Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T40111 Target Info
Target Name Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)
Synonyms Superoxide-inducible protein 12; SOI12; Probable inosine-5'-monophosphate dehydrogenase IMD1; NAD-dependent inosine monophosphate dehydrogenase; Inosine dehydrogenase; IMPDH-I; IMPDH 1; IMPDH; IMPD1; IMPD 1; IMPD; IMP dehydrogenase 1; IMP dehydrogenase
Target Type Successful Target
Gene Name IMPDH1
Biochemical Class CH-OH donor oxidoreductase
UniProt ID
IMDH1_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2003053958
Title Quinazolinedione Derivatives.
Abstract A compound of formula (1): wherein: X and Y, which may be the same or different, is each an O or S atom; R1 is an aliphatic, cylcoaliphatic or cycloalkyl-akyl-group; R2 is an optionally substituted heteroaromatic group; R3 is the group Alk1-L1-Alk2-R4in which Alk1 is a covalent bond or an optionally substituted aliphatic or heteroaliphatic chain, L1 is a covalent bond or a linker atom or group, Alk2 is a covalent bond or an optionally substituted aliphatic or thereoaliphatic chain and R4 is a hydrogen atom or an optionally substituted cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates, tautomers, isomers or N-oxides thereof. The compounds of the present invention are potent inhibitors of IMPDH.
Applicant(s) Celltech R&D Limited
Representative Drug(s) D0LH0O Drug Info IC50 = 13 nM Click to Show More [1]
2 D0P6WN Drug Info IC50 = 190 nM [1]
3 D01XUI Drug Info N.A. [1]
Patent ID WO2004022554
Title Quinazolinone Derivatives.
Abstract A compound of formula (1), wherein: X is an oxygen or sulfur atom; R1 is an aliphatic, cycloaliphatic or cycloalkyl-alkyl- group; R2 is an optionally substituted heteroaromatic group or a -CN group; R3 is a group -(Alk1)mL1(AIk2)nR4 in which m and n, which may be the same or different, is each zero or the integer 1, Alk1 and AIk2, which may be the same or different, is each an optionally substituted aliphatic or heteroaliphatic chain, L1 is a covalent bond or a linker atom or group and R4 is a hydrogen atom or an optionally substituted cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; A is an optionally substituted cycloaliphatic or heterocycloaliphatic group optionally fused to an optionally substituted aryl or heteroaryl group; R5, which may be attached to any available C or N atom present in the cycloaliphatic or heterocycloaliphatic, or where fused, aryl or heteroaryl group, is a group -(AIk3)tL2(AIk4)vR6 in which t and v, which may be the same or different, is each zero or the integer 1, Alk3 and AIk4, which may be the same or different, is each an optionally substituted aliphatic or heteroaliphatic chain, L2 is a covalent bond or a linker atom or group and R6 is a hydrogen or halogen atom or a -CN group or an optionally substituted cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates, tautomers, isomers or N-oxides thereof. The compounds of the present invention are potent inhibitors of IMPDH.
Applicant(s) Celltech R&D Limited
Representative Drug(s) D06KXL Drug Info IC50 = 100 nM Click to Show More [1]
2 D0NK9Y Drug Info N.A. [1]
Patent ID WO2009018344
Title Anticancer Agents.
Abstract The invention provides a compound of the invention, which is a compound of formula A-X-L-B, or a salt thereof, as well as compositions comprising a compound of the invention, and therapeutic methods that include the administration of a compound of the invention. The compounds of the invention are useful as therapeutic agents for the treatment of diseases such as cancer.
Applicant(s) Regents of the University of Minnesota
Representative Drug(s) D0EX3N Drug Info N.A. Click to Show More [1]
2 D0R3QC Drug Info N.A. [1]
Patent ID WO2013131409
Title Phenyl-Oxazolyl Derivatives, Preparation Method Thereof, and Related Application of The Phenyl-Oxazolyl Derivatives As An Impdh Inhibitor.
Abstract Disclosed are phenyl-oxazolyl derivatives having a general formula (I), a preparation method thereof, and an application of the phenyl-oxazolyl derivatives as an inosine monophosphate dehydrogenase (I.
Applicant(s) Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
Patent ID WO2004096287
Title Inosine Monophosphate Dehydrogenase Inhibitory Phosphonate Compounds.
Abstract The invention is related to phosphorus substituted IMPDH inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Applicant(s) Gilead Sciences, Inc
Patent ID WO2003045901
Title Guanidine Derivatives.
Abstract Guanidine derivatives of formula (I) are described: wherein: R' is an aliphatic, cycloaliphatic or cycloalkyl-alkyl- group; R2 is an optionally substituted aromatic, heteroaromatic group, aryl-fused cycloaliphatic, heteroaryl-fused cycloaliphatic, aryl-fused heterocycloaliphatic or heteroaryl-fused heterocycloaliphatic group; R3 is a -CN, -COR5, -OR6, -CON(R7)R8, S02R5 or S02N(R7)R8 group; R4 is an optionally substituted heteroaromatic group; and the salts, solvates, hydrates, tautomers, isomers, N-oxides thereof. The compounds are potent inhibitors of IMPDH and are of use as immunosuppressants, anti-cancer agents, anti-inflammatory agents, antipsoriatic and anti-viral agents.
Applicant(s) Celltech R&D Limited
Representative Drug(s) D05QMA Drug Info N.A. [1]
United States Patent and Trademark Office (USPTO)
Patent ID US20120264760
Title Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections.
Applicant(s) Brandeis University
Representative Drug(s) D06UKM Drug Info IC50 = 0.5 nM Click to Show More [1]
2 D0PN7H Drug Info IC50 = 0.7 nM [1]
3 D06HLW Drug Info IC50 = 8 nM [1]
4 D01FPR Drug Info IC50 = 13 nM [1]
5 D0J0EP Drug Info IC50 = 13 nM [1]
6 D0B7FH Drug Info IC50 = 20 nM [1]
7 D0SG2L Drug Info IC50 = 29 nM [1]
Patent ID US20100022547
Title Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections.
Applicant(s) Brandeis University
Representative Drug(s) D0J9WP Drug Info IC50 = 0.5 nM Click to Show More [1]
2 D0X6FX Drug Info IC50 = 0.7 nM [1]
3 D03XKM Drug Info IC50 = 8 nM [1]
4 D07NDT Drug Info IC50 = 13 nM [1]
5 D0IQ5V Drug Info IC50 = 13 nM [1]
6 D03KFN Drug Info IC50 = 20 nM [1]
7 D00XRN Drug Info IC50 = 29 nM [1]
Patent ID US20056919335
Title Heterocyclic Acridone Inhibitors of Impdh Enzyme.
Representative Drug(s) D08EIA Drug Info IC50 = 8 nM Click to Show More [1]
2 D07ZCP Drug Info IC50 = 17 nM [1]
3 D03GSK Drug Info N.A. [1]
4 D0KN3S Drug Info N.A. [1]
Patent ID US20026399773
Title Compounds Derived From An Amine Nucleus That Are Inhibitors of Impdh Enzyme.
Applicant(s) Bristol-Myers Squibb Co
Representative Drug(s) D0HO8C Drug Info N.A. Click to Show More [1]
2 D0UD3K Drug Info N.A. [1]
Patent ID US20087427636
Title Inosine Monophosphate Dehydrogenase Inhibitory Phosphonate Compounds.
Applicant(s) Gilead Sciences Inc
Representative Drug(s) D04DRI Drug Info N.A. Click to Show More [1]
2 D05YHV Drug Info N.A. [1]
3 D0FZ1H Drug Info N.A. [1]
4 D0G9BO Drug Info N.A. [1]
5 D0GR7W Drug Info N.A. [1]
6 D0J4CI Drug Info N.A. [1]
7 D0K4AQ Drug Info N.A. [1]
8 D0L7QE Drug Info N.A. [1]
9 D0OS2M Drug Info N.A. [1]
10 D0TZ1Y Drug Info N.A. [1]
11 D0XQ3W Drug Info N.A. [1]
Patent ID US20036617323
Title Amino-Substituted Compounds Useful As Inhibitors of Impdh Enzyme.
Applicant(s) Bristol-Myers Squibb Co
Representative Drug(s) D0L5UM Drug Info N.A. Click to Show More [1]
2 D0QL7X Drug Info N.A. [1]
Patent ID US20036518291
Title Inhibitors of Impdh Enzyme.
Applicant(s) Vertex Pharmaceuticals, Inc
Representative Drug(s) D05BGS Drug Info N.A. Click to Show More [1]
2 D07WXU Drug Info N.A. [1]
Patent ID US20026420403
Title Inhibitors of Impdh Enzyme.
Applicant(s) Bristol-Myers Squibb Co
Representative Drug(s) D0NN4P Drug Info N.A. Click to Show More [1]
2 D0QA8T Drug Info N.A. [1]
Patent ID US20040023901
Title Nucleoside 5-Monophosphate Mimics and Their Prodrugs.
Applicant(s) Biota Inc
Representative Drug(s) D0OI4X Drug Info Ki = 940 nM [1]
Patent ID US20169447134
Title Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections.
Applicant(s) Brandeis University
Representative Drug(s) D0P8WC Drug Info N.A. [1]
Patent ID US20158969342
Title Compounds and Methods for Treating Mammalian Gastrointestinal Microbial Infections.
Applicant(s) Brandeis University
Representative Drug(s) D0V3HE Drug Info N.A. [1]
Patent ID US20128268873
Title Inhibitors of Impdh Enzyme.
Applicant(s) Vertex Pharmaceuticals, Inc
Patent ID US20128202889
Title Inhibitors of Bacterial Impdh.
Applicant(s) Vertex Pharmaceuticals Inc
Representative Drug(s) D0H5UL Drug Info N.A. [1]
Patent ID US20117989498
Title Inhibitors of Impdh Enzyme Technical Field of The Invention.
Applicant(s) Vertex Pharmaceuticals Inc
Patent ID US20107777069
Title Prodrugs of Carbamate Inhibitors of Impdh.
Applicant(s) Vertex Pharmaceuticals, Inc
Patent ID US20087432290
Title Inhibitors of Impdh Enzyme.
Applicant(s) Vertex Pharmaceuticals, Inc
Representative Drug(s) D05QIS Drug Info N.A. [1]
Patent ID US20087329681
Title Inhibitors of Impdh Enzyme.
Applicant(s) Vertex Pharmaceuticals, Inc
Patent ID US20077205324
Title Inhibitors of Impdh Enzyme.
Applicant(s) Bristol-Myers Squibb Co
Representative Drug(s) D0D5YK Drug Info N.A. [1]
Patent ID US20067087642
Title Inhibitors of Impdh Enzyme.
Applicant(s) Vertex Pharmaceuticals, Inc
Representative Drug(s) D00RJA Drug Info N.A. [1]
Patent ID US20067060720
Title Inhibitors of Impdh Enzyme.
Applicant(s) Bristol-Myers Squibb Co
Representative Drug(s) D0S7VL Drug Info N.A. [1]
Patent ID US20067053111
Title Inhibitors of Impdh Enzyme.
Applicant(s) Bristol-Myers Squibb Co
Representative Drug(s) D0Z7SK Drug Info N.A. [1]
Patent ID US20067008958
Title 2-Substituted 5-Oxazolyl Indole Compounds Useful As Impdh Inhibitors and Pharmaceutical Compositions Comprising Same.
Applicant(s) Bristol-Myers Squibb Co
Representative Drug(s) D0FY8B Drug Info N.A. [1]
Patent ID US20056967214
Title Inhibitors of Impdh Enzyme.
Applicant(s) Vertex Pharmaceuticals, Inc
Patent ID US20056867299
Title Oxamide Impdh Inhibitors.
Applicant(s) Hoffmann-La Roche Inc
Representative Drug(s) D0W3KK Drug Info N.A. [1]
Patent ID US20046825224
Title Prodrugs of Carbamate Inhibitors of Impdh.
Applicant(s) Vertex Pharmaceuticals, Inc
Patent ID US20036653309
Title Inhibitors of Impdh Enzyme Technical Field of The Invention.
Applicant(s) Vertex Pharmaceuticals Inc
Patent ID US20036624184
Title Amide and Diamide Inhibitors of Impdh Enzyme for Use In Treating Impdh-Associated Disorders.
Applicant(s) Bristol-Myers Squibb Co
Representative Drug(s) D07IOO Drug Info N.A. [1]
Patent ID US20036596747
Title Compounds Derived From An Amine Nucleus and Pharmaceutical Compositions Comprising Same.
Applicant(s) Bristol-Myers Squibb Co
Patent ID US20036541496
Title Inhibitors of Impdh Enzyme.
Applicant(s) Vertex Pharmaceuticals, Inc
Patent ID US20030105073
Title Quinolone Derivatives.
Applicant(s) Celltech R & D Ltd
Representative Drug(s) D0C8GW Drug Info N.A. [1]
Patent ID US20026498178
Title Inhibitors of Impdh Enzyme.
Applicant(s) Vertex Pharmaceuticals, Inc
Patent ID US20026395763
Title Prodrugs of Carbamate Inhibitors of Impdh.
Applicant(s) Vertex Pharmaceuticals, Inc
Representative Drug(s) D0F0ZE Drug Info N.A. [1]
Patent ID US20026344465
Title Inhibitors of Impdh Enzyme.
Applicant(s) Vertex Pharmaceuticals, Inc
Representative Drug(s) D0F0ZE Drug Info N.A. [1]
Patent ID US19985807876
Title Inhibitors of Impdh Enzyme.
Applicant(s) Vertex Pharmaceuticals, Inc
References  Top
REF 1 Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.

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