Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00RJA
|
|||
| Former ID |
DNC001506
|
|||
| Drug Name |
VX-148
|
|||
| Synonyms |
VX-148; SCHEMBL12343182; BDBM248095; VX-148 (3)
Click to Show/Hide
|
|||
| Drug Type |
Small molecular drug
|
|||
| Indication | Psoriasis vulgaris [ICD-11: EA90; ICD-9: 696] | Patented | [1] | |
| Structure |
 |
Download2D MOL |
||
| Formula |
C23H25N5O4
|
|||
| Canonical SMILES |
CCC(CC#N)OC(=O)NC(C)C1=CC(=CC=C1)NC(=O)NC2=CC(=C(C=C2)C#N)OC
|
|||
| InChI |
1S/C23H25N5O4/c1-4-20(10-11-24)32-23(30)26-15(2)16-6-5-7-18(12-16)27-22(29)28-19-9-8-17(14-25)21(13-19)31-3/h5-9,12-13,15,20H,4,10H2,1-3H3,(H,26,30)(H2,27,28,29)/t15-,20?/m0/s1
|
|||
| InChIKey |
PJFQWSNOXLEDDZ-OOJLDXBWSA-N
|
|||
| PubChem Compound ID | ||||
| PubChem Substance ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) | Target Info | Inhibitor | [2], [3] |
| Target's Patent Info | Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1) | Target's Patent Info | [2], [3] | |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013965) | |||
| REF 2 | Characterization of pharmacological efficacy of VX-148, a new, potent immunosuppressive inosine 5'-monophosphate dehydrogenase inhibitor. J Pharmacol Exp Ther. 2002 Sep;302(3):1272-7. | |||
| REF 3 | Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690. | |||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.