TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T15139	Phosphoglycerate dehydrogenase	B1IJ9Y	1,3-Diphenyl-N-{4-[(pyrimidin-2-yl)sulfamoyl]phenyl}-1H-pyrazole-5-carboxamide	Investigative	2120805	C26H20N6O3S	496.5	C1=CC=C(C=C1)C2=NN(C(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CC=N4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	B1M0SN	PHGDH-inactive	Investigative	49853203	C17H21N5S	327.4	CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)C3=CC=NC=C3)C	IC50 ~ 57000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	B23UKE	BrC1=C(C=CC=C1)C(C(=S)N1CCOCC1)=O	Investigative	130429939	C12H12BrNO2S	314.2	C1COCCN1C(=S)C(=O)C2=CC=CC=C2Br	IC50 = 160700 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	B39GBL	3-(2-Aminopyridin-3-yl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	Investigative	118947462	C19H16N8O3S	436.4	C1=CC(=C(N=C1)N)C2=NNC(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CC=N4	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	B3FST9	1-(4-Fluorophenyl)-2-morpholino-2-thioxoethanone	Investigative	101879233	C12H12FNO2S	253.29	C1COCCN1C(=S)C(=O)C2=CC=C(C=C2)F	IC50 = 64400 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	B3VAI6	3-Phenyl-N-[4-(pyridin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	Investigative	118947501	C21H17N5O3S	419.5	C1=CC=C(C=C1)C2=NNC(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=CC=CC=N4	IC50 = 50000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	B53SRT	5-Phenyl-N-{4-[(pyrimidin-2-ylamino)sulfonyl]phenyl}isoxazole-3-carboxamide	Investigative	17011425	C20H15N5O4S	421.4	C1=CC=C(C=C1)C2=CC(=NO2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CC=N4	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	B58AEN	Chembl4127643	Investigative	145961091	C17H21N5S	327.4	CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)C3=CN=CC=C3)C	IC50 = 50000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	B68APD	Chembl4126930	Investigative	145961708	C18H23N5S	341.5	CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)CC3=CC=NC=C3)C	IC50 = 59000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	B8ET0F	IC1=CC=C(C=C1)C(C(=S)N1Ccocc1)=O	Investigative	130429940	C12H12INO2S	361.2	C1COCCN1C(=S)C(=O)C2=CC=C(C=C2)I	IC50 = 177700 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	B8KC5X	N-(3-Methylphenyl)-4-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide	Investigative	8615611	C19H20F3N3S	379.4	CC1=CC(=CC=C1)NC(=S)N2CCN(CC2)C3=CC=CC(=C3)C(F)(F)F	IC50 ~ 57000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BA2GT5	3-(2-Hydroxyphenyl)-N-[4-[methyl(pyrimidin-2-yl)sulfamoyl]phenyl]-1H-pyrazole-5-carboxamide	Investigative	136937731	C21H18N6O4S	450.5	CN(C1=NC=CC=N1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BA35MB	ClC1=C(C=CC=C1)C(C(=S)N1CCOCC1)=O	Investigative	130429986	C12H12ClNO2S	269.75	C1COCCN1C(=S)C(=O)C2=CC=CC=C2Cl	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BBT95P	4-Chloro-N-(2-nitrophenyl)benzamide	Investigative	346675	C13H9ClN2O3	276.67	C1=CC=C(C(=C1)NC(=O)C2=CC=C(C=C2)Cl)[N+](=O)[O-]	IC50 = 57500 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BHGR63	3-(2-Hydroxyphenyl)-N-[4-(pyridin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	Investigative	137651355	C21H17N5O4S	435.5	C1=CC=C(C(=C1)C2=NNC(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=CC=CC=N4)O	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BIE54V	1-(3-Phenyl-1H-pyrazole-5-carbonyl)-N-pyrimidin-2-yl-2,3,3a,7a-tetrahydroindole-5-sulfonamide	Investigative	137647070	C22H20N6O3S	448.5	C1CN(C2C1C=C(C=C2)S(=O)(=O)NC3=NC=CC=N3)C(=O)C4=CC(=NN4)C5=CC=CC=C5	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BIQ65M	5-(2-Hydroxyphenyl)-N-[4-(piperidin-1-ylsulfonyl)phenyl]-1H-pyrazole-3-carboxamide	Investigative	2026662	C21H22N4O4S	426.5	C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BK23QS	Chembl4128162	Investigative	121485232	C18H23N5S	341.5	CC1=CC(=NC(=C1)NC(=S)N2CCN(CC2)CC3=CC=CC=N3)C	IC50 = 50000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BN5AU6	Ethanone, 2-(morpholin-4-yl)-1-phenyl-2-thioxo-	Investigative	292706	C12H13NO2S	235.3	C1COCCN1C(=S)C(=O)C2=CC=CC=C2	IC50 = 71700 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BO2H9D	1-(4-Bromophenyl)-2-morpholino-2-thioxoethanone	Investigative	5010967	C12H12BrNO2S	314.2	C1COCCN1C(=S)C(=O)C2=CC=C(C=C2)Br	IC50 = 130700 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BP3UA2	ClC=1C=C(C=CC=1)C(C(=S)N1CCOCC1)=O	Investigative	130429950	C12H12ClNO2S	269.75	C1COCCN1C(=S)C(=O)C2=CC(=CC=C2)Cl	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BQKL02	3-(2-Hydroxyphenyl)-N-[4-(3-morpholin-4-ylpropylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	Investigative	137657956	C23H27N5O5S	485.6	C1COCCN1CCCNS(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4O	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BQP31B	4-Methyl-3-phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1H-pyrazole-5-carboxamide	Investigative	118947349	C21H18N6O3S	434.5	CC1=C(NN=C1C2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CC=N4	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BQRC51	2-[5-[[4-(Pyrimidin-2-ylsulfamoyl)phenyl]carbamoyl]-1H-pyrazol-3-yl]benzoic acid	Investigative	118947495	C21H16N6O5S	464.5	C1=CC=C(C(=C1)C2=NNC(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CC=N4)C(=O)O	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BS3N9G	N-[4-[Methyl(pyrimidin-2-yl)sulfamoyl]phenyl]-3-phenyl-1H-pyrazole-5-carboxamide	Investigative	118947481	C21H18N6O3S	434.5	CN(C1=NC=CC=N1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC(=NN3)C4=CC=CC=C4	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BSP05N	5-(2-Hydroxyphenyl)-N-(4-sulfamoylphenyl)-1H-pyrazole-3-carboxamide	Investigative	1838078	C16H14N4O4S	358.4	C1=CC=C(C(=C1)C2=NNC(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)N)O	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BUY0T1	1-(4-Chlorophenyl)-2-morpholino-2-thioxoethan-1-one	Investigative	15544085	C12H12ClNO2S	269.75	C1COCCN1C(=S)C(=O)C2=CC=C(C=C2)Cl	IC50 = 50500 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BV9Z7C	N-[4-(Furan-2-ylmethylsulfamoyl)phenyl]-3-(2-hydroxyphenyl)-1H-pyrazole-5-carboxamide	Investigative	137655343	C21H18N4O5S	438.5	C1=CC=C(C(=C1)C2=NNC(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NCC4=CC=CO4)O	IC50 ~ 100000 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BWUP45	[N+](=O)([O-])C=1C=C(C=CC=1)C(C(=S)N1Ccocc1)=O	Investigative	130429937	C12H12N2O4S	280.3	C1COCCN1C(=S)C(=O)C2=CC(=CC=C2)[N+](=O)[O-]	IC50 = 88100 nM	Poor binder
T15139	Phosphoglycerate dehydrogenase	BX92WR	3-Phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]-1,2-oxazole-5-carboxamide	Investigative	118947388	C20H15N5O4S	421.4	C1=CC=C(C=C1)C2=NOC(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)NC4=NC=CC=N4	IC50 ~ 100000 nM	Poor binder