miRNA General Information
miRNA Mature ID hsa-miR-449b-5p
miRNA Stemloop AC MI0003673
miRNA Stemloop ID hsa-mir-449b
Sequence aggcaguguauuguuagcuggc
TTD Target(s) Regulated by This miRNA Histone deacetylase 1 (HDAC1) Successful Target Target Info [1]
Cyclin-dependent kinase 4 (CDK4) Successful Target Target Info [2]
Cyclin-dependent kinase 6 (CDK6) Successful Target Target Info [2]
Proto-oncogene c-Met (MET) Successful Target Target Info [1]
NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Target Info [1]
M-phase inducer phosphatase 1 (MPIP1) Literature-reported Target Target Info [2]
Geminin (GMNN) Literature-reported Target Target Info [1]
N-myc proto-oncogene protein (MYCN) Literature-reported Target Target Info [3]
G1/S-specific cyclin-E2 (CCNE2) Literature-reported Target Target Info [1]
References
REF 1 miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. Mol Cancer. 2011 Mar 18;10:29.
REF 2 miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev. 2009 Oct 15;23(20):2388-93.
REF 3 A combined gene expression and functional study reveals the crosstalk between N-Myc and differentiation-inducing microRNAs in neuroblastoma cells. Oncotarget. 2016 Nov 29;7(48):79372-79387.

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