TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T32369	Influenza Polymerase acidic endonuclease	D07HBX	Salicyclic acid	Approved	338	C7H6O3	138.12	C1=CC=C(C(=C1)C(=O)O)O	EC50 > 250000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	B2A9VM	(3Z,5S)-4-Benzyl-3-[(3-fluorophenyl)methylidene]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70692395	C24H27FN2O4	426.5	CC(C)C[C@H]1C(=O)N(C(=O)/C(=C/C2=CC(=CC=C2)F)/N1CC3=CC=CC=C3)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	B2FN0S	(3S,5S)-4-Benzyl-3-[(R)-(4-fluorophenyl)-hydroxymethyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70690223	C24H29FN2O5	444.5	CC(C)C[C@H]1C(=O)N(C(=O)[C@@H](N1CC2=CC=CC=C2)[C@@H](C3=CC=C(C=C3)F)O)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	B2S4AE	2-Amino-1,2,3,4-tetrahydroisoquinoline-1,3-dione	Investigative	97273	C9H8N2O2	176.17	C1C2=CC=CC=C2C(=O)N(C1=O)N	IC50 = 800000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	B31FTP	(Z)-4-Cyclohexyl-2-hydroxy-4-oxo-but-2-enamide	Investigative	6479290	C10H15NO3	197.23	C1CCC(CC1)C(=O)/C=C(/C(=O)N)\\O	IC50 > 500000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	B3B4XM	N-Hexyl-5-hydroxy-6-oxo-2-pyrazin-2-yl-1H-pyrimidine-4-carboxamide	Investigative	136254258	C15H19N5O3	317.34	CCCCCCNC(=O)C1=C(C(=O)NC(=N1)C2=NC=CN=C2)O	EC50 > 250000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	B3TYC6	(Z)-4-Hydroxy-2-oxo-4-pyridin-3-ylbut-3-enoic acid	Investigative	40637838	C9H7NO4	193.16	C1=CC(=CN=C1)/C(=C/C(=O)C(=O)O)/O	EC50 > 250000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	B5E6UV	N-Hydroxybenzamide	Investigative	10313	C7H7NO2	137.14	C1=CC=C(C=C1)C(=O)NO	IC50 > 500000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	B5MWN7	(3S,5S)-4-Benzyl-3-[(R)-hydroxy(phenyl)methyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70690222	C24H30N2O5	426.5	CC(C)C[C@H]1C(=O)N(C(=O)[C@@H](N1CC2=CC=CC=C2)[C@@H](C3=CC=CC=C3)O)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	B5UB9O	(3Z,5S)-4-Benzyl-3-[(2-fluorophenyl)methylidene]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70683950	C24H27FN2O4	426.5	CC(C)C[C@H]1C(=O)N(C(=O)/C(=C/C2=CC=CC=C2F)/N1CC3=CC=CC=C3)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	B9WT8X	(3S,5S)-4-Benzyl-3-[(R)-(2-fluorophenyl)-hydroxymethyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70681844	C24H29FN2O5	444.5	CC(C)C[C@H]1C(=O)N(C(=O)[C@@H](N1CC2=CC=CC=C2)[C@@H](C3=CC=CC=C3F)O)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BAF8D1	3-Hydroxy-1,5-dihydro-3-benzazepine-2,4-dione	Investigative	514104	C10H9NO3	191.18	C1C2=CC=CC=C2CC(=O)N(C1=O)O	IC50 > 500000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BB4IQ7	(3S,5S)-4-Benzyl-3-[(R)-(3-fluorophenyl)-hydroxymethyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70692391	C24H29FN2O5	444.5	CC(C)C[C@H]1C(=O)N(C(=O)[C@@H](N1CC2=CC=CC=C2)[C@@H](C3=CC(=CC=C3)F)O)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BB68EW	(3Z,5S)-4-Benzyl-3-benzylidene-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70692393	C24H28N2O4	408.5	CC(C)C[C@H]1C(=O)N(C(=O)/C(=C/C2=CC=CC=C2)/N1CC3=CC=CC=C3)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BBL2H6	(3S,5S)-3,4-Dibenzyl-5-[(R)-hydroxy-(4-methoxyphenyl)methyl]-1-(methoxymethoxy)piperazine-2,6-dione	Investigative	70690224	C28H30N2O6	490.5	COCON1C(=O)[C@@H](N([C@H](C1=O)[C@@H](C2=CC=C(C=C2)OC)O)CC3=CC=CC=C3)CC4=CC=CC=C4	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BD25QI	N-Hydroxyphthalimide	Investigative	10665	C8H5NO3	163.13	C1=CC=C2C(=C1)C(=O)N(C2=O)O	IC50 > 500000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BDS89B	(3S,5Z)-4-Benzyl-1-(methoxymethoxy)-3-(2-methylpropyl)-5-(2-methylpropylidene)piperazine-2,6-dione	Investigative	70686073	C21H30N2O4	374.5	CC(C)C[C@H]1C(=O)N(C(=O)/C(=C/C(C)C)/N1CC2=CC=CC=C2)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BE27LB	2-Oxo-4-phenylbutyric acid	Investigative	69732	C10H10O3	178.18	C1=CC=C(C=C1)CCC(=O)C(=O)O	IC50 > 500000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BF4S2H	4(3H)-Pteridinone, 3-hydroxy-	Investigative	514103	C6H4N4O2	164.12	C1=CN=C2C(=N1)C(=O)N(C=N2)O	IC50 > 500000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BFKE04	(3S,5Z)-3,4-Dibenzyl-1-(methoxymethoxy)-5-(2-methylpropylidene)piperazine-2,6-dione	Investigative	70686074	C24H28N2O4	408.5	CC(C)/C=C\\1/C(=O)N(C(=O)[C@@H](N1CC2=CC=CC=C2)CC3=CC=CC=C3)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BGL4K1	(3S,5S)-4-Benzyl-3-[(1R)-1-hydroxy-2-methylpropyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70694446	C21H32N2O5	392.5	CC(C)C[C@H]1C(=O)N(C(=O)[C@@H](N1CC2=CC=CC=C2)[C@@H](C(C)C)O)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BI4DZ9	(2Z)-2-Hydroxy-4-oxo-2-pentenoic acid	Investigative	6508940	C5H6O4	130.1	CC(=O)/C=C(/C(=O)O)\\O	IC50 = 307000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BJK73G	(3S,5Z)-3,4-Dibenzyl-5-[(4-fluorophenyl)methylidene]-1-(methoxymethoxy)piperazine-2,6-dione	Investigative	70696513	C27H25FN2O4	460.5	COCON1C(=O)[C@@H](N(/C(=C\\C2=CC=C(C=C2)F)/C1=O)CC3=CC=CC=C3)CC4=CC=CC=C4	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BK6PL2	(3S,5E)-4-Benzyl-1-(methoxymethoxy)-3-(2-methylpropyl)-5-(2-methylpropylidene)piperazine-2,6-dione	Investigative	70696514	C21H30N2O4	374.5	CC(C)C[C@H]1C(=O)N(C(=O)/C(=C\\C(C)C)/N1CC2=CC=CC=C2)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BM7H3O	(3S,5S)-3,4-Dibenzyl-5-[(1S)-1-hydroxy-2-methylpropyl]-1-(methoxymethoxy)piperazine-2,6-dione	Investigative	70692392	C24H30N2O5	426.5	CC(C)[C@@H]([C@H]1C(=O)N(C(=O)[C@@H](N1CC2=CC=CC=C2)CC3=CC=CC=C3)OCOC)O	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BM94SD	(3S,5E)-3,4-Dibenzyl-1-(methoxymethoxy)-5-(2-methylpropylidene)piperazine-2,6-dione	Investigative	70686075	C24H28N2O4	408.5	CC(C)/C=C/1\\C(=O)N(C(=O)[C@@H](N1CC2=CC=CC=C2)CC3=CC=CC=C3)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BP97JB	3-Benzoylacrylic acid	Investigative	676116	C10H8O3	176.17	C1=CC=C(C=C1)C(=O)/C=C/C(=O)O	EC50 > 250000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BPI60N	8-Hydroxyquinoline-7-carboxylic acid	Investigative	231363	C10H7NO3	189.17	C1=CC2=C(C(=C(C=C2)C(=O)O)O)N=C1	EC50 > 250000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BQ71PT	(3S,5S)-3,4-Dibenzyl-5-[(R)-(4-fluorophenyl)-hydroxymethyl]-1-(methoxymethoxy)piperazine-2,6-dione	Investigative	70686071	C27H27FN2O5	478.5	COCON1C(=O)[C@@H](N([C@H](C1=O)[C@@H](C2=CC=C(C=C2)F)O)CC3=CC=CC=C3)CC4=CC=CC=C4	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BQW73F	alpha-Amino-beta-benzoylpropionic acid	Investigative	412786	C10H11NO3	193.2	C1=CC=C(C=C1)C(=O)CC(C(=O)O)N	IC50 > 500000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BR6G5Z	2-Methoxy-4H-isoquinoline-1,3-dione	Investigative	514102	C10H9NO3	191.18	CON1C(=O)CC2=CC=CC=C2C1=O	IC50 = 710000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BRG1K4	(3S,5S)-3,4-Dibenzyl-5-[(1R)-1-hydroxy-2-methylpropyl]-1-(methoxymethoxy)piperazine-2,6-dione	Investigative	70681845	C24H30N2O5	426.5	CC(C)[C@H]([C@H]1C(=O)N(C(=O)[C@@H](N1CC2=CC=CC=C2)CC3=CC=CC=C3)OCOC)O	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BS6Q5K	5-Hydroxy-6-oxo-N-(2-phenylethyl)-2-pyrazin-2-yl-1H-pyrimidine-4-carboxamide	Investigative	136254248	C17H15N5O3	337.33	C1=CC=C(C=C1)CCNC(=O)C2=C(C(=O)NC(=N2)C3=NC=CN=C3)O	EC50 > 250000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BSZG02	(3Z,5S)-4-Benzyl-1-(methoxymethoxy)-3-[(4-methoxyphenyl)methylidene]-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70692394	C25H30N2O5	438.5	CC(C)C[C@H]1C(=O)N(C(=O)/C(=C/C2=CC=C(C=C2)OC)/N1CC3=CC=CC=C3)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BT0NJ2	(3S,5S)-4-Benzyl-3-[(S)-(2-fluorophenyl)-hydroxymethyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70686072	C24H29FN2O5	444.5	CC(C)C[C@H]1C(=O)N(C(=O)[C@@H](N1CC2=CC=CC=C2)[C@H](C3=CC=CC=C3F)O)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BT3J2I	2-Hydroxy-4,5-dihydro-2-benzazepine-1,3-dione	Investigative	514105	C10H9NO3	191.18	C1CC(=O)N(C(=O)C2=CC=CC=C21)O	IC50 > 1000000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BTU19A	2-Hydroxy-4-oxo-4-phenylbutanoic acid	Investigative	516699	C10H10O4	194.18	C1=CC=C(C=C1)C(=O)CC(C(=O)O)O	IC50 > 500000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BV40GN	3-Benzoylpropionic acid	Investigative	72871	C10H10O3	178.18	C1=CC=C(C=C1)C(=O)CCC(=O)O	EC50 > 250000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BW23LZ	(3Z,5S)-4-Benzyl-3-[(4-fluorophenyl)methylidene]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70683949	C24H27FN2O4	426.5	CC(C)C[C@H]1C(=O)N(C(=O)/C(=C/C2=CC=C(C=C2)F)/N1CC3=CC=CC=C3)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BXJP86	Methyl 4-hydroxy-2-oxo-4-phenylbut-3-enoate	Investigative	514095; 5395730	C11H10O4	206.19	COC(=O)C(=O)C=C(C1=CC=CC=C1)O	EC50 > 250000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BY28GF	(3S,5S)-4-Benzyl-3-[(R)-hydroxy-(4-methoxyphenyl)methyl]-1-(methoxymethoxy)-5-(2-methylpropyl)piperazine-2,6-dione	Investigative	70683948	C25H32N2O6	456.5	CC(C)C[C@H]1C(=O)N(C(=O)[C@@H](N1CC2=CC=CC=C2)[C@@H](C3=CC=C(C=C3)OC)O)OCOC	IC50 > 200000 nM	Non binder
T32369	Influenza Polymerase acidic endonuclease	BY97JD	(3S,5Z)-3,4-Dibenzyl-1-(methoxymethoxy)-5-[(4-methoxyphenyl)methylidene]piperazine-2,6-dione	Investigative	70690225	C28H28N2O5	472.5	COCON1C(=O)[C@@H](N(/C(=C\\C2=CC=C(C=C2)OC)/C1=O)CC3=CC=CC=C3)CC4=CC=CC=C4	IC50 > 200000 nM	Non binder