Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T38996 Target Info
Target Name Phospholipase D1 (PLD1)
Synonyms Phosphatidylcholine-hydrolyzing phospholipase D1; PLD 1; HPLD1; Choline phosphatase 1
Target Type Patented-recorded Target
Gene Name PLD1
Biochemical Class Phosphoric diester hydrolase
UniProt ID
PLD1_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US9453017
Title Antiviral therapies with phospholipase D inhibitors
Abstract Disclosed are methods of treating viral infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to antiviral therapies. For example, compounds having Phospholipase D activity (e.g., isoform selective Phospholipase D inhibitors) can be useful in antiviral therapies (e.g., influenza treatments).
Applicant(s) Vanderbilt University
Representative Drug(s) D0X0NV Drug Info IC50 = 3.7 nM Click to Show More [1]
2 D0CI4A Drug Info IC50 = 80 nM [1]
3 D08SLU Drug Info IC50 = 1500 nM [1]
Patent ID US9453017
Title Antiviral therapies with phospholipase D inhibitors
Abstract Disclosed are methods of treating viral infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to antiviral therapies. For example, compounds having Phospholipase D activity (e.g., isoform selective Phospholipase D inhibitors) can be useful in antiviral therapies (e.g., influenza treatments).
Applicant(s) Vanderbilt University
Representative Drug(s) D0X0NV Drug Info IC50 = 3.7 nM Click to Show More [1]
2 D0CI4A Drug Info IC50 = 80 nM [1]
3 D08SLU Drug Info IC50 = 1500 nM [1]
Patent ID US9453017
Title Antiviral therapies with phospholipase D inhibitors
Abstract Disclosed are methods of treating viral infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to antiviral therapies. For example, compounds having Phospholipase D activity (e.g., isoform selective Phospholipase D inhibitors) can be useful in antiviral therapies (e.g., influenza treatments).
Applicant(s) Vanderbilt University
Representative Drug(s) D0X0NV Drug Info IC50 = 3.7 nM Click to Show More [1]
2 D0CI4A Drug Info IC50 = 80 nM [1]
3 D08SLU Drug Info IC50 = 1500 nM [1]
Patent ID US9127005
Title Isoform selective phospholipase D inhibitors
Abstract Disclosed are isoform selective Phospholipase D inhibitors. In one aspect, the disclosed compounds can have a structure represented by a formula (I): Also disclosed are methods of making and using the compounds. Also disclosed are pharmaceutical compositions and kits comprising the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Applicant(s) Vanderbilt University
Representative Drug(s) D0OX9E Drug Info IC50 = 100 nM Click to Show More [2]
2 D09BSA Drug Info IC50 = 9440 nM [2]
3 D06OKT Drug Info IC50 > 20000nM [2]
Patent ID US9127005
Title Isoform selective phospholipase D inhibitors
Abstract Disclosed are isoform selective Phospholipase D inhibitors. In one aspect, the disclosed compounds can have a structure represented by a formula (I): Also disclosed are methods of making and using the compounds. Also disclosed are pharmaceutical compositions and kits comprising the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Applicant(s) Vanderbilt University
Representative Drug(s) D0OX9E Drug Info IC50 = 100 nM Click to Show More [2]
2 D09BSA Drug Info IC50 = 9440 nM [2]
3 D06OKT Drug Info IC50 > 20000nM [2]
Patent ID US9127005
Title Isoform selective phospholipase D inhibitors
Abstract Disclosed are isoform selective Phospholipase D inhibitors. In one aspect, the disclosed compounds can have a structure represented by a formula (I): Also disclosed are methods of making and using the compounds. Also disclosed are pharmaceutical compositions and kits comprising the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Applicant(s) Vanderbilt University
Representative Drug(s) D0OX9E Drug Info IC50 = 100 nM Click to Show More [2]
2 D09BSA Drug Info IC50 = 9440 nM [2]
3 D06OKT Drug Info IC50 > 20000nM [2]
References  Top
REF 1 Antiviral therapies with phospholipase D inhibitors. US9453017.
REF 2 Isoform selective phospholipase D inhibitors. US9127005.

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