Protein-Protein Interaction Details
Protein General Information | Top | ||||
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Full Name | Mothers against decapentaplegic homolog 4 (SMAD4) | ||||
UniProt ID | SMAD4_HUMAN | ||||
Gene Name | SMAD4 | ||||
Gene ID | 4089 |
Interacting TTD Target Information | Top | ||||
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Interacting Clinical trial Target(s) | Transcription factor Sp1 (SP1) | Target Info | PPI Info | [1] | |
Histone acetyltransferase p300 (EP300) | Target Info | PPI Info | [2] | ||
Interacting Literature-reported Target(s) | JUN activation domain binding protein (COPS5) | Target Info | PPI Info | [3] | |
Interacting Preclinical Target(s) | Mothers against decapentaplegic homolog 3 (SMAD3) | Target Info | PPI Info | [4] |
References | Top | ||||
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REF 1 | Growth-dependent repression of human adenine nucleotide translocator-2 (ANT2) transcription: evidence for the participation of Smad and Sp family proteins in the NF1-dependent repressor complex. Biochem J. 2008 May 15;412(1):123-30. | ||||
REF 2 | A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction. Genes Dev. 2000 Jul 1;14(13):1605-16. | ||||
REF 3 | Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. EMBO Rep. 2002 Feb;3(2):171-6. | ||||
REF 4 | A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Nature. 2002 Aug 8;418(6898):641-6. |
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