Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T73694 Target Info
Target Name Tyrosine-protein kinase BRK (PTK6)
Synonyms Protein-tyrosine kinase 6; Breast tumor kinase; BRK
Target Type Clinical trial Target
Gene Name PTK6
Biochemical Class Kinase
UniProt ID
PTK6_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 2 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Protein-peptide [2]
Interacting Target Name Erbb3 tyrosine kinase receptor (Erbb-3) Clinical trial Target Interacting Protein Info
UniProt ID
ERBB3_HUMAN 
Synonyms Tyrosine kinase-type cell surface receptor HER3; Receptor tyrosine-protein kinase erbB-3; Proto-oncogene-like protein c-ErbB-3; HER3; C-erbB-3 protein; C-erbB3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Protein-peptide [2]
References  Top
REF 1 Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor. J Biol Chem. 1996 Nov 29;271(48):30956-63.
REF 2 A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 2006 Jan 12;439(7073):168-74.
REF 3 Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation. Oncogene. 2000 Nov 16;19(48):5471-6.

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