Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T64553 Target Info
Target Name Tyrosine-protein kinase ZAP-70 (ZAP-70)
Synonyms Syk-related tyrosine kinase; SRK; 70 kDa zeta-chain associated protein
Target Type Patented-recorded Target
Gene Name ZAP70
Biochemical Class Kinase
UniProt ID
ZAP70_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US8546370
Title Compounds and compositions as kinase inhibitors
Abstract The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS, or combinations thereof.
Applicant(s) IRM LLC
Representative Drug(s) D0VE2A Drug Info IC50 = 1 nM Click to Show More [1]
2 D09OGH Drug Info IC50 = 58 nM [1]
3 D00HGD Drug Info IC50 = 475 nM [1]
Patent ID US8546370
Title Compounds and compositions as kinase inhibitors
Abstract The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS, or combinations thereof.
Applicant(s) IRM LLC
Representative Drug(s) D0VE2A Drug Info IC50 = 1 nM Click to Show More [1]
2 D09OGH Drug Info IC50 = 58 nM [1]
3 D00HGD Drug Info IC50 = 475 nM [1]
Patent ID US8546370
Title Compounds and compositions as kinase inhibitors
Abstract The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS, or combinations thereof.
Applicant(s) IRM LLC
Representative Drug(s) D0VE2A Drug Info IC50 = 1 nM Click to Show More [1]
2 D09OGH Drug Info IC50 = 58 nM [1]
3 D00HGD Drug Info IC50 = 475 nM [1]
References  Top
REF 1 Compounds and compositions as kinase inhibitors. US8546370.

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