Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14252 | Target Info | |||
| Target Name | Gamma-aminobutyric acid transporter 4 (SLC6A11) | ||||
| Synonyms |
Sodium- and chloride-dependent GABA transporter 4; Slc6a11; GAT4; GABA transporter 4
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| Target Type | Literature-reported Target | ||||
| Gene Name | Slc6a11 | ||||
| Biochemical Class | Neurotransmitter:sodium symporter | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 24 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(R)-nipecotic acid
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|
Investigative | Compound Info | ||
| Synonyms |
(R)-piperidine-3-carboxylic acid; 25137-00-2; (R)-(-)-Nipecotic acid; (3R)-piperidine-3-carboxylic acid; (R)-(-)-3-Piperidinecarboxylic acid; (-)-nipecotic acid; (3R)-nipecotic acid; (3R)-(-)-piperidine-3-carboxylic acid; D(-)-Nipecotic acid; r-(-)-3-piperidinecarboxylic acid; 3-Piperidinecarboxylic acid, (R)-; (R)-hexahydronicotinic acid; (R)-(-)-piperidine-3-carboxylic acid; (-)-hexahydronicotinic acid; (3R)-hexahydronicotinic acid; CHEMBL77575; (r)-3-piperidinecarboxylic acid
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| Activity |
IC50 = 51000 nM
|
[1] | |||
| Compound Name |
N-(1-benzylpiperidine-4-yl)-2-naphthamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL228972; N-(1-benzylpiperidin-4-yl)naphthalene-2-carboxamide; N-(1-benzylpiperidine-4-yl)-2-naphthamide; MolPort-005-630-484; BDBM50203383; ZINC12985947; STK491618; AKOS003382305; MCULE-1935524858; N-(1-benzylpiperidin-4-yl)-2-naphthamide; ST50877721; 2-naphthyl-N-[1-benzyl(4-piperidyl)]carboxamide; Z32353863
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
4-substituted 2,4-dioxobutanoic acids
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Investigative | Compound Info | ||
| Synonyms |
Guvacine; 1,2,5,6-tetrahydropyridine-3-carboxylic acid; 498-96-4; 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid; UNII-41538P325K; 1,2,5,6-Tetrahydronicotinic acid; CHEBI:5576; 1,2,3,6-tetrahydropyridine-5-carboxylic acid; 41538P325K; 1,2,5,6-Tetrahydro-pyridine-3-carboxylic acid; MLS000859975; SMR000326834; Spectrum_001426; Tocris-0234; SpecPlus_000808; Lopac-G-007; AC1Q5RCN; Spectrum2_001474; Spectrum4_001753; Spectrum3_001511; Spectrum5_000606; Biomol-NT_000253; C10149; AC1L1G5E; Lopac0_000571; BSPBio_003181; KBioSS_001906
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| Activity |
IC50 = 110000 nM
|
[3] | |||
| Compound Name |
2,4-Dichloro-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072046; BDBM50250320
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(2-cyanophenyl)methyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4091409; BDBM50250285
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(4-cyanophenyl)methyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097791; BDBM50250287
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-[1-(quinolin-2-ylmethyl)piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4097124; BDBM50250321
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|
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
(1s,2s,5r)-5-Aminobicyclo[3.1.0]hexane-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3326391; BDBM50101329
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|
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| Activity |
IC50 = 76300 nM
|
[4] | |||
| Compound Name |
(R)-1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL419823; NCGC00025217-01; Tocris-1561; BDBM50039248; J-009426; (R)-1-(2-(Tris(4-methoxyphenyl)methoxy)ethyl)piperidine-3-carboxylic acid; (3R)-1-[2-[(4,4',4''-Trimethoxytrityl)oxy]ethyl]piperidine-3-carboxylic acid
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| Activity |
IC50 = 86000 nM
|
[5] | |||
| Compound Name |
1-(2-Tritylsulfanyl-ethyl)-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308528; BDBM50039244
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| Activity |
IC50 = 91000 nM
|
[5] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(4-iodophenyl)methyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070660; BDBM50250288
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(2-nitrophenyl)methyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4102978; BDBM50250284
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(1-Benzyl-4-piperidinyl)-1,3-benzodioxole-5-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4068983; N-(1-benzylpiperidin-4-yl)-1,3-benzodioxole-5-carboxamide; SCHEMBL9852093; BDBM50250301; STL504545; ZINC13328606; AKOS003397212; MCULE-5385083599; ST50940646; AO-854/43461125; Z32353898; N-(1-benzylpiperidin-4-yl)-2H-1,3-benzodioxole-5-carboxamide; 2H-benzo[3,4-d]1,3-dioxolan-5-yl-N-[1-benzyl(4-piperidyl)]carboxamide
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(E)-3-phenylprop-2-enyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071982; BDBM50250319
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Methyl 4-[[4-[(2,4-dichlorobenzoyl)amino]piperidin-1-yl]methyl]benzoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090080; BDBM50250289
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-2,4-dichlorobenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
BPDBA; CHEMBL1882801; N-(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamide; CBMicro_018714; Cambridge id 5349520; Oprea1_510498; MLS001185535; REGID_for_CID_1069892; HMS2820D15; ZINC756543; CCG-6976; BDBM50250267; STK053506; AKOS001766690; MCULE-7422285654; SMR000502170; ST047807; BIM-0018815.P001; AB00082098-01; SR-01000519597; SR-01000519597-1; (2,4-dichlorophenyl)-N-[1-benzyl(4-piperidyl)]carboxamide
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|
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-(1-phenacylpiperidin-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4070193; BDBM50250265
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(R,E)-1-(4-(2-Fluorophenyl)-4-o-tolylbut-3-enyl)piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1641613; BDBM50334247
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|
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
2,4-Dichloro-N-[1-[(4-nitrophenyl)methyl]piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069676; BDBM50250255
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|
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
1-{2-[Tris-(4-methoxy-phenyl)-methylsulfanyl]-ethyl}-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL307361; BDBM50039236
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|
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| Activity |
IC50 = 142000 nM
|
[5] | |||
| Compound Name |
1-[2-[9-(4-Methoxyphenyl)fluoren-9-yl]oxyethyl]piperidine-3-carboxylic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL75800; SNAP-5294; BDBM50039233; 1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-ethyl}-piperidine-3-carboxylic acid
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|
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| Activity |
IC50 = 142000 nM
|
[7] | |||
| Compound Name |
1-{3-[Tris-(4-methoxy-phenyl)-methoxy]-propyl}-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL308391; BDBM50039237
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|
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| Activity |
IC50 = 169000 nM
|
[5] | |||
| Compound Name |
1-{2-[(4-Methoxy-phenyl)-diphenyl-methoxy]-ethyl}-piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL77111; BDBM50039249
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|
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| Activity |
IC50 = 178000 nM
|
[5] | |||
| Compound Name |
1-{2-[(3-Fluoro-4-methoxy-phenyl)-(3-fluoro-phenyl)-phenyl-methoxy]-ethyl}-piperidine-3-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL74138; BDBM50039252
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|
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| Activity |
IC50 = 198000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 32 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Tiagabine
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|
Approved | Compound Info | ||
| Synonyms |
tiagabine; 115103-54-3; Gabitril; Tiagabinum; Tiagabina; (R)-Tiagabine; Tiagabinum [INN-Latin]; Tiagabina [INN-Spanish]; Tiagabine [INN:BAN]; Tiagabine [INN]; Abbott-70569; UNII-Z80I64HMNP; Tiagabine (INN); ABBOTT-70569-1; Gabitril (TN); CHEMBL1027; Z80I64HMNP; ABT-569; CHEBI:9586; NO-328; (-)-(R)-1-(4,4-Bis(3-methyl-2-thienyl)-3-butenyl)nipecotic acid; A-70569-1; (R)-1-(4,4-Bis(3-methylthiophen-2-yl)but-3-en-1-yl)piperidine-3-carboxylic acid; Gabatril; NO 329; Gabitril; NO-329; Tiagabina [INN-Spanish];Tiagabine (INN); N-(4,4-di(3-methylthien-2-yl)but-3-enyl)nipecotic acid; (3R)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic acid; (3R)-1-[4,4-bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid; [3H]tiagabine
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|
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| Activity |
IC50 = 917000 nM
|
[5] | |||
| Compound Name |
CI-966
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|
Phase 1 | Compound Info | ||
| Synonyms |
1-[2-[Bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride
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| Activity |
IC50 = 333000 nM
|
[5] | |||
| Compound Name |
HINOKININ
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Investigative | Compound Info | ||
| Synonyms |
Hinokinin; (-)-Hinokinin; 26543-89-5; CHEBI:5722; CHEMBL242011; (3R,4R)-3,4-Bis(benzo[d][1,3]dioxol-5-ylmethyl)dihydrofuran-2(3H)-one; (3R,4R)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydrofuran-2(3H)-one; (3R-trans)-3,4-bis(1,3-benzodioxol-5-ylmethyl)dihydrofuran-2(3H)-one; hinoquinin; (-)-hinoquinin; AC1L9DKH; Epitope ID:116880; SCHEMBL1121862; MolPort-039-338-821; ZINC1872258; BDBM50218812; AKOS027324070; LS-190466; C10627; (2r,3r)-2,3-di-(3,4-methylenedioxybenzyl)-butyrolactone
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| Activity |
IC50 > 500000 nM
|
[8] | |||
| Compound Name |
SKF89976A
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Investigative | Compound Info | ||
| Synonyms |
SKF-89976A; SKF 89976A
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| Activity |
IC50 = 944000 nM
|
[9] | |||
| Compound Name |
(S)-Piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
59045-82-8; (S)-(+)-Nipecotic acid; (3S)-piperidine-3-carboxylic acid; (S)-nipecotic acid; (3S)-nipecotic acid; (S)-(+)-3-Piperidinecarboxylic acid; (S)-hexahydronicotinic acid; L(+)-NIPECOTIC ACID; (3S)-hexahydronicotinic acid; CHEBI:222169; (3S)-3-piperidinecarboxylic acid; 3-Piperidinecarboxylic acid, (3S)-; (S)-(+)-PIPERIDINE-3-CARBOXYLIC ACID; UNII-2635N2PS4Q; (3S)-(+)-piperidine-3-carboxylic acid; L-PIPERIDINE-3-CARBOXYLIC ACID
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|
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| Activity |
IC50 = 2320000 nM
|
[1] | |||
| Compound Name |
1-{2-[(4-Methoxy-3-trifluoromethyl-phenyl)-phenyl-(3-trifluoromethyl-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL77166; BDBM50039241
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| Activity |
IC50 = 212000 nM
|
[5] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-4-fluorobenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4080696; CBMicro_022999; Cambridge id 5524786; Oprea1_465872; Oprea1_626089; SCHEMBL1425074; ZINC84471; CCG-9823; BDBM50250253; STK006992; AKOS000673109; MCULE-3904225512; ST029666; BIM-0022886.P001; N-(1-benzyl-4-piperidinyl)-4-fluorobenzamide; AB00087319-01; AG-690/11635812; SR-01000407328; SR-01000407328-1; Z32353707; (4-fluorophenyl)-N-[1-benzyl(4-piperidyl)]carboxamide
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| Activity |
IC50 > 300000 nM
|
[2] | |||
| Compound Name |
2-Ethoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1710951; N-(1-benzylpiperidin-4-yl)-2-ethoxybenzamide; MLS001179109; HMS2847J17; ZINC7039831; BDBM50250278; STK413823; AKOS003387340; CCG-300452; MCULE-7182820341; SMR000477296; ST50943613; N-(1-benzyl-4-piperidinyl)-2-ethoxybenzamide; Q27183433; (2-ethoxyphenyl)-N-[1-benzyl(4-piperidyl)]carboxamide
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| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-3-(trifluoromethyl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078727; BDBM50250272; STK491613; ZINC12820866; AKOS003382124; CCG-300437; MCULE-2073961827; NCGC00330960-01; AB01324863-02; AO-854/43461993; Z32353728; N-(1-benzyl-4-piperidinyl)-3-(trifluoromethyl)benzamide
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| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-2,3-dimethoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL123282; Benzamide, 2,3-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-; ACMC-20lvjh; CTK3G1860; DTXSID80536473; BDBM50007525; STK491510; ZINC13820638; AKOS003382241; CCG-300432; MCULE-7445608673; ST50942926; N-[1-Benzyl-4-piperidinyl]-2,3-dimethoxybenzamide; N-(1-Benzyl-piperidin-4-yl)-2,3-dimethoxy-benzamide; (2,3-dimethoxyphenyl)-N-[1-benzyl(4-piperidyl)]carboxamide
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| Activity |
IC50 > 500000 nM
|
[2] | |||
| Compound Name |
(3S,8R)-8-Benzhydryl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine-3-carboxylic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2094022
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|
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| Activity |
IC50 = 782000 nM
|
[9] | |||
| Compound Name |
(3S)-8-Benzhydrylidene-1,2,3,4,6,7,9,9a-octahydroquinolizine-3-carboxylic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2093977
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|
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| Activity |
IC50 = 876000 nM
|
[9] | |||
| Compound Name |
2,4-Dichloro-N-{1-[(pyridin-2-yl)methyl]piperidin-4-yl}benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069761; BDBM50250317; ZINC48356032; AKOS034525333; CCG-300720; MCULE-2170841553; Z667591870
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
Tert-butyl 2-[4-[(2,4-dichlorobenzoyl)amino]piperidin-1-yl]acetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075412; BDBM50250282
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|
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-[1-(pyridin-3-ylmethyl)piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4063054; BDBM50250318
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|
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-[1-(3-diethoxyphosphorylpropyl)piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072002; BDBM50250283
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|
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-[1-(pyridin-4-ylmethyl)piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4079046; BDBM50250316
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|
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
N-(1-(Benzyl)-4-piperidyl)benzamide; CHEMBL1603838; N-[1-(BENZYL)-4-PIPERIDYL]BENZAMIDE; N1-(1-Benzyl-4-piperidyl)benzamide; EINECS 213-538-8; N-(1-Benzyl-piperidin-4-yl)-benzamide; (Indoramin Impurity)'; Maybridge1_006192; ChemDiv2_000250; Cambridge id 5357691; Oprea1_272991; Oprea1_804305; MLS001182250; SCHEMBL694949; 1-benzyl-4-benzamidopiperidine; 1-benzyl-4-benzamido-piperidine; CTK5H9110; HMS559B10; DTXSID00242701; HMS1369L08; HMS2880E21; ZINC247186; KS-000031BO; BDBM50250266; CCG-40855; STK007131; N-(1-Benzyl-4-piperidinyl)benzamide; AKOS000671616; MCULE-3265010155; N-(1-Benzyl-4-piperidinyl)benzamide #; NCGC00246644-01; 12N-312S; SMR000567875; N-[1-(phenylmethyl)piperidin-4-yl]benzamide; phenyl-N-[1-benzyl(4-piperidyl)]carboxamide; ST50449722; AB00082791-01; Benzamide, N-[1-(phenylmethyl)-4-piperidinyl]-; N-[1-(BENZYL)-PIPERIDIN-4-YL]BENZAMIDE; SR-01000630966-1; Z32353754
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-(1-ethylpiperidin-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4101561; BDBM50250275; STK484443; ZINC13325962; AKOS003397123; MCULE-5433262397; ST50879941; Z85145662; (2,4-dichlorophenyl)-N-(1-ethyl(4-piperidyl))carboxamide
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-(1-methylpiperidin-4-yl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4072452; BDBM50250274; STK484800; ZINC13326354; AKOS003394651; MCULE-2479589844; ST50846723; N-(1-Methylpiperidine-4-yl)-2,4-dichlorobenzamide; benzamide, 2,4-dichloro-N-(1-methyl-4-piperidinyl)-; (2,4-dichlorophenyl)-N-(1-methyl(4-piperidyl))carboxamide
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-[1-(3-cyanopropyl)piperidin-4-yl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4076258; BDBM50250281
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| Activity |
IC50 > 1000000 nM
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[2] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-2,6-dichloropyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060376; BDBM50250295
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| Activity |
IC50 > 1000000 nM
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[2] | |||
| Compound Name |
2,4-Dichloro-N-piperidin-4-ylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4066152; BDBM50250302; ZINC37382809; AKOS009375943
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-(1-propylpiperidin-4-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075423; BDBM50250279; STK484461; ZINC13325985; AKOS003396540; MCULE-8663330192; ST50894261; Z90656452; (2,4-dichlorophenyl)-N-(1-propyl(4-piperidyl))carboxamide
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
2,4-Dichloro-N-(1-prop-2-ynylpiperidin-4-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4077212; BDBM50250280
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
N-(1-Benzylpiperidin-4-yl)-2-methylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4089518; N-(1-Benzyl-piperidin-4-yl)-isobutyramide; N-(1-benzylpiperidin-4-yl)isobutyramide; N-(1-benzyl-4-piperidyl)-2-methyl-propanamide; Oprea1_472165; SCHEMBL3306841; CTK1B9881; DTXSID90364148; ZINC4551463; BDBM50250322; STK012158; AKOS003820004; MCULE-3952577164; Propanamide, 2-methyl-N-[1-(phenylmethyl)-4-piperidinyl]-
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
2-[4-[(2,4-Dichlorobenzoyl)amino]piperidin-1-yl]acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4075865; BDBM50250254
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| Activity |
IC50 > 1000000 nM
|
[2] | |||
| Compound Name |
1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL405620; BDBM50039247
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| Activity |
IC50 = 1080000 nM
|
[5] | |||
| Compound Name |
1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL77626; SCHEMBL676997; 3-Piperidinecarboxylic acid, 1-(4,4-diphenyl-3-butenyl)-, (R)-; CTK3G8883; ZINC3995837; (R)-SKF-89976A; BDBM50020891; (3R)-1-(4,4-diphenylbut-3-enyl)piperidine-3-carboxylic acid; (R)-1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxylic acid
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| Activity |
IC50 = 1990000 nM
|
[5] | |||
| Compound Name |
(3R,8R)-8-Benzhydryl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine-3-carboxylic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2093978
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||||
| Activity |
IC50 = 2043000 nM
|
[9] | |||
| Compound Name |
(3R)-8-Benzhydrylidene-1,2,3,4,6,7,9,9a-octahydroquinolizine-3-carboxylic acid;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2094024
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| Activity |
IC50 = 3233000 nM
|
[9] | |||
| Compound Name |
1-{2-[Tris-(4-fluoro-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL77423; BDBM50039253
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||||
| Activity |
IC50 = 6740000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports. Bioorg Med Chem. 2013 Sep 1;21(17):4938-50. | ||||
| REF 2 | Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/-Aminobutyric Acid Transporter 1 (BGT1). J Med Chem. 2017 Nov 9;60(21):8834-8846. | ||||
| REF 3 | Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship. Eur J Med Chem. 2010 Jun;45(6):2453-66. | ||||
| REF 4 | Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT-1 Inhibitor. ACS Med Chem Lett. 2014 Jun 16;5(8):889-93. | ||||
| REF 5 | Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human GABA transporter GAT-3. J Med Chem. 1994 Jul 22;37(15):2334-42. | ||||
| REF 6 | Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors. Bioorg Med Chem Lett. 2011 Jan 1;21(1):602-5. | ||||
| REF 7 | Synthesis and biological evaluation of a series of N-alkylated imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors. Eur J Med Chem. 2016 Nov 29;124:852-880. | ||||
| REF 8 | The lignan (-)-hinokinin displays modulatory effects on human monoamine and GABA transporter activities. J Nat Prod. 2013 Oct 25;76(10):1889-95. | ||||
| REF 9 | On the bioactive conformation of the gaba uptake inhibitor SK&F 89976-A. Bioorg Med Chem Lett. 1996 Jul 9;6(13):1535-40. | ||||
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