Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T38763 | Target Info | |||
| Target Name | Hepatitis C virus Non-structural 5 (HCV NS5) | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 175 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Vidarabine
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|
Approved | Compound Info | ||
| Synonyms |
Araadenosine; Arabinosyladenine; Armes; RAB; Spongoadenosine; VIRDARABINE; Vidarabin; Vidarabina; Vidarabinum; Xylosyladenine; Adenine arabinoside; Adenine xyloside; Adenosine arabinose; Ara A; Arabinoside adenine; Arabinosyl adenine; Vidarabina [DCIT]; Vidarabine anhydrous; Vira ATM; Xylosyl A; A 9251; ARA-A NSC 247519; Alpha-Ara A; Ara-A; Arabinosyl-adenine; Arasena-A; Armes (TN); Beta-Ara A; Vidarabine (JAN); Vira-A; Adenosine-8-14C; Vira-A, Vidarabine; ADENOSINE, U.S.P.; (+)-Cyclaradine; 9-Arabinosyladenine
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 50000 nM
|
[1] | ||
| Compound Name |
3-Deoxyguanosine
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Investigative | Compound Info | ||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 = 50000 nM
|
[1] | ||
| Compound Name |
2,4-Dioxo-5,5-diphenyl-pentanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL177767; BDBM50137871; Benzenepentanoic acid, a,g-dioxo-d-phenyl-
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
6-(4-Methoxyphenethyl)-6-propyl-dihydro-3H-pyran-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL215351; SCHEMBL3988113; BDBM50190955; 6-[2-(4-methoxyphenyl)ethyl]-6-propyloxane-2,4-dione; 6-[2-(4-methoxyphenyl)ethyl]-6-propyl-tetrahydropyran-2,4-dione
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[3] | ||
| Compound Name |
4-(4-Tert-butylphenyl)-2,4-dioxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL177776; 4-(4-Tert-Butyl-phenyl)-2,4-dioxo-butyric acid; BDBM50137877; ZINC13531952; 4-(4-tert-butylphenyl)-2,4-dioxo-butanoic acid
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
4-(4-Bromophenyl)-6-oxo-2-(tetrahydropyran-2-ylmethylsulfanyl)-1H-pyrimidine-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2236457; BDBM50486380
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 50000 nM
|
[4] | ||
| Compound Name |
5,6-Dihydroxy-2-[3-(phenethyloxycarbonylamino)-2-thienyl]pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL379881; BDBM50183508; 5,6-Dihydroxy-2-{3-[(2-phenylethoxy)carbonylamino](2-thienyl)}pyrimidine-4-carboxylic acid; 5,6-dihydroxy-2-(3-{[(2-phenylethoxy)carbonyl]amino}-2-thienyl)pyrimidine-4-carboxylic acid
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
|
[5] | ||
| Compound Name |
2-[Isopropyl-(4-phenoxybenzoyl)amino]thiazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL181831; CTK3D7487; DTXSID50414956; BDBM50157183; 2-[Isopropyl-(4-phenoxy-benzoyl)-amino]-thiazole-5-carboxylic acid; 2-[(R)-Isopropyl-(4-phenoxy-benzoyl)-amino]-thiazole-5-carboxylic acid; 5-Thiazolecarboxylic acid, 2-[(1-methylethyl)(4-phenoxybenzoyl)amino]-
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
2'-O-Methyladenosine
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Investigative | Compound Info | ||
| Synonyms |
Adenosine, 2'-O-methyl-; cordysinin B; 2'-O-Methyl adenosine; UNII-02YX82IHZ5; CHEMBL73237; 2'-O-METHYL-ADENOSINE; 02YX82IHZ5; (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol; MFCD00056002; 2`-O-Methyladenosine; 2''-O-Methyladenosine; 2'-O-Me-Ado; SCHEMBL25936; 2'-O-Me-A; CTK1A7124; DTXSID50175671; BCP17411; ZINC3776540; 0883AB; ANW-64052; BDBM50144945; HG1274; PDSP1_001054; PDSP2_001038; AKOS016003815; AC-8216; CS-W012268; HY-W011552; DS-14586; SC-43502; K-6125; 140M796; Q63392855; 5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
(2R,3R,4R,5R)-2-(6-Aminopurin-9-yl)-3-ethyl-5-(hydroxymethyl)oxolane-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL311635; Adenosine, 2'-C-ethyl-; SCHEMBL5559348; BDBM50144935; 9H-Purin-6-amine, 9-(2-C-ethyl-beta-D-ribofuranosyl)-; (2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-3-ethyl-5-(hydroxymethyl)oxolane-3,4-diol; (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-3-ethyl-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
3'-Deoxy-3'-fluoroguanosine
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Investigative | Compound Info | ||
| Synonyms |
Guanosine, 3'-deoxy-3'-fluoro-; 3fluoro-3deoxyguanosine; CHEMBL420751; 9-[3-Deoxy-3-C-fluoro-beta-D-ribofuranosyl]guanine; 3-Deoxy-3-fluoroguanosine; SCHEMBL1737325; DTXSID10154008; ZINC6585355; BDBM50144938; MFCD09263707; AC-32289; AS-60089; A805067; 9-[3-Deoxy-3-C-fluoro-beta-D-rbiofuranosyl]guanine
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
5,6-Dihydroxy-2-[3-(phenethylcarbamoylamino)-2-thienyl]pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL379470; BDBM50183490; 5,6-Dihydroxy-2-(3-{[(2-phenylethyl)amino]carbonylamino}(2-thienyl))pyrimidine-4-carboxylic acid; 5,6-dihydroxy-2-[3-({[(2-phenylethyl)amino]carbonyl}amino)-2-thienyl]-pyrimidine-4-carboxylic acid
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
|
[5] | ||
| Compound Name |
2-[Isopropyl-(4-phenoxybenzoyl)amino]thiazole-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL359522; CTK3D7484; DTXSID30414959; BDBM50157200; 2-[Isopropyl-(4-phenoxy-benzoyl)-amino]-thiazole-4-carboxylic acid; 2-[(R)-Isopropyl-(4-phenoxy-benzoyl)-amino]-thiazole-4-carboxylic acid; 4-Thiazolecarboxylic acid, 2-[(1-methylethyl)(4-phenoxybenzoyl)amino]-
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
2-(4-Phenoxy-benzoylamino)-thiazole-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL183651; CTK3D7485; DTXSID70414958; BDBM50157187; 2-[(4-phenoxybenzoyl)amino]thiazole-4-carboxylic acid; 4-Thiazolecarboxylic acid, 2-[(4-phenoxybenzoyl)amino]-
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
5-Hydroxy-6-methoxy-2-(2-thienyl)pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL183018; BDBM50153251; 4-Pyrimidinecarboxylic acid, 5-hydroxy-6-methoxy-2-(2-thienyl)-; 5-Hydroxy-6-methoxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 50000 nM
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[7] | ||
| Compound Name |
3-Cyclohexyl-2-phenyl-4H-pyrrolo[2,3-d]imidazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL213082; BDBM50187150; 3-cyclohexyl-2-phenyl-3,4-dihydropyrrolo[2,3-d]imidazole-5-carboxylic acid; Pyrrolo[2,3-d]imidazole-5-carboxylic acid, 3-cyclohexyl-3,4-dihydro-2-phenyl-
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
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[8] | ||
| Compound Name |
1-Cyclohexyl-3-(1,1-dioxo-4H-1$l^{6},2,4-benzothiadiazin-3-yl)-4-hydroxy-1,8-naphthyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL359910; SCHEMBL1522235; BDBM50162618; 1,8-Naphthyridin-2(1H)-one, 1-cyclohexyl-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 50000 nM
|
[9] | ||
| Compound Name |
5,6-Dihydroxy-2-[3-(phenylcarbamoylamino)-2-thienyl]pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL380869; BDBM50183492; 2-{3-[(anilinocarbonyl)amino]-2-thienyl}-5,6-dihydroxypyrimidine-4-carboxylic acid; 5,6-Dihydroxy-2-{3-[(phenylamino)carbonylamino](2-thienyl)}pyrimidine-4-carboxylic acid
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
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[5] | ||
| Compound Name |
2'-Deoxy-2'-fluoroguanosine
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Investigative | Compound Info | ||
| Synonyms |
2'-Fluoro-2'-deoxyguanosine; 2'-Fluoro -2'-deoxyguanosine; Guanosine, 2'-deoxy-2'-fluoro-; 2-Fluoro -2-deoxyguanosine; CHEMBL308759; 2'-Dfgs; deoxyfluoroguanosine; SCHEMBL236684; SCHEMBL15532083; CTK5E6163; Guanosine,2'-deoxy-2'-fluoro-; DTXSID40229334; ZINC3797144; 2341AC; ANW-64050; BDBM50144930; HG1070; MFCD00923832; AKOS016003829; AC-9551; SB13161; VZ21749; AS-49377; X-1454; 842A134; 9-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)guanine; J-700052
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
2'-O-Methylguanosine
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Investigative | Compound Info | ||
| Synonyms |
2'-O-METHYL-GUANOSINE; 2'-O-Methyl guanosine; Guanosine, 2'-O-methyl-; 2-O-Methylguanosine; UNII-W722H4PA1S; CHEMBL308370; W722H4PA1S; MFCD00057053; 2-amino-9-(2-O-methyl-beta-D-ribofuranosyl)-1,9-dihydro-6H-purin-6-one; 2`-O-Methylguanosine; Guanosine, 2'-O-methyl; 2'-OMe G; SCHEMBL26515; CTK1A5635; DTXSID80175669; 2'-O-Methyl-D-guanosine hydrate; ZINC5998211; ANW-59848; BDBM50144947; HG1298; AKOS016004412; AC-8217; AM84746; DS-12216; SC-53996; AB0088078; DB-021466; X-3625; 140M718; Q15632796
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
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[1] | ||
| Compound Name |
2-(3-Benzamido-2-thienyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL206569; BDBM50183481; 2-[3-(benzoylamino)-2-thienyl]-5,6-dihydroxypyrimidine-4-carboxylic acid; 5,6-Dihydroxy-2-[3-(phenylcarbonylamino)(2-thienyl)]pyrimidine-4-carboxylic acid
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
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[5] | ||
| Compound Name |
9-(beta-D-Xylofuranosyl)guanine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2021379; Guanine, 9-(beta-D-xylofuranosyl)-; NSC 115607; BRN 1225953; 6H-Purin-6-one, 1,9-dihydro-2-amino-9-beta-D-xylofuranosyl-; SCHEMBL6745514; ZINC6119283; BDBM50409930; 2-Amino-9-(beta-D-xylofuranosyl)-1,9-dihydro-6H-purin-6-one; 6H-Purin-6-one, 2-amino-1,7-dihydro-9-beta-D-xylofuranosyl- (9CI)
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
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[1] | ||
| Compound Name |
9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3H-purin-6-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL76105; 2'-c-methylinosine; SCHEMBL1144880; SCHEMBL12149438; CTK4H8231; Inosine, 2'-C-methyl-(9CI); DTXSID70388382; BDBM50144934; 9H-Purin-6-ol, 9-(2-C-methyl-beta-D-ribofuranosyl)-
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
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[1] | ||
| Compound Name |
1-(4-Methyl-cyclohexyl)-2-pyridin-2-yl-1H-benzoimidazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL177835; BDBM50137491
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 50000 nM
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[10] | ||
| Compound Name |
2-(4-Phenoxy-benzoylamino)-thiazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL360125; CTK3D7488; DTXSID90414955; BDBM50157197; 2-[(4-phenoxybenzoyl)amino]thiazole-5-carboxylic acid; 5-Thiazolecarboxylic acid, 2-[(4-phenoxybenzoyl)amino]-
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
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[6] | ||
| Compound Name |
(Z)-4-(2-Furyl)-2-hydroxy-4-oxo-but-2-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL199039; SCHEMBL3308210; SCHEMBL3308214; CHEMBL1829069; (z)-4-(furan-2-yl)-2-hydroxy-4-oxobut-2-enoic acid
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 50000 nM
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[11] | ||
| Compound Name |
2-Oxo-4-phenylbutyric acid
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Investigative | Compound Info | ||
| Synonyms |
2-oxo-4-phenylbutanoic acid; 2-Oxo-4-phenyl-butyric acid; Benzenebutanoic acid, a-oxo-; CHEMBL16281; Benzenebutanoic acid, alpha-oxo-; 2-oxo-4-phenyl-butanoic acid; benzylpyruvic acid; EINECS 211-916-7; oxobenzenebutanoic acid; PubChem18755; 4-phenyl-2-oxobutyric acid; 4-phenyl-2-oxobutanoic acid; 2-oxo-4-phenyl butyric acid; KSC497Q3R; SCHEMBL258545; 4-Phenyl-2-Ketobutanoic Acid; CTK3J7838; DTXSID10221224; 2-OXO-4-PHENYL-BUTYRICACID; ALBB-014726; KS-00000N7B; ZINC1845776; 1012AC; BDBM50125828; MFCD00969471; SBB063374; AKOS005174543; AC-3539; CS-W019322; DS-3613; MCULE-5355166420; 2-oxo-4-phenyl-butyric acid, AldrichCPR; AK107119; AB0063071; DB-055479; FT-0632864; O0389; C20327; W-7725; 710O112; W-104537
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
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[2] | ||
| Compound Name |
5,6-Dihydroxy-2-{3-[(1H-indol-3-ylacetyl)amino]-2-thienyl}-pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL203729; BDBM50183496; 5,6-Dihydroxy-2-[3-(2-indol-3-ylacetylamino)(2-thienyl)]pyrimidine-4-carboxylic acid; 5,6-dihydroxy-2-[3-[[2-(1H-indol-3-yl)acetyl]amino]-2-thienyl]pyrimidine-4-carboxylic acid
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
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[5] | ||
| Compound Name |
5,6-Dihydroxy-2-[3-(3-phenylpropanoylamino)-2-thienyl]pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL203383; BDBM50183479; 5,6-Dihydroxy-2-[3-(3-phenylpropanoylamino)(2-thienyl)]pyrimidine-4-carboxylic acid; 5,6-dihydroxy-2-{3-[(3-phenylpropanoyl)amino]-2-thienyl}pyrimidine-4-carboxylic acid
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
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[5] | ||
| Compound Name |
(2R,3R,4R,5R)-5-(6-Aminopurin-9-yl)-2-(hydroxymethyl)-4-methoxy-4-methyl-tetrahydrofuran-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL307872; SCHEMBL14036758; BDBM50144941; 9H-Purin-6-amine, 9-(2-C-methyl-2-O-methyl-beta-D-ribofuranosyl)-; (2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxy-4-methyloxolan-3-ol
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
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[1] | ||
| Compound Name |
4-(Furan-2-yl)-2,4-dioxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
2-Furanbutanoic acid, a,g-dioxo-; 4-(2-furyl)-2,4-dioxobutanoic acid; CHEMBL177529; ACMC-1BTXY; CTK4A3762; DTXSID70333519; 2,4-dioxo-4-furyl-butanoic acid; KS-00001OQ9; BDBM50137880; MFCD06245358; ZINC19850352; AKOS005257492; MCULE-7253681569; 4-(2-furyl)-2,4-dioxo-butanoic acid; 4-(Fur-2-yl)-2,4-dioxobutanoic acid; 4-Furan-2-yl-2,4-dioxo-butyric acid; 2-Furanbutanoic acid, alpha,gamma-dioxo-; 4-(2-furyl)-2,4-dioxobutanoic acid, AldrichCPR
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
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[2] | ||
| Compound Name |
2,4-Dioxo-4-pyridin-4-ylbutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
2,4-dioxo-4-(pyridin-4-yl)butanoic acid; CHEMBL177297; 2,4-Dioxo-4-pyridin-4-yl-butyric acid; DIETHANOLAMINESULFATE; SCHEMBL17179998; CTK5H9989; DTXSID10333674; 4-Pyridinebutanoicacid, a,g-dioxo-; KS-00001OQ7; BDBM50137852; MFCD06245354; ZINC19850341; AKOS005257494; MCULE-5649903364; 2,4-dioxo-4-(4-pyridyl)butanoic acid; FT-0694451; 2,4-Dioxo-4-pyridin-4-ylbutanoic acid, AldrichCPR
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
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[2] | ||
| Compound Name |
(2R,3R,4R,5R)-2-(2-Amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL306299; BDBM50144939; MFCD25542506; ZINC13560603; 9H-Purin-2-amine, 9-(2-C-methyl-beta-D-ribofuranosyl)-; (2R,3R,4R,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol; (2R,3R,4R,5R)-2-(2-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
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[1] | ||
| Compound Name |
2-Butyl-5,6-dihydroxy-pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL204488; CTK6D6510; BDBM50183505; AKOS015965739; 2-butyl-5,6-dihydroxypyrimidine-4-carboxylic acid
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
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[5] | ||
| Compound Name |
5,6-Dihydroxy-2-(3-{[(2-phenyl-1H-indol-3-yl)acetyl]amino}-2-thienyl)pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL205118; BDBM50183498; 5,6-dihydroxy-2-[3-[[2-(2-phenyl-1H-indol-3-yl)acetyl]amino]-2-thienyl]pyrimidine-4-carboxylic acid; 5,6-Dihydroxy-2-{3-[2-(2-phenylindol-3-yl)acetylamino](2-thienyl)}pyrimidine-4-carboxylic acid
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
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[5] | ||
| Compound Name |
(2R,3R,4R,5R)-5-(6-Aminopurin-9-yl)-2-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2311161; BDBM50422565; 9-(3-C-Methyl-beta-D-xylofuranosyl)-9H-purin-6-amine; 9H-Purin-6-amine, 9-(3-C-methyl-beta-D-xylofuranosyl)-
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
3'-C-Methyladenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL480143; (2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-3-methyloxolane-3,4-diol; 3'-C-Methyl Ado; Adenosine, 3'-C-methyl-; SCHEMBL1066935; BDBM50408410; 9-(3'-C-Methyl-.beta.-D-ribofuranosyl) adenine; (2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol; (2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-2-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
5-[[2-(3-Chloro-4-fluorophenyl)acetyl]amino]-N,3-dihydroxy-4-(hydroxymethyl)pyridine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3763201; BDBM50500818
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
|
[12] | ||
| Compound Name |
4(3H)-Pyrimidinone, 5-hydroxy-2-(3-hydroxyphenyl)-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL188428; BDBM50154440; 2-(3-hydroxyphenyl)pyrimidine-4,5-diol; 2-(3-Hydroxy-phenyl)-pyrimidine-4,5-diol; 4,5-Pyrimidinediol, 2-(3-hydroxyphenyl)-
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[13] | ||
| Compound Name |
5-Hydroxy-2-(3-hydroxyphenyl)-6-methoxy-pyrimidine-4-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL362571; BDBM50154445; 4-Pyrimidinecarboxylic acid, 5-hydroxy-2-(3-hydroxyphenyl)-6-methoxy-; 5-Hydroxy-2-(3-hydroxy-phenyl)-6-methoxy-pyrimidine-4-carboxylic acid
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[13] | ||
| Compound Name |
(2R,3S,4R,5R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL75667; SCHEMBL1738608; BDBM50144940; ZINC13560596; 9H-Purin-6-amine, 9-(2-C-methyl-beta-D-arabinofuranosyl)-; (3S)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol; (2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol; (2R,3S,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
2'-Fluoro-2'-deoxyadenosine
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Investigative | Compound Info | ||
| Synonyms |
2'-Deoxy-2'-fluoroadenosine; Adenosine, 2'-deoxy-2'-fluoro-; (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol; CHEMBL309579; MFCD09750859; 9-(2-Fluoro-2-deoxy-beta-D-ribofuranosyl)-purin-6-amine; 2-Fluoro-2-deoxyadenosine; 2'F-dA; SCHEMBL237404; Adenosine,2'-deoxy-2'-fluoro-; CTK5C0885; 2'-?Fluoro-?2'-?deoxyadenosine; ZINC5163038; 9826AB; ANW-64051; BDBM50144932; HG1028; AKOS015900907; AC-9552; SB13162; VZ21761; AS-49376; SC-20135; CS-0097284; 2'-BETA-FLUORO-2',3'-DEOXYADENOSINE; F10137; X-1455; 183F273; 9-(2-Deoxy-2-fluoro-beta-D-ribofuranosyl)adenine; 6-Amino-9-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-9H-purine
Click to Show/Hide
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||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
5,5-Dimethyl-2,4-dioxohexanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL178016; 5,5-Dimethyl-2,4-dioxo-hexanoic acid; Hexanoic acid, 5,5-dimethyl-2,4-dioxo-; pivaloylpyruvic acid; SCHEMBL98194; CTK2A7061; DTXSID80333520; BDBM50137859
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
2-Benzyl-5,6-dihydroxy-pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
2-benzyl-5,6-dihydroxypyrimidine-4-carboxylic acid; CHEMBL204900; pyrimidinol carboxylic acid, 7; SCHEMBL10077157; BDBM33415; CTK8A0761; DTXSID10715936; 1570AJ; MFCD09031862; ZINC13683427; 1,6-Dihydro-5-hydroxy-6-oxo-2-(phenylmethyl)-4-pyrimidinecarboxylic acid; AKOS015965737; NE64312; SB39306; DB-077121; FT-0748285; 2-benzyl-5-hydroxy-4-oxo-1H-pyrimidine-6-carboxylic acid; 2-Benzyl-5-hydroxy-6-oxo-3,6-dihydropyrimidine-4-carboxylic acid
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[5] | ||
| Compound Name |
Acetylpyruvic acid
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Investigative | Compound Info | ||
| Synonyms |
2,4-DIOXOPENTANOIC ACID; Acetylpyruvate; 2,4-Dioxovaleric acid; acetopyruvic acid; 2,4-dioxopentanoate; CHEMBL46789; 2,4-Dioxovalerate; Pentanoic acid, 2,4-dioxo-; acetyl pyruvic acid; EINECS 227-181-0; 2,4-Dioxo-Pentanoic Acid; SCHEMBL19423; CTK8J3877; DTXSID40205597; BDBM50137860; STL490525; ZINC26542741; Acetopyruvate2,4-Dioxo-Pentanoic Acid; AKOS006380874; DB-008263; FT-0706144; C02132; Q27105660
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
2-(4-Chlorophenyl)-6-hydroxy-5-methoxy-pyrimidine-4-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL186437; BDBM50154443; 2-(4-Chloro-phenyl)-6-hydroxy-5-methoxy-pyrimidine-4-carboxylic acid; 4-Pyrimidinecarboxylic acid, 2-(4-chlorophenyl)-6-hydroxy-5-methoxy-
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[13] | ||
| Compound Name |
2-Hydroxy-4-oxo-4-phenylbutanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
2-Hydroxy-4-oxo-4-phenyl-butyric acid; CHEMBL177826; BENZOYLLACTICACID; SCHEMBL4967701; DTXSID30983852; 3-benzoyl-2-hydroxy-propionic acid; EINECS 265-659-0; BDBM50137857; 2-hydroxy-4-oxo-4-phenyl-butanoic acid; alpha-Hydroxy-gamma-oxobenzenebutanoic acid; DB-054785; FT-0641002; FT-0669926; FT-0669927
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
2-[(1,1-Dioxothian-4-yl)-(4-phenoxybenzoyl)amino]thiazole-5-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL183403; BDBM50157189
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[6] | ||
| Compound Name |
2-{3-[(1-Benzothien-3-ylacetyl)amino]-2-thienyl}-5,6-dihydroxypyrimidine-4-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL204663; BDBM50183504; 2-[3-(2-Benzo[b]thiophen-3-ylacetylamino)(2-thienyl)]-5,6-dihydroxypyrimidine-4-carboxylic acid; 2-[3-[[2-(benzothiophen-3-yl)acetyl]amino]-2-thienyl]-5,6-dihydroxy-pyrimidine-4-carboxylic acid
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
|
[5] | ||
| Compound Name |
(2R,3R,4R,5R)-5-(Hydroxymethyl)-3-methyl-2-purin-9-yloxolane-3,4-diol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL75343; SCHEMBL4001514; BDBM50144943; 9H-Purine, 9-(2-C-methyl-beta-D-ribofuranosyl)-; (2R,3R,4R,5R)-5-(hydroxymethyl)-3-methyl-2-(9H-purin-9-yl)oxolane-3,4-diol; (2R,3R,4R,5R)-5-(Hydroxymethyl)-3-methyl-2-(9H-purin-9-yl)tetrahydrofuran-3,4-diol; (2R,3R,4R,5R)-5-(hydroxymethyl)-3-methyl-2-purin-9-yl-tetrahydrofuran-3,4-diol
Click to Show/Hide
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||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 50000 nM
|
[1] | ||
| Compound Name |
2-Cyclohexyl-5,6-dihydroxy-pyrimidine-4-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL203976; CTK8A0788; BDBM50183484; AKOS015965738; 2-cyclohexyl-5,6-dihydroxypyrimidine-4-carboxylic acid
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[5] | ||
| Compound Name |
3-Cyclohexyl-2-phenylquinoline-7-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL211712; BDBM50187143
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[8] | ||
| Compound Name |
3-(4-Cyclohexyl-5-(pyridin-2-yl)-1H-pyrrol-2-yl)acrylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL425788; BDBM50193061
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[14] | ||
| Compound Name |
2,4-Dioxo-4-pyridin-3-ylbutanoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
2,4-Dioxo-4-(pyridin-3-yl)butanoic acid; CHEMBL177968; 3-Pyridinebutanoicacid, a,g-dioxo-; 2,4-Dioxo-4-pyridin-3-yl-butyric acid; CTK4I1384; DTXSID50333673; KS-00001OQ8; BDBM50137869; MFCD06245355; ZINC19850344; AKOS005257489; MCULE-1902418859; 2,4-dioxo-4-(3-pyridyl)butanoic acid; FT-0694450; 2,4-Dioxo-4-pyridin-3-ylbutanoic acid, AldrichCPR
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
Methyl 2,4-dioxo-4-phenylbutanoate
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Investigative | Compound Info | ||
| Synonyms |
methyl 2,4-dioxo-4-phenyl-butanoate; CHEMBL177429; 2,4-Dioxo-4-phenyl-butyric acid methyl ester; benzenebutanoic acid, alpha,gamma-dioxo-, methyl ester; NSC208703; methyl benzoylpyruvate; SCHEMBL1109662; CTK4E4588; KS-00001WQA; DTXSID60308731; ALBB-022011; Methyl 4-phenyl-2,4-dioxobutanoate; 6966AD; BBL028426; BDBM50125832; MFCD00225528; SBB038852; STK741586; AKOS000267039; ZINC100013641; 4N-551S; MCULE-5236692657; NSC-208703; VZ32498; SC-22037; AB0058067; DB-045292; BB 0219194; FT-0638012; ST45128193; 2,4-dioxo-4-phenylbutanoic acid methyl ester; AZ0001-0279; EN300-11205; C-4099; alpha,gamma-Dioxobenzenebutyric acid methyl ester; A814716; Benzenebutanoic acid,; A-dioxo-, methyl ester; methyl 2,4-bis(oxidanylidene)-4-phenyl-butanoate; SR-01000389887; J-521892; SR-01000389887-1; Z57040451; F2135-0578; (Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid methyl ester
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 50000 nM
|
[2] | ||
| Compound Name |
[[(2R,3S,4R,5S)-4-Amino-5-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4107429; SCHEMBL15682899
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 51000 nM
|
[15] | ||
| Compound Name |
1-[6,7-Bis-(4-fluoro-phenyl)-pteridin-4-ylamino]-pyrrolidine-2-carboxylic acid methyl ester
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL180951; BDBM50160201
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 51000 nM
|
[16] | ||
| Compound Name |
3-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL109448; 4H-Pyran-2-carboxylic acid, 3-hydroxy-4-oxo-; SCHEMBL289813; BDBM50147504; ZINC26973446; 3-hydroxy-4-oxo-pyran-2-carboxylic acid; SC-97488; 3-HYDROXY-4-OXOPYRAN-2-CARBOXYLIC ACID
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 51000 nM
|
[17] | ||
| Compound Name |
6-(4-Hydroxyphenethyl)-6-cyclohexyl-dihydro-3H-pyran-2,4-dione
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL215001; SCHEMBL5880858; BDBM50190949; 6-cyclohexyl-6-[2-(4-hydroxyphenyl)ethyl]oxane-2,4-dione; 6-cyclohexyl-6-[2-(4-hydroxyphenyl)ethyl]tetrahydropyran-2,4-dione
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 52000 nM
|
[3] | ||
| Compound Name |
2-[(3-Bromophenyl)methyl-(2,4-dichlorobenzoyl)amino]acetic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL276969; BDBM50126662; [(3-Bromo-benzyl)-(2,4-dichloro-benzoyl)-amino]-acetic acid; 2-{(2,4-Dichlorophenyl)-N-[(3-bromophenyl)methyl]carbonylamino}acetic acid
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 53000 nM
|
[18] | ||
| Compound Name |
2-(3-{[(2-Chlorophenyl)acetyl]amino}-2-thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL202911; BDBM50183499; 2-{3-[2-(2-Chlorophenyl)acetylamino](2-thienyl)}-5,6-dihydroxypyrimidine-4-carboxylic acid; 2-[3-[[2-(2-chlorophenyl)acetyl]amino]-2-thienyl]-5,6-dihydroxy-pyrimidine-4-carboxylic acid
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 = 53300 nM
|
[5] | ||
| Compound Name |
Chembl4212840
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
BDBM50451636
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 54000 nM
|
[19] | ||
| Compound Name |
4-Amino-1-[(4R,5R)-5-hydroxy-6-(hydroxymethyl)-1,7-dioxaspiro[3.4]octan-8-yl]pyrimidin-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9909472; CHEMBL4114490; BDBM240845; US9394331, 52; US9394331, 140
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 54490 nM
|
[20] | ||
| Compound Name |
4-(2,4-Difluorophenyl)-2-(m-tolylmethylsulfanyl)-6-oxo-1H-pyrimidine-5-carbonitrile
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2236425; BDBM50486361; 4-(2,4-Difluorophenyl)-2-[(3-methylbenzyl)sulfanyl]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 57000 nM
|
[4] | ||
| Compound Name |
(2R,3R,4R,5R)-5-(4-Amino-5-iodopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-(1-hydroxyethyl)-4-methyloxolan-3-ol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111818; SCHEMBL15960576; BDBM241870; US9416154, 13
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 = 58000 nM
|
[21] | ||
| Compound Name |
2-(Benzofuran-2-yl)-1-cyclohexyl-benzimidazole-5-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL176038; BDBM50137486; 2-Benzofuran-2-yl-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid; 1H-Benzimidazole-5-carboxylic acid, 2-(2-benzofuranyl)-1-cyclohexyl-
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 58000 nM
|
[10] | ||
| Compound Name |
6-Furan-3-yl-7-furan-2-yl-pteridin-4-ol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL180689; BDBM50160214
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 58000 nM
|
[16] | ||
| Compound Name |
1-Benzyloxy-3-(1,1-dioxo-4H-1$l^{6},2,4-benzothiadiazin-3-yl)-4-hydroxy-1,8-naphthyridin-2-one
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL360256; SCHEMBL1376325; BDBM50162608
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 58000 nM
|
[9] | ||
| Compound Name |
(2R,3R,4R,5R)-2-{4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-[(1R)-1-hydroxyethyl]-3-methyloxolane-3,4-diol
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4107686; SCHEMBL14643346; BDBM241859; SB13334; US9416154, 1
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 = 61000 nM
|
[21] | ||
| Compound Name |
1-Cyclohexyl-2-ethoxycarbonyl-benzimidazole-5-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL177701; BDBM50137478; 1-Cyclohexyl-1H-benzoimidazole-2,5-dicarboxylic acid 2-ethyl ester; 1H-Benzimidazole-2,5-dicarboxylic acid, 1-cyclohexyl-, 2-ethyl ester
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 62000 nM
|
[10] | ||
| Compound Name |
[[(1R)-1-[(2S,3R,4R,5R)-5-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]ethoxy]-hydroxyphosphoryl] phosphono hydrogen phosphate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4112513; SCHEMBL14643345; BDBM241898; US9416154, 36
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 65000 nM
|
[21] | ||
| Compound Name |
(Z)-2-Benzamido-3-[5-[3-(trifluoromethoxy)phenyl]furan-2-yl]prop-2-enoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL363178; SCHEMBL5895930; BDBM50166394; 2-Benzoylamino-3-[5-(3-trifluoromethoxy-phenyl)-furan-2-yl]-acrylic acid; (Z)-2-benzamido-3-[5-[3-(trifluoromethoxy)phenyl]-2-furyl]prop-2-enoic acid; (Z)-2-Benzoylamino-3-[5-(3-trifluoromethoxy-phenyl)-furan-2-yl]-acrylic acid
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 66000 nM
|
[22] | ||
| Compound Name |
6,7-Bis(4-fluorophenyl)-4-(1-piperidyl)pteridine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL181773; BDBM50160202; 6,7-Bis-(4-fluoro-phenyl)-4-piperidin-1-yl-pteridine; Pteridine, 6,7-bis(4-fluorophenyl)-4-(1-piperidinyl)-
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 68000 nM
|
[16] | ||
| Compound Name |
(Z)-2-Hydroxy-4-oxo-4-(5-benzyl-2-thienyl)-2-butenoic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL196421; CHEMBL573874; SCHEMBL4673394; BDBM50480818
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 68000 nM
|
[11] | ||
| Compound Name |
1-Allyl-5-hydroxy-2-(3-nitro-2-thienyl)-6-oxo-pyrimidine-4-carboxylic acid
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL206511; BDBM50183506; 1-allyl-5-hydroxy-2-(3-nitro-2-thienyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid; 1-Allyl-5-hydroxy-2-(3-nitro-thiophen-2-yl)-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid
Click to Show/Hide
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||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 69300 nM
|
[5] | ||
| Compound Name |
(Z)-2-Benzamido-3-[4-(2-nitrophenoxy)phenyl]prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372498; SCHEMBL5894917; BDBM50166365; 2-Benzoylamino-3-[4-(2-nitro-phenoxy)-phenyl]-acrylic acid; (Z)-2-Benzoylamino-3-[4-(2-nitro-phenoxy)-phenyl]-acrylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 73000 nM
|
[22] | ||
| Compound Name |
N-(3-Butoxypropyl)-6,7-bis(4-fluorophenyl)pteridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL181882; BDBM50160209; 4-Pteridinamine, N-(3-butoxypropyl)-6,7-bis(4-fluorophenyl)-; [6,7-Bis-(4-fluoro-phenyl)-pteridin-4-yl]-(3-butoxy-propyl)-amine
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 73000 nM
|
[16] | ||
| Compound Name |
1-Cyclobutyl-2-(2-pyridyl)benzimidazole-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL175685; BDBM50137461; 1-Cyclobutyl-2-pyridin-2-yl-1H-benzoimidazole-5-carboxylic acid; 1H-Benzimidazole-5-carboxylic acid, 1-cyclobutyl-2-(2-pyridinyl)-
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 76000 nM
|
[10] | ||
| Compound Name |
3-(1-Cyclohexyl-2-(4-methoxyphenyl)-1H-imidazol-4-yl)acrylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214165; BDBM50187136; (E)-3-[1-cyclohexyl-2-(4-methoxyphenyl)imidazol-4-yl]prop-2-enoic acid; 2-Propenoic acid, 3-[1-cyclohexyl-2-(4-methoxyphenyl)-1H-imidazol-4-yl]-, (2E)-
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 77300 nM
|
[8] | ||
| Compound Name |
1-Benzyl-5-hydroxy-2-(3-nitro-2-thienyl)-6-oxo-pyrimidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL205086; BDBM50183511; 1-benzyl-5-hydroxy-2-(3-nitro-2-thienyl)-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid; 1-Benzyl-5-hydroxy-2-(3-nitro-thiophen-2-yl)-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 79300 nM
|
[5] | ||
| Compound Name |
6,7-Bis(4-fluorophenyl)-N-[2-(2-methoxyphenyl)ethyl]pteridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL426244; BDBM50160225; 4-Pteridinamine, 6,7-bis(4-fluorophenyl)-N-[2-(2-methoxyphenyl)ethyl]-; [6,7-Bis-(4-fluoro-phenyl)-pteridin-4-yl]-[2-(2-methoxy-phenyl)-ethyl]-amine
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 80000 nM
|
[16] | ||
| Compound Name |
4-Pteridinamine, N-(3-butoxypropyl)-6,7-diphenyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL182741; BDBM50160216; N-(3-butoxypropyl)-6,7-diphenyl-pteridin-4-amine; (3-Butoxy-propyl)-(6,7-diphenyl-pteridin-4-yl)-amine
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 87000 nM
|
[16] | ||
| Compound Name |
5,6-Dihydroxy-2-thiophen-2-yl-pyrimidine-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL181653; 5,6-dihydroxy-2-(2-thienyl)pyrimidine-4-carboxylic Acid; 5,6-dihydroxy-2-(thiophen-2-yl)pyrimidine-4-carboxylic acid; C9H6N2O4S; SCHEMBL3838465; CTK1B4225; CTK8I5592; DTXSID20388438; ZINC6142725; 3045AJ; BDBM50153250; MFCD09701385; SB36991; DB-069770; FT-0730764; Z-7590; 2-(2-thienyl)-5,6-dihydroxy-4-carboxypyrimidine; 4-Pyrimidinecarboxylic acid, 5,6-dihydroxy-2-(2-thienyl)-; 5,6-dihydroxy-2-thiophen-2-ylpyrimidine-4-carboxylic acid; 5-hydroxy-4-oxo-2-thiophen-2-yl-1H-pyrimidine-6-carboxylic acid; 5-hydroxy-6-oxo-2-(2-thienyl)-1H-pyrimidine-4-carboxylic acid; 4-Pyrimidinecarboxylic acid, 1,6-dihydro-5-hydroxy-6-oxo-2-(2-thienyl)-; 5-Hydroxy-6-oxo-2-(thiophen-2-yl)-1,6-dihydropyrimidine-4-carboxylic acid; 5-Hydroxy-6-oxo-2-(thiophen-2-yl)-3,6-dihydropyrimidine-4-carboxylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 92000 nM
|
[5] | ||
| Compound Name |
6-(4-Hydroxyphenethyl)-6-cyclobutyl-dihydro-3H-pyran-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215925; BDBM50190970; 6-cyclobutyl-6-[2-(4-hydroxyphenyl)ethyl]tetrahydropyran-2,4-dione
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 93000 nM
|
[3] | ||
| Compound Name |
(Z)-4-[1-[(4-Fluorophenyl)methyl]pyrrol-2-yl]-2-hydroxy-4-oxo-but-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL421353; CHEMBL499273; SCHEMBL4676625; 4-[1-(4-fluorobenzyl)-1h-pyrrol-2-yl]-2-hydroxy-4-oxo-butenoic acid; 2-Butenoic acid, 4-[1-[(4-fluorophenyl)methyl]-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-, (2Z)-
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 93000 nM
|
[11] | ||
| Compound Name |
4-Amino-1-[(5S,9R)-9-hydroxy-8-(hydroxymethyl)-1,7-dioxaspiro[4.4]nonan-6-yl]pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9909481; CHEMBL4110694; BDBM240839; US9394331, 50; US9394331, 138
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[20] | ||
| Compound Name |
Butyl (2S)-2-[[[(1R)-1-[(2S,3R,4R,5R)-5-(4-amino-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]ethoxy]-naphthalen-1-yloxyphosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902137; SCHEMBL14643934; BDBM241864; US9416154, 4
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
2,4,6,9-Tetrazatetracyclo[8.6.0.03,8.011,16]hexadeca-1,3(8),4,9-tetraen-7-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL360715; BDBM50160197; 1,2,3,4,4a,10b-Hexahydro-5,6,8,10-tetraaza-benzo[b]biphenylen-9-ol
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
1-[(4R,5R)-5-Hydroxy-6-(hydroxymethyl)-1,7-dioxaspiro[3.4]octan-8-yl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9909490; CHEMBL4106882
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[20] | ||
| Compound Name |
6,7-Bis(4-fluorophenyl)-N-hexyl-pteridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL369765; BDBM50160204; 4-Pteridinamine, 6,7-bis(4-fluorophenyl)-N-hexyl-; [6,7-Bis-(4-fluoro-phenyl)-pteridin-4-yl]-hexyl-amine
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
1-[(5S,9R)-9-Hydroxy-8-(hydroxymethyl)-1,7-dioxaspiro[4.4]nonan-6-yl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9909483; CHEMBL4108205
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[20] | ||
| Compound Name |
6,7-Bis(2-pyridyl)pteridin-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL180443; 4(3H)-Pteridinone, 6,7-di-2-pyridinyl-; BDBM50160228; 4-Pteridinol, 6,7-di-2-pyridinyl-; 6,7-Di-pyridin-2-yl-pteridin-4-ol; 6,7-bis(2-pyridyl)-3H-pteridin-4-one
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
(2R,3R,4R,5S)-2-{4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(2-hydroxypropan-2-yl)-3-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111604; SCHEMBL15960626; BDBM241897; SB13339; US9416154, 31
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
Butyl (2S)-2-[[[(1S)-1-[(2S,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]ethoxy]-naphthalen-1-yloxyphosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892245; SCHEMBL14643243; BDBM239050; US9408863, 6
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[23] | ||
| Compound Name |
6,7-Bis(2-chlorophenyl)pteridin-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183800; BDBM50160210; 4-Pteridinol, 6,7-bis(2-chlorophenyl)-; 6,7-Bis-(2-chloro-phenyl)-pteridin-4-ol
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
Ethyl (2S)-2-[[1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]ethoxy-(4-chlorophenoxy)phosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3977780; SCHEMBL15960617; BDBM241877; US9416154, 20
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
6,7-Diphenyl-4-(1-piperidyl)pteridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362597; BDBM50160231; 6,7-Diphenyl-4-piperidin-1-yl-pteridine; Pteridine, 6,7-diphenyl-4-(1-piperidinyl)-
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
Butyl (2S)-2-[[[(1R)-1-[(2S,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]ethoxy]-naphthalen-1-yloxyphosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3914808; SCHEMBL14643911
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[23] | ||
| Compound Name |
(2R,3R,4R,5R)-2-(4-Amino-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl)-5-[(1R)-1-hydroxyethyl]-3-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4107246; SCHEMBL15960575; BDBM241860; US9416154, 3
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
Methyl (2S)-2-[[[(1S)-1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]ethoxy]-phenoxyphosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970960; SCHEMBL14643344; BDBM241887; US9416154, 35
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
(2R,3R,4R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(1S)-1-hydroxyethyl]-3-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3946716; BDBM241884; US9416154, 28
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
1-[(4S,5R,6R,8R)-5-Hydroxy-6-(hydroxymethyl)-3,7-dioxaspiro[3.4]octan-8-yl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL441005; CHEMBL3121386; 1-(2-O,2-Ethylene-beta-D-arabinofuranosyl)uracil
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[20] | ||
| Compound Name |
3-Cyclopentyl-2-(furan-3-yl)-1,1-dioxo-1-benzothiophene-6-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217360; BDBM50193070; 3-cyclopentyl-2-furan-3-yl-1,1-dioxo-1H-1lambda*6*-benzo[b]thiophene-6-carboxylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
Methyl (2S)-2-[[[(1R)-1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]ethoxy]-phenoxyphosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3941379; SCHEMBL14643253; BDBM241886; US9416154, 34
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
Guanosine, 2',5'-di-C-methy-, (5'S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902303; SCHEMBL14643294
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[23] | ||
| Compound Name |
Meconic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Poppy acid; 3-Hydroxy-4-oxopyran-2,6-dicarboxylic acid; 3-HYDROXY-4-OXO-4H-PYRAN-2,6-DICARBOXYLIC ACID; UNII-V502I79516; CHEMBL109516; NSC805; 4H-Pyran-2,6-dicarboxylic acid, 3-hydroxy-4-oxo-; V502I79516; Mekonsaure; Opium acid; NSC 805; EINECS 207-848-2; 3-Hydroxy-4-oxo-1,4-pyran-2,6-dicarboxylic acid; SCHEMBL546968; SCHEMBL600257; DTXSID2060096; CTK1D7773; NSC-805; 4H-Pyran-2, 3-hydroxy-4-oxo-; ZINC1587602; BDBM50147502; 3-hydroxy-4-pyrone-2,6-dicarboxylic acid; DB-083476; FT-0710230; 3-hydroxy-4-oxo-pyran-2,6-dicarboxylic acid; C20209; Q421116; 4H-Pyran-2,6-dicarboxylicacid, 3-hydroxy-4-oxo-
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[17] | ||
| Compound Name |
Ethyl (2S)-2-[[1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]ethoxy-naphthalen-1-yloxyphosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3891663; SCHEMBL15960597; BDBM241875; US9416154, 18
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
(2R,3R,4R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(1R)-1-hydroxyethyl]-3-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4111623; BDBM241901; US9416154, 27
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
7-[(4Ar,6R,7S,7aS)-7-amino-7-methyl-2-oxo-2-propan-2-yloxy-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]imidazo[2,1-f][1,2,4]triazin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4109938; SCHEMBL15682882; BDBM249193; US9457039, 18; US9457039, 19
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
Methyl 2-(4-chlorophenyl)-5,6-dihydroxy-pyrimidine-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL188277; SCHEMBL3837264; BDBM50154441; methyl 2-(4-chlorophenyl)-5-hydroxy-4-oxo-1H-pyrimidine-6-carboxylate; 2-(4-Chloro-phenyl)-5,6-dihydroxy-pyrimidine-4-carboxylic acid methyl ester; 4-Pyrimidinecarboxylic acid, 2-(4-chlorophenyl)-5,6-dihydroxy-, methyl ester
Click to Show/Hide
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||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[13] | ||
| Compound Name |
(Z)-2-Benzamido-3-[4-(2-tert-butylphenoxy)phenyl]prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363165; SCHEMBL5897122; BDBM50166391; 2-Benzoylamino-3-[4-(2-tert-butyl-phenoxy)-phenyl]-acrylic acid; (Z)-2-Benzoylamino-3-[4-(2-tert-butyl-phenoxy)-phenyl]-acrylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[22] | ||
| Compound Name |
N-{1-Benzylcarbamoyl-2-[4-(2-bromo-phenoxy)-phenyl]-vinyl}-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372277; BDBM50167669; N-[(Z)-1-(benzylcarbamoyl)-2-[4-(2-bromophenoxy)phenyl]vinyl]benzamide; N-{(Z)-1-Benzylcarbamoyl-2-[4-(2-bromo-phenoxy)-phenyl]-vinyl}-benzamide
Click to Show/Hide
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||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[24] | ||
| Compound Name |
(Z)-2-Benzamido-3-[5-(4-sulfamoylphenyl)furan-2-yl]prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192108; SCHEMBL5896135; BDBM50166400; 2-Benzoylamino-3-[5-(4-sulfamoyl-phenyl)-furan-2-yl]-acrylic acid; (Z)-2-benzamido-3-[5-(4-sulfamoylphenyl)-2-furyl]prop-2-enoic acid; (Z)-2-Benzoylamino-3-[5-(4-sulfamoyl-phenyl)-furan-2-yl]-acrylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[22] | ||
| Compound Name |
(2R,3S,4R,5S)-5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-4-azido-2-(hydroxymethyl)-4-methyloxolan-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4114953; SCHEMBL13471043; BDBM249179; US9457039, 2
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
(2R,3R,4S,5R)-3-Amino-2-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-4-hydroxy-5-(hydroxymethyl)-3-methyloxolane-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4114266; SCHEMBL15682921; BDBM249186; US9457039, 9
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
4-Amino-1-[(4S,5R)-5-hydroxy-6-(hydroxymethyl)-1,7-dioxaspiro[3.4]octan-8-yl]pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9909495; CHEMBL4111873; BDBM240841; US9394331, 51; US9394331, 139
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[20] | ||
| Compound Name |
(2R,3S,4R,5R)-4-Amino-5-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-2-(hydroxymethyl)-4-methyloxolan-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4108680; SCHEMBL15682919; BDBM249183; US9457039, 6
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
(2R,3S,4R,5S)-4-Amino-5-(4-aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-2-(hydroxymethyl)-5-methoxy-4-methyloxolan-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4112400; BDBM249188; US9457039, 11
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
(4R,5R)-8-(2-Amino-6-methoxypurin-9-yl)-6-(hydroxymethyl)-1,7-dioxaspiro[3.4]octan-5-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9909478; CHEMBL4112983; BDBM240848; US9394331, 76
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[20] | ||
| Compound Name |
(2R,3R,4R,5R)-5-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-(1-hydroxyethyl)-4-methyloxolan-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4107549; SCHEMBL14643211; BDBM241871; US9416154, 14
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
Guanosine, 2',5'-di-C-methy-, (5'R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4107865; SCHEMBL14644461
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[23] | ||
| Compound Name |
6-(4-Hydroxyphenethyl)-6-methyl-dihydro-3H-pyran-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215350; BDBM50190961; 6-[2-(4-hydroxyphenyl)ethyl]-6-methyl-tetrahydropyran-2,4-dione
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[3] | ||
| Compound Name |
(2R,3R,4R,5R)-5-[4-Amino-5-(1H-pyrazol-5-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-4-fluoro-2-(1-hydroxyethyl)-4-methyloxolan-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4107076; SCHEMBL15962789; BDBM241882; US9416154, 33
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
N-Hexyl-6,7-diphenyl-pteridin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL359952; BDBM50160224; 4-Pteridinamine, N-hexyl-6,7-diphenyl-; (6,7-Diphenyl-pteridin-4-yl)-hexyl-amine
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
Uridine, 2',5'-di-C-methyl-, (5'R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL800821; CHEMBL4113656
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[23] | ||
| Compound Name |
N-[1-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(1-hydroxyethyl)-3-methyloxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4114109; SCHEMBL14644459; BDBM239051; US9408863, 7
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[23] | ||
| Compound Name |
(Z)-2-Benzamido-3-[5-[3-(hydroxymethyl)phenyl]furan-2-yl]prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364976; SCHEMBL5896859; BDBM50166390; (Z)-2-benzamido-3-[5-[3-(hydroxymethyl)phenyl]-2-furyl]prop-2-enoic acid; (Z)-2-Benzoylamino-3-[5-(3-hydroxymethyl-phenyl)-furan-2-yl]-acrylic acid; 2-Benzoylamino-3-[5-(3-hydroxymethyl-phenyl)-furan-2-yl]-acrylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[22] | ||
| Compound Name |
Cytidine, 2',5'-di-C-methyl-, (5'R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL800386; CHEMBL4111741; BDBM239045; US9408863, 1
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[23] | ||
| Compound Name |
6,7-Bis(p-tolyl)pteridin-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183058; Oprea1_432625; 6,7-Di-p-tolyl-pteridin-4-ol; BDBM50160219; ZINC28355630; 4-Pteridinol, 6,7-bis(4-methylphenyl)-
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
(Z)-2-Benzamido-3-[5-(3-sulfamoylphenyl)furan-2-yl]prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195576; SCHEMBL5896192; BDBM50166381; 2-Benzoylamino-3-[5-(3-sulfamoyl-phenyl)-furan-2-yl]-acrylic acid; (Z)-2-benzamido-3-[5-(3-sulfamoylphenyl)-2-furyl]prop-2-enoic acid; (Z)-2-Benzoylamino-3-[5-(3-sulfamoyl-phenyl)-furan-2-yl]-acrylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[22] | ||
| Compound Name |
Ethyl (2S)-2-[[1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]ethoxy-phenoxyphosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961780; SCHEMBL15960586; BDBM241873; US9416154, 16
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
(2S)-1-(3,4,5-Trichloro-2-hydroxy-phenyl)sulfonylpyrrolidine-2-carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210597; SCHEMBL4609713; BDBM50187218; (S)-1-(3,4,5-trichloro-2-hydroxyphenylsulfonyl)pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[25] | ||
| Compound Name |
3-(1-Cyclohexyl-5-(pyridin-2-yl)-1H-pyrazol-3-yl)acrylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384169; BDBM50193065
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[14] | ||
| Compound Name |
3-Hydroxy-4-oxo-4H-pyran-2,6-dicarboxylic acid diethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL110021; BDBM50147497; diethyl 3-hydroxy-4-oxo-pyran-2,6-dicarboxylate; 4H-Pyran-2,6-dicarboxylic acid, 3-hydroxy-4-oxo-, diethyl ester
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[17] | ||
| Compound Name |
Propan-2-yl (2S)-2-[[1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]ethoxy-phenoxyphosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3916157; SCHEMBL15960620; BDBM241874; US9416154, 17
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
(2R,3R,4S,5R)-3-Amino-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-4-hydroxy-5-(hydroxymethyl)-3-methyloxolane-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4110207; SCHEMBL15682912; BDBM249185; US9457039, 8
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
(3R,4R,5R)-5-(4-Amino-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-(1-hydroxyethyl)-4-methyloxolan-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4112165; BDBM241903; US9416154, 24
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
6,7-Bis(3-methoxyphenyl)pteridin-4-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL179903; SCHEMBL17089216; BDBM50160212; 4-Pteridinol, 6,7-bis(3-methoxyphenyl)-; 6,7-Bis-(3-methoxy-phenyl)-pteridin-4-ol
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
(2S,3R,4R,5R)-5-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-(2-hydroxypropan-2-yl)-4-methyloxolan-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4112860; SCHEMBL14643351; BDBM241896; US9416154, 30
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
2-Benzoylamino-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195565; BDBM50166399; (Z)-2-benzamido-3-[5-(4-nitrophenyl)-2-furyl]prop-2-enoic acid; (Z)-2-Benzoylamino-3-[5-(4-nitro-phenyl)-furan-2-yl]-acrylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[22] | ||
| Compound Name |
(2R,3S,4R,5S)-4-Amino-5-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-2-(hydroxymethyl)-4-methyloxolan-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4114124; SCHEMBL15682922; BDBM249184; US9457039, 7
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
1-[(5R)-9-Hydroxy-8-(hydroxymethyl)-1,7-dioxaspiro[4.4]nonan-6-yl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9909509; CHEMBL4114827
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[20] | ||
| Compound Name |
(2R,3R,4R,5R)-2-(4-Amino-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl)-5-[(1S)-1-hydroxyethyl]-3-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3945722; SCHEMBL15960577; BDBM241900; US9416154, 9
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
(2R,3R,4R,5R)-2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(1R)-1-hydroxypropyl]-3-methyloxolane-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4110729; SCHEMBL14644465; BDBM241862; US9416154, 7
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
5-Hydroxy-6-methoxycarbonyl-4-oxo-pyran-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109823; BDBM50147501; 3-Hydroxy-4-oxo-4H-pyran-2,6-dicarboxylic acid 2-methyl ester; 4H-Pyran-2,6-dicarboxylic acid, 3-hydroxy-4-oxo-, 2-methyl ester
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[17] | ||
| Compound Name |
(Z)-2-Benzamido-3-[5-[4-(hydroxymethyl)phenyl]furan-2-yl]prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL193520; SCHEMBL5896582; BDBM50166380; (Z)-2-benzamido-3-[5-[4-(hydroxymethyl)phenyl]-2-furyl]prop-2-enoic acid; (Z)-2-Benzoylamino-3-[5-(4-hydroxymethyl-phenyl)-furan-2-yl]-acrylic acid; 2-Benzoylamino-3-[5-(4-hydroxymethyl-phenyl)-furan-2-yl]-acrylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[22] | ||
| Compound Name |
(6,7-Diphenyl-pteridin-4-yl)-(4-methyl-benzyl)-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183225; BDBM50160218; 6,7-diphenyl-N-(p-tolylmethyl)pteridin-4-amine; 4-Pteridinamine, N-[(4-methylphenyl)methyl]-6,7-diphenyl-
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
(2R,3S,4R,5S)-5-(4-Aminoimidazo[2,1-f][1,2,4]triazin-7-yl)-4-azido-2-(hydroxymethyl)-4-methyloxolan-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4115514; SCHEMBL15682805; BDBM249180; US9457039, 3
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
4-Amino-1-[(5R,9R)-9-hydroxy-8-(hydroxymethyl)-1,7-dioxaspiro[4.4]nonan-6-yl]pyrimidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL9909494; CHEMBL4110895; BDBM240843; US9394331, 49; US9394331, 137
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[20] | ||
| Compound Name |
(Z)-2-Benzamido-3-[5-(2-chlorophenyl)pyridin-3-yl]prop-2-enoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195310; SCHEMBL5895974; BDBM50166373; 2-Benzoylamino-3-[5-(2-chloro-phenyl)-pyridin-3-yl]-acrylic acid; (Z)-2-benzamido-3-[5-(2-chlorophenyl)-3-pyridyl]prop-2-enoic acid; (Z)-2-Benzoylamino-3-[5-(2-chloro-phenyl)-pyridin-3-yl]-acrylic acid
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[22] | ||
| Compound Name |
Cytidine, 2',5'-di-C-methyl-, (5'S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL800824; CHEMBL3984618; BDBM239049; US9408863, 5
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[23] | ||
| Compound Name |
7-[(4Ar,6R,7S,7aS)-7-amino-2-(2,2-dimethylpropoxy)-7-methyl-2-oxo-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrrolo[2,1-f][1,2,4]triazin-4-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4107380; SCHEMBL15682917; BDBM249192; US9457039, 16; US9457039, 17
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
6-(Diethylcarbamoyl)-3-hydroxy-4-oxo-pyran-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL109258; BDBM50147494; 6-Diethylcarbamoyl-3-hydroxy-4-oxo-4H-pyran-2-carboxylic acid; 4H-Pyran-2-carboxylic acid, 6-[(diethylamino)carbonyl]-3-hydroxy-4-oxo-
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[17] | ||
| Compound Name |
N-{2-[4-(2-Bromo-phenoxy)-phenyl]-1-phenylcarbamoyl-vinyl}-benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL193333; BDBM50167636; N-[(Z)-2-[4-(2-bromophenoxy)phenyl]-1-(phenylcarbamoyl)vinyl]benzamide; N-{(Z)-2-[4-(2-Bromo-phenoxy)-phenyl]-1-phenylcarbamoyl-vinyl}-benzamide
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[24] | ||
| Compound Name |
(2R,3S,4R,5R)-4-Amino-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-(hydroxymethyl)-4-methyloxolan-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4115582; SCHEMBL15682916; BDBM249182; US9457039, 5
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
(3R,4R,5R)-5-(4-Amino-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-[(1S)-1-hydroxyethyl]-4-methyloxolan-3-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3936841; BDBM241902; US9416154, 25
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
Ethyl (2S)-2-[[[(1S)-1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]ethoxy]-phenoxyphosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3956429; SCHEMBL14643217; BDBM241889; US9416154, 39
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
Ethyl (2S)-2-[[1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]ethoxy-(2-chlorophenoxy)phosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3906060; SCHEMBL15960621; BDBM241879; US9416154, 22
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL262711; ethyl 5-hydroxy-4-oxopyran-2-carboxylate; CTK4J2975; DTXSID20388397; BDBM50147495; MFCD10574826; ZINC22200340; DB-071237; ethyl 5-hydroxy-4-oxo-pyran-2-carboxylate; FT-0746131; ethyl 5-hydroxy-4-oxo-4H-pyran-2-carboxylate; 4H-Pyran-2-carboxylic acid, 5-hydroxy-4-oxo-, ethyl ester; 5-Hydroxy-4-oxo-4H-pyran-2-carboxylic acid methyl ester, 95%
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[17] | ||
| Compound Name |
Propan-2-yl (2S)-2-[[1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]ethoxy-(2-chlorophenoxy)phosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898834; SCHEMBL15960598; BDBM241880; US9416154, 23
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
Propan-2-yl (2S)-2-[[[(2R,3S,4R,5S)-4-amino-5-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3920673; SCHEMBL15682804; BDBM249190; US9457039, 14; US9457039, 15
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
4-Pteridinamine, N-[2-(4-fluorophenyl)ethyl]-6,7-diphenyl-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183482; BDBM50160207; N-[2-(4-fluorophenyl)ethyl]-6,7-diphenyl-pteridin-4-amine; (6,7-Diphenyl-pteridin-4-yl)-[2-(4-fluoro-phenyl)-ethyl]-amine
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
Phenanthro[9,10-g]pteridin-13-ol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL361772; Phenanthro[9,10-g]pteridin-13(12H)-one; Oprea1_562173; Oprea1_829741; HMS1689H06; BDBM50160223; ZINC10040184; AKOS000604680; MCULE-7029314547; ST45097643
Click to Show/Hide
|
||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
(2R,3S,4R,5S)-4-Amino-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2-(hydroxymethyl)-5-methoxy-4-methyloxolan-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4109465; BDBM249187; US9457039, 10
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
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[15] | ||
| Compound Name |
8-[(4Ar,6S,7S,7aS)-7-amino-7-methyl-2-oxo-2-propan-2-yloxy-4,4a,6,7a-tetrahydrofuro[3,2-d][1,3,2]dioxaphosphinin-6-yl]pyrazolo[1,5-a][1,3,5]triazin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4106992; SCHEMBL15685887; BDBM249195; US9457039, 20; US9457039, 21
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
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[15] | ||
| Compound Name |
(3R,4R,5R)-5-(4-Amino-5-fluoropyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-2-[(1R)-1-hydroxyethyl]-4-methyloxolan-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4108957; BDBM241883; US9416154, 26
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
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[21] | ||
| Compound Name |
Butyl (2S)-2-[[[(1R)-1-[(2S,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]ethoxy]-naphthalen-1-yloxyphosphoryl]amino]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898846; SCHEMBL14644655
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[23] | ||
| Compound Name |
Propan-2-yl (2S)-2-[[1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]ethoxy-(4-chlorophenoxy)phosphoryl]amino]propanoate
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3909564; SCHEMBL15960595; BDBM241878; US9416154, 21
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
(2R,3S,4R,5S)-5-(4-Aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)-4-azido-2-(hydroxymethyl)-4-methyloxolan-3-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4107423; SCHEMBL15682885; BDBM249181; US9457039, 4
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[15] | ||
| Compound Name |
6,7-Bis(4-methoxyphenyl)pteridin-4-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL263310; SCHEMBL14983475; ZINC9589123; BDBM50160198; 4-Pteridinol, 6,7-bis(4-methoxyphenyl)-; 6,7-Bis-(4-methoxy-phenyl)-pteridin-4-ol; SR-01000554222; SR-01000554222-1
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||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[16] | ||
| Compound Name |
Ethyl (2S)-2-[[[(1R)-1-[(2S,3R,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]ethoxy]-phenoxyphosphoryl]amino]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3932400; SCHEMBL15960614; BDBM241888; US9416154, 38
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| Activity | Hepatitis C virus Non-structural 5B |
EC50 ~ 100000 nM
|
[21] | ||
| Compound Name |
6-Benzyloxymethyl-3-hydroxy-4-oxo-4H-pyran-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL109969; BDBM50147493
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 ~ 100000 nM
|
[17] | ||
| Compound Name |
1-Cyclohexyl-2-(2,4,6-trimethylphenyl)benzimidazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL178067; BDBM50137494; 1-Cyclohexyl-2-(2,4,6-trimethyl-phenyl)-1H-benzoimidazole-5-carboxylic acid; 1H-Benzimidazole-5-carboxylic acid, 1-cyclohexyl-2-(2,4,6-trimethylphenyl)-
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 120000 nM
|
[10] | ||
| Compound Name |
1-(1-Ethylpropyl)-2-(2-pyridyl)benzimidazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL175762; BDBM50137505; 1-(1-Ethyl-propyl)-2-pyridin-2-yl-1H-benzoimidazole-5-carboxylic acid; 1H-Benzimidazole-5-carboxylic acid, 1-(1-ethylpropyl)-2-(2-pyridinyl)-
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 139000 nM
|
[10] | ||
| Compound Name |
1-Cyclohexylbenzodiazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
1-cyclohexyl-1H-benzimidazole-5-carboxylic acid; 1-cyclohexylbenzimidazole-5-carboxylic acid; CHEMBL177122; SMR000132614; ChemDiv3_014195; MLS000522206; MLS004820239; SCHEMBL4288972; HMS1513F05; HMS2484H04; ZINC4638824; BDBM50137497; KM5720; AKOS002134418; MCULE-2976953448; IDI1_029993; EU-0099957; V7202; VU0151854-5; 1-Cyclohexyl-1H-benzoimidazole-5-carboxylic acid; SR-01000103826; 1H-Benzimidazole-5-carboxylic acid, 1-cyclohexyl-; SR-01000103826-1; F0920-6925
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 186000 nM
|
[10] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 6 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-trihydroxyphosphanium
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161754; BDBM50410390
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| Activity | Hepatitis C virus Non-structural 5B |
Ki = 201000 nM
|
[26] | ||
| Compound Name |
[[[(1S,2S,3S,4R)-4-(6-Aminopurin-9-yl)-2,3-dihydroxycyclopentyl]oxymethyl-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-trihydroxyphosphanium
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161753; BDBM50410391
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| Activity | Hepatitis C virus Non-structural 5B |
Ki = 229000 nM
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[26] | ||
| Compound Name |
[[2-[(2R,3R,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]ethyl-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-trihydroxyphosphanium
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161773; BDBM50410392
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| Activity | Hepatitis C virus Non-structural 5B |
Ki = 327000 nM
|
[26] | ||
| Compound Name |
1-Phenyl-2-(2-pyridyl)benzimidazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL175454; BDBM50137466; 1-Phenyl-2-pyridin-2-yl-1H-benzoimidazole-5-carboxylic acid; 1H-Benzimidazole-5-carboxylic acid, 1-phenyl-2-(2-pyridinyl)-
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 360000 nM
|
[10] | ||
| Compound Name |
1-Isopropyl-2-(2-pyridyl)benzimidazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL369640; BDBM50137489; 1-Isopropyl-2-pyridin-2-yl-1H-benzoimidazole-5-carboxylic acid; 1H-Benzimidazole-5-carboxylic acid, 1-(1-methylethyl)-2-(2-pyridinyl)-
Click to Show/Hide
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| Activity | Hepatitis C virus Non-structural 5B |
IC50 = 408000 nM
|
[10] | ||
| Compound Name |
2-(Pyridin-2-yl)-1H-benzo[d]imidazole-6-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
2-pyridin-2-yl-3H-benzimidazole-5-carboxylic acid; 2-(2-Pyridinyl)-1H-benzimidazole-6-carboxylic acid; CHEMBL174331; 2-(2-pyridinyl)-1h-benzimidazole-5-carboxylic acid; 2-Pyridin-2-yl-1H-benzoimidazole-5-carboxylic acid; 2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboxylic acid; SCHEMBL179109; 2-Pyridin-2-yl-3H-benzoimidazole-5-carboxylic acid; SCHEMBL19970726; CTK5C5380; CTK7I8393; KS-00000OAL; DTXSID60333604; ZINC3626301; BDBM50137474; MFCD06245483; STK360623; AKOS000549590; AKOS005442381; AS-3249; MCULE-6444062393; AK-66878; DB-111479; 2-(2-pyridyl)-1H-benzimidazole-5-carboxylic acid; 2-(2-Pyridyl)-1H-benzoimidazole-5-carboxylic acid; 2-(pyridin-2-yl)-1H-benzimidazole-6-carboxylic acid; BRD-K74581401-001-01-8; 1H-Benzimidazole-5-carboxylic acid, 2-(2-pyridinyl)-; Z637700744; 2-(PYRIDIN-2-YL)-1H-BENZO[D]IMIDAZOLE-5-CARBOXYLIC ACID
Click to Show/Hide
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||||
| Activity | Hepatitis C virus Non-structural 5B |
IC50 > 500000 nM
|
[10] | ||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem. 2004 Apr 22;47(9):2283-95. | ||||
| REF 2 | Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase. J Med Chem. 2004 Jan 1;47(1):14-7. | ||||
| REF 3 | Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4834-8. | ||||
| REF 4 | 3D QSAR kNN-MFA studies on thiouracil derivatives as hepatitis C virus inhibitors. Med Chem Res. 2010 Oct 06;20:1616-21. | ||||
| REF 5 | 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis. J Med Chem. 2006 Mar 9;49(5):1693-705. | ||||
| REF 6 | Aminothiazole inhibitors of HCV RNA polymerase. Bioorg Med Chem Lett. 2005 Jan 3;15(1):115-9. | ||||
| REF 7 | Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5085-8. | ||||
| REF 8 | Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4026-30. | ||||
| REF 9 | Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1577-82. | ||||
| REF 10 | Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives. Bioorg Med Chem Lett. 2004 Jan 5;14(1):119-24. | ||||
| REF 11 | Simple but highly effective three-dimensional chemical-feature-based pharmacophore model for diketo acid derivatives as hepatitis C virus RNA-dependent RNA polymerase inhibitors. J Med Chem. 2005 Oct 6;48(20):6304-14. | ||||
| REF 12 | Pyridoxine hydroxamic acids as novel HIV-integrase inhibitors. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1233-6. | ||||
| REF 13 | HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis. J Med Chem. 2004 Oct 21;47(22):5336-9. | ||||
| REF 14 | Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds. Bioorg Med Chem Lett. 2006 Oct 1;16(19):4987-93. | ||||
| REF 15 | US patent application no. 9457039B2, 2'-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases | ||||
| REF 16 | Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase. Bioorg Med Chem Lett. 2005 Feb 1;15(3):675-8. | ||||
| REF 17 | The monoethyl ester of meconic acid is an active site inhibitor of HCV NS5B RNA-dependent RNA polymerase. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3257-61. | ||||
| REF 18 | Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase. J Med Chem. 2003 Apr 10;46(8):1283-5. | ||||
| REF 19 | Concise syntheses and HCV NS5B polymerase inhibition of (2'R)-3 and (2'S)-2'-ethynyluridine-10 and related nucleosides. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5349-5352. | ||||
| REF 20 | US patent application no. 9394331B2, 2'-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections | ||||
| REF 21 | US patent application no. 9416154B2, 5'-substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases | ||||
| REF 22 | Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid. Bioorg Med Chem Lett. 2005 May 16;15(10):2481-6. | ||||
| REF 23 | US patent application no. 9408863B2, 5'-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases | ||||
| REF 24 | Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2812-8. | ||||
| REF 25 | Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site. J Med Chem. 2006 Jun 1;49(11):3052-5. | ||||
| REF 26 | Design, synthesis, and antiviral activity of adenosine 5'-phosphonate analogues as chain terminators against hepatitis C virus. J Med Chem. 2005 Apr 21;48(8):2867-75. | ||||
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