Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14945 | Target Info | |||
| Target Name | Centromeric protein E (CENPE) | ||||
| Synonyms |
Centromere-associated protein E; CENPE; CENP-E
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| Target Type | Literature-reported Target | ||||
| Gene Name | CENPE | ||||
| Biochemical Class | TRAFAC class myosin-kinesin ATPase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
MK-0731
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|
Phase 1 | Compound Info | ||
| Synonyms |
C-4251; MK-731
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Physodic acid
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|
Investigative | Compound Info | ||
| Synonyms |
Physodalin; UNII-X901BNT6BF; NSC-685589; X901BNT6BF; CHEMBL171637; NSC5916; C26H30O8; NSC685589; SMR000386934; CCRIS 5524; NSC 5916; Physodic acid, 5; cid_65751; MLS001049102; MLS003901469; REGID_for_CID_65751; SCHEMBL10383128; CTK3E8706; DTXSID40232883; HMS2271M06; NSC-5916; ZINC1687300; BDBM50056904; STL564806; AKOS030492944; MCULE-5934067170; NCGC00246211-01; Q27293701
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| Activity |
IC50 = 91400 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Kinesin spindle protein (KSP) inhibitors. 9. Discovery of (2S)-4-(2,5-difluorophenyl)-n-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the treatment of taxane-refractory cancer. J Med Chem. 2008 Jul 24;51(14):4239-52. | ||||
| REF 2 | Depsidones from Lichens as Natural Product Inhibitors of M-Phase Phosphoprotein 1, a Human Kinesin Required for Cytokinesis. J Nat Prod. 2016 Jun 24;79(6):1576-85. | ||||
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