TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T14252	Gamma-aminobutyric acid transporter 4	D0ED7U	Tiagabine	Approved	60648	C20H25NO2S2	375.6	CC1=C(SC=C1)C(=CCCN2CCC[C@H](C2)C(=O)O)C3=C(C=CS3)C	IC50 = 917000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	D08ESA	CI-966	Phase 1	198693	C23H21F6NO3	473.4	C1CN(CC(=C1)C(=O)O)CCOC(C2=CC=C(C=C2)C(F)(F)F)C3=CC=C(C=C3)C(F)(F)F	IC50 = 333000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	B01XGU	2,4-Dichloro-N-{1-[(pyridin-2-yl)methyl]piperidin-4-yl}benzamide	Investigative	47058964	C18H19Cl2N3O	364.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=CC=N3	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	B04AGQ	Tert-butyl 2-[4-[(2,4-dichlorobenzoyl)amino]piperidin-1-yl]acetate	Investigative	137651374	C18H24Cl2N2O3	387.3	CC(C)(C)OC(=O)CN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	B0ID7G	1-{2-[Tris-(4-fluoro-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10050339	C27H26F3NO3	469.5	C1CC(CN(C1)CCOC(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)C(=O)O	IC50 = 6740000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	B0L6AI	1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid	Investigative	9983570	C30H33NO6	503.6	COC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)OCCN4CCC=C(C4)C(=O)O	IC50 = 1080000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	B1RV5K	2,4-Dichloro-N-[1-(pyridin-3-ylmethyl)piperidin-4-yl]benzamide	Investigative	137637846	C18H19Cl2N3O	364.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CN=CC=C3	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	B1Y8RO	2,4-Dichloro-N-[1-(3-diethoxyphosphorylpropyl)piperidin-4-yl]benzamide	Investigative	137639281	C19H29Cl2N2O4P	451.3	CCOP(=O)(CCCN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl)OCC	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	B24HDT	(3R,8R)-8-Benzhydryl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine-3-carboxylic acid;hydrochloride	Investigative	70689233	C23H28ClNO2	385.9	C1CC2C[C@@H](CCN2C[C@@H]1C(=O)O)C(C3=CC=CC=C3)C4=CC=CC=C4.Cl	IC50 = 2043000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	B24YZS	2-Ethoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide	Investigative	8181355	C21H26N2O2	338.4	CCOC1=CC=CC=C1C(=O)NC2CCN(CC2)CC3=CC=CC=C3	IC50 > 500000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	B39IXZ	2,4-Dichloro-N-[1-(pyridin-4-ylmethyl)piperidin-4-yl]benzamide	Investigative	137650102	C18H19Cl2N3O	364.3	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC3=CC=NC=C3	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	B4E2FN	1-{2-[(4-Methoxy-3-trifluoromethyl-phenyl)-phenyl-(3-trifluoromethyl-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid	Investigative	10031163	C30H29F6NO4	581.5	COC1=C(C=C(C=C1)C(C2=CC=CC=C2)(C3=CC(=CC=C3)C(F)(F)F)OCCN4CCCC(C4)C(=O)O)C(F)(F)F	IC50 = 212000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BA5BR3	N-(1-Benzylpiperidin-4-yl)benzamide	Investigative	40598	C19H22N2O	294.4	C1CN(CCC1NC(=O)C2=CC=CC=C2)CC3=CC=CC=C3	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BAF63S	2,4-Dichloro-N-(1-ethylpiperidin-4-yl)benzamide	Investigative	17174058	C14H18Cl2N2O	301.2	CCN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BAU58Z	N-(1-Benzylpiperidin-4-yl)-3-(trifluoromethyl)benzamide	Investigative	17250318	C20H21F3N2O	362.4	C1CN(CCC1NC(=O)C2=CC(=CC=C2)C(F)(F)F)CC3=CC=CC=C3	IC50 > 500000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BBA38E	2,4-Dichloro-N-(1-methylpiperidin-4-yl)benzamide	Investigative	639062	C13H16Cl2N2O	287.18	CN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BBH5A6	(3R)-8-Benzhydrylidene-1,2,3,4,6,7,9,9a-octahydroquinolizine-3-carboxylic acid;hydrochloride	Investigative	70691308	C23H26ClNO2	383.9	C1CC2CC(=C(C3=CC=CC=C3)C4=CC=CC=C4)CCN2C[C@@H]1C(=O)O.Cl	IC50 = 3233000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BD23TL	N-(1-Benzylpiperidin-4-yl)-4-fluorobenzamide	Investigative	702501	C19H21FN2O	312.4	C1CN(CCC1NC(=O)C2=CC=C(C=C2)F)CC3=CC=CC=C3	IC50 > 300000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BDV06W	2,4-Dichloro-N-[1-(3-cyanopropyl)piperidin-4-yl]benzamide	Investigative	137650910	C16H19Cl2N3O	340.2	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CCCC#N	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BE8Z6U	1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxylic acid	Investigative	9797818	C22H25NO2	335.4	C1C[C@H](CN(C1)CCC=C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 = 1990000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BF46GZ	N-(1-Benzylpiperidin-4-yl)-2,6-dichloropyridine-3-carboxamide	Investigative	137635197	C18H19Cl2N3O	364.3	C1CN(CCC1NC(=O)C2=C(N=C(C=C2)Cl)Cl)CC3=CC=CC=C3	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BK79IQ	(3S)-8-Benzhydrylidene-1,2,3,4,6,7,9,9a-octahydroquinolizine-3-carboxylic acid;hydrochloride	Investigative	70684990	C23H26ClNO2	383.9	C1CC2CC(=C(C3=CC=CC=C3)C4=CC=CC=C4)CCN2C[C@H]1C(=O)O.Cl	IC50 = 876000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BOL61T	(3S,8R)-8-Benzhydryl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizine-3-carboxylic acid;hydrochloride	Investigative	70691306	C23H28ClNO2	385.9	C1CC2C[C@@H](CCN2C[C@H]1C(=O)O)C(C3=CC=CC=C3)C4=CC=CC=C4.Cl	IC50 = 782000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BOU75T	2,4-Dichloro-N-piperidin-4-ylbenzamide	Investigative	43345728	C12H14Cl2N2O	273.15	C1CNCCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BRMG32	N-(1-Benzylpiperidin-4-yl)-2,3-dimethoxybenzamide	Investigative	13314232	C21H26N2O3	354.4	COC1=CC=CC(=C1OC)C(=O)NC2CCN(CC2)CC3=CC=CC=C3	IC50 > 500000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BS1KV0	2,4-Dichloro-N-(1-propylpiperidin-4-yl)benzamide	Investigative	17173775	C15H20Cl2N2O	315.2	CCCN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BUTF86	2,4-Dichloro-N-(1-prop-2-ynylpiperidin-4-yl)benzamide	Investigative	137651669	C15H16Cl2N2O	311.2	C#CCN1CCC(CC1)NC(=O)C2=C(C=C(C=C2)Cl)Cl	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BW3N0X	N-(1-Benzylpiperidin-4-yl)-2-methylpropanamide	Investigative	1530639	C16H24N2O	260.37	CC(C)C(=O)NC1CCN(CC1)CC2=CC=CC=C2	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	BX5LG2	2-[4-[(2,4-Dichlorobenzoyl)amino]piperidin-1-yl]acetic acid	Investigative	137652511	C14H16Cl2N2O3	331.2	C1CN(CCC1NC(=O)C2=C(C=C(C=C2)Cl)Cl)CC(=O)O	IC50 > 1000000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	D03IWW	(S)-Piperidine-3-carboxylic acid	Investigative	6575389	C6H11NO2	129.16	C1C[C@@H](CNC1)C(=O)O	IC50 = 2320000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	D08YGM	SKF89976A	Investigative	92409	C22H25NO2	335.4	C1CC(CN(C1)CCC=C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O	IC50 = 944000 nM	Non binder
T14252	Gamma-aminobutyric acid transporter 4	D0X3CF	HINOKININ	Investigative	442879	C20H18O6	354.4	C1[C@@H]([C@H](C(=O)O1)CC2=CC3=C(C=C2)OCO3)CC4=CC5=C(C=C4)OCO5	IC50 > 500000 nM	Non binder