Protein-Protein Interaction Details
Protein General Information (TTD Target) | Top | ||||
---|---|---|---|---|---|
Full Name | Erbb3 tyrosine kinase receptor (Erbb-3) | Clinical trial | Target Info | ||
UniProt ID | ERBB3_HUMAN | ||||
Gene Name | ERBB3 |
Interacting TTD Target Information | Top | ||||
---|---|---|---|---|---|
Interacting Successful Target(s) | Epidermal growth factor receptor (EGFR) | Target Info | PPI Info | [1] | |
Erbb2 tyrosine kinase receptor (HER2) | Target Info | PPI Info | [2] | ||
PI3-kinase alpha (PIK3CA) | Target Info | PPI Info | [3] | ||
Interacting Clinical trial Target(s) | Protein-tyrosine phosphatase SHP-2 (PTPN11) | Target Info | PPI Info | [4] | |
Tyrosine-protein kinase BRK (PTK6) | Target Info | PPI Info | [5] |
References | Top | ||||
---|---|---|---|---|---|
REF 1 | Differential erbB signaling in astrocytes from the cerebral cortex and the hypothalamus of the human brain. Glia. 2009 Mar;57(4):362-79. | ||||
REF 2 | Neuregulin-1 enhances survival of human astrocytic glioma cells. Glia. 2005 Aug 15;51(3):217-28. | ||||
REF 3 | Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 co-receptor. J Biol Chem. 2001 Nov 9;276(45):42153-61. | ||||
REF 4 | A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Mol Cell. 2017 Jan 19;65(2):347-360. | ||||
REF 5 | Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation. Oncogene. 2000 Nov 16;19(48):5471-6. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.