Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15139 | Target Info | |||
| Target Name | Phosphoglycerate dehydrogenase (PHGDH) | ||||
| Synonyms |
PGDH3; Malate dehydrogenase; D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | PHGDH | ||||
| Biochemical Class | Short-chain dehydrogenases reductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 30 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-Phenyl-N-[4-(pyridin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087786; SCHEMBL17593242; BDBM50232868
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
Chembl4127643
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Investigative | Compound Info | ||
| Synonyms |
BDBM50271478
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
Chembl4128162
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL17927194; BDBM50271432
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| Activity |
IC50 = 50000 nM
|
[2] | |||
| Compound Name |
1-(4-Chlorophenyl)-2-morpholino-2-thioxoethan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096521; SCHEMBL19357077; BDBM50230347; alpha-Thioxo-alpha-morpholino-4'-chloroacetophenone; 1-(4-chlorophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone
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| Activity |
IC50 = 50500 nM
|
[3] | |||
| Compound Name |
PHGDH-inactive
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Investigative | Compound Info | ||
| Synonyms |
N-(4,6-dimethylpyridin-2-yl)-4-pyridin-4-ylpiperazine-1-carbothioamide; CHEMBL3559931; SCHEMBL17927189; BDBM195607; ZINC198405642; NCGC00242266-01; NCT-503 Inactive Control, >=98% (HPLC); N-(4,6-dimethyl-2-pyridinyl)-4-(4-pyridinyl)-1-piperazinecarbothioamide
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| Activity |
IC50 ~ 57000 nM
|
[1] | |||
| Compound Name |
N-(3-Methylphenyl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3125071; SCHEMBL20063198; BDBM50232860; AKOS003722051; NCGC00238580-01
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| Activity |
IC50 ~ 57000 nM
|
[1] | |||
| Compound Name |
4-Chloro-N-(2-nitrophenyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4061896; NSC404961; DTXSID30323835; ZINC4377641; BDBM50230351; 4-CHLORO-2'-NITROBENZANILIDE; N-(2-Nitrophenyl)-4-chlorobenzamide; AKOS002983735; MCULE-2248802052; NSC-404961
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| Activity |
IC50 = 57500 nM
|
[3] | |||
| Compound Name |
Chembl4126930
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50271433
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| Activity |
IC50 = 59000 nM
|
[2] | |||
| Compound Name |
1-(4-Fluorophenyl)-2-morpholino-2-thioxoethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060605; SCHEMBL19357126; BDBM50230344; 1-(4-Fluorophenyl)-2-thioxo-2-morpholinoethanone
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| Activity |
IC50 = 64400 nM
|
[3] | |||
| Compound Name |
Ethanone, 2-(morpholin-4-yl)-1-phenyl-2-thioxo-
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086943; 2-morpholin-4-yl-1-phenyl-2-sulfanylideneethanone; NSC158634; SCHEMBL19357132; CTK5A3039; 4-(Benzoylthiocarbonyl)morpholine; DTXSID40970455; ZINC409909; BDBM50230352; AKOS004906874; NSC-158634; 1-Phenyl-2-morpholino-2-thioxoethanone; 2-morpholino-1-phenyl-2-thioxo-1-ethanone; 2-(Morpholin-4-yl)-1-phenyl-2-sulfanylideneethan-1-one
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| Activity |
IC50 = 71700 nM
|
[3] | |||
| Compound Name |
[N+](=O)([O-])C=1C=C(C=CC=1)C(C(=S)N1Ccocc1)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094885; SCHEMBL19357114; BDBM50230361
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|
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| Activity |
IC50 = 88100 nM
|
[3] | |||
| Compound Name |
1,3-Diphenyl-N-{4-[(pyrimidin-2-yl)sulfamoyl]phenyl}-1H-pyrazole-5-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095229; ZINC2657044; BDBM50232858; AKOS000940657; MCULE-8909491279; Z27739308
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(2-Aminopyridin-3-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097684; SCHEMBL17593188; BDBM50232853
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-Phenyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}isoxazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087527; BDBM50232856; STL204301; ZINC27581215; AKOS001530825; MCULE-2321727019; 5-phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1,2-oxazole-3-carboxamide
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(2-Hydroxyphenyl)-N-[4-[methyl(pyrimidin-2-yl)sulfamoyl]phenyl]-1H-pyrazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093068; SCHEMBL17593236; BDBM50232866
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
ClC1=C(C=CC=C1)C(C(=S)N1CCOCC1)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4088826; SCHEMBL19357183; BDBM50230345
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(2-Hydroxyphenyl)-N-[4-(pyridin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075057; BDBM50232869
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(3-Phenyl-1H-pyrazole-5-carbonyl)-N-pyrimidin-2-yl-2,3,3a,7a-tetrahydroindole-5-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4085313; BDBM50232859
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-(2-Hydroxyphenyl)-N-[4-(piperidin-1-ylsulfonyl)phenyl]-1H-pyrazole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
TCMDC-124310; CHEMBL579882; ZINC9293016; BDBM50232877; STK588283; AKOS002199720; AKOS005510990; MCULE-3393334038
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
ClC=1C=C(C=CC=1)C(C(=S)N1CCOCC1)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069286; SCHEMBL19357136; BDBM50230346
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(2-Hydroxyphenyl)-N-[4-(3-morpholin-4-ylpropylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102836; BDBM50232872
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-Methyl-3-phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079651; SCHEMBL17593038; BDBM50232854
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[5-[[4-(Pyrimidin-2-ylsulfamoyl)phenyl]carbamoyl]-1H-pyrazol-3-yl]benzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068860; SCHEMBL17593234; BDBM50232852
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[4-[Methyl(pyrimidin-2-yl)sulfamoyl]phenyl]-3-phenyl-1H-pyrazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4103244; SCHEMBL17593212; BDBM50232865
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|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
5-(2-Hydroxyphenyl)-N-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1438334; MLS001214443; SCHEMBL15503777; HMS2858B05; BDBM50232867; STK585684; ZINC12475330; AKOS002199789; AKOS005508604; CCG-275187; MCULE-2907497283; SMR000543718
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[4-(Furan-2-ylmethylsulfamoyl)phenyl]-3-(2-hydroxyphenyl)-1H-pyrazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4092091; BDBM50232871
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3-Phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1,2-oxazole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4105394; SCHEMBL17593090; BDBM50232855
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-(4-Bromophenyl)-2-morpholino-2-thioxoethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4087895; Oprea1_461021; SCHEMBL19357092; 1-(4-bromophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone; BDBM50230350
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|
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| Activity |
IC50 = 130700 nM
|
[3] | |||
| Compound Name |
BrC1=C(C=CC=C1)C(C(=S)N1CCOCC1)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080013; SCHEMBL19357117; BDBM50230348
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|
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| Activity |
IC50 = 160700 nM
|
[3] | |||
| Compound Name |
IC1=CC=C(C=C1)C(C(=S)N1Ccocc1)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075188; SCHEMBL19357118; BDBM50230353
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|
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| Activity |
IC50 = 177700 nM
|
[3] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 7 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
FC=1C=C(C=CC=1)C(C(=S)N1Ccocc1)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4094815; SCHEMBL19357121; BDBM50230343
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
2-Morpholin-4-yl-1-(4-phenylphenyl)-2-sulfanylideneethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102631; SCHEMBL19357214; BDBM50230359
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
BrC=1C=C(C=CC=1)C(C(=S)N1CCOCC1)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4104245; SCHEMBL19357180; BDBM50230349
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
[N+](=O)([O-])C1=C(C=CC=C1)C(C(=S)N1Ccocc1)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074399; SCHEMBL19357133; BDBM50230358
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
FC1=C(C=CC=C1)C(C(=S)N1Ccocc1)=O
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074316; SCHEMBL19357204; BDBM50230342
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
1-(2-Iodophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066572; SCHEMBL19357235; BDBM50230360
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Compound Name |
1-(3-Iodophenyl)-2-morpholin-4-yl-2-sulfanylideneethanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095597; SCHEMBL19357218; BDBM50230357
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|
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| Activity |
IC50 > 200000 nM
|
[3] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy. J Med Chem. 2017 Feb 23;60(4):1227-1237. | ||||
| REF 2 | Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors. Bioorg Med Chem. 2018 May 1;26(8):1727-1739. | ||||
| REF 3 | alpha-Ketothioamide Derivatives: A Promising Tool to Interrogate Phosphoglycerate Dehydrogenase (PHGDH). J Med Chem. 2017 Feb 23;60(4):1591-1597. | ||||
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