TTD_Target_ID	Target_Name	TTD_Drug_ID	Drug_Name	Drug_Highest_Status	Drug_PubchemID	Molecular_Formula	Molecular_Weight	Canonical_SMILES	Activity	Binder_Type
T10265	Phosphodiesterase 4B	D05MQK	Tadalafil	Approved	110635	C22H19N3O4	389.4	CN1CC(=O)N2[C@@H](C1=O)CC3=C([C@H]2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36	IC50 ~ 50000 nM	Poor binder
T10265	Phosphodiesterase 4B	D03XTA	PMID28870136-Compound-49	Patented	4740	C13H18N4O3	278.31	CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C	IC50 ~ 90000 nM	Poor binder
T10265	Phosphodiesterase 4B	D0BK6B	CI-930	Discontinued in Phase 2	3021729	C14H14N4O	254.29	CC1CC(=O)NN=C1C2=CC=C(C=C2)N3C=CN=C3	Ki ~ 50000 nM	Poor binder
T10265	Phosphodiesterase 4B	D00YPW	ZAPRINAST	Terminated	135399235	C13H13N5O2	271.27	.	Ki ~ 50000 nM	Poor binder
T10265	Phosphodiesterase 4B	B09IQX	Chembl4205157	Investigative	145977095	C24H27N7O6	509.5	CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)NCC3=CC=CO3)CCCC(=O)N/N=C/C4=C(C=C(C=C4)OC)O	IC50 = 70800 nM	Poor binder
T10265	Phosphodiesterase 4B	B0GL6A	[2-(4-Bromophenyl)-1,3-oxazol-4-yl]-pyrazol-1-ylmethanone	Investigative	137660145	C13H8BrN3O2	318.12	C1=CN(N=C1)C(=O)C2=COC(=N2)C3=CC=C(C=C3)Br	IC50 = 58700 nM	Poor binder
T10265	Phosphodiesterase 4B	B0KNS3	(2R,8R)-2-(2,4-Dichlorophenyl)-6-ethyl-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione	Investigative	50925469	C22H19Cl2N3O2	428.3	CCN1CC(=O)N2[C@@H](C1=O)CC3=C([C@H]2C4=C(C=C(C=C4)Cl)Cl)NC5=CC=CC=C35	IC50 ~ 50000 nM	Poor binder
T10265	Phosphodiesterase 4B	B19PJI	Chembl4166361	Investigative	145955201	C20H16N2O4	348.4	C1CN(CC2=CC=CC=C21)C(=O)C3=CC=C(O3)C4=CC=CC=C4[N+](=O)[O-]	IC50 = 66300 nM	Poor binder
T10265	Phosphodiesterase 4B	B2NUP5	(2-Phenyl-1,3-oxazol-4-yl)-pyrazol-1-ylmethanone	Investigative	137633685	C13H9N3O2	239.23	C1=CC=C(C=C1)C2=NC(=CO2)C(=O)N3C=CC=N3	IC50 = 88700 nM	Poor binder
T10265	Phosphodiesterase 4B	B2XIL4	Chembl4209972	Investigative	145964973	C31H36N4O4	528.6	COC1=C(C=C(C=C1)C2=NN(C(=O)[C@@H]3[C@H]2CC=CC3)C4CCCCCC4)C5=CC=C(C=C5)C(=O)NCC(=O)N	Ki = 50118.72 nM	Poor binder
T10265	Phosphodiesterase 4B	B31FGL	Chembl4292859	Investigative	145989866	C16H14N2O2	266.29	CC1=CC(=NN1C(=O)C2=CC=C(O2)C3=CC=CC=C3)C	IC50 = 70300 nM	Poor binder
T10265	Phosphodiesterase 4B	B3R4FW	Chembl4284587	Investigative	145990360	C16H13BrN2O2	345.19	CC1=CC(=NN1C(=O)C2=CC=C(O2)C3=CC=C(C=C3)Br)C	IC50 = 51100 nM	Poor binder
T10265	Phosphodiesterase 4B	B41GVQ	(3,5-Dimethylpyrazol-1-yl)-[2-(2-hydroxyphenyl)-1,3-oxazol-4-yl]methanone	Investigative	137642910	C15H13N3O3	283.28	CC1=CC(=NN1C(=O)C2=COC(=N2)C3=CC=CC=C3O)C	IC50 = 54800 nM	Poor binder
T10265	Phosphodiesterase 4B	B54WZB	3-Tert-butyl-5-[3-(2,4-difluorophenyl)-4-methoxyphenyl]-1-(3-hydroxypropyl)-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-one	Investigative	71624752	C26H28F2N4O3	482.5	CC(C)(C)C1=NN(C2=C1N=C(CNC2=O)C3=CC(=C(C=C3)OC)C4=C(C=C(C=C4)F)F)CCCO	IC50 = 100000 nM	Poor binder
T10265	Phosphodiesterase 4B	B57EDV	7-Hydroxy-8-methoxy-1,5,10,10a-tetrahydro-[1,3]oxazolo[3,4-b]isoquinolin-3-one	Investigative	137632496	C12H13NO4	235.24	COC1=C(C=C2CN3C(CC2=C1)COC3=O)O	IC50 ~ 100000 nM	Poor binder
T10265	Phosphodiesterase 4B	B6M1HS	(4-(3-(1,2-Dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3,2-d]pyridazin-4-ylamino)propyl)piperazin-1-yl)(pyridin-4-yl)methanone	Investigative	46884257	C27H30N8O3	514.6	CC1=CC2=C(N1C)C(=NN=C2NCCCN3CCN(CC3)C(=O)C4=CC=NC=C4)C5=CC(=CC=C5)[N+](=O)[O-]	Ki = 52200 nM	Poor binder
T10265	Phosphodiesterase 4B	B6S2ZY	2-Isopropyl-3-(6-methoxypyridazin-3-yl)pyrazolo[1,5-a]pyridine	Investigative	54585432	C15H16N4O	268.31	CC(C)C1=NN2C=CC=CC2=C1C3=NN=C(C=C3)OC	IC50 = 115000 nM	Poor binder
T10265	Phosphodiesterase 4B	B70YIG	Chembl4203037	Investigative	145976252	C29H32F3NO6	547.6	COC1=C(C=C2CN(C(CC2=C1)C(=O)OC3CCCC3)C(=O)C4=CC=C(C=C4)OC(F)(F)F)OC5CCCC5	IC50 ~ 50000 nM	Poor binder
T10265	Phosphodiesterase 4B	B74GVY	Chembl4159546	Investigative	145959620	C20H16BrNO2	382.2	C1CN(CC2=CC=CC=C21)C(=O)C3=CC=C(O3)C4=CC=C(C=C4)Br	IC50 = 58400 nM	Poor binder
T10265	Phosphodiesterase 4B	B7CX0M	(5-Phenylfuran-2-yl)-(1,2,4-triazol-1-yl)methanone	Investigative	56834626	C13H9N3O2	239.23	C1=CC=C(C=C1)C2=CC=C(O2)C(=O)N3C=NC=N3	IC50 = 65700 nM	Poor binder
T10265	Phosphodiesterase 4B	B7OFK4	[5-(2-Nitrophenyl)furan-2-yl]-(1,2,4-triazol-1-yl)methanone	Investigative	56834532	C13H8N4O4	284.23	C1=CC=C(C(=C1)C2=CC=C(O2)C(=O)N3C=NC=N3)[N+](=O)[O-]	IC50 = 56800 nM	Poor binder
T10265	Phosphodiesterase 4B	B7SO5L	(7-Cyclopentyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)-[(3R,4S,5R)-3,4,5-trihydroxycyclohexen-1-yl]methanone	Investigative	122190073	C22H29NO6	403.5	COC1=C(C=C2CN(CCC2=C1)C(=O)C3=C[C@H]([C@H]([C@@H](C3)O)O)O)OC4CCCC4	IC50 ~ 50000 nM	Poor binder
T10265	Phosphodiesterase 4B	B8K5FV	3-Tert-butyl-5-[3-(2,4-dimethoxyphenyl)-4-methoxyphenyl]-1-(3-hydroxypropyl)-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-one	Investigative	71624869	C28H34N4O5	506.6	CC(C)(C)C1=NN(C2=C1N=C(CNC2=O)C3=CC(=C(C=C3)OC)C4=C(C=C(C=C4)OC)OC)CCCO	IC50 = 100000 nM	Poor binder
T10265	Phosphodiesterase 4B	B8P1EV	[2-(4-Bromophenyl)-1,3-oxazol-4-yl]-(3,5-dimethylpyrazol-1-yl)methanone	Investigative	137636108	C15H12BrN3O2	346.18	CC1=CC(=NN1C(=O)C2=COC(=N2)C3=CC=C(C=C3)Br)C	IC50 = 54800 nM	Poor binder
T10265	Phosphodiesterase 4B	BAH72C	Chembl4207920	Investigative	145978852	C31H30F3NO6	569.6	COC1=C(C=C2CN(C(CC2=C1)C(=O)OCC3=CC=CC=C3)C(=O)C4=CC=C(C=C4)OC(F)(F)F)OC5CCCC5	IC50 ~ 50000 nM	Poor binder
T10265	Phosphodiesterase 4B	BC7D6N	Chembl4209377	Investigative	145966342	C21H26N6O4	426.5	CCCOC1=NC2=C(N1CCCC(=O)N/N=C/C3=CC=CC=C3)C(=O)N(C(=O)N2C)C	IC50 = 51800 nM	Poor binder
T10265	Phosphodiesterase 4B	BCA3S8	Chembl4276935	Investigative	145983920	C16H13ClN2O2	300.74	CC1=CC(=NN1C(=O)C2=CC=C(O2)C3=CC=CC=C3Cl)C	IC50 = 52400 nM	Poor binder
T10265	Phosphodiesterase 4B	BCE62K	3,4,11,12-Tetrazatetracyclo[8.7.0.02,7.012,17]heptadeca-1(17),2,10,13,15-pentaen-5-one	Investigative	54580521	C13H12N4O	240.26	C1CC2=NN3C=CC=CC3=C2C4=NNC(=O)CC41	IC50 = 200000 nM	Poor binder
T10265	Phosphodiesterase 4B	BD35VI	Chembl4280337	Investigative	145981927	C22H29N5O4	427.5	CC(C)(C)C1=CC=C(C=C1)NC(=O)CCCN2C3=C(N=C2OC)N(C(=O)N(C3=O)C)C	IC50 = 87490 nM	Poor binder
T10265	Phosphodiesterase 4B	BFD14Z	3-Tert-butyl-1-(3-hydroxypropyl)-5-[4-methoxy-3-(2-methylsulfanylphenyl)phenyl]-6,7-dihydropyrazolo[4,3-e][1,4]diazepin-8-one	Investigative	71624751	C27H32N4O3S	492.6	CC(C)(C)C1=NN(C2=C1N=C(CNC2=O)C3=CC(=C(C=C3)OC)C4=CC=CC=C4SC)CCCO	IC50 = 100000 nM	Poor binder
T10265	Phosphodiesterase 4B	BFYW04	Chembl4159877	Investigative	145957385	C20H17NO2	303.4	C1CC2=CC=CC=C2N(C1)C(=O)C3=CC=C(O3)C4=CC=CC=C4	IC50 = 70900 nM	Poor binder
T10265	Phosphodiesterase 4B	BFZN93	Chembl4203545	Investigative	145977528	C21H26N6O6	458.5	CCCOC1=NC2=C(N1CCCC(=O)N/N=C/C3=C(C=C(C=C3)O)O)C(=O)N(C(=O)N2C)C	IC50 = 116100 nM	Poor binder
T10265	Phosphodiesterase 4B	BG87XN	6-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)pyridazin-3(2H)-one	Investigative	24751843	C14H14N4O	254.29	CC(C)C1=NN2C=CC=CC2=C1C3=NNC(=O)C=C3	IC50 = 114000 nM	Poor binder
T10265	Phosphodiesterase 4B	BGE8O1	5,6-Dihydro-2H-1,2,7,7a-tetraaza-benzo[c]fluoren-3-one	Investigative	54582527	C13H10N4O	238.24	C1CC2=NN3C=CC=CC3=C2C4=NNC(=O)C=C41	IC50 = 73000 nM	Poor binder
T10265	Phosphodiesterase 4B	BH0MQ2	7,8-Dimethoxy-1,5,10,10a-tetrahydro-[1,3]oxazolo[3,4-b]isoquinolin-3-one	Investigative	137648937	C13H15NO4	249.26	COC1=C(C=C2CN3C(CC2=C1)COC3=O)OC	IC50 = 52100 nM	Poor binder
T10265	Phosphodiesterase 4B	BHNT59	(5-Phenylfuran-2-yl)-pyrazol-1-ylmethanone	Investigative	56834432	C14H10N2O2	238.24	C1=CC=C(C=C1)C2=CC=C(O2)C(=O)N3C=CC=N3	IC50 = 78100 nM	Poor binder
T10265	Phosphodiesterase 4B	BI5W8Y	N-({4-[(1H-1,2,4-Triazol-1-yl)methyl]phenyl}methyl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide	Investigative	45862748	C23H23N5O	385.5	C1CCC2=C(C1)C3=C(N2)C=CC(=C3)C(=O)NCC4=CC=C(C=C4)CN5C=NC=N5	IC50 = 68000 nM	Poor binder
T10265	Phosphodiesterase 4B	BKSW15	[5-(2-Chlorophenyl)furan-2-yl]-pyrazol-1-ylmethanone	Investigative	56834425	C14H9ClN2O2	272.68	C1=CC=C(C(=C1)C2=CC=C(O2)C(=O)N3C=CC=N3)Cl	IC50 = 68100 nM	Poor binder
T10265	Phosphodiesterase 4B	BN35JO	Chembl4287175	Investigative	145991365	C16H13N3O4	311.29	CC1=CC(=NN1C(=O)C2=CC=C(O2)C3=CC=CC=C3[N+](=O)[O-])C	IC50 = 62700 nM	Poor binder
T10265	Phosphodiesterase 4B	BN3X6B	[2-(2-Hydroxyphenyl)-1,3-oxazol-4-yl]-pyrazol-1-ylmethanone	Investigative	137634455	C13H9N3O3	255.23	C1=CC=C(C(=C1)C2=NC(=CO2)C(=O)N3C=CC=N3)O	IC50 = 85600 nM	Poor binder
T10265	Phosphodiesterase 4B	BN9BK4	Chembl4171565	Investigative	145950282	C20H16FNO2	321.3	C1CC2=CC=CC=C2N(C1)C(=O)C3=CC=C(O3)C4=CC=CC=C4F	IC50 = 50300 nM	Poor binder
T10265	Phosphodiesterase 4B	BNX8H3	Chembl4176072	Investigative	145972902	C20H16N2O4	348.4	C1CC2=CC=CC=C2N(C1)C(=O)C3=CC=C(O3)C4=CC=CC=C4[N+](=O)[O-]	IC50 = 66900 nM	Poor binder
T10265	Phosphodiesterase 4B	BO6XU9	[5-(2-Nitrophenyl)furan-2-yl]-pyrazol-1-ylmethanone	Investigative	56834322	C14H9N3O4	283.24	C1=CC=C(C(=C1)C2=CC=C(O2)C(=O)N3C=CC=N3)[N+](=O)[O-]	IC50 = 75800 nM	Poor binder
T10265	Phosphodiesterase 4B	BQ7B1P	Chembl4203562	Investigative	145978004	C29H34F3NO6	549.6	CCCCCOC(=O)C1CC2=CC(=C(C=C2CN1C(=O)C3=CC=C(C=C3)OC(F)(F)F)OC4CCCC4)OC	IC50 ~ 50000 nM	Poor binder
T10265	Phosphodiesterase 4B	BQA75C	(5Z)-2-Sulfanylidene-5-[(3,4,5-trimethoxyphenyl)methylidene]-1,3-thiazolidin-4-one	Investigative	1390827	C13H13NO4S2	311.4	COC1=CC(=CC(=C1OC)OC)/C=C\\2/C(=O)NC(=S)S2	IC50 = 64820 nM	Poor binder
T10265	Phosphodiesterase 4B	BQCH65	Chembl4170936	Investigative	145952205	C20H17NO2	303.4	C1CN(CC2=CC=CC=C21)C(=O)C3=CC=C(O3)C4=CC=CC=C4	IC50 = 79600 nM	Poor binder
T10265	Phosphodiesterase 4B	BQP86D	Thiazolidin-4-one, 5-(2,3-dimethoxybenzylidene)-2-thioxo-	Investigative	1418559	C12H11NO3S2	281.4	COC1=CC=CC(=C1OC)/C=C\\2/C(=O)NC(=S)S2	IC50 = 54650 nM	Poor binder
T10265	Phosphodiesterase 4B	BS2QU3	(3,5-Dimethylpyrazol-1-yl)-(2-phenyl-1,3-oxazol-4-yl)methanone	Investigative	137639441	C15H13N3O2	267.28	CC1=CC(=NN1C(=O)C2=COC(=N2)C3=CC=CC=C3)C	IC50 = 75800 nM	Poor binder
T10265	Phosphodiesterase 4B	BSO0M8	4-[2-[3-[(3-Cyclopentyloxy-4-methoxyphenyl)methyl]-6-imino-7H-purin-8-yl]-2-methylpropoxy]benzoic acid	Investigative	136132229	C29H33N5O5	531.6	CC(C)(COC1=CC=C(C=C1)C(=O)O)C2=NC3=C(N2)C(=N)N=CN3CC4=CC(=C(C=C4)OC)OC5CCCC5	Ki ~ 50000 nM	Poor binder
T10265	Phosphodiesterase 4B	BT82QS	Chembl4163701	Investigative	27659634	C20H16ClNO2	337.8	C1CN(CC2=CC=CC=C21)C(=O)C3=CC=C(O3)C4=CC=CC=C4Cl	IC50 = 51600 nM	Poor binder
T10265	Phosphodiesterase 4B	BW3UK8	Chembl4292772	Investigative	145989417	C25H35N5O4	469.6	CCCCOC1=NC2=C(N1CCCC(=O)NC3=CC=C(C=C3)C(C)CC)C(=O)N(C(=O)N2C)C	IC50 = 109820 nM	Poor binder
T10265	Phosphodiesterase 4B	BYT37B	[5-(2-Fluorophenyl)furan-2-yl]-pyrazol-1-ylmethanone	Investigative	56834427	C14H9FN2O2	256.23	C1=CC=C(C(=C1)C2=CC=C(O2)C(=O)N3C=CC=N3)F	IC50 = 65100 nM	Poor binder
T10265	Phosphodiesterase 4B	BZ18IE	(4-Aminocyclohexyl)-(7-cyclopentyloxy-6-methoxy-3,4-dihydro-1H-isoquinolin-2-yl)methanone;hydrochloride	Investigative	122190074	C22H33ClN2O3	409	COC1=C(C=C2CN(CCC2=C1)C(=O)C3CCC(CC3)N)OC4CCCC4.Cl	IC50 ~ 50000 nM	Poor binder
T10265	Phosphodiesterase 4B	D00MBG	BRL50481	Investigative	2921148	C9H12N2O4S	244.27	CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)C	IC50 = 175000 nM	Poor binder