Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T10265 | Target Info | |||
| Target Name | Phosphodiesterase 4B (PDE4B) | ||||
| Synonyms |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B; Type 4B cAMP phosphodiesterase; Type 4 cyclic adenosine monophosphate phosphodiesterase (type 4 PDE); PDE32; DPDE4
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | PDE4B | ||||
| Biochemical Class | Phosphoric diester hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 54 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Tadalafil
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
ADCIRCA; Acdirca; Cialis; Tadanafil; Lilly brand of tadalafil; Tadalafil [USAN]; GF 196960; IC 351; ICOS 351; Ic351; Cialis (TN); GF-196960; IC-351; KS-1117; Tadalafil (JAN/USAN/INN); Cialis, GF 196960, IC 351, ICOS 351, Tadalafil; (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione; (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione; (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
PMID28870136-Compound-49
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 ~ 90000 nM
|
[2] | |||
| Compound Name |
CI-930
Click to Show/Hide
|
Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
CI-930; CI 930; 86798-59-6; 4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone; 3(2H)-Pyridazinone, 4,5-dihydro-6-(4-(1H-imidazol-1-yl)phenyl)-5-methyl-; AC1MIBTH; CHEMBL440593; SCHEMBL6052113; CTK5F7194; BDBM14362; AEZZPAQOEUQNBB-UHFFFAOYSA-N; 90791-23-4 (hydrochloride); BDBM50225945; LS-187480; LS-186812; 6-[4-(1-Imidazolyl)phenyl]-5-methyl-3-oxo-2,3,4,5-tetrahydropyridazine; 3-(4-imidazol-1-ylphenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
ZAPRINAST
Click to Show/Hide
|
Terminated | Compound Info | ||
| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
BRL50481
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BRL-50481; BRL 50481
Click to Show/Hide
|
||||
| Activity |
IC50 = 175000 nM
|
[4] | |||
| Compound Name |
(2R,8R)-2-(2,4-Dichlorophenyl)-6-ethyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650866; BDBM50335827
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Chembl4203037
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455392
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
(7-Cyclopentyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-[(3R,4S,5R)-3,4,5-trihydroxycyclohexen-1-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617185; BDBM50121859
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Chembl4207920
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455393
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Chembl4203562
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455398
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434332
Click to Show/Hide
|
||||
| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(4-Aminocyclohexyl)-(7-cyclopentyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)methanone;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3617186; BDBM50121860
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Chembl4209972
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
NPD-008; BDBM50453169
Click to Show/Hide
|
||||
| Activity |
Ki = 50118.72 nM
|
[7] | |||
| Compound Name |
Chembl4171565
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466954
Click to Show/Hide
|
||||
| Activity |
IC50 = 50300 nM
|
[8] | |||
| Compound Name |
Chembl4284587
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466928
Click to Show/Hide
|
||||
| Activity |
IC50 = 51100 nM
|
[9] | |||
| Compound Name |
Chembl4163701
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466952; ZINC17321960; AKOS016883696; MCULE-6939699967; Z71324719; 2-[5-(2-chlorophenyl)furan-2-carbonyl]-1,2,3,4-tetrahydroisoquinoline
Click to Show/Hide
|
||||
| Activity |
IC50 = 51600 nM
|
[8] | |||
| Compound Name |
Chembl4209377
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457962
Click to Show/Hide
|
||||
| Activity |
IC50 = 51800 nM
|
[2] | |||
| Compound Name |
7,8-Dimethoxy-1,5,10,10a-tetrahydro-[1,3]oxazolo[3,4-b]isoquinolin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078521; BDBM50261622
Click to Show/Hide
|
||||
| Activity |
IC50 = 52100 nM
|
[10] | |||
| Compound Name |
(4-(3-(1,2-Dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyridin-4-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1090703; BDBM50314576
Click to Show/Hide
|
||||
| Activity |
Ki = 52200 nM
|
[11] | |||
| Compound Name |
Chembl4276935
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466929
Click to Show/Hide
|
||||
| Activity |
IC50 = 52400 nM
|
[9] | |||
| Compound Name |
Thiazolidin-4-one, 5-(2,3-dimethoxybenzylidene)-2-thioxo-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255821; SCHEMBL8310322; BDBM50372903; STK795671; ZINC12339020; AKOS001314851; CCG-256372; MCULE-7034856473; (Z)-5-(2,3-dimethoxybenzylidene)-2-thioxothiazolidin-4-one; (5Z)-5-(2,3-Dimethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one; (5Z)-5-(2,3-Dimethoxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one #
Click to Show/Hide
|
||||
| Activity |
IC50 = 54650 nM
|
[12] | |||
| Compound Name |
(3,5-Dimethylpyrazol-1-yl)-[2-(2-hydroxyphenyl)-1,3-oxazol-4-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086798; BDBM50231323
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[13] | |||
| Compound Name |
[2-(4-Bromophenyl)-1,3-oxazol-4-yl]-(3,5-dimethylpyrazol-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4060219; BDBM50231316
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[13] | |||
| Compound Name |
[5-(2-Nitrophenyl)furan-2-yl]-(1,2,4-triazol-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823528; BDBM50185735
Click to Show/Hide
|
||||
| Activity |
IC50 = 56800 nM
|
[14] | |||
| Compound Name |
Chembl4159546
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466961
Click to Show/Hide
|
||||
| Activity |
IC50 = 58400 nM
|
[8] | |||
| Compound Name |
[2-(4-Bromophenyl)-1,3-oxazol-4-yl]-pyrazol-1-ylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4096961; BDBM50231290
Click to Show/Hide
|
||||
| Activity |
IC50 = 58700 nM
|
[13] | |||
| Compound Name |
Chembl4287175
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466927
Click to Show/Hide
|
||||
| Activity |
IC50 = 62700 nM
|
[9] | |||
| Compound Name |
(5Z)-2-Sulfanylidene-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256425; SCHEMBL8310172; BDBM50372915; STL314507; ZINC12339010; AKOS001054545; AKOS022114372; 5-(3,4,5-Trimethoxybenzylidene)rhodanine; ST50148457; SR-01000005859; SR-01000005859-1; (Z)-2-Thioxo-5-(3,4,5-trimethoxybenzylidene)thiazolidin-4-one; 2-thioxo-5-[(3,4,5-trimethoxyphenyl)methylene]-1,3-thiazolan-4-one; 2-thioxo-5-[(3,4,5-trimethoxyphenyl)methylene]-1,3-thiazolidin-4-one; (5Z)-4-hydroxy-5-(3,4,5-trimethoxybenzylidene)-1,3-thiazole-2(5H)-thione
Click to Show/Hide
|
||||
| Activity |
IC50 = 64820 nM
|
[12] | |||
| Compound Name |
[5-(2-Fluorophenyl)furan-2-yl]-pyrazol-1-ylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823656; BDBM50185737
Click to Show/Hide
|
||||
| Activity |
IC50 = 65100 nM
|
[14] | |||
| Compound Name |
(5-Phenylfuran-2-yl)-(1,2,4-triazol-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3822510; BDBM50185728
Click to Show/Hide
|
||||
| Activity |
IC50 = 65700 nM
|
[14] | |||
| Compound Name |
Chembl4166361
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466948
Click to Show/Hide
|
||||
| Activity |
IC50 = 66300 nM
|
[8] | |||
| Compound Name |
Chembl4176072
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466940
Click to Show/Hide
|
||||
| Activity |
IC50 = 66900 nM
|
[8] | |||
| Compound Name |
N-({4-[(1H-1,2,4-Triazol-1-yl)methyl]phenyl}methyl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2326946; BDBM50427447; ZINC40024665; AKOS033788895; MCULE-8410754802; Z218211102
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[15] | |||
| Compound Name |
[5-(2-Chlorophenyl)furan-2-yl]-pyrazol-1-ylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3824099; BDBM50185747
Click to Show/Hide
|
||||
| Activity |
IC50 = 68100 nM
|
[14] | |||
| Compound Name |
Chembl4292859
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466931
Click to Show/Hide
|
||||
| Activity |
IC50 = 70300 nM
|
[9] | |||
| Compound Name |
Chembl4205157
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457954
Click to Show/Hide
|
||||
| Activity |
IC50 = 70800 nM
|
[2] | |||
| Compound Name |
Chembl4159877
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466934
Click to Show/Hide
|
||||
| Activity |
IC50 = 70900 nM
|
[8] | |||
| Compound Name |
5,6-Dihydro-2H-1,2,7,7a-tetraaza-benzo[c]fluoren-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779433; BDBM50344315
Click to Show/Hide
|
||||
| Activity |
IC50 = 73000 nM
|
[16] | |||
| Compound Name |
[5-(2-Nitrophenyl)furan-2-yl]-pyrazol-1-ylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3823913; BDBM50185748
Click to Show/Hide
|
||||
| Activity |
IC50 = 75800 nM
|
[14] | |||
| Compound Name |
(3,5-Dimethylpyrazol-1-yl)-(2-phenyl-1,3-oxazol-4-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4071585; BDBM50231315
Click to Show/Hide
|
||||
| Activity |
IC50 = 75800 nM
|
[13] | |||
| Compound Name |
(5-Phenylfuran-2-yl)-pyrazol-1-ylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3822769; BDBM50185741
Click to Show/Hide
|
||||
| Activity |
IC50 = 78100 nM
|
[14] | |||
| Compound Name |
Chembl4170936
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50466960
Click to Show/Hide
|
||||
| Activity |
IC50 = 79600 nM
|
[8] | |||
| Compound Name |
[2-(2-Hydroxyphenyl)-1,3-oxazol-4-yl]-pyrazol-1-ylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4064162; BDBM50231246
Click to Show/Hide
|
||||
| Activity |
IC50 = 85600 nM
|
[13] | |||
| Compound Name |
Chembl4280337
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467432
Click to Show/Hide
|
||||
| Activity |
IC50 = 87490 nM
|
[4] | |||
| Compound Name |
(2-Phenyl-1,3-oxazol-4-yl)-pyrazol-1-ylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4069028; BDBM50231321
Click to Show/Hide
|
||||
| Activity |
IC50 = 88700 nM
|
[13] | |||
| Compound Name |
3-Tert-butyl-5-[3-(2,4-difluorophenyl)-4-methoxyphenyl]-1-(3-hydroxypropyl)-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2387432; BDBM50491687
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[17] | |||
| Compound Name |
7-Hydroxy-8-methoxy-1,5,10,10a-tetrahydro-[1,3]oxazolo[3,4-b]isoquinolin-3-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067625; BDBM50261632
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-Tert-butyl-5-[3-(2,4-dimethoxyphenyl)-4-methoxyphenyl]-1-(3-hydroxypropyl)-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2387436; BDBM50491692
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[17] | |||
| Compound Name |
3-Tert-butyl-1-(3-hydroxypropyl)-5-[4-methoxy-3-(2-methylsulfanylphenyl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2387431; BDBM50491688
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[17] | |||
| Compound Name |
Chembl4292772
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467421
Click to Show/Hide
|
||||
| Activity |
IC50 = 109820 nM
|
[4] | |||
| Compound Name |
6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)pyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1777830; BDBM50344309
Click to Show/Hide
|
||||
| Activity |
IC50 = 114000 nM
|
[16] | |||
| Compound Name |
2-Isopropyl-3-(6-methoxypyridazin-3-yl)pyrazolo[1,5-a]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779442; BDBM50344324
Click to Show/Hide
|
||||
| Activity |
IC50 = 115000 nM
|
[16] | |||
| Compound Name |
Chembl4203545
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457964
Click to Show/Hide
|
||||
| Activity |
IC50 = 116100 nM
|
[2] | |||
| Compound Name |
3,4,11,12-Tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,10,13,15-pentaen-5-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779429; BDBM50344311; rac-4,4a,5,6-Tetrahydro-2H-1,2,7,7a-tetraaza-benzo[c]fluoren-3-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[16] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 22 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
PMID28870136-Compound-48
Click to Show/Hide
|
Patented | Compound Info | ||
| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
HC-030031
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
TRPA1 inhibitor (pain/inflammation), Hydra Biosciences/Cubist Pharmaceuticals
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4284046
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467434
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4294138
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467440
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4276743
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467430
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4290575
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467438
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4290979
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467433
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4216676
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457946
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
Chembl4294370
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467422
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4213058
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457944
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
Chembl4280678
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467431
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4279233
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467442
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4207716
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457963
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
Chembl4290814
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467441
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4280173
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467426
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4218669
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457956
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
Chembl4283794
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467429
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4287403
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467424
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
Chembl4210386
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50457957
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[2] | |||
| Compound Name |
Chembl4287148
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50467425
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[4] | |||
| Compound Name |
3-(6-Chloro-4-methylpyridazin-3-yl)-2-isopropylpyrazolo[1,5-a]pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779441; BDBM50344323
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[16] | |||
| Compound Name |
6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-5-methylpyridazin-3(2H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1779428; BDBM50344310
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[16] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and molecular modeling of novel tetrahydro--carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties. J Med Chem. 2011 Jan 27;54(2):495-509. | ||||
| REF 2 | Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation. Eur J Med Chem. 2018 Feb 25;146:381-394. | ||||
| REF 3 | 8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors. J Med Chem. 2005 Feb 24;48(4):1237-43. | ||||
| REF 4 | Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain. Eur J Med Chem. 2018 Oct 5;158:517-533. | ||||
| REF 5 | Structure-based design and structure-activity relationships of 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors. Bioorg Med Chem Lett. 2018 Apr 15;28(7):1188-1193. | ||||
| REF 6 | Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as potential PDE4 inhibitors. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4610-4. | ||||
| REF 7 | Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity. J Med Chem. 2018 May 10;61(9):3870-3888. | ||||
| REF 8 | Tetrahydroquinoline and tetrahydroisoquinoline derivatives as potential selective PDE4B inhibitors. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3271-3275. | ||||
| REF 9 | Synthesis and bioactivity of 3,5-dimethylpyrazole derivatives as potential PDE4 inhibitors. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3276-3280. | ||||
| REF 10 | Rational design of conformationally constrained oxazolidinone-fused 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors. Bioorg Med Chem. 2017 Oct 15;25(20):5709-5717. | ||||
| REF 11 | Identification of pyridazino[4,5-b]indolizines as selective PDE4B inhibitors. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2163-7. | ||||
| REF 12 | Rhodanine derivatives as novel inhibitors of PDE4. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2032-7. | ||||
| REF 13 | Design, synthesis and biological evaluation of 2,4-disubstituted oxazole derivatives as potential PDE4 inhibitors. Bioorg Med Chem. 2017 Mar 15;25(6):1852-1859. | ||||
| REF 14 | Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3632-5. | ||||
| REF 15 | Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure. J Med Chem. 2013 Mar 14;56(5):2087-96. | ||||
| REF 16 | Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3307-12. | ||||
| REF 17 | Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3443-7. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.