miRNA General Information
miRNA Mature ID hsa-miR-543
miRNA Stemloop AC MI0005565
miRNA Stemloop ID hsa-mir-543
Sequence aaacauucgcggugcacuucuu
TTD Target(s) Regulated by This miRNA Matrix metalloproteinase-7 (MMP-7) Successful Target Target Info [1]
NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Target Info [2]
Nitric-oxide synthase endothelial (NOS3) Clinical trial Target Target Info [3]
Focal adhesion kinase 1 (FAK) Clinical trial Target Target Info [4]
Metastasis associated gene-1 (MTA1) Literature-reported Target Target Info [5]
Vitiligo-associated protein 1 (FBXO11) Literature-reported Target Target Info [6]
High mobility group protein HMGI-C (HMGA2) Literature-reported Target Target Info [7]
Protein(s) Regulated by This miRNA Twist-related protein 1 Regulated Protein [8]
Twist-related protein 1 Regulated Protein [4]
References
REF 1 Placental growth factor promotes metastases of ovarian cancer through MiR-543-regulated MMP7. Cell Physiol Biochem. 2015;37(3):1104-12.
REF 2 miR-543 promotes gastric cancer cell proliferation by targeting SIRT1. Biochem Biophys Res Commun. 2016 Jan 1;469(1):15-21.
REF 3 MicroRNA-335 and -543 suppress bone metastasis in prostate cancer via targeting endothelial nitric oxide synthase. Int J Mol Med. 2015 Nov;36(5):1417-25.
REF 4 MicroRNA-543 suppresses endometrial cancer oncogenicity via targeting FAK and TWIST1 expression. Arch Gynecol Obstet. 2014 Sep;290(3):533-41.
REF 5 MicroRNA-543 suppresses colorectal cancer growth and metastasis by targeting KRAS, MTA1 and HMGA2. Oncotarget. 2016 Apr 19;7(16):21825-39.
REF 6 MiRNA-543 promotes osteosarcoma cell proliferation and glycolysis by partially suppressing PRMT9 and stabilizing HIF-1 protein. Oncotarget. 2017 Jan 10;8(2):2342-2355.
REF 7 A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins. Nat Methods. 2011 May 15;8(7):559-64.
REF 8 MicroRNAs in the imprinted DLK1-DIO3 region repress the epithelial-to-mesenchymal transition by targeting the TWIST1 protein signaling network. J Biol Chem. 2012 Dec 14;287(51):42695-707.
REF 9 MicroRNA-543 suppresses endometrial cancer oncogenicity via targeting FAK and TWIST1 expression. Arch Gynecol Obstet. 2014 Sep;290(3):533-41.

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