Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16987 | Target Info | |||
| Target Name | Carbonic anhydrase XII (CA-XII) | ||||
| Synonyms |
Tumor antigen HOM-RCC-3.1.3; Carbonic anhydrase 12; Carbonate dehydratase XII
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| Target Type | Successful Target | ||||
| Gene Name | CA12 | ||||
| Biochemical Class | Alpha-carbonic anhydrase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 67 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Temozolomide
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|
Approved | Compound Info | ||
| Synonyms |
Methazolastone; Temodal; Temodar; Temozolamide; Temozolodida; Temozolomidum; Essex brand of temozolomide; Scheringbrand of temozolomide; Temozolodida [Spanish]; Temozolomidum [Latin]; M B 39831; MB 39831; Sch 52365; M & B 39831; M&B 39831; M-39831; Sch-52365; Schering-Plough brand of temozolomide; TMZ-Bioshuttle; Temodal (TN); Temodar (TN); Temozolomide [INN:BAN]; M&B-39831; Temozolomide (JAN/USAN/INN); 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-1,2,3,5-tetrazine-8-carboxamide; 3,4-Dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide; 3-Methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamide; 3-Methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetraazine-8-carboxamide; 3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide; 8-Carbamoyl-3-methylimidazo(5,1-d)-1,2,3,5-tetrazin-4(3H)-one; TMZ
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Chlorambucil
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Approved | Compound Info | ||
| Synonyms |
Ambochlorin; Amboclorin; Chlocambucil; Chloorambucol; Chlorambucilum; Chloraminophen; Chloraminophene; Chlorbutin; Chlorbutine; Chlorbutinum; Chloroambucil; Chlorobutin; Chlorobutine; Clorambucile; Clorambucilo; Ecloril; Elcoril; Elcorin; Leukeran; Leukersan; Leukoran; Linfolizin; Linfolysin; Lympholysin; Clorambucile [DCIT]; Glaxo Wellcome Brand of Chlorambucil; GlaxoSmithKline Brand of Chlorambucil; Leuk ersan; Leukeran tablets; Phenylbutyric acid nitrogen mustard; Wellcome Brand of Chlorambucil; C0253; CB 1348; CB1348; Cb l348; CB-1348; Chlorambucil [INN:BAN]; Chlorambucilum [INN-Latin]; Clorambucilo [INN-Spanish]; LEUKERAN (TN); Leukeran (TN); Phenylbuttersaeure-lost; Phenylbuttersaeure-lost[German]; Chlorambucil (USP/INN)
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|
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Tirapazamine
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Phase 3 | Compound Info | ||
| Synonyms |
TPZ; Tirazone; SR-259075; SR-4233; SR-4317; SR-4330; SR-4482; Win-59075
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
PMID30074415-Compound-20
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Patented | Compound Info | ||
| Activity |
Ki = 95200 nM
|
[2] | |||
| Compound Name |
Phenformin
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Withdrawn from market | Compound Info | ||
| Synonyms |
Azucaps; Cronoformin; DBI; Debeone; Debinyl; Diabis; Dibein; Dibiraf; Dibotin; Dipar; Feguanide; Fenfoduron; Fenformin; Fenformina; Fenormin; Glukopostin; Glyphen; Insoral; Lentobetic; Meltrol; Normoglucina; Pedg; Phenethyldiguanide; Phenformine; Phenforminum; Phenformix; Phenylethylbiguanide; Retardo; D Bretard; DB Comb; DBI monohydrochloride; Phenformine HCl; Phenoformine hydrochloride; W 32; Beta-PEBG; Beta-Phenethybiguanide; Beta-Phenethylbiguanide; Db-retard; Debeone (TN); Fenformina [INN-Spanish]; Meltrol-50; N-Phenethylbiguanide hydrochloride; Phenformin (BAN); Phenformin [INN:BAN]; Phenformine [INN-French]; Phenforminum [INN-Latin]; N'-beta-Fenetilformamidiniliminourea; N'-beta-Fenetilformamidiniliminourea [Italian]; N'-beta-Phenethylformamidinylliminourea; N-(2-Phenylethyl)imidodicarbonimidic diamide; PHENFORMIN (SEE ALSO PHENFORMIN HYDROCHLORIDE 834-28-6); 1-(diaminomethylidene)-2-phenethylguanidine; 1-Phenethylbiguanide
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Phenyl Boronic acid
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Investigative | Compound Info | ||
| Synonyms |
Phenylboronic acid
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
VE-821
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Investigative | Compound Info | ||
| Synonyms |
ATR serine/threonine protein kinase inhibitors (cancer), Oxford University; ATR serine/threonine protein kinase inhibitors (cancer), Vertex Pharmaceuticals
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
Benzo[c][1,2]oxaborol-1(3H)-ol
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Investigative | Compound Info | ||
| Synonyms |
5735-41-1; 1-Hydroxy-2,1-benzoxaborolane; benzo[c][1,2]oxaborol-1(3H)-ol; 2,1-benzoxaborol-1(3h)-ol; monoester; 1,3-dihydro-1-hydroxy-2,1-benzoxaborole; 1,3-DIHYDRO-2,1-BENZOXABOROL-1-OL; 2,1-Benzoxaborole, 1,3-dihydro-1-hydroxy-; CHEBI:78238; 1-hydroxy-3H-2,1-benzoxaborole; 2-(Hydroxymethyl)phenylboronic Acid Cyclic Monoester; 2-(HYDROXYMETHYL)PHENYLBORONIC ACID, DEHYDRATE; KSC-6-288; NSC719278; PubChem5079; 2,1-benzoxaborol-1-ol; 2-Oxa-1-boraindan-1-ol; AMTB152; C7H7BO2; 3H-2,1-benzoxaborol-1-ol; 1-hydroxy-2,1-benzoxaborole
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
3,5-difluorophenol
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|
Investigative | Compound Info | ||
| Synonyms |
3,5-Difluorophenol; 2713-34-0; Phenol, 3,5-difluoro-; 3,5-difluoro phenol; 3,5-difluoro-phenol; Phenol,3,5-difluoro-; HJSSBIMVTMYKPD-UHFFFAOYSA-N; MFCD00002255; 3,5difluorophenol; 3,5-difluorphenol; 3.5-difluorophenol; PubChem1496; phenol derivative, 6; ACMC-209gvc; AC1Q4NDO; AC1L2PTJ; 3,5-Difluorophenol, 99%; KSC203O5T; SCHEMBL156265; AC1Q78L9; CHEMBL259068; CTK1A3759; BDBM26192; HJSSBIMVTMYKPD-UHFFFAOYSA-; DTXSID10181596; ABLOCK AB-12-1639; MolPort-000-154-449; ZINC406989; ACT11666; JRD-0083; CS-D1731; SBB085756; ANW-26134
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| Activity |
Ki = 70220 nM
|
[4] | |||
| Compound Name |
(1R,2S)-2-[(2,3-Dibromo-4,5-dimethoxyphenyl)methyl]cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4082617; BDBM50233595
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
Benzyl 4-[2-[(4-sulfamoylphenyl)carbamoylamino]ethyl]piperazine-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4081575; BDBM50237173
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
(1R,2S)-2-[(2,6-Dibromo-3,4-dimethoxyphenyl)methyl]cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060739; BDBM50233594
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
N-(4-Sulfamoylphenyl)-2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067239; BDBM50237182
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
(1R,2R)-2-[(2,3,6-Tribromo-4,5-dimethoxyphenyl)methyl]cyclopropane-1-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099098; BDBM50233551
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
2-[4-(4-Methylphenyl)piperazin-1-yl]-N-(4-sulfamoylphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094688; BDBM50237195
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
Ethyl (1R,2S)-2-[(2,6-dibromo-3,4-dimethoxyphenyl)methyl]cyclopropane-1-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095455; BDBM50233547
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylic acid; 1H-Pyrazole-3-carboxylicacid, 5-(4-methoxyphenyl)-; 5-(4-Methoxy-phenyl)-1H-pyrazole-3-carboxylic acid; CHEMBL1532040; 5-(4-methoxyphenyl)-2H-pyrazole-3-carboxylic acid; 5-(4-Methoxy-phenyl)-2H-pyrazole-3-carboxylic acid; MLS-0091962.0001; MFCD03716564; 3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylicacid; SCHEMBL1413939; SCHEMBL14152359; BDBM45777; cid_1085887; CTK1A1583; CTK7A3142; KS-00001NGG; DTXSID40949823; ALBB-006557; KS-00000EZ2; ZINC3882498; ANW-51012; BBL008305; BDBM50096128; HTS000455; KM2793; RW2315; SBB006940; STK299947; AKOS000147051; AKOS000264928; AB15826; BS-4260; CS-W022248; DS-0120; MCULE-3575361861; 5-p-methoxy-phenyl-3-pyrazolecarboxylic; AK-17517; BR-17517; AB0023869; DB-001927; ST4133992; AM20060584; BB 0217969; BB 0258868; FT-0688914; W5020; EN300-83622; VU0607276-1; 3-(4-methoxyphenyl)pyrazole-5-carboxylic acid; 5-(4-methoxyphenyl)pyrazole-3-carboxylic acid; S-4096; SR-01000325126; 1H-Pyrazole-3-carboxylicacid,5-(4-methoxyphenyl)-; J-016668; J-516255; SR-01000325126-1; 5-(4-methoxy-phenyl)-2 h-pyrazole-3-carboxylic acid; BRD-K65870873-001-01-5; Z57044182; F3250-0569; 3-(4-Methoxyphenyl)-1H-pyrazole-5-carboxylic acid, 97%; 5-(4-METHOXY-PHENYL)-2H-PYRAZOLE-3-CARBOXYLICACID; 5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid, AldrichCPR
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
[(3-Methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonyl)amino] sulfamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091278; BDBM50226856
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| Activity |
Ki ~ 50000 nM
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[1] | |||
| Compound Name |
N-Methylsaccharin
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Investigative | Compound Info | ||
| Synonyms |
2-Methylbenzo[d]isothiazol-3(2H)-one 1,1-dioxide; 2-Methyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide; UNII-T63VBY3AYH; 2-methyl-1,1-dioxo-1,2-benzothiazol-3-one; NSC 39120; T63VBY3AYH; CHEMBL131790; 2-Methyl-1,2-benzisothiazole-3(2H)-one-1,1-dioxide; 1,2-Benzisothiazol-3(2H)-one, 2-methyl-, 1,1-dioxide; 2-methyl-1,2-benzothiazol-3(2H)-one 1,1-dioxide; Methylsaccharin; NSC39120; EINECS 239-466-7; AI3-23674; 2-Methyl-1,1-dioxide; SCHEMBL107126; 1,2-Benzisothiazolin-3-one, 2-methyl-, 1,1-dioxide; 1, 2-methyl-, 1,1-dioxide; DTXSID10165639; KS-000013ZW; ZINC1671133; 7756AA; BBL023072; BDBM50496471; MFCD00059263; NSC-39120; RW3386; STL293362; AKOS016011169; DS-6404; MCULE-4320541414; AK121869; DB-007773; FT-0650583; H2468; M0427; 2-methyl-1,1-dioxo-benzo[d]isothiazol-3-one; A20846; Q27289719; 1,2-Benzisothiazolin-3-one, 2-methyl-, 1,1-dioxide (8CI); 2-Methyl-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one
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| Activity |
Ki ~ 50000 nM
|
[8] | |||
| Compound Name |
2-[4-(4-Chlorophenyl)piperazin-1-yl]-N-(4-sulfamoylphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104861; BDBM50237196; SR-01000594961; SR-01000594961-1
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| Activity |
Ki ~ 50000 nM
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[6] | |||
| Compound Name |
Ethyl (1R,2S)-2-[(2-bromo-4,5-dimethoxyphenyl)methyl]cyclopropane-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087756; BDBM50233546
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
3-(3,4-Dimethylphenyl)-1H-pyrazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
5-(3,4-dimethylphenyl)-1H-pyrazole-3-carboxylic acid; MLS-0091994.0001; 3-(3,4-dimethylphenyl)pyrazole-5-carboxylic acid; SCHEMBL1413940; CHEMBL1570910; BDBM45838; cid_4598704; CTK7J0812; CTK8F6402; ALBB-004590; KS-00001NH7; ZINC6849143; 0761AD; HTS005211; MFCD05170048; SBB014039; STK501290; AKOS000266408; AKOS002657248; MCULE-6858085780; NE32474; BS-10094; AB0174296; ST4139960; BB 0239282; L-4411; F3250-0624; Z111781308; 5-(3,4-Dimethyl-phenyl)-2H-pyrazole-3-carbo xylic acid
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
5-(4-Chlorophenyl)-1H-pyrazole-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid; 1H-Pyrazole-3-carboxylicacid, 5-(4-chlorophenyl)-; SMR000109742; MLS000113852; CHEMBL129261; 5-(4-Chloro-phenyl)-2H-pyrazole-3-carboxylic acid; MFCD03715908; 3-(4-chlorophenyl)pyrazole-5-carboxylic acid; 3-(4-Chlorophenyl)-1H-pyrazole-5-carboxylic acid, AldrichCPR; SCHEMBL645330; cid_738819; BDBM44423; CTK1H2732; CTK5G1341; KS-00000EYY; DTXSID001008344; HMS2184I09; ALBB-012101; ZINC4139217; ANW-51015; BBL011724; BDBM50096131; HTS000461; RW2321; SBB006938; STK061341; AKOS000263427; AKOS000265792; AB15822; CS-W006564; FS-1859; MCULE-9822572395; AK-17505; BR-17505; AB0001097; DB-021658; ST4066213; AM20060787; BB 0219128; BB 0310051; EU-0008277; FT-0677056; FT-0688915; W6831; 5-(4-Chlorophenyl)pyrazole-3-carboxylic Acid; EN300-26175; C-1505; L-3434; MLS-0040500.0001; 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOICACID; J-516227; 1H-pyrazole-5-carboxylic acid, 3-(4-chlorophenyl)-; 5-(4-chloro-phenyl)-2 h-pyrazole-3-carboxylic acid; F0914-5977; 2-(4-CHLOROPHENYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID
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| Activity |
Ki = 50000 nM
|
[7] | |||
| Compound Name |
1-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074004; BDBM50237174
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
4-[[4-(Dimethylamino)phenyl]methylamino]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3759945; ZINC3852427; BDBM50139131; AKOS002639550
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| Activity |
Ki ~ 50000 nM
|
[9] | |||
| Compound Name |
3-[(3-Bromophenyl)methoxy]-1,2-benzothiazole 1,1-dioxide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3125558; BDBM50496466
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| Activity |
Ki ~ 50000 nM
|
[8] | |||
| Compound Name |
6-(4-Methylsulfonylphenyl)-N-phenyl-3-(sulfamoylamino)pyrazine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4073065; SCHEMBL17806396; BDBM50226745
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| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
2beta-(2,3-Dibromo-4,5-dimethoxybenzyl)cyclopropane-1beta-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063516; BDBM50233550
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
1-[2-(4-Benzylpiperazin-1-yl)ethyl]-3-(4-sulfamoylphenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080884; BDBM50237197
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
1-(4-Sulfamoylphenyl)-3-[2-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethyl]urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094554; BDBM50237190
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
3-(4-Isopropylphenyl)-1H-pyrazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
3-(4-propan-2-ylphenyl)-1H-pyrazole-5-carboxylic acid; MLS-0091970.0001; 3-[4-(propan-2-yl)phenyl]-1H-pyrazole-5-carboxylic acid; 5-[4-(Propan-2-yl)phenyl]-1H-pyrazole-3-carboxylic acid; 3-[4-(methylethyl)phenyl]pyrazole-5-carboxylic acid; cid_975396; SCHEMBL1414110; CHEMBL1605831; BDBM45816; KS-00001NH9; ZINC6839339; BBL007572; MFCD05170043; SBB039866; STL145881; AKOS000266713; AKOS008968051; MCULE-3793457219; NCGC00334535-01; 3-p-cumenyl-1H-pyrazole-5-carboxylic acid; BB 0239277; ST50109063; T9709; VU0049588-2; AB00335700-03; SR-01000269696; SR-01000269696-1; 5-(4-Isopropylphenyl)-1H-pyrazole-3-carboxylic acid; 5-(4-Isopropyl-phenyl)-2H-pyrazole-3-carbox ylic acid; F3250-0570
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| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
2beta-(2,6-Dibromo-3,4-dimethoxybenzyl)cyclopropane-1beta-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091363; BDBM50233597
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
1-[2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098919; BDBM50237175
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
Ethyl (1R,2R)-2-[(2,3-dibromo-4,5-dimethoxyphenyl)methyl]cyclopropane-1-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086787; BDBM50233535
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| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]-N-(4-sulfamoylphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061487; BDBM50237185
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
1-[2-[4-(4-Acetylphenyl)piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068266; BDBM50237178
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| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
3-(4-Methylphenyl)-1H-pyrazole-5-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
3-(p-Tolyl)-1H-pyrazole-5-carboxylic acid; 5-(4-methylphenyl)-1h-pyrazole-3-carboxylic acid; 5-p-Tolyl-1H-pyrazole-3-carboxylic acid; 5-p-Tolyl-2H-pyrazole-3-carboxylic acid; CHEMBL341154; 5-(4-methylphenyl)-2H-pyrazole-3-carboxylic acid; 3-p-tolyl-1h-pyrazole-5-carboxylic acid; 5-(p-Tolyl)-1H-pyrazole-3-carboxylic acid; 3-(4-methylphenyl)pyrazole-5-carboxylic acid; MLS000124028; 1H-Pyrazole-3-carboxylic acid, 5-(4-methylphenyl)-; cid_818267; SCHEMBL1413993; 3-(4-METHYLPHENYL)-1H-PYRAZOLE-5-CARBOXYLICACID; SCHEMBL15094586; CTK1D5064; KS-00001NGQ; KS-00003HQT; DTXSID10355932; ALBB-006819; ZINC5126258; 4693AC; BBL008302; BDBM50132133; HTS000458; KM2794; MFCD03030169; MFCD04209141; SBB006942; STK299946; AKOS000263469; AKOS000271407; AB20803; BS-4122; MCULE-7007143054; NE12837; SMR000124591; 5-p-tolyl-2 h-pyrazole-3-carboxylic acid; AB0001096; ST4140388; BB 0217970; FT-0677278; 5-(4-Methylphenyl)pyrazole-3-carboxylic Acid; EN300-26176; VU0607278-1; MLS-0091963.0001; AF-399/40987696; J-510735; 1H-Pyrazole-5-carboxylic acid, 3-(4-methylphenyl)-; 3-p-Tolyl-1H-pyrazole-5-carboxylic acid, AldrichCPR; Z57683741; F3250-0576; 3-(4-Methylphenyl)-1H-pyrazole-5-carboxylic acid, AldrichCPR; 5-(4-Methylphenyl)-1H-pyrazole-3-carboxylic acid, AldrichCPR
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||||
| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
1-[2-(4-Phenylpiperazin-1-yl)ethyl]-3-(4-sulfamoylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099828; BDBM50237191; AKOS006910333
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|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
3-[4-(Methylaminomethyl)phenyl]-5-[6-(4-propan-2-ylsulfonylphenyl)-3-(sulfamoylamino)pyrazin-2-yl]-1,2-oxazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099032; SCHEMBL17806463; BDBM50226747
Click to Show/Hide
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||||
| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Compound Name |
[(1R,2R)-2-[(3,4-Dimethoxyphenyl)methyl]cyclopropyl]methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089410; BDBM50233543
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
1-[2-(4-Benzhydrylpiperazin-1-yl)ethyl]-3-(4-sulfamoylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4059623; BDBM50237170
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(4-Benzhydrylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091108; BDBM50237194
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
1-[2-(4-Pyrimidin-2-ylpiperazin-1-yl)ethyl]-3-(4-sulfamoylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102291; BDBM50237177
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|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4083316; BDBM50237171; ZINC21847639; AKOS000811226; MCULE-4754847454; Z46205348; F0307-0509; 2-{4-[(2H-1,3-benzodioxol-5-yl)methyl]piperazin-1-yl}-N-(4-sulfamoylphenyl)acetamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
1-[2-[4-(4-Fluorophenyl)piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072947; BDBM50237192
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
1-[2-[4-(4-Methylphenyl)piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4084329; BDBM50237176
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
(1R,2S)-2-[(3,4-Dimethoxyphenyl)methyl]cyclopropane-1-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068228; BDBM50233539
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[5] | |||
| Compound Name |
2-[4-(4-Bromophenyl)piperazin-1-yl]-N-(4-sulfamoylphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086993; BDBM50237181
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|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
3-(2,4-Dimethylphenyl)-1H-pyrazole-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-(2,4-DIMETHYLPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID; MLS-0091993.0001; 3-(2,4-dimethylphenyl)pyrazole-5-carboxylic acid; 5-(2,4-dimethylphenyl)-2H-pyrazole-3-carboxylic Acid; SCHEMBL1413956; CHEMBL1532279; BDBM45837; cid_4274816; CTK6B6665; KS-00001NGU; ALBB-020842; ZINC6849075; BBL008313; MFCD05170046; SBB014029; STK392448; AKOS000139316; AKOS000266418; MCULE-3500830747; NE37219; VS-01882; ST4140378; BB 0219054; L-4408; F3250-0622; 1H-pyrazole-5-carboxylic acid, 3-(2,4-dimethylphenyl)-
Click to Show/Hide
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||||
| Activity |
Ki ~ 50000 nM
|
[7] | |||
| Compound Name |
4-(1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3h)-yl)butanenitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3125557; NSC45115; 4-(1,1,3-trioxo-1,2-benzothiazol-2-yl)butanenitrile; SCHEMBL10908151; CTK4A1768; DTXSID70286379; ZINC1677219; BBL025590; BDBM50496472; NSC-45115; STL364462; AKOS000167290; MCULE-3250413846; T7274; 1,2-Benzisothiazole-2(3H)-butanenitrile,3-oxo-, 1,1-dioxide; 4-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)butanenitrile; 2-(3-Cyanopropyl)-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[8] | |||
| Compound Name |
2-(4-Benzylpiperazin-1-yl)-N-(4-sulfamoylphenyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1518113; SMR000074218; N-[4-(aminosulfonyl)phenyl]-2-(4-benzyl-1-piperazinyl)acetamide; CBKinase1_004086; CBKinase1_016486; MLS000099526; MLS002545828; HMS2184L14; BDBM50237183; ZINC20058159; AKOS001695407; MCULE-1488349731; ST086367; EU-0016775; BRD-K62327261-001-01-9; 2-[4-benzylpiperazinyl]-N-(4-sulfamoylphenyl)acetamide; N-[4-(aminosulfonyl)phenyl]-2-(4-benzylpiperazin-1-yl)acetamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
1-[2-[4-[Bis(4-fluorophenyl)methyl]piperazin-1-yl]ethyl]-3-(4-sulfamoylphenyl)urea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089446; BDBM50237193
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||||
| Activity |
Ki ~ 50000 nM
|
[6] | |||
| Compound Name |
(2S)-2-[[(Tert-Butyloxycarbonyl)sulfamoyl]amino]propionic acid methyl ester
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2335234; BDBM50428797
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||||
| Activity |
Ki = 54500 nM
|
[10] | |||
| Compound Name |
N-(N-Boc-sulfamoyl)glycine Methyl Ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL450699; Methyl 2-(Tert-Butoxycarbonylsulfamoylamino)Acetate; methyl (N-(tert-butoxycarbonyl)sulfamoyl)glycinate; BDBM50428799; MFCD23134041; CS-12553; SY060757; [[(tert-Butyloxycarbonyl)sulfamoyl]amino]acetic acid methyl ester
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||||
| Activity |
Ki = 56300 nM
|
[10] | |||
| Compound Name |
Triethylenetetramine
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Investigative | Compound Info | ||
| Synonyms |
trientine; Trien; Tecza; 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-; Triethylene tetramine; Araldite hardener HY 951; DEH 24; Araldite HY 951; 1,4,7,10-Tetraazadecane; 1,8-Diamino-3,6-diazaoctane; N,N'-Bis(2-aminoethyl)-1,2-ethanediamine; Syprine; 3,6-Diazaoctane-1,8-diamine; N,N'-Bis(2-aminoethyl)ethylenediamine; NSC 443; UNII-SJ76Y07H5F; HY 951; MFCD00008169; triethylenetetraamine; 2,2,2-tetramine; Ethylenediamine, N,N'-bis(2-aminoethyl)-; N,N'-bis(2-aminoethyl)ethane-1,2-diamine; CHEMBL609; N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine; 3,6-Diazaoctanethylenediamin; SJ76Y07H5F; NSC-443; 1,2-Ethanediamine, N1,N2-bis(2-aminoethyl)-; NCGC00091695-01; NCGC00091695-03; DSSTox_CID_3702; Triethylenetetramine, 60%; DSSTox_RID_77156; DSSTox_GSID_23702; N1,N1'-(Ethane-1,2-diyl)diethane-1,2-diamine; Trientinum; Trientina; Trientinum [INN-Latin]; Trientina [INN-Spanish]; CCRIS 6279; HSDB 1002; (2-aminoethyl){2-[(2-aminoethyl)amino]ethyl}amine; EINECS 203-950-6; UN2259; BRN 0605448; triene; Trientene; N,N-Bis(2-aminoethyl)-1,2-diaminoethane; AI3-24384; 1,6-diazaoctane; EPH 925; Trientine [INN]; 3,8-diamine; Tomography, x-ray computed trientine; triethylene tetraamine; 1,7,10-Tetraazadecane; bmse000773; Texlin 300 (Salt/Mix); ACMC-1C99K; SCHEMBL15439; WLN: Z2M2M2Z; 4-04-00-01242 (Beilstein Handbook Reference); BIDD:ER0303; BIDD:GT0014; NSC443; SCHEMBL6423840; DTXSID9023702; CTK8A9256; KS-00000WWF; STR03562; Tox21_111162; Tox21_201066; ANW-16423; BDBM50323751; SBB058767; STL477736; ZINC19364225; N,N'-Di(2-aminoethyl)ethylenediamine; AKOS006223906; Tox21_111162_1; Triethylenetetramine, >=97.0% (T); DB06824; Ethylenediamine,N'-bis(2-aminoethyl)-; MCULE-3203769500; NCGC00091695-04; NCGC00258619-01; BP-30180; Ethanediamine, N,N'-bis(2-aminoethyl)-; SBI-0206814.P001; DB-041060; N,N'-Bis(2-aminoethyl)-1,2-diaminoethane; Triethylenetetramine, technical grade, 60%; ST50824040; Triethylenetetramine [UN2259] [Corrosive]; 12T243; C07166; AB00573244_07; N,N''-Bis-(2-amino-ethyl)-ethane-1,2-diamine; 133105-EP2272849A1; 133105-EP2295438A1; Q418386; J-018026; N,N''-BIS(2-AMINOETHYL)-1,2-ETHANEDIAMINE; W-109064
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||||
| Activity |
Ki = 57000 nM
|
[11] | |||
| Compound Name |
Methyl 3-(Butylsulfamoylamino)Propanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL199831; BDBM50428800
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||||
| Activity |
Ki = 61200 nM
|
[10] | |||
| Compound Name |
Methyl 3-[(2-Hydroxyphenoxy)Sulfonylamino]Propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL466083; BDBM50428796; methyl 3-{[(2-hydroxyphenoxy)sulfonyl]amino}propanoate
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||||
| Activity |
Ki = 65000 nM
|
[10] | |||
| Compound Name |
Methyl 3-[[(2-methylpropan-2-yl)oxycarbonyl-(2-propylpentyl)sulfamoyl]amino]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL511132; BDBM50428798
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||||
| Activity |
Ki = 65400 nM
|
[10] | |||
| Compound Name |
N,N'-Bis(2-aminoethyl)-1,3-propanediamine
Click to Show/Hide
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Investigative | Compound Info | ||
| Synonyms |
1,4,8,11-Tetraazaundecane; 2,3,2-Tetramine; N,N'-Bis(2-aminoethyl)propane-1,3-diamine; N1,N1'-(Propane-1,3-diyl)bis(ethane-1,2-diamine); 1,3-Propanediamine, N,N'-bis(2-aminoethyl)-; 1,4,8,11-Tetrazaundecane; Ethylenetrimethyleneethylenetetramine; 1,9-Diamino-3,7-diazanonane; 3,7-Diazanonane-1,9-diamine; UNII-3J941O9333; 2,3,2-tet; N,N-Bis(2-aminoethyl)-1,3-propanediamine; 3,7-Diaza-1,9-nonanediamine; CHEMBL1214193; MFCD00008174; 3J941O9333; 1,3-Propanediamine, N1,N3-bis(2-aminoethyl)-; 1,7-diazanonane; C7H20N4; N,3-diamine; NSC19173; 3,9-diamine; EINECS 225-254-1; NSC 19173; AI3-61714; 232-tet; 1,8,11-Tetrazaundecane; 1,3-Propanediamine, N,N-bis(2-aminoethyl)-; 1,8,11-Tetraazaundecane; KSC498C6F; SCHEMBL345134; ACMC-209k96; DTXSID8063591; CTK3J8162; KS-00000GPO; BCP15359; 6461AB; ANW-30520; BDBM50323738; NSC-19173; ZINC19364631; AKOS015900395; DS-5421; N,N'-Bis(2-aminoethyl)-propanediamine; VZ20625; AK112068; SC-54553; FT-0635420; N,N'-bis (2-aminoethyl)-1,3-propanediamine; N,N'-bis(2-aminoethyl)-1,3-pro-panediamine; N,N'-bis(2-aminoethyl)-1,3-propylenediamine; N,N'-bis(2-azanylethyl)propane-1,3-diamine; Diethylenetriamine, 4-(3-aminopropyl)- (8CI); N,N''-bis-(3-aminoethyl)-1,3-propanediamine; N,N???-Bis(2-aminoethyl)-1,3-propanediamine; N,N'-bis-(2-amino-ethyl)-propane-1,3-diamine; 741B995; A827221; N1,N1'-(propane-1,3-diyl)diethane-1,2-diamine; N,N'-Bis(2-aminoethyl)-1,3-propanediamine, 97%; Q27111948; (2-aminoethyl)({3-[(2-aminoethyl)amino]propyl})amine; N,N'-Bis(2-aminoethyl)-1,3-propanediamine, purum, >=97.0% (NT)
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||||
| Activity |
Ki = 68000 nM
|
[11] | |||
| Compound Name |
Methyl 3-[(3-methoxy-3-oxopropyl)sulfamoylamino]propanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL461137; BDBM50428803
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| Activity |
Ki = 70800 nM
|
[10] | |||
| Compound Name |
N,N'-Sulfonyl Bis-L-valine Dimethyl Ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471637; BDBM50428801; Bis[[(S)-1-(methoxycarbonyl)-2-methylpropyl]amino] sulfone; methyl (2S)-2-[[(2S)-1-methoxy-3-methyl-1-oxobutan-2-yl]sulfamoylamino]-3-methylbutanoate
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||||
| Activity |
Ki = 73000 nM
|
[10] | |||
| Compound Name |
N,N'-Dibenzylsulfamide
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|
Investigative | Compound Info | ||
| Synonyms |
Benzyl(Benzylsulfamoyl)Amine; C14H16N2O2S; N,N'-Dibenzylsulfamid; N-(benzylsulfamoyl)-1-phenylmethanamine; N,N''''-Dibenzylsulfamide; Oprea1_472786; MLS000755930; CHEMBL229190; SCHEMBL2298224; n,n'-bis(phenylmethyl)sulfamide; KS-00003FZQ; HMS2586C24; ZINC1403234; BDBM50428812; AKOS005104515; MCULE-5595548882; SMR000337964; 9L-028
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|
||||
| Activity |
Ki = 81500 nM
|
[10] | |||
| Compound Name |
2H-1-Benzothiopyran-2-thione
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Investigative | Compound Info | ||
| Synonyms |
2H-thiochromene-2-thione; dithiocoumarin; thiochromene-2-thione; SCHEMBL8514755; CHEMBL3759932; CTK0J8745; DTXSID30348780; ZINC32299612
Click to Show/Hide
|
||||
| Activity |
Ki = 96000 nM
|
[2] | |||
| Compound Name |
N1,N3-Bis(2-(2,2,2-trifluoroacetamido)ethyl)-propane-1,3-diaminium trifluoroacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214249; BDBM50323746
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|
||||
| Activity |
Ki = 112000 nM
|
[11] | |||
| Compound Name |
Spermine(hbbh)
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Investigative | Compound Info | ||
| Synonyms |
NSC685984; CHEMBL209126; di-boc-spermine; SCHEMBL1274075; CTK8C8100; ZINC5713956; BDBM50184773; MFCD08274632; N4,N8-Bis(t-butoxycarbonyl)spermine; AKOS030214416; NSC-685984; NCI60_030966; di-tert-butyl butane-1,4-diylbis[(3-aminopropyl)carbamate]; N2,N3-Bis-(t-butyloxycarbonyl)-1,5,10,14-tetra-aza-quatrodecan; Carbamic acid, 1,4-butanediylbis[(3-aminopropyl)-,bis(1,1-dimethylethyl) ester
Click to Show/Hide
|
||||
| Activity |
Ki = 165000 nM
|
[11] | |||
| Compound Name |
N1,N12-Bis(trifluoroacetyl)-N4,N8-bis(t-butoxycarbonyl)spermine
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Investigative | Compound Info | ||
| Synonyms |
NSC685983; CHEMBL1212954; SCHEMBL1274571; CTK8C8096; BDBM50323745; NSC-685983; NCI60_030965; di-tert-butyl butane-1,4-diylbis({3-[(trifluoroacetyl)amino]propyl}carbamate)
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|
||||
| Activity |
Ki = 175000 nM
|
[11] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity |
Ki ~ 50000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 15 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Foscavir
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Foscarmet; Foscarnet; Phosphonoformate; Triapten; Virudin; Carboxyphosphonic acid; Dihydroxyphosphanecarboxylic acid oxide; Dihydroxyphosphinecarboxylic acid oxide; Dihydroxyphosphinecarboxylic acid oxide trisodium salt; Dihydroxyphosphinecarboxylic acid oxide trisodium salt hexahydrate; FOSCARNET SODIUM; Forscarnet sodium; Foscarnet sodico; Foscarnet sodico [Spanish]; Foscarnet sodique; Foscarnet sodique [French]; Foscarnet sodium hexahydrate; Foscarnet sodium hydrate; Foscarneto sodico; Foscarnetum natricum; Foscarnetum natricum [Latin]; Phgosphonocarboxylic acid; Phosphonoformic acid; Phosphonomethanoic acid; Trisodium carboxyphosphate; Trisodium dioxidophosphanecarboxylate oxide; Trisodium dioxidophosphinecarboxylate oxide; Trisodium phosphonatoformate; Trisodium phosphonatoformate hexahydrate; Trisodium phosphonoformate; Trisodium phosphonoformate hexahydrate; Trisodium phosphonoformte hexahydrate; A 29622; EHB 776; A-29622; DRG-0017; Dihydroxyphosphinecarboxylic acid oxide and MSL, neutralizing monoclonal antibody; EHB-776; Foscarnet sodique [INN-French]; Foscarnet sodium hydrate (JAN); Foscarneto sodico [INN-Spanish]; Foscarnetum natricum [INN-Latin]; Foscavir (TN); HS-0008; MSL & PFA; Phosphonoformic acid, trisodium salt; Trisodium carboxyphosphate (anhydrous); Trisodium phosphonoformate (anhydrous); Foscarnet & IFN-ALPHA; Foscarnet sodium (USAN/INN); Foscarnet sodium [USAN:INN:BAN]; Phosphonoformic acid & IFN-ALPHA; Phosphonoformic acid, trisodium salt, hexahydrate; PFA & rIFN.alpha.A; Phosphinecarboxylic acid, dihydroxy-, oxide; Phosphonoformate(trisodium) & Recombinant Alpha-A Interferon; Sodium dioxidophosphanecarboxylate oxide hydrate(3:1:6); Formic acid, phosphono-, trisodium salt, hexahydrate; Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt; Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt, hexahydrate
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|
||||
| Activity |
Ki = 1290000 nM
|
[12] | |||
| Compound Name |
SULFAMIDE
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|
Phase 1 | Compound Info | ||
| Synonyms |
Sulfuric diamide; 7803-58-9; Sulfamamide; Sulfuryl amide; Sulfuryl diamide; Sulfonyl diamide; sulfamoylamine; sulphamide; Sulphuric diamide; UNII-VS7TZW634V; Imidosulfamic acid; H4N2O2S; H2NSO2NH2; VS7TZW634V; CHEMBL355001; CHEBI:29368; NVBFHJWHLNUMCV-UHFFFAOYSA-N; MFCD00011606; Sulfamide, 98+%; Imidosulfamic acid (VAN); aminosulfonamide; NSC 252; diamidodioxidosulfur; EINECS 232-262-9; Sulfamide, 99%; AI3-30237; NH2SO2NH2; AC1Q55HN; KSC377O7F; NSC252; AC1L332P; DTXSID5064885; CTK2H7772; BDBM26995; NSC-252; MolPort-000-146-081
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|
||||
| Activity |
Ki = 830000 nM
|
[13] | |||
| Compound Name |
4-AMINOPHENOL
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|
Investigative | Compound Info | ||
| Synonyms |
4-aminophenol; 123-30-8; p-aminophenol; 4-hydroxyaniline; p-hydroxyaniline; Phenol, 4-amino-; Paranol; Certinal; Citol; Azol; 4-aminobenzenol; Fouramine P; Ursol P Base; Rodinal; p-Hydroxyphenylamine; Benzofur P; Fourrine P Base; Pelagol P Base; Tertral P Base; Ursol P; Furro P Base; Nako Brown R; Durafur Brown RB; 4-Amino-1-hydroxybenzene; Renal AC; Fourrine 84; Phenol, p-amino-; Zoba Brown P Base; 4-AMINO-PHENOL; UNAL; C.I. Oxidation Base 6; 1-Amino-4-hydroxybenzene; Pelagol Grey P Base; BASF Ursol P Base; p-Aminofenol; Para-aminophenol
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| Activity |
Ki = 479000 nM
|
[14] | |||
| Compound Name |
2,5-difluorophenol
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Investigative | Compound Info | ||
| Synonyms |
2,5-Difluorophenol; 2713-31-7; Phenol, 2,5-difluoro-; 1,4-Difluoro-2-hydroxybenzene; Phenol,2,5-difluoro-; INXKVYFOWNAVMU-UHFFFAOYSA-N; 2,5-difluorphenol; MFCD00042501; 2,5-Difluorophenol;2,5-Difluorophenol;; NSC10288; PubChem3464; phenol derivative, 5; 2,5-difluoro-phenol; 2,5-difluoro phenol; ACMC-209gva; 2,5-Difluorophenol 97%; AC1Q78DB; SCHEMBL70273; 2,5-Difluorophenol, 95%; KSC493C1H; CHEMBL261219; AC1L3T96; INXKVYFOWNAVMU-UHFFFAOYSA-; BDBM26191; CTK3J3113; DTXSID90181594; MolPort-000-154-447; ZINC409280; CS-D1368; JRD-0251
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| Activity |
Ki = 598000 nM
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[14] | |||
| Compound Name |
Phenylarsonic acid
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Investigative | Compound Info | ||
| Synonyms |
BENZENEARSONIC ACID; 1998/5/5; Monophenylarsonic acid; Arsonic acid, phenyl-; UNII-57F9KU116M; Kyselina benzenarsonova [Czech]; HSDB 6381; EINECS 202-631-9; NSC 15566; Arsonic acid, As-phenyl-; BRN 2935741; AI3-16050; CHEMBL364571; CHEBI:29851; 57F9KU116M; Kyselina benzenarsonova; C6H7AsO3; benzenarsonic acid; Benzenearsonie acid; ACMC-20ajwq; PhAsO3H2; PhAsO(OH)2; AC1Q1HDM; AC1L1OLG; KSC489M9F; 4-16-00-01183 (Beilstein Handbook Reference); SCHEMBL707127; WLN: Q-AS-QO & DTXSID6059158; CTK3I9692; BDBM26997
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| Activity |
Ki = 840000 nM
|
[15] | |||
| Compound Name |
N-(Dipropylsulfamoyl)-N-propylpropan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL441884; BDBM50428805
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| Activity |
Ki > 200000 nM
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[10] | |||
| Compound Name |
N,N,N',N'-Tetrabutylsulfamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL229902; BDBM50428804; N,N,N'''',N''''-Tetrabutylsulfamide; N-butyl-N-(dibutylsulfamoyl)butan-1-amine
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| Activity |
Ki > 200000 nM
|
[10] | |||
| Compound Name |
N,N'-Dipropylsulfamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL229740; N,N''''-Dipropylsulfamide; SCHEMBL9651043; N-(propylsulfamoyl)propan-1-amine; BDBM50428809
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| Activity |
Ki > 200000 nM
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[10] | |||
| Compound Name |
N,N'-Sulfonyl Bis-L-alanine Dimethyl Ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL501961; BDBM50428802; methyl (2S)-2-[[(2S)-1-methoxy-1-oxopropan-2-yl]sulfamoylamino]propanoate
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| Activity |
Ki > 200000 nM
|
[10] | |||
| Compound Name |
2-Phenyl-N-(2-phenylethylsulfamoyl)ethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1630902; BDBM50428811
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| Activity |
Ki > 200000 nM
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[10] | |||
| Compound Name |
Di-tert-butylethane-1,2-diylbis(2-(2,2,2-trifluoroacetamido)ethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214322; SCHEMBL10231797; BDBM50323749; 1,10-Bis(trifluoroacetyl)-4,7-bis(tert-butoxycarbonyl)-1,4,7,10-tetraazadecane
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| Activity |
Ki > 500000 nM
|
[11] | |||
| Compound Name |
Di-tert-butylpropane-1,3-diylbis(2-(2,2,2-trifluoroacetamido)-ethylcarbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214320; BDBM50323747
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| Activity |
Ki > 500000 nM
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[11] | |||
| Compound Name |
N1,N2-(2-(2,2,2-Trifluoroacetamido)ethyl)ethane-1,2-diaminium Trifluoroacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1214321; SCHEMBL10231803; BDBM50323748; 2,2,2-trifluoro-N-[2-[2-[2-[(2,2,2-trifluoroacetyl)amino]ethylamino]ethylamino]ethyl]acetamide
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| Activity |
Ki > 500000 nM
|
[11] | |||
| Compound Name |
Sulfamic acid
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Investigative | Compound Info | ||
| Synonyms |
Amidosulfonic acid; Aminosulfonic acid; Sulphamic acid; Amidosulfuric acid; Imidosulfonic acid; Sulfamidic acid; Sulfaminic acid; Jumbo; Sulphamidic acid; Aminosulfuric acid; Kyselina sulfaminova; Kyselina amidosulfonova; sulfuramidic acid; NSC 1871; MFCD00011603; UNII-9NFU33906Q; amidohydroxidodioxidosulfur; H2NSO3H; CHEMBL68253; [S(NH2)O2(OH)]; 9NFU33906Q; Sulfamic acid, 99%; DSSTox_CID_14005; DSSTox_RID_79107; DSSTox_GSID_34005; Caswell No. 809; Kyselina sulfaminova [Czech]; HSDB 795; Kyselina amidosulfonova [Czech]; EINECS 226-218-8; UN2967; SULFAMIC ACID, ACS; EPA Pesticide Chemical Code 078101; SULFAMIC ACID, REAG; sulfoamine; Sulfamidsaeure; AI3-15024; Sulphamic-acid-; Amidoschwefelsaeure; amidosulphuric acid; sulfamic acid group; Sulfamic acid [UN2967] [Corrosive]; WLN: ZSWQ; sulfuric acid amide group; NH2SO3H; Sulfamic acid, ACS grade; ACMC-20a47z; NH3SO3; EC 226-218-8; NCIOpen2_000675; KSC269M4H; ARONIS25155; Molybdenum, Quant Test Strips; DTXSID6034005; BDBM26994; CTK1G9643; NSC1871; Sulfamic acid, p.a., 99.5%; Sulfamic acid, analytical standard; NS([O])(=O)=O; KS-000000UE; NSC-1871; Sulfamic acid, reagent grade, 98%; Tox21_201905; Tox21_303482; 8894AF; ANW-56397; STL282725; 7773-06-0 (mono-ammonium salt); AKOS005287325; Sulfamic acid, ACS reagent, 99.3%; ZINC238809066; MCULE-8047713803; UN 2967; KS-0000472G; NCGC00090927-01; NCGC00090927-02; NCGC00257489-01; NCGC00259454-01; Sulfamic acid [UN2967] [Corrosive]; Sulfamic acid, ReagentPlus(R), >=99%; Sulfamic acid, >=99.5% (alkalimetric); FT-0688102; Sulfamic acid, 99.999% trace metals basis; Sulfamic acid, SAJ first grade, >=99.0%; Sulfamic acid, JIS special grade, >=99.5%; Q412304; W-105754; Sulfamic acid, analytical standard (for acidimetry), ACS reagent
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| Activity |
Ki = 700000 nM
|
[15] | |||
| Compound Name |
2-Hydroxycinnamic acid
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Investigative | Compound Info | ||
| Synonyms |
o-Coumaric acid; trans-2-Hydroxycinnamic acid; 2-Coumaric acid; trans-o-Coumaric acid; trans-o-Hydroxycinnamic acid; 2-Hydroxycinnamate; 2-Coumarate; (E)-o-Hydroxycinnamic acid; trans-2-Hydroxycinnamate; (2E)-3-(2-hydroxyphenyl)prop-2-enoic acid; o-Hydroxy-trans-cinnamic acid; 3-(2-hydroxyphenyl)acrylic acid; (E)-3-(2-Hydroxyphenyl)-2-propenoic acid; (2E)-3-(2-HYDROXYPHENYL)ACRYLIC ACID; 2-Hydroxycinamic acid; (E)-3-(2-hydroxyphenyl)prop-2-enoic acid; trans-2-coumaric acid; (2E)-3-(2-Hydroxyphenyl)-2-propenoic acid; 2-Hydroxycinnamic acid, (E)-; CINNAMIC ACID, o-HYDROXY-, (E)-; UNII-23AU5FZB9C; (E)-2-hydroxycinnamic acid; 2-Propenoic acid, 3-(2-hydroxyphenyl)-, (2E)-; trans-ortho-coumaric acid; MFCD00004379; 2-Propenoic acid, 3-(2-hydroxyphenyl)-, (E)-; 23AU5FZB9C; (2E)-2-hydroxycinnamic acid; 2-Propenoic acid, 3-(2-hydroxyphenyl)-; CHEMBL52564; 2-Hydroxycinnamic acid, predominantly trans; 3-(2-hydroxyphenyl)prop-2-enoic acid; o-coumarate; (E)-3-(2-hydroxyphenyl)acrylic acid; 2-Hydroxy Cinnamic Acid; (E)-3-(2-HYDROXY-PHENYL)-ACRYLIC ACID; 3-(2-hydroxyphenyl)prop-2-enoate; CCRIS 5834; cis-2-hydroxycinnamic acid; EINECS 210-386-4; NSC 32952; BRN 1100900; o-Hydroxycinnamate; 3-(2-Hydroxyphenyl)-2-propenoic acid; trans-o-Coumarate; (2Z)-3-(2-hydroxyphenyl)acrylic acid; ortho-Hydroxycinnamate; PubChem8214; (E)-Coumarinic Acid; (2Z)-3-(2-hydroxyphenyl)acrylate; trans-o-Hydroxycinnamate; (E)-ortho-coumaric acid; o-Hydroxy-trans-cinnamate; (E)-o-Hydroxycinnamicacid; bmse000347; Cinnamic acid, o-hydroxy-; WLN: QV1U1R BQ; SCHEMBL64885; QSPL 150; trans-o-HydroxyzimtsA currencyure; 2-Hydroxycinnamic acid, (2E)-; DTXSID10883240; ZINC895911; ALBB-025832; NSC32952; BBL013048; BDBM50146462; NSC-32952; SBB065726; STK301745; AKOS003790794; CS-W013247; DB01650; MCULE-5451854573; (E)-3-(2-hydroxyphenyl)-acrylic acid; CINNAMIC ACID,2-HYDROXY (TRANS); trans-3-(2-hydroxyphenyl)propenoic acid; AS-12449; ST097457; R1101; C01772; 2-Hydroxycinnamic acid, predominantly trans, 97%; 614H608; 3-(4-OXOQUINAZOLIN-3(4H)-YL)PROPANOICACID; Q7072006; TRANS-2-HYDROXYCINNAMIC ACID; O-COUMARIC ACID; 2-Propenoic acid, 3-(2-hydroxyphenyl)-, (E)- (9CI); F2191-0203; (2E)-3-(2-hydroxyphenyl)acrylic acid predominately trans-; 90E8F55A-AB69-4720-95AF-747C2DCA5471; UNII-2S0H1PX3LM component PMOWTIHVNWZYFI-AATRIKPKSA-N
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| Activity |
Ki > 1000000 nM
|
[16] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs. Eur J Med Chem. 2017 Feb 15;127:691-702. | ||||
| REF 2 | Thioxocoumarins Show an Alternative Carbonic Anhydrase Inhibition Mechanism Compared to Coumarins. J Med Chem. 2016 Jan 14;59(1):462-73. | ||||
| REF 3 | Bortezomib inhibits mammalian carbonic anhydrases. Bioorg Med Chem. 2017 Oct 1;25(19):5064-5067. | ||||
| REF 4 | Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors. Bioorg Med Chem. 2013 Mar 15;21(6):1511-5. | ||||
| REF 5 | Synthesis and carbonic anhydrase isoenzymes I, II, IX, and XII inhibitory effects of dimethoxybromophenol derivatives incorporating cyclopropane moieties. J Med Chem. 2015 Jan 22;58(2):640-50. | ||||
| REF 6 | Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment. J Med Chem. 2017 Mar 23;60(6):2456-2469. | ||||
| REF 7 | 5-Aryl-1H-pyrazole-3-carboxylic acids as selective inhibitors of human carbonic anhydrases IX and XII. Bioorg Med Chem. 2015 Aug 1;23(15):4649-4659. | ||||
| REF 8 | Design, synthesis and evaluation of N-substituted saccharin derivatives as selective inhibitors of tumor-associated carbonic anhydrase XII. Bioorg Med Chem. 2014 Mar 15;22(6):1821-31. | ||||
| REF 9 | Synthesis of 4-sulfamoylphenyl-benzylamine derivatives with inhibitory activity against human carbonic anhydrase isoforms I, II, IX and XII. Bioorg Med Chem. 2016 Mar 1;24(5):982-8. | ||||
| REF 10 | Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV. Bioorg Med Chem. 2013 Mar 15;21(6):1410-8. | ||||
| REF 11 | Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule. J Med Chem. 2010 Aug 12;53(15):5511-22. | ||||
| REF 12 | Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2210-5. | ||||
| REF 13 | Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mamm... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3601-5. | ||||
| REF 14 | Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem. 2008 Aug 1;16(15):7424-8. | ||||
| REF 15 | Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1532-7. | ||||
| REF 16 | Kinetic and docking studies of phenol-based inhibitors of carbonic anhydrase isoforms I, II, IX and XII evidence a new binding mode within the enzyme active site. Bioorg Med Chem. 2011 Feb 15;19(4):1381-9. | ||||
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