Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D0V2YJ
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| Former ID |
DIB002509
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| Drug Name |
MK-0731
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| Synonyms |
C-4251; MK-731
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199, 210-229] | Phase 1 | [1] | |
| Company |
Merck & Co Inc
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| Structure |
 |
Download2D MOL |
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| Formula |
C25H28F3N3O2
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| Canonical SMILES |
CN1CCC(C(C1)F)N(C)C(=O)N2CC(=CC2(CO)C3=CC=CC=C3)C4=C(C=CC(=C4)F)F
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| InChI |
1S/C25H28F3N3O2/c1-29-11-10-23(22(28)15-29)30(2)24(33)31-14-17(20-12-19(26)8-9-21(20)27)13-25(31,16-32)18-6-4-3-5-7-18/h3-9,12-13,22-23,32H,10-11,14-16H2,1-2H3/t22-,23+,25-/m1/s1
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| InChIKey |
MYBGWENAVMIGMM-GIFXNVAJSA-N
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| CAS Number |
CAS 845256-65-7
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Kinesin-like protein KIF11 (KIF11) | Target Info | Inhibitor | [2] |
| Reactome | MHC class II antigen presentation | |||
| Kinesins | ||||
| WikiPathways | MHC class II antigen presentation | |||
| Kinesins | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT00104364) A Study of MK0731 in Patients With Advanced Solid Tumors (0731-002)(COMPLETED). U.S. National Institutes of Health. | |||
| REF 2 | Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39. | |||
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