Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00HGD
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| Drug Name |
US8546370, 102
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| Synonyms |
SCHEMBL1043246; CHEMBL3639414; BDBM103514; US8546370, 102
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H21ClN4O2
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| Canonical SMILES |
C1COCCN1C2=CC=C(C=C2)NC3=C4C(=CC(=N3)C5=CC=CC=C5Cl)C=CNC4=O
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| InChI |
1S/C24H21ClN4O2/c25-20-4-2-1-3-19(20)21-15-16-9-10-26-24(30)22(16)23(28-21)27-17-5-7-18(8-6-17)29-11-13-31-14-12-29/h1-10,15H,11-14H2,(H,26,30)(H,27,28)
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| InChIKey |
BMPOWIIBXCMAFL-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tyrosine-protein kinase ZAP-70 (ZAP-70) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Tyrosine-protein kinase ZAP-70 (ZAP-70) | Target's Patent Info | [1] | |
| KEGG Pathway | Ras signaling pathway | |||
| NF-kappa B signaling pathway | ||||
| Natural killer cell mediated cytotoxicity | ||||
| T cell receptor signaling pathway | ||||
| Primary immunodeficiency | ||||
| Panther Pathway | T cell activation | |||
| Pathway Interaction Database | TCR signaling in naï | |||
| TCR signaling in naï | ||||
| Class I PI3K signaling events | ||||
| Reactome | Translocation of ZAP-70 to Immunological synapse | |||
| Generation of second messenger molecules | ||||
| WikiPathways | TCR Signaling Pathway | |||
| Interferon type I signaling pathways | ||||
| Inflammatory Response Pathway | ||||
| JAK/STAT | ||||
| T-Cell Receptor and Co-stimulatory Signaling | ||||
| TCR signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Compounds and compositions as kinase inhibitors. US8546370. | |||
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