenosine; C16427; D05726; 724G767; Q973089; SR-01000883994; SR-01000883994-1
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| Activity |
IC50 > 5000000 nM
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[5] | |||
| Compound Name |
(2R,3S,4R)-2-(Hydroxymethyl)-5-[6-(2-methylbutylamino)purin-9-yl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL608350; BDBM50369415
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| Activity |
IC50 > 5400000 nM
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[5] | |||
| Compound Name |
2-Methyladenine
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Investigative | Compound Info | ||
| Synonyms |
2-Methyl-1H-purin-6-amine; 2-methyl-7H-purin-6-amine; methyladenine; 2-Methyl-6-aminopurine; SQ 23354; ADENINE, 2-METHYL-; 1H-Purin-6-amine, 2-methyl- (9CI); CHEMBL330897; 1H-Purin-6-amine, 2-methyl-; 2-methyladenin; methyl-3h-adenine; 2-methylpurin-6-amine; SCHEMBL19779; 2-methyl-9H-purin-6-amine; 1h-purin-6-amine,2-methyl-; 2-Methyl-9H-purin-6-ylamine; 9H-Purin-6-amine, 2-methyl-; KS-00000SCH; DTXSID80162731; (2-methyl-9H-purin-6-yl)-amine; BCP29033; NSC26364; ZINC1628368; BDBM50030961; MFCD01674065; NSC-26364; AKOS006338122; AKOS015905348; AKOS024463815; DS-8040; AK163291; SQ 23,354; 1H-Purin-6-amine pound not 2-methyl- (9CI); A808223; Q15632702
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| Activity |
IC50 = 6000000 nM
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[6] | |||
| Compound Name |
8-Methoxy-2'-[benzoylamino]-2'-deoxyadenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143013; adenosine, 2'-(benzoylamino)-2'-deoxy-8-methoxy-
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| Activity |
IC50 = 9000000 nM
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[6] | |||
| Compound Name |
2'-[Benzylamino]-2'-deoxyadenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143016
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| Activity |
IC50 > 10000000 nM
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[6] | |||
| Compound Name |
2'-[(Isobutoxycarbonyl)amino]-2'-deoxyadenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143022
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| Activity |
IC50 > 10000000 nM
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[6] | |||
| Compound Name |
2-Methyl-2'-[(3-methoxybenzoyl)amino]-2'-deoxyadenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3143023
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| Activity |
IC50 > 10000000 nM
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[6] | |||
| Compound Name |
(2R,3S,4R)-2-(Hydroxymethyl)-5-[6-[(4-hydroxy-3-methylbutyl)amino]purin-9-yl]oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL608173; BDBM50369412
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| Activity |
IC50 = 34003000 nM
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[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. J Med Chem. 2001 Jun 21;44(13):2080-93. | ||||
| REF 2 | Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. J Med Chem. 1994 Oct 14;37(21):3605-13. | ||||
| REF 3 | Structure-activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase. Bioorg Med Chem Lett. 2004 May 3;14(9):2199-204. | ||||
| REF 4 | A disubstituted NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Bioorg Med Chem Lett. 2001 Jan 22;11(2):95-8. | ||||
| REF 5 | Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design. J Med Chem. 1998 Nov 19;41(24):4790-9. | ||||
| REF 6 | Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase. J Med Chem. 1995 Sep 15;38(19):3838-49. | ||||
| REF 7 | Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5' and 8. Bioorg Med Chem Lett. 1998 Dec 15;8(24):3505-10. | ||||
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