Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D07XPE
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| Former ID |
DAP000206
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| Drug Name |
Phenformin
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| Synonyms |
Azucaps; Cronoformin; DBI; Debeone; Debinyl; Diabis; Dibein; Dibiraf; Dibotin; Dipar; Feguanide; Fenfoduron; Fenformin; Fenformina; Fenormin; Glukopostin; Glyphen; Insoral; Lentobetic; Meltrol; Normoglucina; Pedg; Phenethyldiguanide; Phenformine; Phenforminum; Phenformix; Phenylethylbiguanide; Retardo; D Bretard; DB Comb; DBI monohydrochloride; Phenformine HCl; Phenoformine hydrochloride; W 32; Beta-PEBG; Beta-Phenethybiguanide; Beta-Phenethylbiguanide; Db-retard; Debeone (TN); Fenformina [INN-Spanish]; Meltrol-50; N-Phenethylbiguanide hydrochloride; Phenformin (BAN); Phenformin [INN:BAN]; Phenformine [INN-French]; Phenforminum [INN-Latin]; N'-beta-Fenetilformamidiniliminourea; N'-beta-Fenetilformamidiniliminourea [Italian]; N'-beta-Phenethylformamidinylliminourea; N-(2-Phenylethyl)imidodicarbonimidic diamide; PHENFORMIN (SEE ALSO PHENFORMIN HYDROCHLORIDE 834-28-6); 1-(diaminomethylidene)-2-phenethylguanidine; 1-Phenethylbiguanide
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| Drug Type |
Small molecular drug
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| Indication | Diabetic complication [ICD-11: 5A2Y; ICD-9: 253.5, 588.1] | Withdrawn from market | [1] | |
| Therapeutic Class |
Hypoglycemic Agents
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| Company |
Eli Lilly
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| Structure |
 |
Download2D MOL |
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| Formula |
C10H15N5
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| Canonical SMILES |
C1=CC=C(C=C1)CCN=C(N)N=C(N)N
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| InChI |
1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H6,11,12,13,14,15)
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| InChIKey |
ICFJFFQQTFMIBG-UHFFFAOYSA-N
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| CAS Number |
CAS 114-86-3
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| PubChem Compound ID | ||||
| PubChem Substance ID |
9875, 615911, 4583360, 10504499, 11112448, 11364804, 11367366, 11369928, 11372968, 11375528, 11378095, 11466207, 11467327, 11485734, 14773187, 29226965, 46505230, 47217161, 47736859, 47811132, 47960115, 47960116, 48416408, 49698378, 49854764, 50100445, 57288470, 57324876, 78063341, 85787916, 88835501, 94569120, 96025038, 99452969, 103426218, 104098499, 104317320, 117524452, 117879477, 124882390, 124882391, 124882392, 125325517, 125823034, 126687817, 128146967, 131850042, 134223094, 134337521, 134974542
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| ChEBI ID |
CHEBI:8064
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| SuperDrug ATC ID |
A10BA01
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| SuperDrug CAS ID |
cas=000114863
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| Interaction between the Drug and Microbe | Top | |||
|---|---|---|---|---|
| The Abundace of Studied Microbe(s) Regulated by Drug | ||||
| The Order in the Taxonomic Hierarchy of the following Microbe(s): Erysipelotrichales | ||||
|
Studied Microbe: Clostridium cocleatum
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[2] | |||
| Hierarchy | ||||
| Abundance Change | Increase | |||
| Experimental Species | C57BL/6 mice | Experimental Sample | Faeces | |
| Disease or Condition | High fat diet | |||
| Description | The abundance of Clostridium cocleatum was increased by Phenformin. | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Drug information of Phenformin, 2008. eduDrugs. | |||
| REF 2 | Effect of metformin on metabolic improvement and gut microbiota. Appl Environ Microbiol. 2014 Oct;80(19):5935-43. | |||
| REF 3 | Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators. Biochem J. 2008 Jan 15;409(2):449-59. | |||
| REF 4 | Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res. 2000 Oct;10(10):1546-60. | |||
| REF 5 | Mammalian AMP-activated protein kinase subfamily. J Biol Chem. 1996 Jan 12;271(2):611-4. | |||
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