Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T32369 | Target Info | |||
| Target Name | Influenza Polymerase acidic endonuclease (Influ PA) | ||||
| Synonyms |
RNA-directed RNA polymerase subunit P2; Polymerase acidic protein
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| Target Type | Successful Target | ||||
| Gene Name | Influ PA | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 14 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-Cyclohexyl-3-[(3Z)-1-hydroxy-3-[hydroxy(phenyl)methylene]-2-oxo-indolin-6-yl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL277284; BDBM50409795; Urea, N-cyclohexyl-N'-[(3Z)-2,3-dihydro-1-hydroxy-3-(hydroxyphenylmethylene)-2-oxo-1H-indol-6-yl]-
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
1-(2-Chlorophenyl)-3-[(3Z)-1-hydroxy-3-(1-hydroxypropylidene)-2-oxo-indolin-6-yl]urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL16665; BDBM50409807
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
5,6-Dihydroxy-2-pyridin-2-YL-pyrimidine-4-carboxylic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
Methyl 5-hydroxy-6-oxo-2-(pyridin-2-yl)-1,6-dihydropyrimidine-4-carboxylate; CHEMBL2040565; METHYL 5,6-DIHYDROXY-2-(PYRIDIN-2-YL)PYRIMIDINE-4-CARBOXYLATE; SCHEMBL13728189; KS-00000TZJ; DTXSID00696149; 3044AJ; BDBM50385511; MFCD09701380; ZINC84704413; ACN-045365; SB39011; AK554556; DS-19638; DB-076177; CS-0061865; Z-7589; methyl 5-hydroxy-6-oxo-2-pyridin-2-yl-1H-pyrimidine-4-carboxylate
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| Activity |
Ki = 50420 nM
|
[2] | |||
| Compound Name |
2-[3-(Acetylamino)phenyl]-5-Hydroxy-6-Oxo-1,6-Dihydropyrimidine-4-Carboxylic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040562; BDBM50385507; Q27455540
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| Activity |
EC50 = 58900 nM
|
[2] | |||
| Compound Name |
5-(2-Chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2424783; 5-[(2-chlorophenyl)methyl]-2-hydroxy-3-nitrobenzaldehyde; Oprea1_103578; SCHEMBL16798067; BDBM50109352; STK086291; ZINC49946777; AKOS000112945; MCULE-3810057944; ST012549; Q27454871
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| Activity |
IC50 = 63000 nM
|
[3] | |||
| Compound Name |
5-Hydroxy-6-oxo-3,7,13-triazatricyclo[7.4.0.02,7]trideca-1(9),2,4,10,12-pentaene-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040561; BDBM50385506
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| Activity |
EC50 = 67400 nM
|
[2] | |||
| Compound Name |
5-Hydroxy-N-(2-methylbutyl)-6-oxo-2-pyrazin-2-yl-1H-pyrimidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040571; BDBM50385517
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| Activity |
Ki = 70500 nM
|
[2] | |||
| Compound Name |
Methyl 5-hydroxy-2-(1-methylimidazol-4-yl)-4-oxo-1H-pyrimidine-6-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040564; SCHEMBL13731146; BDBM50385509
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| Activity |
EC50 = 71300 nM
|
[2] | |||
| Compound Name |
3-Benzyl-5-(4-fluoro-benzyl)-1-hydroxy-piperazine-2,6-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040639; BDBM50385561; 3-benzyl-5-[(4-fluorophenyl)methyl]-1-hydroxy-piperazine-2,6-dione
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| Activity |
IC50 = 85000 nM
|
[4] | |||
| Compound Name |
N-Butyl-5-hydroxy-6-oxo-2-pyrazin-2-yl-1H-pyrimidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040570; BDBM50385516
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| Activity |
EC50 = 88120 nM
|
[2] | |||
| Compound Name |
3-Hydroxy-1H-pteridine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL16384; 3-hydroxypteridine-2,4(1H,3H)-dione; CTK0D7355; DTXSID10430753; BDBM50125803; 2,4(1H,3H)-Pteridinedione, 3-hydroxy-
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| Activity |
IC50 = 95000 nM
|
[5] | |||
| Compound Name |
2-Hydroxy-1,4-dihydroisoquinolin-3-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL16419; SCHEMBL7898985; BDBM23987; N-Substituted dihydro-isoquinolinone, 4c; 2-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-one; 3(2H)-Isoquinolinone, 1,4-dihydro-2-hydroxy-
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
5-Hydroxy-2-(3-methylpyridin-2-yl)-6-oxo-1H-pyrimidine-4-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040567; BDBM50385513
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|
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| Activity |
EC50 = 119700 nM
|
[2] | |||
| Compound Name |
5-Hydroxy-1-methyl-6-oxo-2-pyridin-2-ylpyrimidine-4-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040566; BDBM50385512
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|
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| Activity |
EC50 = 151800 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 42 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Salicyclic acid
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|
Approved | Compound Info | ||
| Synonyms |
Salicylic acid; salicylic acid; 2-Hydroxybenzoic acid; 69-72-7; o-hydroxybenzoic acid; 2-Carboxyphenol; o-Carboxyphenol; Salonil; Rutranex; Retarder W; Keralyt; Freezone; Duoplant; Saligel; Ionil; Psoriacid-S-stift; salicylate; Stri-Dex; Salicylic acid soap; Benzoic acid, 2-hydroxy-; Salicylic acid collodion; Verrugon; Phenol-2-carboxylic acid; Acidum salicylicum; Trans-Ver-Sal; Orthohydroxybenzoic acid; 2-Hydroxybenzenecarboxylic acid; Acido salicilico; Ionil-Plus; Salicylic acid, tech; Kyselina salicylova; Clear away wart remover; Duofil wart; Domerine; Duofilm; Occlusal; SAX; Salicylate; Sebucare; Sebulex; Acido salicilico [Italian]; Advanced pain relief callus removers; Advanced pain relief corn removers; Akurza Cream; Akurza Lotion; DHS Sal Shampoo; DuoPlant Gel; Duofil wart remover; Hydrisalic Gel; Ionil plus; Kyselina salicylova [Czech]; Mediplast pads; O Hydroxybenzoic Acid; Ortho Hydroxybenzoic Acid; Retarder SAX; Salex Cream; Salex Lotion; CMC_13852; K 537; ATA fraction 10, ammonium salt; Acid, Salicylic; Acido o-idrossibenzoico; Acido o-idrossibenzoico [Italian]; Kyselina 2-hydroxybenzoova; Kyselina 2-hydroxybenzoova [Czech]; O-Carboxyphenol; O-hydroxybenzoic acid; Ortho-Hydroxybenzoic Acid; P&S Shampoo; Phenol derivative, 7; Propa pH Peel-Off Acne Mask; SALICYLIC ACID (SEE ALSO ALPHA HYDROXY ACIDS); SALICYLIC ACID, ACS; Salicylic acid & Sulfur Soap; Salicylic acid (TN); Salicylic acid [USAN:JAN]; Acid, 2-Hydroxybenzoic; Acid, o-Hydroxybenzoic; Acid, ortho-Hydroxybenzoic; BENZOIC ACID,2-HYDROXY SALICYLIC ACID; Dr Scholl's callus removers; Dr Scholl's corn removers; Dr Scholl's wart remover kit; Salicylic acid (6CI,8CI); Salicylic acid (JP15/USP); Alpha/Beta Hydroxy Acids (Glycolic Acid, Salicylic Acid); Salicylic acid-ring-UL-14C; ALPHA/BETA HYDROXY ACIDS (SALICYLIC ACID) (SEE ALPHA/BETA HYDROXY ACIDS); Benzoic acid, 2-hydroxy-(9CI); E9A559BE-383B-4F83-BC02-3031D03D558A; 2 Hydroxybenzoic Acid; 2-hydroxy(1-14c)benzoic acid; SALICYLATE
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| Activity |
EC50 > 250000 nM
|
[2] | |||
| Compound Name |
(3Z,5S)-4-Benzyl-3-[(3-fluorophenyl)methylidene]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040624; BDBM50385564
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5S)-4-Benzyl-3-[(R)-(4-fluorophenyl)-hydroxymethyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040612; BDBM50385540
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5S)-4-Benzyl-3-[(R)-hydroxy(phenyl)methyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040610; BDBM50385538
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3Z,5S)-4-Benzyl-3-[(2-fluorophenyl)methylidene]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040625; BDBM50385550
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5S)-4-Benzyl-3-[(R)-(2-fluorophenyl)-hydroxymethyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040614; BDBM50385542
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5S)-4-Benzyl-3-[(R)-(3-fluorophenyl)-hydroxymethyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040613; BDBM50385541
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3Z,5S)-4-Benzyl-3-benzylidene-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040621; BDBM50385547
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5S)-3,4-Dibenzyl-5-[(R)-hydroxy-(4-methoxyphenyl)methyl]-1-(methoxymethoxy)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040616; BDBM50385543
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5Z)-4-Benzyl-1-(methoxymethoxy)-3-(2-methylpropyl)-5-(2-methylpropylidene)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040620; BDBM50385546
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5Z)-3,4-Dibenzyl-1-(methoxymethoxy)-5-(2-methylpropylidene)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040626; BDBM50385551
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5S)-4-Benzyl-3-[(1R)-1-hydroxy-2-methylpropyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040609; BDBM50385537
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5Z)-3,4-Dibenzyl-5-[(4-fluorophenyl)methylidene]-1-(methoxymethoxy)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040628; BDBM50385565
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5E)-4-Benzyl-1-(methoxymethoxy)-3-(2-methylpropyl)-5-(2-methylpropylidene)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040629; BDBM50385553
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5S)-3,4-Dibenzyl-5-[(1S)-1-hydroxy-2-methylpropyl]-1-(methoxymethoxy)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040619; BDBM50385563
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5E)-3,4-Dibenzyl-1-(methoxymethoxy)-5-(2-methylpropylidene)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040630; BDBM50385554
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5S)-3,4-Dibenzyl-5-[(R)-(4-fluorophenyl)-hydroxymethyl]-1-(methoxymethoxy)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040617; BDBM50385544
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5S)-3,4-Dibenzyl-5-[(1R)-1-hydroxy-2-methylpropyl]-1-(methoxymethoxy)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040615; BDBM50385562
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3Z,5S)-4-Benzyl-1-(methoxymethoxy)-3-[(4-methoxyphenyl)methylidene]-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040622; BDBM50385548
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5S)-4-Benzyl-3-[(S)-(2-fluorophenyl)-hydroxymethyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040618; BDBM50385545
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3Z,5S)-4-Benzyl-3-[(4-fluorophenyl)methylidene]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040623; BDBM50385549
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5S)-4-Benzyl-3-[(R)-hydroxy-(4-methoxyphenyl)methyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040611; BDBM50385539
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
(3S,5Z)-3,4-Dibenzyl-1-(methoxymethoxy)-5-[(4-methoxyphenyl)methylidene]piperazine-2,6-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040627; BDBM50385552
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|
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| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
N-Hexyl-5-hydroxy-6-oxo-2-pyrazin-2-yl-1H-pyrimidine-4-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040572; BDBM50385527
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|
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| Activity |
EC50 > 250000 nM
|
[2] | |||
| Compound Name |
(Z)-4-Hydroxy-2-oxo-4-pyridin-3-ylbut-3-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040556
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| Activity |
EC50 > 250000 nM
|
[2] | |||
| Compound Name |
3-Benzoylacrylic acid
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Investigative | Compound Info | ||
| Synonyms |
(E)-4-oxo-4-phenylbut-2-enoic acid; 4-Oxo-4-phenyl-2-butenoic acid; Benzoylacrylic acid; Acrylic acid, 3-benzoyl-; 2-Butenoic acid, 4-oxo-4-phenyl-; Crotonic acid, 4-oxo-4-phenyl-; trans-3-Benzoylacrylic acid; NSC 143; .beta.-Benzoylacrylic acid; 4-oxo-4-phenylbut-2-enoic acid; (2E)-4-oxo-4-phenylbut-2-enoic acid; CHEMBL16365; NSC-143; MFCD00014015; 4-Phenyl-4-oxo-2-butenoic acid; EINECS 209-496-5; (E)-3-BENZOYLACRYLIC ACID; 4-Oxo-4-phenyl-but-2-enoic acid; AI3-26616; (E)-4-oxo-4-phenyl-2-butenoic acid; ss-Benzoyl-acrylsaure; ss-Benzoylacrylic acid; (E)-4-oxo-4-phenyl-but-2-enoic acid; 3-benzoyl acrylic acid; Acrylic acid, 3-benzoyl- (6CI,7CI,8CI); trans-3-Benzoylacrylicacid; 4-Oxo-4-phenylcrotonic acid; trans-beta-benzoylacrylic acid; ARONIS24072; SCHEMBL312429; NSC143; DTXSID1060392; ZINC39041; HMS1579K08; ALBB-025661; 6046AE; BBL007891; BDBM50125821; SBB007952; STK358786; AKOS000267606; (2E)-4-Oxo-4-phenyl-2-butenoic acid; NCGC00341436-01; AC-14424; AS-57498; SC-14183; 3-Benzoylacrylic acid, predominantly trans; BB 0218773; CS-0040775; 2-butenoic acid, 4-oxo-4-phenyl-, (2E)-; 7N-710; Z-0814; AB01332184-02; AE-641/02009001; A1-01400; W-111702; F2103-0016
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| Activity |
EC50 > 250000 nM
|
[2] | |||
| Compound Name |
8-Hydroxyquinoline-7-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
8-Hydroxy-7-quinolinecarboxylic acid; 7-Quinolinecarboxylic acid, 8-hydroxy-; MLS000738075; CHEMBL374569; MFCD00671539; NSC27445; ACMC-1C3IO; 7-carboxy-8-hydroxyquinoline; SCHEMBL1759043; CTK0I0112; DTXSID20282700; HMS2762E14; 8-hydroxyquinolin-7-carboxylic acid; 8-Hydroxyquinoline-7-carboxylicAcid; NSC35082; ZINC1641403; 0195AB; 8-hydroxyquinoline 7-carboxylic acid; ANW-23813; BBL102771; BDBM50370827; NSC-27445; NSC-35082; STL556577; 7-Quinolinecarboxylicacid, 8-hydroxy-; AKOS006230410; MCULE-3710426304; KS-0000122J; AS-37866; SC-26084; SMR000393747; AB0076465; DB-044997; FT-0637915; EN300-45043; Z-0666; 8-Hydroxy-7-quinolinecarboxylic acid, AldrichCPR; 829H799; Z1695797797
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| Activity |
EC50 > 250000 nM
|
[2] | |||
| Compound Name |
5-Hydroxy-6-oxo-N-(2-phenylethyl)-2-pyrazin-2-yl-1H-pyrimidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040579; BDBM50385489
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| Activity |
EC50 > 250000 nM
|
[2] | |||
| Compound Name |
3-Benzoylpropionic acid
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Investigative | Compound Info | ||
| Synonyms |
4-Oxo-4-phenylbutanoic acid; 4-Oxo-4-phenylbutyric acid; 3-Benzoylpropanoic acid; Benzoylpropionic acid; beta-Benzoylpropionic acid; 3-BENZOYLPROPIONICACID; Benzenebutanoic acid, .gamma.-oxo-; Propanoic acid, 3-benzoyl-; Benzenebutanoic acid, gamma-oxo-; Propionic acid, 3-benzoyl-; MFCD00002792; 4-phenyl-4-oxobutyric acid; .beta.-Benzoylpropionic acid; 4-oxo-4-phenyl-butyric acid; CHEMBL461681; 3-Benzoylpropionic acid, 98%; 4-oxo-4-phenyl-butanoic acid; NSC 2092; EINECS 218-135-0; NSC 51010; NSC 229040; ACMC-209fbk; AI3-03666; 3-Benzoylpropionic acid,; ChemDiv3_013347; 4-phenyl-4oxobutyric acid; beta-benzoyl-propionic acid; Epitope ID:167704; UNII-UV05GZ4D9Z; 4-oxo4-phenylbutanoic acid; Cambridge id 5118846; UV05GZ4D9Z; KSC497E1R; ARONIS25132; SCHEMBL354105; 3-Benzoylpropionic acid, 99%; DTXSID4062149; CTK3J7218; NSC2092; Phenylbutyrate Related Compound A; HMS1510O15; ZINC155985; BCP09655; NSC-2092; NSC51010; Propionic acid, 3-benzoyl- (8CI); ANW-24126; BBL010613; BDBM50385525; CX1085; NSC-51010; NSC229040; SBB057733; STK328119; AKOS000120508; CM11066; CS-W001943; GS-6768; MCULE-2271267445; NSC-229040; VZ35007; KS-00000C27; KS-0000471G; AC-11220; AC-31093; AK-96642; SC-18799; SY011505; AM20030310; B0868; BB 0218424; EU-0096486; FT-0615089; ST45053915; K-5978; AC-907/25014276; SR-01000391537; Q-200363; SR-01000391537-1; Q27133281; F0349-0592
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| Activity |
EC50 > 250000 nM
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[2] | |||
| Compound Name |
Methyl 4-hydroxy-2-oxo-4-phenylbut-3-enoate
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Investigative | Compound Info | ||
| Synonyms |
2-Butenoic acid, 2-hydroxy-4-oxo-4-phenyl-, methyl ester; CHEMBL456227; CTK1D4007; CTK2C7791; ZINC5248793; ZINC101174920; 2-Hydroxy-4-oxo-4-phenyl-2-butenoic acid methyl ester; 3-Butenoic acid, 4-hydroxy-2-oxo-4-phenyl-, methyl ester; (2Z)-2-Hydroxy-4-oxo-4-phenyl-2-butenoic acid methyl ester
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| Activity |
EC50 > 250000 nM
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[2] | |||
| Compound Name |
(2Z)-2-Hydroxy-4-oxo-2-pentenoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2040643; SCHEMBL6253196; AKOS006374354
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| Activity |
IC50 = 307000 nM
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[6] | |||
| Compound Name |
(Z)-4-Cyclohexyl-2-hydroxy-4-oxo-but-2-enamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL461059; BDBM50024266; (2Z)-2-Hydroxy-4-oxo-4-cyclohexyl-2-buteneamide; 2-Butenamide, 4-cyclohexyl-2-hydroxy-4-oxo-, (2Z)-
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| Activity |
IC50 > 500000 nM
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[1] | |||
| Compound Name |
N-Hydroxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
BENZOHYDROXAMIC ACID; Benzhydroxamic acid; Benzamide, N-hydroxy-; Benzohydroxamate; N-Hydroxy-benzamide; Phenylhydroxamic acid; Benzohyroxamate; Hydroxylamine, N-benzoyl-; Benzoylhydroxamic acid; benzenecarbohydroxamic acid; UNII-K8YW73872D; benzoyl hydroxamic acid; MFCD00002109; CHEMBL16300; K8YW73872D; NCGC00091044-02; Benzenecarboximidicacid, N-hydroxy-, (Z)- (9CI); BHAM; Benzenehydroxamic acid; Benzhydroxamic acid; Benzohydroximic acid; benzohydroxamsaure; Benzohydroxamicacid; CCRIS 6046; EINECS 207-797-6; NSC 147248; benzohydroxamic; AI3-15939; N-oxidanylbenzamide; benzoylamino-alcohol; benzenehydroximic acid; ACMC-20mpyb; ACMC-209kgh; Enamine_005424; DSSTox_CID_5421; Benzhydroxamic acid, 99%; Benzohydroxamic acid, 98%; DSSTox_RID_77777; DSSTox_GSID_25421; SCHEMBL133061; DTXSID7025421; CTK0H0326; CTK1D6409; NSC3136; HMS1409G12; KS-000014MP; NSC-3136; STR01815; ZINC4701351; Tox21_400060; ANW-30783; BDBM50015184; NSC147248; SBB058405; STL280246; AKOS000120941; AKOS004905605; DB01924; MCULE-6084710046; NSC-147248; NCGC00091044-01; NCGC00091044-03; AT-42546; benzenecarboximidic acid,n-hydroxy-,(z)-; DB-051637; B0061; FT-0622703; ST51021108; 495B181; A827734; J-509878; Q27093030; Z56912029
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| Activity |
IC50 > 500000 nM
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[1] | |||
| Compound Name |
3-Hydroxy-1,5-dihydro-3-benzazepine-2,4-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL16444; BDBM50125806; 3-Hydroxy-1,5-dihydro-benzo[d]azepine-2,4-dione; 3-hydroxy-1H-benzo[d]azepine-2,4(3H,5H)-dione; 1H-3-Benzazepine-2,4(3H,5H)-dione, 3-hydroxy-
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| Activity |
IC50 > 500000 nM
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[5] | |||
| Compound Name |
N-Hydroxyphthalimide
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Investigative | Compound Info | ||
| Synonyms |
2-hydroxyisoindoline-1,3-dione; 2-Hydroxy-1H-isoindole-1,3(2H)-dione; 1H-Isoindole-1,3(2H)-dione, 2-hydroxy-; 2-hydroxyisoindole-1,3-dione; Phthalimide, N-hydroxy-; UNII-BXI99M81X0; MFCD00005891; BXI99M81X0; CHEMBL276057; 2-hydroxy-isoindole-1,3-dione; 2-Hydroxyphthalimide; 2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione; N-Hydroxyphthalimide, 98%; 2-hydroxy-1H-isoindole-1,3-dione; NSC 770; EINECS 208-358-1; BRN 0131208; Phthaloxime; AI3-52074; 2-Hydroxyisoindolin-1,3-dione; F 802; N-Hydroxyphalimide; N-hydoxyphthalimide; N-hydroxyphtalimide; N-hydroxypthalimide; N-hyroxyphthalimide; N-hydroxy-phtalimide; N-hydroxylphthalimide; N-hydroxyphthalirnide; HOPHT; N-hydroxy-phthalimide; N-(hydroxy)phthaltmde; PubChem17315; ACMC-209kzf; SCHEMBL1410; N-Hydroxyphthalimide, 97%; N-(HYDROXY)PHTHALIMDE; WLN: T56 BVNVJ CQ; 5-21-11-00100 (Beilstein Handbook Reference); KSC490G1L; ARONIS23889; 1H-Isoindole-1, 2-hydroxy-; 2-oxidanylisoindole-1,3-dione; NSC770; SCHEMBL3182600; 2-hydroxy-1,3-isoindolinedione; DTXSID7060170; CFMZSMGAMPBRBE-UHFFFAOYSA-; CTK3J0315; TIMTEC-BB SBB009098; ZINC98179; EBD1140; NSC-770; HMS1667D19; BCP21904; KS-000001ZF; 2-hydroxybenzo[c]azoline-1,3-dione; ANW-31465; BBL009697; BDBM50125808; SBB009098; STL141048; 2-hydroxybenzo[c]azolidine-1,3-dione; AKOS002387742; AB00534; CS-W008848; FS-3185; MCULE-1235859587; 2-hydroxy-1H-isoindol-1,3(2H)-dione; AK-47868; BP-31016; BR-47868; SC-22617; 2-hydroxyphthalimide;Phthalimide,N-hydroxy-; 2-Hydroxy-1H-isoindole-1,3(2H)-dione #; AM20060443; BB 0255317; FT-0650420; ST50508947; N-Hydroxyphthalimide, purum, >=98.0% (T); M-5965; 47623-EP2275102A1; 47623-EP2292599A1; 47623-EP2298772A1; 47623-EP2301918A1; 47623-EP2308839A1; 47623-EP2308874A1; 47623-EP2311811A1; 139366-EP2270008A1; 139366-EP2292617A1; A829086; J-509677; N-Hydroxyphthalimide, Vetec(TM) reagent grade, 97%; Q26296355; F1565-0110
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| Activity |
IC50 > 500000 nM
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[5] | |||
| Compound Name |
2-Oxo-4-phenylbutyric acid
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Investigative | Compound Info | ||
| Synonyms |
2-oxo-4-phenylbutanoic acid; 2-Oxo-4-phenyl-butyric acid; Benzenebutanoic acid, a-oxo-; CHEMBL16281; Benzenebutanoic acid, alpha-oxo-; 2-oxo-4-phenyl-butanoic acid; benzylpyruvic acid; EINECS 211-916-7; oxobenzenebutanoic acid; PubChem18755; 4-phenyl-2-oxobutyric acid; 4-phenyl-2-oxobutanoic acid; 2-oxo-4-phenyl butyric acid; KSC497Q3R; SCHEMBL258545; 4-Phenyl-2-Ketobutanoic Acid; CTK3J7838; DTXSID10221224; 2-OXO-4-PHENYL-BUTYRICACID; ALBB-014726; KS-00000N7B; ZINC1845776; 1012AC; BDBM50125828; MFCD00969471; SBB063374; AKOS005174543; AC-3539; CS-W019322; DS-3613; MCULE-5355166420; 2-oxo-4-phenyl-butyric acid, AldrichCPR; AK107119; AB0063071; DB-055479; FT-0632864; O0389; C20327; W-7725; 710O112; W-104537
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| Activity |
IC50 > 500000 nM
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[1] | |||
| Compound Name |
4(3H)-Pteridinone, 3-hydroxy-
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Investigative | Compound Info | ||
| Synonyms |
3-hydroxypteridin-4-one; 3-Hydroxy-3H-pteridin-4-one; CHEMBL16513; 3-Hydroxy-4(3H)-pteridinone; 3-hydroxypteridin-4(3H)-one; CTK8H3316; 3-Hydroxy-4(3H)-pteridinone #; BDBM50125799; 3-hydroxy-4-oxo-3,4-dihydropteridine
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| Activity |
IC50 > 500000 nM
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[1] | |||
| Compound Name |
alpha-Amino-beta-benzoylpropionic acid
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Investigative | Compound Info | ||
| Synonyms |
2-amino-4-oxo-4-phenylbutanoic acid; (3-Arylcarbonyl)-alanine; C03450; 2-amino-4-oxo-4-phenyl-butanoic acid; AC1L94A6; SureCN2860324; SCHEMBL2860324; CHEMBL2040644; DTXSID60328636; 2-azaniumyl-4-oxo-4-phenylbutanoate; STL572861; AKOS017515992; MCULE-7684350557; DB-009269; Benzenebutanoic acid, alpha-amino-gamma-oxo-; FT-0703763; F2185-0885
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| Activity |
IC50 > 500000 nM
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[6] | |||
| Compound Name |
2-Hydroxy-4-oxo-4-phenylbutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
2-Hydroxy-4-oxo-4-phenyl-butyric acid; CHEMBL177826; BENZOYLLACTICACID; SCHEMBL4967701; DTXSID30983852; 3-benzoyl-2-hydroxy-propionic acid; EINECS 265-659-0; BDBM50137857; 2-hydroxy-4-oxo-4-phenyl-butanoic acid; alpha-Hydroxy-gamma-oxobenzenebutanoic acid; DB-054785; FT-0641002; FT-0669926; FT-0669927
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| Activity |
IC50 > 500000 nM
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[6] | |||
| Compound Name |
2-Methoxy-4H-isoquinoline-1,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL275148; N-methoxyisoquinolinedione; SCHEMBL13495339; BDBM50125811; 2-methoxyisoquinoline-1,3(2H,4H)-dione; 1,3(2H,4H)-Isoquinolinedione, 2-methoxy-; 2-methoxyisoquinoline-1,3 (2H, 4H)-dione; 2-Methoxy-1,2,3,4-tetrahydroisoquinoline-1,3-dione
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| Activity |
IC50 = 710000 nM
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[5] | |||
| Compound Name |
2-Amino-1,2,3,4-tetrahydroisoquinoline-1,3-dione
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Investigative | Compound Info | ||
| Synonyms |
2-Amino-4H-isoquinoline-1,3-dione; 2-Aminoisoquinoline-1,3(2H,4H)-dione; UNII-1IYV36MFF1; 1IYV36MFF1; 1,3(2H,4H)-Isoquinolinedione,2-amino-; CHEMBL277286; 1,3(2H,4H)-Isoquinolinedione, 2-amino-; ATHQD; NSC 110333; Oprea1_224479; SCHEMBL9382466; CTK4E8837; DTXSID80176712; ZINC1702760; BDBM50125802; NSC110333; AKOS006228477; MB02175; MCULE-1273345717; NSC-110333; 2-amino-1,3(2H,4H)-isoquinolinedione; DS-002758; AK-830/13217043
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| Activity |
IC50 = 800000 nM
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[5] | |||
| Compound Name |
2-Hydroxy-4,5-dihydro-2-benzazepine-1,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL277090; BDBM50125823; 2-Hydroxy-4,5-dihydro-benzo[c]azepine-1,3-dione; 1H-2-Benzazepine-1,3(2H)-dione, 4,5-dihydro-2-hydroxy-; 2-hydroxy-4,5-dihydro-1H-benzo[c]azepine-1,3(2H)-dione
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| Activity |
IC50 > 1000000 nM
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[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors. J Med Chem. 2003 Mar 27;46(7):1153-64. | ||||
| REF 2 | Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay. ACS Chem Biol. 2012 Mar 16;7(3):526-34. | ||||
| REF 3 | Structural and computational study on inhibitory compounds for endonuclease activity of influenza virus polymerase. Bioorg Med Chem. 2015 Sep 1;23(17):5466-75. | ||||
| REF 4 | Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus. J Org Chem. 2001 Aug 10;66(16):5504-16. | ||||
| REF 5 | Novel indole-flutimide heterocycles with activity against influenza PA endonuclease and hepatitis C virus. Medchemcomm. 2016;7:447-56. | ||||
| REF 6 | Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds. Antimicrob Agents Chemother. 1994 Dec;38(12):2827-37. | ||||
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