Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D09OGH
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| Drug Name |
US8546370, 11
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| Synonyms |
SCHEMBL1044792; CHEMBL3642577; BDBM103510; US8546370, 11
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| Drug Type |
Small molecular drug
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| Structure |
 |
Download2D MOL |
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| Formula |
C24H22N4O2
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| Canonical SMILES |
C1COCCN1C2=CC=C(C=C2)NC3=C4C(=CC(=N3)C5=CC=CC=C5)C=CNC4=O
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| InChI |
1S/C24H22N4O2/c29-24-22-18(10-11-25-24)16-21(17-4-2-1-3-5-17)27-23(22)26-19-6-8-20(9-7-19)28-12-14-30-15-13-28/h1-11,16H,12-15H2,(H,25,29)(H,26,27)
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| InChIKey |
UNLNOESEDGPPCS-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tyrosine-protein kinase ZAP-70 (ZAP-70) | Target Info | Inhibitor | [1] |
| Target's Patent Info | Tyrosine-protein kinase ZAP-70 (ZAP-70) | Target's Patent Info | [1] | |
| KEGG Pathway | Ras signaling pathway | |||
| NF-kappa B signaling pathway | ||||
| Natural killer cell mediated cytotoxicity | ||||
| T cell receptor signaling pathway | ||||
| Primary immunodeficiency | ||||
| Panther Pathway | T cell activation | |||
| Pathway Interaction Database | TCR signaling in naï | |||
| TCR signaling in naï | ||||
| Class I PI3K signaling events | ||||
| Reactome | Translocation of ZAP-70 to Immunological synapse | |||
| Generation of second messenger molecules | ||||
| WikiPathways | TCR Signaling Pathway | |||
| Interferon type I signaling pathways | ||||
| Inflammatory Response Pathway | ||||
| JAK/STAT | ||||
| T-Cell Receptor and Co-stimulatory Signaling | ||||
| TCR signaling | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Compounds and compositions as kinase inhibitors. US8546370. | |||
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